Abstract：
:Diagnosing cancer using microarray analysis to study differential gene expression has been a recent focus of intense research Although several very sophisticated analysis tools have been developed with this aim in mind, it still remains a challenge to keep these methods free of parametric adjustments as well as maintain their transparency for the final user. Nonparametric methods in general have been associated with these last two characteristics, thus becoming attractive tools for microarray analysis in cancer research. In particular, diagnosing cancer via microarray analysis is an exercise whereby tissue is characterized according to its differential gene expression levels. In this manuscript, two novel nonparametric methods for cancer diagnosis using microarray data are described and their performance assessed against a baseline approach that utilizes the Mann-Whitney test for median differences. Both methods show promising results in terms of their potential use in making diagnoses.
journal_name
P R Health Sci Jjournal_title
Puerto Rico health sciences journalauthors
Rodríguez JA,Rivero L,Sánchez-Peña ML,Isaza CE,Cabrera-Ríos Msubject
Has Abstractpub_date
2010-09-01 00:00:00pages
305-11issue
3eissn
0738-0658issn
2373-6011journal_volume
29pub_type
杂志文章abstract：:Atrial fibrillation (AF) is the most common sustained arrhythmia in adults. It is a significant public health problem in the United States where it affects 2.2 million Americans and almost 10% of the population older than 80 years. It should be emphasized that the prevalence of AF increases with advancing age and with...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章,评审
doi：
更新日期：2004-12-01 00:00:00
abstract：OBJECTIVE:Thyroid cancer has become one of the fastest growing malignancies in several countries worldwide. Few studies have examined thyroid cancer trends in Puerto Rico, and those studies have been conducted over relatively short time frames. This study aimed to describe both overall thyroid cancer incidence trends b...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2011-09-01 00:00:00
abstract：:Alzheimer's Disease. The untold story. After considering the potential relationship between amyloid deposits and myxedematous infiltrations, the hypothesis is formulated that Alzheimer's disease may be due to functional hypothyroidism and may thus respond to thyroid therapy. ...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：1993-06-01 00:00:00
abstract：:Four hundred and sixty six non-institutionalized seniors, 65 years of age and over comprise the sample. The questions pertaining to the specific topic are made up of 17 items: 9 related to background information and 8 relating to nutritional practices. It is part of a larger study of the socio-demographic characterist...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the utility of the substituted judgement standard in terminally ill patients by determining agreement between patients, family proxies and physicians. BACKGROUND:Several studies have addressed the utility of substituted judgement, showing conflicting data whether surrogates are accurate predictin...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：OBJECTIVE:People with type 1 diabetes (T1D) may experience significant changes in their daily routines due to this condition, which frequently results in depressive symptoms and the deterioration of their quality of life. We examined the factors associated with suicidal ideation (SI) and diabetes-related quality of lif...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVE:This study assesses the antitubercular potential of natural products obtained from plants reputed to have medicinal properties and collected from the tropical flora of Puerto Rico. BACKGROUND:The increase in persons infected with Mycobacterium tuberculosis (MTB) the world over and the development of resistan...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：:Osteoporosis in men was not recognized as a major health problem until recently, and increased research in this area resulted in the approval of alendronate for the treatment of osteoporosis in men at the beginning of this decade. Low bone mineral density (BMD) has been demonstrated to be a strong predictor of fractur...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2005-06-01 00:00:00
abstract：:Endothelial cell proliferation and differentiation into blood capillaries (i.e., angiogenesis) are essential for growth and development, wound healing, osetogenesis, etc. But abnormal angiogenesis during tumor progression could lead to serious consequences. Angiogenesis is a complex biochemical process, and is often d...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:Since the year 2000, extracorporeal membrane oxygenation (ECMO) support for cardiac failure has been employed in the post operative care of children at the Centro Cardiovascular de Puerto Rico y el Caribe. Our experience with the application of ECMO had been limited to circulatory support after repair of congenital ca...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2004-03-01 00:00:00
abstract：OBJECTIVE:A cross-sectional study was conducted (2012-2013) to evaluate the prevalence of 1) malocclusion and 2) occlusal characteristics in 13- to 18-yearold adolescents in San Juan, Puerto Rico (PR) from selected high schools in the municipality of San Juan. METHODS:The study sample consisted of 155 adolescents. The...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2017-06-01 00:00:00
abstract：:Patients hospitalized with unstable angina (UA) or with a non-ST segment elevation myocardial infarct (NSTEMI) are at increased risk of suffering refractory angina, recurrent myocardial infarct (MI), and death. These patients need to be evaluated more aggressively. According to the last published guidelines (2002) of ...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章,评审
doi：
更新日期：2005-12-01 00:00:00
abstract：:Significant new findings in the last decade have demonstrated that the vascular endothelium is an important regulatory organ in maintaining cardiovascular homeostasis and that endothelial dysfunction is present in several cardiovascular diseases. With the production of multiple vasoactive substances the normal endothe...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章,评审
doi：
更新日期：1997-06-01 00:00:00
abstract：OBJECTIVE:Bladder cancer is, in Poland, the fourth most common malignancy in men and the eighth most common in women. Radical cystectomy often seems to be the only method of treatment. This mutilating procedure may affect the quality of life of the patient. The aim of our study was to analyze the impact of factors infl...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2018-09-01 00:00:00
abstract：:We tested a dietary supplement formulated with a synergistic combination of vitamins, minerals, herbals in a group of 15 patients with uncontrolled diabetes type II. The supplement was given for 30 days. Fasting blood glucose was measured prior to the supplementation and at the end of the 30 days treatment period. Blo...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
abstract：OBJECTIVE:To determine the frequency of pediatric brain tumors treated at the University Pediatric Hospital of Puerto Rico over a 6-year period and examine the demographic data and tumor histology of patients in different age groups. METHODS:A retrospective study was undertaken at the University Pediatric Hospital. We...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
abstract：:Breastfeeding has experienced a surge in Puerto Rico thanks to the efforts of many women, as well as governmental, non-governmental and private organizations. Among the aspects which can affect the initiation, establishment and maintenance of successful breastfeeding one finds potential ethical conflicts among health ...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：OBJECTIVES:The recent boom in patient education on chronic hepatitis C has resulted in a worldwide increase in the diagnosis of this condition. Available treatment is expensive and associated with significant side effects; therefore, many patients seek for alternative medicine. Silybum marianum is a natural herb known ...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2004-06-01 00:00:00
abstract：OBJECTIVE:A preliminary investigation to test the efficacy of intravenous propranolol in reducing the cesarean section rate in nulliparas in active labor and evaluate its effect on neonatal and maternal outcomes. METHODS:Fifty seven nulliparous patients admitted in active labor were randomly divided into two groups: a...
