Fluoroquinolone resistance among Mycobacterium tuberculosis strains from Karachi, Pakistan: data from community-based field clinics.


:A fluoroquinolone (FQ) resistance rate of 5.9% is reported in 205 Mycobacterium tuberculosis isolates from patients presenting to field clinics in Karachi, Pakistan (2006 to 2009). FQ resistance among multidrug-resistant (MDR) strains was 11.1% (5/45), and it was 4.9% (5/103) in M. tuberculosis strains susceptible to all first-line agents. Spoligotyping of resistant strains did not show dominance of one strain type. Our data reflect considerable FQ-resistant M. tuberculosis isolates and the need to consider inclusion of FQ within first-line sensitivity testing in such settings.


Rafiq Y,Jabeen K,Hasan R,Jafri S,Laiq R,Malik F,Mangi R,Channa A,Hasan Z




Has Abstract


2011-02-01 00:00:00














  • Effects of rifampin and ketoconazole on pharmacokinetics of morinidazole in healthy chinese subjects.

    abstract::Morinidazole, a 5-nitroimidazole antimicrobial drug, has been approved for the treatment of amoebiasis, trichomoniasis, and anaerobic bacterial infections in China. It was reported that drug-drug interaction happened after the coadministration of ornidazole, an analog of morinidazole, and rifampin or ketoconazole. The...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Pang X,Zhang Y,Gao R,Zhong K,Zhong D,Chen X

    更新日期:2014-10-01 00:00:00

  • Activity of hydroxyurea against Leishmania mexicana.

    abstract::Leishmania mexicana is a protozoan parasite that causes a disease in humans with frequent relapses after treatment. It is also highly resistant to the currently available drugs. For this reason, there is an urgent need for more effective antileishmanial drugs. Hydroxyurea, an anticancer drug, is toxic to replicating e...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Martinez-Rojano H,Mancilla-Ramirez J,Quiñonez-Diaz L,Galindo-Sevilla N

    更新日期:2008-10-01 00:00:00

  • Effect of acetyl salicylic acid on production and action of leukocyte-derived interferons.

    abstract::Although acetylsalicylic acid does not itself induce interferon, acetylsalicylic acid was found to significantly enhance the production of both human alpha interferon and human gamma interferon when added with the appropriate inducers to cultures of human peripheral blood mononuclear cells. The mechanisms associated w...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Yousefi S,Chiu J,Carandang G,Archibeque EG,Vaziri N,Cesario TC

    更新日期:1987-01-01 00:00:00

  • Artemisinin and a series of novel endoperoxide antimalarials exert early effects on digestive vacuole morphology.

    abstract::Artermisinin and its derivatives are now the mainstays of antimalarial treatment; however, their mechanism of action is only poorly understood. We report on the synthesis of a novel series of epoxy-endoperoxides that can be prepared in high yields from simple starting materials. Endoperoxides that are disubstituted wi...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: del Pilar Crespo M,Avery TD,Hanssen E,Fox E,Robinson TV,Valente P,Taylor DK,Tilley L

    更新日期:2008-01-01 00:00:00

  • Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan.

    abstract::Ten penicillinase-producing Neisseria gonorrhoeae (PPNG) strains isolated from 2000 to 2008 were characterized by multilocus sequence typing, multiantigen sequence typing, and plasmid typing. Sequence analysis showed that 8 strains contained a TEM-1 beta-lactamase gene. However, two other genetically distinct PPNG str...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ohnishi M,Ono E,Shimuta K,Watanabe H,Okamura N

    更新日期:2010-07-01 00:00:00

  • Inhibition of Rift Valley fever virus replication and perturbation of nucleocapsid-RNA interactions by suramin.

    abstract::Rift Valley fever virus (RVFV) is an emerging infectious pathogen that causes severe disease in humans and livestock and has the potential for global spread. There are currently no proven safe and effective treatment options for RVFV infection. Inhibition of RNA binding to RVFV nucleocapsid protein (N) represents an a...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ellenbecker M,Lanchy JM,Lodmell JS

