Development of long-acting nitrate delivery systems.

abstract：:A 8.5-month prospective study was performed in the Rhône area of France to study the incidence of infectious diseases in children in day care, and the qualitative and quantitative aspects of drug prescriptions for young children. The families of 1.359 children agreed to participate (98.5% of those selected). During th...

journal_title：European journal of clinical pharmacology

authors： Collet JP,Bossard N,Floret D,Gillet J,Honegger D,Boissel JP

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:To investigate the distribution of plasma apixaban levels and their relationships with clinical outcomes in elderly patients with atrial fibrillation (AF). METHOD:The J-ELD AF Registry is a multicenter prospective observational study of Japanese non-valvular AF patients aged ≥75 years taking an on-label dose o...

journal_title：European journal of clinical pharmacology

authors： Suzuki S,Yamashita T,Akao M,Okumura K,J-ELD AF investigators.

更新日期：2020-08-01 00:00:00

abstract：:Pharmacokinetic and metabolic studies with 3H-etilefrine were performed to assess the importance of a first-pass effect on the pharmacodynamic action of this sympathomimetic amine. Identical amounts of 3H-activity, ca. 80% of the dose, were excreted in the urine after intravenous or oral administration, which indicate...

journal_title：European journal of clinical pharmacology

authors： Hengstmann JH,Weyand U,Dengler HJ

更新日期：1975-12-19 00:00:00

abstract：:The pharmacodynamic effects of FCE20700, a new PGE2 derivative, have been investigated in 6 healthy volunteers given single intragastric (i.g.) and intraduodenal (i.d.) doses of 1 and 2 mg and placebo, according to a double-blind, within-subjects design. For 30-270 min following i.g. administration the effect of FCE20...

journal_title：European journal of clinical pharmacology

authors： Caldara R,Guslandi M,Carbone M,Masci E,Cantù A,Ferrari C,Barbieri C,Dubini A

更新日期：1987-01-01 00:00:00

abstract：:For model identification and parameter estimation in the framework of linear pharmacokinetics it is most often assumed that the disposition function is a finite sum of exponential functions with time constants lambda i and associated coefficients Ci. Least-square fitting procedures are used to estimate the coefficient...

journal_title：European journal of clinical pharmacology

authors： Schwilden H,Honerkamp J,Elster C

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Acetaminophen (APAP) protein adducts are a biomarker of APAP metabolism, reflecting oxidation of APAP and generation of the reactive metabolite N-acetyl-p-benzoquinone imine. High levels of adducts correspond to liver toxicity in patients with APAP-related acute liver failure. Adduct formation following low-dos...

journal_title：European journal of clinical pharmacology

authors： James LP,Chiew A,Abdel-Rahman SM,Letzig L,Graudins A,Day P,Roberts D

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:The aim of the study was to develop a European list of potentially inappropriate medications (PIM) for older people, which can be used for the analysis and comparison of prescribing patterns across European countries and for clinical practice. METHODS:A preliminary PIM list was developed, based on the German P...

journal_title：European journal of clinical pharmacology

authors： Renom-Guiteras A,Meyer G,Thürmann PA

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:To assess, with all available trial information, whether the assessment of the PRECIS-2 nine domains could provide a clear distinction between medicine masked pragmatic randomized controlled trials (pRCTs) and open-label pRCTs. METHODS:A search was conducted of participant-level pRCTs on medicines published on...

journal_title：European journal of clinical pharmacology

authors： Dal-Ré R

更新日期：2020-10-26 00:00:00

abstract：:The anti-ischaemic properties of nimodipine 30 mg and 60 mg t.i.d. for 4 days has been tested in a double-blind, placebo-controlled, cross-over study based on the use of hyperventilation to reduce flow velocity in cerebral arteries. Whether the anti-ischaemic properties were due to a vasodilatator action on cerebral b...

journal_title：European journal of clinical pharmacology

authors： Kraaier V,van Huffelen AC,Wieneke GH,Hesselink JM

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Many studies have indicated the adequate use of lipid-lowering drugs (LLDs) as a factor in reducing the risk of cardiovascular disease. However, in clinical practice, a very high percentage of patients are not adequately treated. OBJECTIVE:To analyze the management of hypercholesterolemia in a non-experimen...

journal_title：European journal of clinical pharmacology

authors： Di Martino M,Degli Esposti L,Ruffo P,Bustacchini S,Catte A,Sturani A,Degli Esposti E

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:Theophylline is metabolized to 1,3-dimethyluric acid (1,3-DMU), 3-methylxanthine, and 1-methylxanthine by CYP1A2 and partly by CYP2E1. Because 1,3-DMU is the major metabolite of theophylline, the 1,3-DMU/theophylline ratio is viewed as a good indicator of theophylline metabolic clearance. Here, we investigate...

