A population approach to study the influence of nevirapine administration on lopinavir pharmacokinetics in HIV-1 infected patients.

abstract：:A study, using non-invasive techniques, was carried out in ten patients with essential hypertension to examine the mechanism of the hypotensive effect of propranolol when used in combination with a potent vasodilator antihypertensive - minoxidil. The hypotensive effect of minoxidil, a mean (+/- SEM) decrease of 42.4 +...

journal_title：European journal of clinical pharmacology

authors： O'Malley K,Velasco M,Wells J,McNay J

更新日期：1976-03-22 00:00:00

abstract：:A single dose of 60 mg trimetazidine (the normal daily dose) improved exercise capacity in angina pectoris, as reflected by an increase in the duration of exercise, total work performed, and improvement in ECG signs of ischaemia. All these effects occurred without any detectable chronotropic or vasomotor effect. The i...

journal_title：European journal of clinical pharmacology

authors： Sellier P,Audouin P,Payen B,Corona P,Duong TC,Ourbak P

更新日期：1987-01-01 00:00:00

abstract：:The influence of isosorbide dinitrate (ISDN) and food ingestion on superior mesenteric artery impedance was investigated in 24 healthy volunteers (age 40 +/- 2.7 years). Superior mesenteric artery circulation was assessed by duplex ultrasound. Pulsatility index (PI) was considered as a parameter of vascular resistance...

journal_title：European journal of clinical pharmacology

authors： Voet D,Mareels S,Afschrift M,De Buyzere M,Rietzschel E,Duprez D

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:The use of estimated glomerular filtration rate (eGFR) in daily clinical practice. METHODS:eGFR is a key component in drug therapy management (DTM) in patients with renal impairment. eGFR is routinely reported by laboratories whenever a serum creatinine testing is ordered. In this paper, we will discuss how to...

journal_title：European journal of clinical pharmacology

authors： Eppenga WL,Kramers C,Derijks HJ,Wensing M,Wetzels JF,De Smet PA

更新日期：2016-12-01 00:00:00

abstract：:In an open, randomised, cross-over study we investigated the effect of a single 200 mg oral dose of entacapone, a novel catechol-O-methyltransferase (COMT) inhibitor, on the pharmacokinetics and metabolism of levodopa/carbidopa, and on the cardiovascular responses (blood pressure and pulse rate variation to standard s...

journal_title：European journal of clinical pharmacology

authors： Myllylä VV,Sotaniemi KA,Illi A,Suominen K,Keränen T

更新日期：1993-01-01 00:00:00

abstract：:The pharmacokinetics of lignocaine has been compared after epidural anaesthesia in diabetics and non-diabetic patients. Epidural lignocaine 8 mg.kg-1 was given to 8 well controlled Type II diabetic and 8 non-diabetic patients and the plasma drug concentration in serial blood samples were measured by HPLC. The plasma l...

journal_title：European journal of clinical pharmacology

authors： Peeyush M,Ravishankar M,Adithan C,Shashindran CH

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVES:Designing a safe medication process requires the ability to model its reliability using methods such as probabilistic risk assessment (PRA). However, lack of data, especially on human-error probabilities (HEPs), limits its use. To assess whether small-scale simulations could help generate HEP data, a pilot s...

journal_title：European journal of clinical pharmacology

authors： Garnerin P,Pellet-Meier B,Chopard P,Perneger T,Bonnabry P

更新日期：2007-08-01 00:00:00

abstract：:The cleansing effects on pus and debris of streptokinase-streptodornase and of stabilized crystalline trypsin were compared in 40 patients (12 males, 28 females) with necrotic varicose or arteriosclerotic leg ulcers. Both preparations produced significant partial or total cleansing of the ulcers of necrotic material, ...

journal_title：European journal of clinical pharmacology

authors： Hellgren L

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the impact of the two most common CYP2C9 variant alleles (*2 and *3) on the maintenance dose of warfarin and on the quality of anticoagulation control in Brazilians. METHODS:Patients (n = 103) initiated warfarin therapy with 5 mg/day (or 2.5 mg/day when over 80 years old). The international norma...

journal_title：European journal of clinical pharmacology

authors： Lima MV,Ribeiro GS,Mesquita ET,Victer PR,Vianna-Jorge R

更新日期：2008-01-01 00:00:00

abstract：:Effects on psychomotor and cognitive performance of adinazolam (15 or 30 mg), alone and in combination with ethanol (0.8 g/kg), were studied in healthy male volunteers and compared to effects of 10 mg diazepam. Adinazolam 30 mg produced relatively long-lasting impairments on tests of tracking, attention, verbal and no...

journal_title：European journal of clinical pharmacology

authors： Linnoila M,Stapleton JM,Lister R,Moss H,Lane E,Granger A,Greenblatt DJ,Eckardt MJ

