Medial thickening of hepatic artery branches in biliary atresia. A morphometric study.

Abstract:

BACKGROUND/PURPOSE:Medial layer hypertrophy of hepatic arterial branches may be associated with biliary atresia (BA) pathogenesis. This study aimed at evaluating medial layer thickness in hepatic arterial branches at portoenterostomy and liver transplantation. METHODS:The authors evaluated 1274 arterial branches both in BA cases and in control subjects involving a total of 1108 arterioles and 166 arteries. Arterial branch characteristics were morphometrically evaluated in 47 BA patients at the time of portoenterostomy. Controls were patients with intrahepatic cholestasis (n = 3), immature neonates (n = 7), and infants (n = 7) without liver disease. Progression of medial layer thickening between the time of portoenterostomy and transplantation was evaluated in 7 BA patients. Biliary atresia patients at the time of transplantation were compared with non-BA-transplanted patients (n = 4). RESULTS:The arterial medial layer of BA cases at portoenterostomy was thicker than that of infants without liver disease ( P = .03). The arterial medial thickness increased during the interval between portoenterostomy and transplantation ( P = .05). Arterioles and arteries with thickened medial layers were found in transplanted BA patients but not in patients transplanted for other liver diseases (P = .05 and P = .01). Thickening of the medial layer of the hepatic arteries was associated with focal distribution of interlobular bile ducts in portal spaces in BA ( P = .02). CONCLUSIONS:In BA, there is a progressive thickening of the arterial medial layer, suggestive of vascular remodeling, which is associated to the disappearance of interlobular bile ducts.

journal_name

J Pediatr Surg

authors

dos Santos JL,da Silveira TR,da Silva VD,Cerski CT,Wagner MB

doi

10.1016/j.jpedsurg.2004.12.002

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

637-42

issue

4

eissn

0022-3468

issn

1531-5037

pii

S0022346804008681

journal_volume

40

pub_type

杂志文章
  • Three-dimensional visualization and virtual simulation of resections in pediatric solid tumors.

    abstract:PURPOSE:Three-dimensional visualization of solid tumors is possible because of high-resolution computed tomography and magnetic resonance imaging scans. However, additional preoperative information is often desirable in complex malignancies. For the first time, the authors present a model of preoperative 3-dimensional ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2004.10.026

    authors: Fuchs J,Warmann SW,Szavay P,Kirschner HJ,Schäfer JF,Hennemuth A,Scheel-Walter HG,Bourquain H,Peitgen HO

    更新日期:2005-02-01 00:00:00

  • Fatty liver caused by portal vein thrombosis after living donor liver transplantation: a case report.

    abstract::Portal vein thrombosis (PVT) is a rare complication that occurs after liver transplantation: however, it cannot be ignored as a cause of graft loss and death. We herein report a pediatric case of PVT that caused a fatty change in the graft after living donor liver transplantation. The portal vein was successfully reco...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2005.05.029

    authors: Ogita K,Taguchi T,Soejima Y,Ieiri S,Katsura S,Takada N,Matsuura T,Yoshizumi T,Shimada M,Maehara Y,Suita S

    更新日期:2005-08-01 00:00:00

  • Fetal bone marrow homing of donor mesenchymal stem cells after transamniotic stem cell therapy (TRASCET).

    abstract:PURPOSE:Donor cell engraftment patterns following transamniotic stem cell therapy (TRASCET) with amniotic fluid mesenchymal stem cells (afMSCs) are incompatible with solely direct amniotic seeding. We sought to determine whether fetal bone marrow is a component of such engraftment and to examine the chronology of afMSC...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2017.10.033

    authors: Shieh HF,Ahmed A,Tracy SA,Zurakowski D,Fauza DO

    更新日期:2017-10-12 00:00:00

  • Characterization and treatment of biliary anastomotic stricture after segmental liver transplantation.

    abstract:BACKGROUND/PURPOSE:Biliary anastomotic strictures (BAS) after left lateral segment liver transplantation (LLST) may cause graft dysfunction, sepsis, and patient mortality. A review of the authors' experience was performed to better characterize the risk factors and corrective management. METHODS:The medical records of...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1053/jpsu.2000.6932

    authors: Schindel D,Dunn S,Casas A,Billmire D,Vinocur C,Weintraub W

    更新日期:2000-06-01 00:00:00

  • Surveillance of Barrett's esophagus in children.

    abstract:PURPOSE:The aim of this study was to review the need for regular endoscopic biopsy of Barrett's esophagus in children. METHODS:This was a retrospective case-notes review of 38 children with Barrett's esophagus treated between January 1982 and August 1997. The mean age at diagnosis was 6.3 years (range, 1 to 15 years)....