journal_title：European journal of clinical pharmacology

authors： Yoon Y,Park HD,Park KU,Kim JQ,Chang YS,Song J

更新日期：2006-08-01 00:00:00

abstract：:We have studied the pharmacokinetics of fluconazole in five patients on long-term haemodialysis. The single-pass extraction rate of the dialyzer was 59 (3.5)% (n = 4), and the serum concentration was reduced by haemodialysis for 3 or 4 h by 26 (3.2)% (n = 5) and 39 (2.2)% (n = 9) respectively. The estimated amount ext...

journal_title：European journal of clinical pharmacology

authors： Oono S,Tabei K,Tetsuka T,Asano Y

更新日期：1992-01-01 00:00:00

abstract：:The present study was designed to investigate the effects of raised intragastric pH on the absorption of theophylline from a sustained-release formulation. Six healthy male volunteers participated in the cross-over randomised study and on one of two occasions were pretreated with 240 mg omeprazole, administered in thr...

journal_title：European journal of clinical pharmacology

authors： Sommers DK,van Wyk M,Snyman JR,Moncrieff J

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:The European Committee for Human Medicinal Products (CHMP) requested a multinational study with the aim to investigate the risk of acute liver failure (ALF) leading to registration for transplantation in patients exposed to non-steroidal anti-inflammatory drugs (NSAIDs). The method of this multinational, multic...

journal_title：European journal of clinical pharmacology

authors： Gulmez SE,Larrey D,Pageaux GP,Lignot-Maleyran S,de Vries C,Sturkenboom M,Perez-Gutthann S,Bénichou J,Bissoli F,Horsmans Y,Bernuau J,Stricker B,Thorburn D,Blin P,Moore N

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:The influence of nevirapine (NVP) on lopinavir (LPV) pharmacokinetics was investigated by a population analysis based on a non-linear mixed-effect modelling method. METHODS:In this analysis, 95 HIV-1 infected patients were studied [52 treated with LPV/ritonavir (400/100 mg twice a day) plus nucleoside revers...

journal_title：European journal of clinical pharmacology

authors： Dailly E,Reliquet V,Raffi F,Jolliet P

更新日期：2005-04-01 00:00:00

abstract：:Exposure to reserpine was compared in 181 women interviewed prior to biopsy and found to have breast cancer and 307 women found to have a benign disorder of the breast. The age-adjusted relative risk of breast cancer in those who had taken reserpine was 0.6 (95% confidence limits: 0.4 and 1.1). When the 181 breast can...

journal_title：European journal of clinical pharmacology

authors： Kewitz H,Jesdinsky HJ,Schröter PM,Lindtner E

更新日期：1977-01-03 00:00:00

abstract：:Protein binding of phenytoin was assesed in one patient with dialysis encephalopathy before and after haemodialysis. Phenytoin concentrations were measured by radioimmunoassay and continuous ultrafiltration was used to assess phenytoin binding. At a serum concentration of 60 micromol.1-1 the percentage of phenytoin bo...

journal_title：European journal of clinical pharmacology

authors： Steele WH,Lawrence JR,Elliott HL,Whiting B

更新日期：1979-02-19 00:00:00

abstract：:A new acid thiol, 2-mercaptopropionate, has been identified by GC-MS in urine from cystinuric patients on treatment with 2-mercaptopropionylglycine. The amount excreted was 50-300 mumol/24h and it was correlated with the oral dose of 2-mercaptopropionyl-glycine. The observation may be of clinical importance as the met...

journal_title：European journal of clinical pharmacology

authors： Mårtensson J,Denneberg T,Kågedal B

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:We investigated the effects of treatment with Saint John's wort (hypericum perforatum) extract on the urinary excretion of D-glucaric acid, 6beta-hydroxycortisol, and free cortisol in order to assess the effect of this extract on the activity of hepatic xenobiotic metabolizing enzymes. METHODS:Forty-eight he...

journal_title：European journal of clinical pharmacology

authors： Bauer S,Störmer E,Kerb R,Johne A,Brockmöller J,Roots I

更新日期：2002-12-01 00:00:00

abstract：PURPOSE:Pharmacodynamic studies of naloxone require opioid agonism. Steady state condition may be achieved by remifentanil TCI (target controlled infusion). Opioid agonism can be measured by pupillometry. It is not known whether there are arteriovenous concentration differences for naloxone. The aim was thus to further...