更新日期：1990-01-01 00:00:00

abstract：:The effect of spironolactone on cardiac contractility indices was studied by externally recording systolic time intervals in four digitalized and four non-digitalized patients with ischaemic heart disease. A negative inotropic effect was found after spironolactone 100mg b.i.d. in all eight patients, as measured by an ...

journal_title：European journal of clinical pharmacology

authors： Waldorff S,Berning J,Buch J,Steiness E

更新日期：1982-01-01 00:00:00

abstract：:The pharmacokinetics of phenylethylmalonamide (PEMA) were studied in 6 elderly men after oral administration of a single 400 mg dose. Peak PEMA serum levels were obtained within 4 h of intake, half-life values ranged from 30.7-57.9 h in these elderly men. The elimination half-life was twice as long when compared to a ...

journal_title：European journal of clinical pharmacology

authors： Streete JM,Berry DJ,Newberry JE,Crome P

更新日期：1987-01-01 00:00:00

abstract：:To assess the type and degree of innovation of the cardiovascular drugs centrally approved in the European Union between 1995 and 2002. Sources of information were the European Public Assessment Reports and the Summaries of Product Characteristics published by the European Medicines Evaluation Agency. The Agency appro...

journal_title：European journal of clinical pharmacology

authors： Garattini S,Bertele' V

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:Tacrolimus is a commonly used immunosuppressant in solid organ transplantation recipients, but it is characterized by a narrow therapeutic range and large inter-individual variability. The purpose of this study was to establish a population pharmacokinetic (PK) model of tacrolimus and evaluate the influence of ...

journal_title：European journal of clinical pharmacology

authors： Han N,Yun HY,Hong JY,Kim IW,Ji E,Hong SH,Kim YS,Ha J,Shin WG,Oh JM

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:To study the influence of CYP3A4 inhibition by ketoconazole on the disposition of venlafaxine in individuals with different CYP2D6 pheno- and genotypes. METHODS:In an open two-phase study, 21 healthy volunteers with known CYP2D6 pheno- and genotype [14 extensive metabolisers (EMs), 7 poor metabolisers (PMs)]...

journal_title：European journal of clinical pharmacology

authors： Lindh JD,Annas A,Meurling L,Dahl ML,AL-Shurbaji A

更新日期：2003-09-01 00:00:00

abstract：:The blood level versus time curve for unchanged cimetidine after a 200 mg oral dose has been determined in 20 apparently healthy subjects, ranging from 22 to 84 years of age. A significant relationship between the area under the curve (AUC) and age was found (r = 0.81; P less than 0.001). The peak concentrations of ci...

journal_title：European journal of clinical pharmacology

authors： Redolfi A,Borgogelli E,Lodola E

更新日期：1979-05-21 00:00:00

abstract：OBJECTIVE:Although the treatment of schizophrenia with many second generation antipsychotics is known to be associated with metabolic changes, such as hyperglycemia or hypercholesterolemia, the underlying mechanisms of these adverse reactions remain unclear. In light of the recent focus on the involvement of semicarbaz...

journal_title：European journal of clinical pharmacology

authors： Roessner V,Weber A,Becker A,Beck G,Frieling H,Bleich S

更新日期：2007-05-01 00:00:00

abstract：:The concentrations of lormetazepam and its glucuronide in plasma and milk were determined during administration of 10 daily doses of lormetazepam 2 mg (2 tablets of Noctamid-1) to five mothers delivered by Caesarian section. Their babies were breast-fed throughout the study, and the plasma levels of lormetazepam and i...

journal_title：European journal of clinical pharmacology

authors： Hümpel M,Stoppelli I,Milia S,Rainer E

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:To determine the effects of itraconazole, a potent inhibitor of CYP3A4, on the pharmacokinetics of cerivastatin, a competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. METHODS:A randomized, double-blind, cross-over study design with two phases, which were separated by a washout pe...

journal_title：European journal of clinical pharmacology

authors： Kantola T,Kivistö KT,Neuvonen PJ

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:Ultraviolet radiation exposure is the most important exogenous risk factor for cutaneous malignancies. It is possible that phototoxic drugs promote the development of cutaneous melanoma (CM) by intensifying the effect of ultraviolet light on the skin. We investigated the association between the use of common sy...

journal_title：European journal of clinical pharmacology

authors： Siiskonen SJ,Koomen ER,Visser LE,Herings RM,Guchelaar HJ,Stricker BH,Nijsten TE

更新日期：2013-07-01 00:00:00

abstract：PURPOSE:Fibroblast growth factor receptor 4 (FGFR4) expression has association with tumor malignancy. In thyroid cancers, FGFR4 has been reported to be characteristically expressed in aggressive thyroid tumors, such as anaplastic thyroid carcinoma (ATC). METHODS:We investigated FGFR4 expression in patients with ATC an...

