Abstract：
:The present study was performed in order to study the development of sinusoidal blood flow heterogeneity during stepwise bleeding and during prolonged hemorrhagic hypotension. Two methods have been applied: Hepatic surface oxygen tension was measured by a multi-gold-wire-cathode. Sinusoidal perfusion patterns were demonstrated by use of fluorochromed plasma proteins. During stepwise bleeding the relative decrease of the five individual sPO2 curves showed different slopes in the same rat thus indicating a flow dependent heterogeneity. The corresponding perfusion patterns were characterized by an irregular convection front. Time dependent flow heterogeneity resulted in a perfusion pattern showing predominantly perfused sinusoids and low or no flow sinusoids, whereby the predominantly perfused sinusoids might be taken as sinusoidal shunts. It is concluded that stepwise bleeding results in a functional redistribution depending upon the degree of reduced flow, while long time induced microcirculatory changes result in sinusoidal shunt flow depending upon morphological alterations.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Schywalsky M,Metzger HPdoi
10.1007/978-1-4684-8181-5_79subject
Has Abstractpub_date
1990-01-01 00:00:00pages
697-703eissn
0065-2598issn
2214-8019journal_volume
277pub_type
杂志文章abstract：:Besides mechanical and protective function, bone serves as a keeper for marrow cells and an organ for regulation of calcium ion homeostasis. During aging, significant amounts of the bone are lost due to the loss of this delicate balance toward increased bone resorption coupled with decreased formation, which leads to ...
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journal_title：Advances in experimental medicine and biology
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更新日期：1996-01-01 00:00:00
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更新日期：2019-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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journal_title：Advances in experimental medicine and biology
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更新日期：2006-01-01 00:00:00
