Abstract:
PURPOSE:The harmonic spectrum of magnetic nanoparticles contains valuable information about the quantity and environment of the particles. Harmonic amplitudes have been used to produce quantitative images and ratios of these amplitudes have been used to monitor changes in the particle environment. Harmonic phase angles have not yet been utilized in these pursuits. The authors explore harmonic phase angle as a concentration-independent means of remotely monitoring the dynamic magnetization of nanoparticles. METHODS:A magnetic nanoparticle spectrometer was used to explore the impacts of viscosity and excitation frequency and amplitude on the phase angle of magnetization harmonics. A dynamic model, which accounts for particle relaxation times, was used to model some results. RESULTS:Harmonic phase angle can undergo large changes when a nanoparticle's Brownian motion is altered. Excitation parameters and particle characteristics have a profound effect on the extent of these changes. CONCLUSIONS:Phase angle can allow for monitoring of various impacts on a nanoparticle's Brownian motion. When combined with other concentration-independent metrics, such as ratios of harmonic amplitudes, valuable information about the particle's environment can be gathered.
journal_name
Med Physjournal_title
Medical physicsauthors
Rauwerdink AM,Weaver JBdoi
10.1118/1.3426294subject
Has Abstractpub_date
2010-06-01 00:00:00pages
2587-92issue
6eissn
0094-2405issn
2473-4209journal_volume
37pub_type
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