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(99)90235-x

    authors: Beddow EC,Wilcox DT,Drake DP,Pierro A,Kiely EM,Spitz L

    更新日期:1999-01-01 00:00:00

  • The epidemiology of infant injuries and alarming health disparities.

    abstract:PURPOSE:Injury epidemiology is the underappreciated foundation of injury prevention and control strategies. Given the substantial disparity of infant injury-related mortality between African Americans (AA) and whites in our region, we sought to better understand the epidemiology of infant injury-related mortality rates...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2006.09.015

    authors: Falcone RA Jr,Brown RL,Garcia VF

    更新日期:2007-01-01 00:00:00

  • Intraoperative colonic lavage in a premature infant: a case report.

    abstract::Left-sided colonic obstruction in the neonate traditionally is managed with a multistaged defunctioning colostomy and resection. In adults, one-stage primary anastomosis has become increasingly popular with the use of on-table antegrade colonic lavage. In infants, and especially in premature neonates, enterostomies po...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1053/jpsu.2002.36205

    authors: Ognibene SJ,Koniaris LG,Pegoli W Jr,Drugas GT

    更新日期:2002-11-01 00:00:00

  • Outcome analysis of neonates with congenital diaphragmatic hernia treated with venovenous vs venoarterial extracorporeal membrane oxygenation.

    abstract:PURPOSE:Venoarterial extracorporeal membrane oxygenation (ECMO) (VA) is used more commonly in neonates with congenital diaphragmatic hernia (CDH) than venovenous ECMO (VV). We hypothesized that VV may result in comparable outcomes in infants with CDH requiring ECMO. METHODS:We retrospectively analyzed the Extracorpore...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2009.01.017

    authors: Guner YS,Khemani RG,Qureshi FG,Wee CP,Austin MT,Dorey F,Rycus PT,Ford HR,Friedlich P,Stein JE

    更新日期:2009-09-01 00:00:00

  • The implication of intestinal bacterial translocation in central line associated blood stream infections in the pediatric population.

    abstract:INTRODUCTION:Bacterial intestinal translocation plays an important role in neonatal sepsis. We aimed to elucidate the importance of such translocation in causing central line associated blood stream infection (CLABSI) in patients undergoing gastrointestinal surgery (GIS). METHODS:Using a database of pediatric patients...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2020.02.012

    authors: Haddad FC,Rao R,Kaur S,Redkey J,Karcz A,Ladd AP

    更新日期:2020-08-01 00:00:00

  • Assessment of anastomotic reliability with pulse oximetry in graded intestinal ischemia: an experimental study in dogs.

    abstract:BACKGROUND/PURPOSE:Pulse oximetry has been proposed as an appropriate and feasible technique in the assessment of intestinal ischemia in recent years. In this study the authors aimed to assess the reliability of anastomoses in the dog small intestine in which there is graded irreversible ischemia as measured by pulse o...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(97)90517-0

    authors: Türkyilmaz Z,Sönmez K,Başaklar AC,Demiroğullari B,Numanoğlu V,Ekingen G,Dursun A,Altin MA,Kale N

    更新日期:1997-12-01 00:00:00

  • New techniques in the diagnosis and operative management of Siamese twins.

    abstract::New techniques of 2-D sonography and radionucleotide Disofenin scanning allowed noninvasive evaluation of thoracoomphalopagus Siamese twins and successful separation at four days of age. Twin girls joined at the lower sternum and upper abdomen and weighing 15 lbs, were transferred at five hours of age after caesarian-...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(83)80184-5

    authors: Miller D,Colombani P,Buck JR,Dudgeon DL,Haller JA Jr

    更新日期:1983-08-01 00:00:00

  • Erythropoietin restores bowel damage and hypoperistalsis in gastroschisis.

    abstract:BACKGROUND AND PURPOSE:Despite the decreased mortality in gastroschisis (Gx), patients experience postoperative intestinal hypoperistalsis, malabsorption, and shortened bowel length. The trophic effects of recombinant human erythropoietin (rEpo) in the developing small bowel have been reported, increasing the length an...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2005.11.012

    authors: Ozdamar A,Topcu K,Gumustekin M,Gurel D,Gelal A,Ozer E,Ucan B,Temir G,Karkiner A,Karaca I,Hosgor M

    更新日期:2006-02-01 00:00:00

  • The great debate: open or thoracoscopic repair for oesophageal atresia or diaphragmatic hernia.

    abstract::Controversy exists over the best method and technique of repair of oesophageal atresia and diaphragmatic hernia. Open surgical repairs have a long established history of over 60 years of experience. Set against this has been a series of successful thoracoscopic repairs of both congenital anomalies reported over the pa...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.jpedsurg.2014.11.008

    authors: Davenport M,Rothenberg SS,Crabbe DC,Wulkan ML

    更新日期:2015-02-01 00:00:00

  • Unusual presentation of heteropagus attached to the thorax.