    更新日期:2014-12-01 00:00:00

  • Activity of Meropenem-Vaborbactam in Mouse Models of Infection Due to KPC-Producing Carbapenem-Resistant Enterobacteriaceae.

    abstract::Meropenem-vaborbactam (Vabomere) is highly active against Gram-negative pathogens, especially Klebsiella pneumoniae carbapenemase (KPC)-producing, carbapenem-resistant Enterobacteriaceae The objective of these studies was to evaluate the efficacy of meropenem alone and in combination with vaborbactam in mouse thigh an...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sabet M,Tarazi Z,Nolan T,Parkinson J,Rubio-Aparicio D,Lomovskaya O,Dudley MN,Griffith DC

    更新日期:2017-12-21 00:00:00

  • In vitro and in vivo activities of a triterpenoid saponin extract (PX-6518) from the plant Maesa balansae against visceral leishmania species.

    abstract::The in vitro and in vivo activities of a mixture of six oleane triterpene saponins, recovered from the methanolic extract of the leaves of the Vietnamese plant Maesa balansae (PX-6518), were evaluated against drug-sensitive visceral Leishmania strains. The in vitro 50% inhibitory concentration (IC(50)) against intrace...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Maes L,Vanden Berghe D,Germonprez N,Quirijnen L,Cos P,De Kimpe N,Van Puyvelde L

    更新日期:2004-01-01 00:00:00

  • Erythromycin resistance in Borrelia burgdorferi.

    abstract::Susceptibility testing of laboratory strains and clinical isolates of Borrelia burgdorferi indicates that resistance to erythromycin is present in them. Evaluation of the MICs, minimal bactericidal concentrations, and kinetics of bacterial killing of erythromycin suggests that this resistance is increased by preexposu...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Terekhova D,Sartakova ML,Wormser GP,Schwartz I,Cabello FC

    更新日期:2002-11-01 00:00:00

  • Staphylococcus aureus isolates with reduced susceptibility to glycopeptides belong to accessory gene regulator group I or II.

    abstract::We used multiplex PCR to determine the agr group membership of 18 European glycopeptide heterointermediate and intermediate-resistant Staphylococcus aureus strains. Of the 15 agr group I strains, 13 were resistant and 2 were susceptible to methicillin. The remaining three strains, like the United States and Japanese c...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Verdier I,Reverdy ME,Etienne J,Lina G,Bes M,Vandenesch F

    更新日期:2004-03-01 00:00:00

  • Treatment of anaerobic infections with metronidazole.

    abstract::The results of treatment of 10 patients with anaerobic infections with metronidazole are presented. Six patients were cured, three showed initial good response but circumstances required a change to another drug, and one patient did not respond. The unique spectrum of the drug, its pharmacology, and limitations are di...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 临床试验,杂志文章


    authors: Tally FP,Sutter VL,Finegold SM

    更新日期:1975-05-01 00:00:00

  • 1H nuclear magnetic resonance study of oxazolidinone binding to bacterial ribosomes.

    abstract::The oxazolidinones are a novel class of antibiotics that inhibit initiation of protein synthesis in bacteria. In order to investigate their novel mechanism of action, the interactions of several oxazolidinones with bacterial 70S ribosomes, 50S subunits, and 30S subunits have been characterized by (1)H nuclear magnetic...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Zhou CC,Swaney SM,Shinabarger DL,Stockman BJ

    更新日期:2002-03-01 00:00:00

  • Direct-current bactericidal effect on intact skin.

    abstract::Positive carbon-containing electrodes conveying 5 or more microA of constant direct current per cm2 showed bactericidal activity on intact back skin of 13 human subjects. This effect increased with the duration of stimulation up to a total surface bacterial kill at 20 h. When total current and current density were var...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Bolton L,Foleno B,Means B,Petrucelli S

