The effects of enteral stimulation on gallbladder bile during total parenteral nutrition in the neonatal piglet.


:The neonatal piglet is a satisfactory model for the human neonate requiring total parenteral nutrition (TPN). Bile status and subsequent liver and gallbladder dysfunction have long been documented as serious complications of long-term TPN. The purpose of this study was to determine whether small amounts of enteral formula during TPN will maintain normal bile appearance and composition. Thirty-one Hanford miniswine, 3 to 6 days old underwent surgery for the placement of central venous catheters. Two days postoperatively, the animals were separated into three groups, according to dietary regimens. Group 1 (n = 10), the control group, received pig formula (SPF-lac) orally (200 cal/kg/d); group 2 (n = 11), was maintained on TPN (180 cal/kg/d) with an enteral supplement of SPF-lac (20 cal/kg/d); group 3 (n = 10), was maintained on TPN only (200 cal/kg/d). The TPN formula consisted of 35 g/kg/d of glucose, 10 g/kg/d of protein, and 3 g/kg/d of lipid. The animals were maintained on these diets for 6 weeks. At necropsy, gallbladder with bile was weighed and bile volume and appearance was recorded. Chemical analyses was performed on 26 bile samples. Gallbladder weight was significantly decreased in groups 2 and 3 compared with group 1 (P less than .0003, P less than .033, respectively, using Students t test with Bonferoni adjustment). Volume was significantly decreased only in group 2 (P less than .003). Group differentiation in relation to bile appearance was determined by the presence or absence of either bile sludge or crystals.(ABSTRACT TRUNCATED AT 250 WORDS)


J Pediatr Surg


Cohen IT,Meunier KM,Hirsh MP




Has Abstract


1990-01-01 00:00:00














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    abstract::Kasai operation for biliary atresia (BA) and living-related liver transplantation (LRLT) for failed Kasai cases have been performed by the same team in our hospital. Outcome of the treatment for BA in the pretransplantation and posttransplantation era in our institution were compared. As the "pre" group, 35 children f...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Inomata Y,Oike F,Okamoto S,Uemoto S,Asonuma K,Egawa H,Kiuchi T,Okajima H,Tanaka K

    更新日期:1997-08-01 00:00:00

  • Gastric contractility in experimental gastroschisis.

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Cavalcante MB,de Lima FJ,Okoba W,Oliveira-Filho FJ,Sbragia L,Magalhães PJ,de Souza MH,Melo-Filho AA

    更新日期:2013-02-01 00:00:00

  • The risk factors and clinical significance of acute postoperative complications after unstented pediatric pyeloplasty: a single surgeon's experience.

    abstract:PURPOSE:To analyze the risk factors and clinical significance of postoperative complications after unstented pediatric pyeloplasty. MATERIALS AND METHODS:We analyzed 285 kidney units (KUs) on which unstented pyeloplasty was performed between April 2002 and March 2010. Measures included preoperative factors, postoperat...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Lee YS,Lee CN,Kim MU,Jang WS,Lee H,Im YJ,Han SW

    更新日期:2014-07-01 00:00:00

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    abstract:PURPOSE:The authors developed a clinical pathway for optimal management after antenatal diagnosis of gastroschisis. This is the outcomes analysis of our first 30 consecutive patients. METHOD:Antenatal counseling was provided for all families with in-utero diagnosis of gastroschisis. Bowel dilatation, thickness, motili...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Vegunta RK,Wallace LJ,Leonardi MR,Gross TL,Renfroe Y,Marshall JS,Cohen HS,Hocker JR,Macwan KS,Clark SE,Ramiro S,Pearl RH

    更新日期:2005-03-01 00:00:00

  • Pediatric genital burns: a 15-year retrospective analysis of outcomes at a level 1 burn center.

    abstract:BACKGROUND/PURPOSE:Burns involving the genitalia and perineum are commonly seen in the context of extensive total body surface area (TBSA) burns and rarely as isolated injuries because of protection provided by the thighs and the abdomen. Genital burns usually result in extended hospital stays and are accompanied by se...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Klaassen Z,Go PH,Mansour EH,Marano MA,Petrone SJ,Houng AP,Chamberlain RS

    更新日期:2011-08-01 00:00:00

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Piper HG,Oltmann SC,Xu L,Adusumilli S,Fischer AC