    abstract::The endoparasitic twin is the most common form of asymmetric fetal duplication (heteropagus). A 2-month-old girl who had a parasitic right lower limb with axial skeleton, vertebral column, uterus, fallopian tube, ovary, and bladder implanted in the sternum region is described as another example of exoparasitic twin, t...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(97)90573-x

    authors: Corona-Rivera JR,Acosta-León J,Velez-Gómez E,Navarro-Ramírez P,Corona-Rivera A,Corona-Rivera E

    更新日期:1997-10-01 00:00:00

  • Perforation of Meckel's diverticulum in infancy.

    abstract::Nine infants underwent operations for perforation of a Meckel's diverticulum over a 21-yr period. All of the infants were acutely ill when initially seen by the surgical service. Lethargy, irritability, anorexia, fever, abdominal tenderness, and passage of blood in the stools were common clinical manifestations. The p...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/0022-3468(75)90277-8

    authors: Canty T,Meguid MM,Eraklis AJ

    更新日期:1975-04-01 00:00:00

  • Inhaled nitric oxide inhibits the release of matrix metalloproteinase-2, but not platelet activation, during extracorporeal membrane oxygenation in adult rabbits.

    abstract:BACKGROUND/PURPOSE:In neonates receiving extracorporeal membrane oxygenation (ECMO), platelet activation and dysfunction occur with the release of matrix metalloproteinase (MMP)-2, which stimulates platelet aggregation. Because inhaled nitric oxide (NO) reduces pulmonary hypertension and inhibits platelet aggregation, ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1053/jpsu.2003.50116

    authors: Cheung PY,Sawicki G,Peliowski A,Etches PC,Schulz R,Radomski MW

    更新日期:2003-04-01 00:00:00

  • The risk factors and clinical significance of acute postoperative complications after unstented pediatric pyeloplasty: a single surgeon's experience.

    abstract:PURPOSE:To analyze the risk factors and clinical significance of postoperative complications after unstented pediatric pyeloplasty. MATERIALS AND METHODS:We analyzed 285 kidney units (KUs) on which unstented pyeloplasty was performed between April 2002 and March 2010. Measures included preoperative factors, postoperat...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2013.11.003

    authors: Lee YS,Lee CN,Kim MU,Jang WS,Lee H,Im YJ,Han SW

    更新日期:2014-07-01 00:00:00

  • Resolution of intractable cholestasis associated with total parenteral nutrition following biliary irrigation.

    abstract::Although the protracted use of total parenteral nutrition (TPN) in infants is known to predispose to cholestasis, which in certain instances may not be reversible, failure to understand the pathogenesis of this condition has hindered the development of an effective medical treatment. That surgical treatment may revers...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(85)80042-7

    authors: Cooper A,Ross AJ 3rd,O'Neill JA Jr,Bishop HC,Templeton JM Jr,Ziegler MM

    更新日期:1985-12-01 00:00:00

  • Reoperation for anastomotic complications of esophageal atresia and tracheoesophageal fistula.

    abstract:BACKGROUND/PURPOSE:The purpose of the study was to review our experience in the re-operative management of anastomotic complications (ACs) following primary repair of esophageal atresia (EA) and tracheoesophageal fistula (TEF) and to assess the outcomes after reoperation. METHODS:We retrospectively reviewed 21 EA pati...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2015.08.015

    authors: Zhu H,Shen C,Xiao X,Dong K,Zheng S

    更新日期:2015-12-01 00:00:00

  • Multiple spontaneous small bowel anastomosis in premature infants with multisegmental necrotizing enterocolitis.

    abstract:BACKGROUND/PURPOSE:Fulminant necrotizing enterocolitis (NEC) may result in extensive bowel necrosis. Resection of involved segments may result in short bowel syndrome. Multiple stomas result in complications and further loss of intestinal length with closure. METHODS:Two patients with extensive multisegmental NEC were...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(00)90004-6

    authors: Lessin MS,Schwartz DL,Wesselhoeft CW Jr

    更新日期:2000-02-01 00:00:00

  • The role of coagulase-negative Staphylococcus in neonatal necrotizing enterocolitis.

    abstract::Coagulase-negative Staphylococcus has emerged as a prominent pathogen in the neonatal intensive care unit and a recent report has implicated this organism in necrotizing enterocolitis (NEC). This same study suggests that Staphylococcus epidermidis is most commonly associated with a "mild form of enterocolitis." This p...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(88)80542-6

    authors: Mollitt DL,Tepas JJ,Talbert JL

    更新日期:1988-01-01 00:00:00

  • Intrathoracic cystic hygroma: a report of three cases.