    更新日期:1980-07-01 00:00:00

  • Effect of DNA gyrase inhibitors pefloxacin, five other quinolones, novobiocin, and clorobiocin on Escherichia coli topoisomerase I.

    abstract::Two coumarins, inhibitors of the B subunit of DNA gyrase, and six quinolones, inhibitors of the A subunit, were tested against Escherichia coli topoisomerase I-catalyzed DNA relaxation. Coumarins had no effect, whereas quinolones were inhibitors of the enzyme. This inhibition was compared with that of DNA gyrase and c...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Tabary X,Moreau N,Dureuil C,Le Goffic F

    更新日期:1987-12-01 00:00:00

  • Multicenter Study of the Relationship between Carbapenem MIC Values and Clinical Outcome of Patients with Acinetobacter Bacteremia.

    abstract::The Clinical and Laboratory Standards Institute (CLSI) and the European Committee on Antimicrobial Susceptibility Testing (EUCAST) offer different recommendations for carbapenem MIC susceptibility breakpoints for Acinetobacter species. In addition, the clinical efficacy of the intermediate category remains uncertain. ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,多中心研究


    authors: Yang YS,Wang YC,Kuo SC,Chen CT,Liu CP,Liu YM,Chen TL,Lee YT

    更新日期:2017-08-24 00:00:00

  • Ruxolitinib and tofacitinib are potent and selective inhibitors of HIV-1 replication and virus reactivation in vitro.

    abstract::The JAK-STAT pathway is activated in both macrophages and lymphocytes upon human immunodeficiency virus type 1 (HIV-1) infection and thus represents an attractive cellular target to achieve HIV suppression and reduced inflammation, which may impact virus sanctuaries. Ruxolitinib and tofacitinib are JAK1/2 inhibitors t...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Gavegnano C,Detorio M,Montero C,Bosque A,Planelles V,Schinazi RF

    更新日期:2014-01-01 00:00:00

  • Use of real-time PCR and fluorimetry to detect lamivudine resistance-associated mutations in hepatitis B virus.

    abstract::Very rapid amplification of DNA by PCR in small volumes can be continuously monitored by the detection of the binding of probes with a rapid cycler with built-in fluorometric detection. Primers were designed to amplify approximately 100 bp of the polymerase gene of hepatitis B virus (HBV) spanning codon 550, where mut...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Cane PA,Cook P,Ratcliffe D,Mutimer D,Pillay D

    更新日期:1999-07-01 00:00:00

  • In vitro activities of penciclovir and acyclovir against herpes simplex virus types 1 and 2.

    abstract::Penciclovir (PCV) and acyclovir are acyclic guanine analogs which inhibit herpes simplex virus (HSV) DNA polymerase. Their 50% infective doses were 0.5 to 0.8 microgram/ml for clinical isolates of HSV-1 and 1.3 to 2.2 micrograms/ml for HSV-2. Furthermore, HSV-infected cultures receiving 2-h pulses of PCV had 2- to 50-...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Weinberg A,Bate BJ,Masters HB,Schneider SA,Clark JC,Wren CG,Allaman JA,Levin MJ

    更新日期:1992-09-01 00:00:00

  • Effect of reduced oxygen on the antifungal susceptibility of clinically relevant aspergilli.

    abstract::The influence of hypoxia on the in vitro activities of amphotericin B, azoles, and echinocandins against Aspergillus spp. was evaluated by comparing MICs, minimal fungicidal concentrations (MFCs), and epidemiological cutoffs (ECOFFs). Changes of MIC distributions due to hypoxia largely depend on the method, the specie...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Binder U,Maurer E,Lackner M,Lass-Flörl C

    更新日期:2015-03-01 00:00:00

  • Outbreak caused by Enterobacteriaceae harboring NDM-1 metallo-β-lactamase carried in an IncFII plasmid in a tertiary care hospital in Mexico City.

