Optimizing wavelength choice for quantitative optoacoustic imaging using the Cramer-Rao lower bound.

Abstract:

:Several papers have recently addressed the issue of estimating chromophore concentration in optoacoustic imaging (OAI) using multiple wavelengths. The choice of wavelengths obviously affects the accuracy and precision of the estimates. One might assume that the wavelengths that maximize the extinction coefficients of the chromophores would be the most suitable. However, this may not always be the case since the distribution of light intensity in the medium is also wavelength dependent. In this paper, we explore a method for optimizing the choice of wavelengths based on the Cramer-Rao lower bound (CRLB) on the variance of the chromophore concentration. This lower bound on variance can be evaluated numerically for different wavelengths using the variation of the extinction coefficients and scattering coefficients with wavelength. The wavelengths that give the smallest variance will be considered optimal for multi-wavelength OAI to estimate the chromophore concentrations. The expression for the CRLB has been derived analytically for estimating the concentration of multiple chromophores for several simple phantom models for the case when the optoacoustic signal is proportional to the product of the optical absorption and the illumination function. This approach could be easily extended to other geometries.

journal_name

Phys Med Biol

authors

Modgil D,La Riviére PJ

doi

10.1088/0031-9155/55/23/004

subject

Has Abstract

pub_date

2010-12-07 00:00:00

pages

7231-51

issue

23

eissn

0031-9155

issn

1361-6560

pii

S0031-9155(10)61775-7

journal_volume

55

pub_type

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