    abstract::Cystic hygromas are relatively uncommon benign tumors of the lymphatic system. The lesions frequently are apparent at birth, and more than 90% are detected before the end of the second year of life. Most commonly, cystic hygroma presents as a soft tissue mass in the posterior triangle of the neck, and only rarely does...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(96)90847-7

    authors: Wright CC,Cohen DM,Vegunta RK,Davis JT,King DR

    更新日期:1996-10-01 00:00:00

  • Wolff-Chaikoff effect in a newborn: is it an overlooked problem?

    abstract::Hypothyroidism is a serious endocrine disorder emerging from deficient production of thyroid hormone (thyroid gland agenesis or dysgenesis, or inborn metabolic defects of thyroid hormone production) or a defect in thyroid hormonal receptor activity. Prevention of iodine organification by means of using iodine-containi...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2006.08.041

    authors: Aliefendioğlu D,Sanli C,Cakmak M,Ağar A,Albayrak M,Evliyaoğlu O

    更新日期:2006-12-01 00:00:00

  • Focal gastrointestinal perforations not associated with necrotizing enterocolitis in very low birth weight neonates.

    abstract::Nine very low birth weight (VLBW) neonates (< 1,000 g) undergoing abdominal exploration for peritonitis were found to have focal perforations of the gastrointestinal (GI) tract and no clinical or histologic evidence of necrotizing enterocolitis (NEC) or other mechanical cause. Although most patients presented initiall...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/0022-3468(93)90345-l

    authors: Mintz AC,Applebaum H

    更新日期:1993-06-01 00:00:00

  • Heterotopic autotransplantation of parathyroid tissue in children undergoing total thyroidectomy.

    abstract:AIM:The purpose of this study was to examine the efficacy of parathyroid autotransplantation in children undergoing total thyroidectomy. METHODS:We have prospectively evaluated 32 cases of total thyroidectomy in children. The ages ranged from 1 year to 15.7 years, and the mean was 8.9 years. In 31 cases, the indicatio...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(97)90618-7

    authors: Skinner MA,Norton JA,Moley JF,DeBenedetti MK,Wells SA Jr

    更新日期:1997-03-01 00:00:00

  • Serum concentration of adhesion molecules in postoperative biliary atresia patients: relationship to disease activity and cirrhosis.

    abstract:BACKGROUND/PURPOSE:Biliary atresia (BA) is associated with progressive liver fibrosis, which may be mediated by immunologic abnormalities involving adhesion molecules. This study investigates the relationship between serum intercellular adhesion molecule-1 (sICAM-1), serum vascular cell adhesion molecule-1 (sVCAM-1), a...

    journal_title:Journal of pediatric surgery

    pub_type: 临床试验,杂志文章

    doi:10.1053/jpsu.2001.25798

    authors: Kobayashi H,Horikoshi K,Long L,Yamataka A,Lane GJ,Miyano T

    更新日期:2001-08-01 00:00:00

  • Cesarean section does not improve outcome in gastroschisis.

    abstract::Elective cesarean section (CS) following prenatal diagnosis of gastroschisis has been advocated to decrease morbidity and mortality. To examine this hypothesis, we reviewed the records of 28 consecutive patients with gastroschisis treated between 1975 and 1987. Fourteen infants were delivered vaginally (V) and fourtee...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(89)80289-1

    authors: Bethel CA,Seashore JH,Touloukian RJ

    更新日期:1989-01-01 00:00:00

  • Perinatal management of congenital diaphragmatic hernia: when and how should babies be delivered? Results from the Canadian Pediatric Surgery Network.

    abstract:PURPOSE:A prenatal diagnosis of congenital diaphragmatic hernia (CDH) enables therapeutic decision making during the intrapartum period. This study seeks to identify the gestational age and delivery mode associated with optimal outcomes. PATIENTS AND METHODS:A national data set was used to study CDH babies born betwee...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2010.08.026

    authors: Safavi A,Lin Y,Skarsgard ED,Canadian Pediatric Surgery Network.

    更新日期:2010-12-01 00:00:00

  • Congenital abdominal wall defects and testicular maldescent--a 10-year single-center experience.

    abstract:PURPOSE:The relationship between congenital abdominal wall defects (AWDs) and undescended testes (UDTs) is poorly defined. We report a study of infants with AWD and UDT. METHODS:Hospital records of newborns with AWD managed during 1998 to 2008 were reviewed. Data analyzed included nature of AWD, position of the testes...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2012.03.011

    authors: Yardley IE,Bostock E,Jones MO,Turnock RR,Corbett HJ,Losty PD

    更新日期:2012-06-01 00:00:00

  • Bladder calculus formation on the tip of a migrated disused ventriculoperitoneal shunt.

    abstract::Bladder stones in children are rare. They generally occur in children with one or more predisposing risk factors to stone formation. In this unique case report we discuss the formation and successful endoscopic treatment of a large stone in a neuropathic bladder on the tip of a migrated VP shunt. ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2013.02.058

    authors: Butler L,Keys C,Lam JP

    更新日期:2013-05-01 00:00:00