Hyperuricemia is associated with sympathovagal imbalance in older adults.

Abstract:

PURPOSE:This study aimed to compare heart rate variability (HRV) parameters obtained through symbolic analysis (SA), between older adults with and without hyperuricemia. METHODS:This is a cross-sectional study including 202 community-dwelling old adults, which was clinically stratified as with or without hyperuricemia, according to the cutoff point of serum uric acid ≥ 6 mg/dL for women and ≥ 7 mg/dL for men. Successive RR intervals were recorded along 5 min and analyzed with SA method. 0 V%, 1 V% and 2 V% patterns were quantified and compared between groups. Comparisons were carried out through parametric or nonparametric tests, according to the data distribution characteristics, evaluated by Kolmogorov-Smirnov test. The significance level was set as p ≤ 0.05 for all statistical procedures. RESULTS:The prevalence of hyperuricemia was 67.8 %, and the hyperuricemic older adults exhibited significant higher values for V0% and lower values for V2% parameters when compared to normouricemic older adults. CONCLUSION:These results suggesting a sympathovagal imbalance in hyperuricemic older adults, characterized by greater sympathetic predominance (0 V%) and lower vagal modulation (2 V%) at rest conditions.

journal_name

Arch Gerontol Geriatr

authors

Passos RS,Ribeiro ÍJS,Freire IV,Teles MF,Pires RA,Schettino L,Oliveira AA,Casotti CA,Pereira R

doi

10.1016/j.archger.2020.104132

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

104132

eissn

0167-4943

issn

1872-6976

pii

S0167-4943(20)30126-6

journal_volume

90

pub_type

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