journal_title：European journal of clinical pharmacology

authors： Tylleskar I,Skulberg AK,Skarra S,Nilsen T,Dale O

更新日期：2018-12-01 00:00:00

abstract：:Of 23 patients with non-insulin-dependent diabetes mellitus (NIDDM), whose fasting blood glucose had not reached less than or equal to 6.0 mmol.l-1 after 10 weeks of dietary regulation, 15, who had had a weight reduction of -2.8 kg by dietary control, did achieve a fasting blood glucose less than or equal to 6.0 mmol....

journal_title：European journal of clinical pharmacology

authors： Bitzén PO,Melander A,Scherstén B,Svensson M,Wåhlin-Boll E

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the effects of benazepril and amlodipine in monotherapy versus in combination with plasma t-PA and PAI-1 activity in hypertensive type-2 diabetic patients. METHODS:After an initial 6-week wash-out, single-blind placebo period, 38 patients, 17 men and 21 females, were rand...

journal_title：European journal of clinical pharmacology

authors： Fogari R,Preti P,Lazzari P,Corradi L,Zoppi A,Fogari E,Mugellini A

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVE:In animal studies, it has been shown that verapamil reduces strength and endurance of the diaphragm and inhibits the beneficial effects of theophylline. We examined whether the use of verapamil in patients with severe chronic obstructive pulmonary disease (COPD) who use theophylline leads to a deterioration o...

journal_title：European journal of clinical pharmacology

authors： Broeders ME,Heijdra YF,Smits P,Folgering HT,Kramers C

更新日期：2000-01-01 00:00:00

abstract：:We have given 12 healthy subjects the H1-antihistamine ebastine (20 mg) or placebo in a double-blind, crossover study for one week each. The subjects were tested for drug effects on Day 6 of each period, and for interactions of ebastine with ethanol (0.8 g.kg-1) on Day 7. On both days, the testing runs were done at ba...

journal_title：European journal of clinical pharmacology

authors： Mattila MJ,Kuitunen T,Plétan Y

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:Losartan was given to subjects with known phenotypes of the polymorphic enzymes CYP2D6 and CYP2C19 to study any possible influence on the metabolism of the drug. METHODS:Plasma concentrations of losartan and E-3174 were studied after oral intake of 50 mg losartan in 24 healthy, male, Swedish Caucasian subjec...

journal_title：European journal of clinical pharmacology

authors： Sandwall P,Lo MW,Jonzon B,Dalén P,Furtek C,Ritter M,Alván G,McCrea J,Sjöqvist F

更新日期：1999-06-01 00:00:00

abstract：:Twenty patients (5 females, 15 males) with severe heart failure (NYHA IV), due to coronary artery disease in 14, and congestive cardiomyopathy in 6, received an intravenous bolus of the calcium blocker nisoldipine 0.2 mg followed by a continuous infusion of 0.2 micrograms.kg-1.min-1. Haemodynamic measurements were per...

journal_title：European journal of clinical pharmacology

authors： Erlemeier HH,Kupper W,Bleifeld W

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to identify structure and language elements affecting the quality of responses from Scandinavian drug information centres (DICs). METHODS:Six different fictitious drug-related queries were sent to each of seven Scandinavian DICs. The centres were blinded for which queries were part of...

journal_title：European journal of clinical pharmacology

authors： Reppe LA,Spigset O,Kampmann JP,Damkier P,Christensen HR,Böttiger Y,Schjøtt J

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the influence of clinical and genetic factors on warfarin dose requirements in the Japanese population. METHODS:We enrolled 125 patients on stable warfarin anticoagulant therapy with an international normalized ratio maintained between 1.5 and 3.0. PCR-based methods w...

journal_title：European journal of clinical pharmacology

authors： Ohno M,Yamamoto A,Ono A,Miura G,Funamoto M,Takemoto Y,Otsu K,Kouno Y,Tanabe T,Masunaga Y,Nonen S,Fujio Y,Azuma J

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:To analyse the contribution of adverse drug reactions (ADR) to hospital readmissions. METHODS:This was a case-control study in which unscheduled admissions of patients who had been admitted to the hospital during the two previous months were assessed during a 21-month period. The patient was considered a cas...

journal_title：European journal of clinical pharmacology

authors： Ruiz B,García M,Aguirre U,Aguirre C

更新日期：2008-07-01 00:00:00

abstract：:The pharmacokinetic profiles of transdermal timolol 6 and 24 mg (as 5 and 20% w/v patches) was studied in four healthy young volunteers. To assess its bioavailability, the pharmacokinetics of an IV infusion of timolol maleate 5 mg was also determined in the same subjects. When the 20% (w/v) timolol patch was applied, ...

journal_title：European journal of clinical pharmacology

authors： Kubota K,Yamada T,Kikuchi K,Koyama E,Ishizaki T

更新日期：1993-01-01 00:00:00