    更新日期:2012-11-01 00:00:00

  • Metabolic bone disease in pediatric intestinal failure patients: prevalence and risk factors.

    abstract:PURPOSE:Patients with intestinal failure (IF) are known to have impaired absorption of nutrients required for maintenance of skeletal mass. Rates and risk factors of low bone mineral density (BMD) are unknown in pediatric IF patients. METHODS:Following IRB approval, patients with IF having undergone DXA scans were ide...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Khan FA,Fisher JG,Bairdain S,Sparks EA,Zurakowski D,Modi BP,Duggan C,Jaksic T

    更新日期:2015-01-01 00:00:00

  • The incidence of long-term hypertension in children after high-grade renal trauma.

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


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    更新日期:2015-11-01 00:00:00

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Shamberger RC,Welch KJ

    更新日期:1988-07-01 00:00:00

  • Acute abdominal symptoms and signs in children and young adults with spina bifida: ten years' experience.

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Worley G,Wiener JS,George TM,Fuchs HE,Mackey JF,Fitch RD,Oldham KT

    更新日期:2001-09-01 00:00:00

  • Transabdominal testicular descent is disrupted in mice with deletion of insulinlike factor 3 receptor.

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Tomiyama H,Hutson JM,Truong A,Agoulnik AI

    更新日期:2003-12-01 00:00:00

  • Thoracoscopic resection of intra- and extralobar pulmonary sequestration in the first 3 months of life.

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Jesch NK,Leonhardt J,Sumpelmann R,Gluer S,Nustede R,Ure BM

    更新日期:2005-09-01 00:00:00

  • Cystosarcoma phylloides in the adolescent female.

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Mollitt DL,Golladay ES,Gloster ES,Jimenez JF

    更新日期:1987-10-01 00:00:00

  • Solitary infantile gastrointestinal myofibroma: case report.

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Menéndez-Arzac R,Valdez-Méndez D,Landa R,Guzmán S,Cárdenas E,Cano AM

    更新日期:2005-08-01 00:00:00

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    journal_title:Journal of pediatric surgery

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Elhalaby EA,Hashish A,Elbarbary MM,Soliman HA,Wishahy MK,Elkholy A,Abdelhay S,Elbehery M,Halawa N,Gobran T,Shehata S,Elkhouly N,Hamza AF

    更新日期:2004-03-01 00:00:00

  • Evaluation of bone mineral density with dual x-ray absorptiometry for osteoporosis in children with bladder augmentation.

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Abeş M,Sarihan H,Madenci E

    更新日期:2003-02-01 00:00:00

  • Review of the radiation exposure during screening of surgically implanted central venous access devices.

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    journal_title:Journal of pediatric surgery

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Moore TC,Landers DB,Lachman RS,Ament ME

    更新日期:1979-04-01 00:00:00

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Toselli L,Millán C,Gallardo CC,Prodan S,Bignón H,Munzón GB,Buela E,Valverde MS,Rabinovich F,Martínez J,Calello S,Cieri P,Martínez-Ferro M

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    journal_title:Journal of pediatric surgery

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    更新日期:2017-08-01 00:00:00

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


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    journal_title:Journal of pediatric surgery

    pub_type: 临床试验,杂志文章


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    更新日期:2004-10-01 00:00:00

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


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    abstract:BACKGROUND:Sacrococcygeal tumors (SCT) are relatively uncommon tumors affecting neonates, infants and children. The aim of this article is to clarify any special characterizations in natural history, clinical presentation and outcome of such tumors treated at South Egypt Cancer Institute, the only research center locat...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Sayed HA,Ali AM,Hamza HM,Mourad AF,Eltayeb AA

    更新日期:2013-07-01 00:00:00

  • A more than 25-year experience with end-to-end versus end-to-side repair for esophageal atresia.

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Poenaru D,Laberge JM,Neilson IR,Nguyen LT,Guttman FM

    更新日期:1991-04-01 00:00:00

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Mahfouz ES,Issa MA,Farag TI,Naguib KK,al-Awadi SA,Schimke RN

    更新日期:1990-06-01 00:00:00

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Hung WT,Su CT

    更新日期:1990-07-01 00:00:00

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    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章


    authors: Vaos G,Demetriou L,Velaoras C,Skondras C

    更新日期:2008-07-01 00:00:00