journal_title：European journal of clinical pharmacology

authors： Yamazaki H,Yokose T,Hayashi H,Iwasaki H,Osanai S,Suganuma N,Nakayama H,Masudo K,Rino Y,Masuda M

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the influence of clinical and genetic factors on warfarin dose requirements in the Japanese population. METHODS:We enrolled 125 patients on stable warfarin anticoagulant therapy with an international normalized ratio maintained between 1.5 and 3.0. PCR-based methods w...

journal_title：European journal of clinical pharmacology

authors： Ohno M,Yamamoto A,Ono A,Miura G,Funamoto M,Takemoto Y,Otsu K,Kouno Y,Tanabe T,Masunaga Y,Nonen S,Fujio Y,Azuma J

更新日期：2009-11-01 00:00:00

abstract：:Twenty-nine cases of self-poisoning with antidepressants (amitriptyline, imipramine, clomipramine, maprotiline, doxepine, nortriptyline, opipramol) were examined by frequent observation of CNS effects, heart rate, blood pressure and standard ECG, 24h-ECG-monitoring, measurement of systolic time intervals, EEG recordin...

journal_title：European journal of clinical pharmacology

authors： Pedersen OL,Gram LF,Kristensen CB,Møller M,Thayssen P,Bjerre M,Kragh-SøRensen P,Klitgaard NA,Sindrup E,Hole P,Brinklø M

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:The prevention of contrast-mediated nephropathy (CMN), which accounts for considerable morbidity and mortality, remains a vexing problem. Contrast induced renal vasoconstriction is believed to play a pivotal role in the CMN mechanism. The aim of this pilot study was to examine the safety and efficacy of two d...

journal_title：European journal of clinical pharmacology

authors： Spargias K,Adreanides E,Giamouzis G,Karagiannis S,Gouziouta A,Manginas A,Voudris V,Pavlides G,Cokkinos DV

更新日期：2006-08-01 00:00:00

abstract：:A new device for IV admixtures has been developed in Israel, the Vialink minibag. It consists of a partly filled minibag, attached by rubber tubing to a sterile receptable into which various types of vials containing drugs can be firmly inserted. Time and motion studies were conducted to determine the time and cost as...

journal_title：European journal of clinical pharmacology

authors： Lustig A

更新日期：1994-01-01 00:00:00

abstract：:Oxitropium bromide (OXBR) is a new anticholinergic drug, which is expected to be useful in the treatment of nocturnal asthma. The only pharmacokinetic data were obtained with the 14C-labelled compound. A sensitive radioreceptor assay for the determination of unlabelled OXBR in plasma was developed, based on competitio...

journal_title：European journal of clinical pharmacology

authors： Ensing K,de Zeeuw RA,in 't Hout WG,Cornelissen PJ

更新日期：1989-01-01 00:00:00

abstract：:This is the first report of the use of DHM 32-550 a dehydrogenated peptide ergot alkaloid with both alpha and beta adrenoceptor blocking activity, in patients with angina-like chest pain. Five patients were studied to assess a dose/response relationship. No deleterious effects on blood pressure occurred at either rest...

journal_title：European journal of clinical pharmacology

authors： Handler CE,Sowton E

更新日期：1984-01-01 00:00:00

abstract：:This study assessed the influence of acetylsalicylic acid (ASA, 1.0 g), ibuprofen (0.8 g) and paracetamol (1.0 g) on the single-dose kinetics of ethanol in 12 healthy volunteers ingesting the drug and a standardised 1840-kJ breakfast 1 h before intake of ethanol. It also assessed the influence of ethanol on the single...

journal_title：European journal of clinical pharmacology

authors： Melander O,Lidén A,Melander A

更新日期：1995-01-01 00:00:00

abstract：:Ten normal adult tobacco smokers and 10 nonsmoking volunteers 20-31 years of age were the subjects of this study. The tobacco smokers all had a history of daily tobacco smoking. They were asked to stop smoking for 12 hours prior to testing. The Hoffmann (H) reflex and its recovery cycle were measured on different days...

journal_title：European journal of clinical pharmacology

authors： Domino EF,Kadoya C,Matsuoka S

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:In elderly patients, both falls and impaired memory are considerable medical problems. Hypnotics, which are frequently administered to this patient group for the treatment of insomnia, should ideally not impair equilibrium or memory functions. This double-blind, randomised, four-way, cross-over study investig...

journal_title：European journal of clinical pharmacology

authors： Allain H,Bentué-Ferrer D,Tarral A,Gandon JM

更新日期：2003-07-01 00:00:00