Intrahepatic cystic lesions in children with biliary atresia after Kasai procedure.

Abstract:

BACKGROUND:Intrahepatic cystic lesion (ICL) is a common complication for biliary atresia post-Kasai portoenterostomy. The purpose of this study was to review the cases in our hospital and assess the correlation between characteristics of ICL and clinical outcomes. METHODS:We retrospectively analyzed 787 cases of biliary atresia from 2012 to 2016. Demographics, clinical details, and postoperative outcomes were reviewed. RESULTS:A total of 76 patients were diagnosed with ICLs using ultrasound post-Kasai procedure, and the incidence was 9.7%. Preoperative characteristics showed no significant differences between ICL (+) and ICL (-) groups. Nearly 70% (53/76) of the patients with ICLs had a history of cholangitis. The 2-year native liver survival rate was 60.4% for those with a history of cholangitis and 87% for those without (P = 0.017). Further analysis showed that the 2-year native liver survival rate was 42.9% for those diagnosed within 3 months post-Kasai procedure, 54.2% for those diagnosed between 3 and 6 months, and 80.0% for those diagnosed beyond 6 months (P = 0.002), while no significance was observed for type (P = 0.094) or site (P = 0.406) of ICL. CONCLUSION:Patients with ICLs had a high incidence of cholangitis. The prognosis was closely related with the history of cholangitis and the onset time of ICLs. LEVEL OF EVIDENCE:Level II.

journal_name

J Pediatr Surg

authors

Jiang J,Wang J,Lu X,Shen Z,Chen G,Huang Y,Dong R,Zheng S

doi

10.1016/j.jpedsurg.2019.08.027

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

2565-2569

issue

12

eissn

0022-3468

issn

1531-5037

pii

S0022-3468(19)30567-6

journal_volume

54

pub_type

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