journal_title：Puerto Rico health sciences journal
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1999-03-01 00:00:00
abstract：OBJECTIVE:Colorectal cancer (CRC) is among the most common cancers in Puerto Rico. Few studies have correlated clinical and pathological variables with the overall survival of CRC patients in Puerto Rico. We report the clinical and pathological characteristics of patients who underwent surgical resection at a community...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2014-06-01 00:00:00
abstract：:A retrospective review was performed from November 2011 through June 2012 in 49 stable patients receiving ambulatory hemodialysis at the dialysis unit of the University Hospital in San Juan. Measurements of serum phosphate, serum calcium (corrected to albumin levels), intact parathyroid hormone (PTH), and pulse pressu...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVE:To determine the IgE reactivity against recombinant protein Blo t 1 from the dust mite Blomia tropicalis (Bt) using serum from patients with positive skin test to this mite and to investigate the cross-reactivity between Bt and Dermatophagoides pteronyssinus. BACKGROUND:Dust mites have an important role as i...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
abstract：:We present the case of a 9 year old girl with history of progressive pneumatoceles and infection since she was 3 years old. A chest computerized tomography revealed a cystic lung mass. The patient was taken to surgery and a left lower lobe lobectomy was performed. The pathologic diagnosis was that of a congenital cyst...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
abstract：:Hypokalemic periodic paralysis (hypoKPP) is a clinical entity characterized by recurrent skeletal muscle paralysis due to a decrease in serum potassium levels; hypoKPP can have either a primary (familial) or a secondary cause. One of the secondary causes of hypoKPP is distal renal tubular acidosis (dRTA). Distal renal...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2017-12-01 00:00:00
abstract：:Primary hepatic actinomycosis is an uncommon entity. We report the case of a young man with past history of an appendectomy who presented with fever, weight loss and a liver mass that was initially suspected to be neoplastic. Percutaneous liver biopsy revealed actinomyces-like organisms. The patient was treated with i...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章,评审
doi：
更新日期：1992-04-01 00:00:00
abstract：OBJECTIVE:To determine the prevalence of hypothyroidism in an adult female population in Puerto Rico and to determine the relationship between hypothyroidism, bone mineral density and vertebral and non-vertebral fractures in this population. METHODS:Data from the 400 subjects' database of the Latin American Vertebral ...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVE:This study was conducted to determine the experience of tooth loss, as well as its associated variables, in a sample of adult Mexicans, aged 60 years and older. MATERIALS AND METHODS:This cross-sectional study was part of a larger project to measure diverse oral health indicators in a convenience sample: it ...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2016-06-01 00:00:00
abstract：:Seventy two partial subperiosteal implants were inserted in 52 patients. Thirty six of these implants had a classical design in which the submerged structure had thick primary and secondary connectors. Thirty six implants had a newly designed submerged structure consisting of long and thin primary connectors with groo...
journal_title：Puerto Rico health sciences journal
pub_type： 临床试验,杂志文章
doi：
更新日期：1994-09-01 00:00:00
abstract：:This brief celebration of the work of Francisco Guerra (1916-2011) highlights his role as mentor for an international community, his study of local events in the context of global developments, and his contributions to the understanding of the medical history of Puerto Rico. A selective review of Francisco Guerra's me...
journal_title：Puerto Rico health sciences journal
pub_type： 传,历史文章,杂志文章
doi：
更新日期：2012-06-01 00:00:00
abstract：:There has been a constant increase in the incidence of dengue in the Americas over the past 15 years. This has been caused by increased frequency of epidemic activity in most countries, as a result of increased numbers of virus serotypes circulating in the region. The change in disease ecology has resulted in the emer...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章,评审
doi：
更新日期：1987-08-01 00:00:00