    abstract::Carbapenem-resistant Enterobacteriaceae carrying New Delhi metallo-β-lactamase 1 (NDM-1) have rarely been reported in Latin America. We report of an outbreak caused by a blaNDM-1-harboring plasmid spread through different bacterial species, including Escherichia coli (ST617) and Enterobacter cloacae (ST182) isolates f...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Torres-González P,Bobadilla-Del Valle M,Tovar-Calderón E,Leal-Vega F,Hernández-Cruz A,Martínez-Gamboa A,Niembro-Ortega MD,Sifuentes-Osornio J,Ponce-de-León A

    更新日期:2015-11-01 00:00:00

  • Topoisomerase mutations in trovafloxacin-resistant Staphylococcus aureus.

    abstract::A total of 201 Staphylococcus aureus isolates were surveyed for susceptibility to ciprofloxacin and trovafloxacin. Of 66 methicillin-resistant isolates, 89% were ciprofloxacin resistant and 6% were also trovafloxacin resistant. Trovafloxacin-resistant strains had unusual patterns of quinoline resistance mutations in D...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Fitzgibbon JE,John JF,Delucia JL,Dubin DT

    更新日期:1998-08-01 00:00:00

  • In Vitro Activity of Ceftaroline against Staphylococcus aureus Isolates Collected in 2012 from Latin American Countries as Part of the AWARE Surveillance Program.

    abstract::The in vitro activities of ceftaroline and comparators, using broth microdilution, were determined against 1,066 Staphylococcus aureus isolates from hospitalized patients. Seventeen medical centers from Latin American countries contributed isolates. Methicillin-resistant S. aureus (MRSA) percentages ranged from 46% (B...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章,多中心研究


    authors: Biedenbach DJ,Hoban DJ,Reiszner E,Lahiri SD,Alm RA,Sahm DF,Bouchillon SK,Ambler JE

    更新日期:2015-12-01 00:00:00

  • Antimicrobial susceptibilities of rough, smooth, and mucoid colony types of Pseudomonas isolated from cystic fibrosis patients.

    abstract::Minimal inhibitory concentrations of carbenicillin, chloramphenicol, tetracycline, gentamicin, tobramycin, and trimethoprim-sulfamethoxazole were determined for rough, smooth, and mucoid Pseudomonas sp. isolates from sputa collected from 40 cystic fibrosis patients. Ninety-four percent of the minimal inhibitory concen...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Maybury BA,Blessing-Moore J,deWit SA,Lewiston NJ,Yeager AS

    更新日期:1979-03-01 00:00:00

  • Efficacy of dalbavancin against methicillin-resistant Staphylococcus aureus in the rat granuloma pouch infection model.

    abstract::Infections due to methicillin-resistant Staphylococcus aureus (MRSA) are an important cause of morbidity and mortality in hospital patients. Moreover, increased incidences of outpatient MRSA have been recently reported. This study investigated the bactericidal activity of dalbavancin, a novel, semisynthetic glycopepti...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Jabés D,Candiani G,Romanó G,Brunati C,Riva S,Cavaleri M

    更新日期:2004-04-01 00:00:00

  • Enhanced killing of Candida albicans by cultured peritoneal exudate cells treated with SM-1213, a synthetic immunomodulator.

    abstract::The effect of SM-1213 [1,2-O-isopropylidene-3-O-3'-(N', N'-dimethylamino-n-propyl)-D-glucofuranose] on the candidastatic and candidacidal capacity of guinea pig peritoneal exudate cells was investigated. Phagocytes treated with SM-1213 demonstrated an enhanced ability to inhibit intracellular hyphal formation and elon...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Morrison CJ,Gordon P,Hashimoto T

    更新日期:1984-07-01 00:00:00

  • In vitro and in vivo antibacterial activities of OPC-20011, a novel parenteral broad-spectrum 2-oxaisocephem antibiotic.

    abstract::OPC-20011, a new parenteral 2-oxaisocephem antibiotic, has an oxygen atom at the 2- position of the cephalosporin frame. OPC-20011 had the best antibacterial activities against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, and penicillin-resistant Streptoc...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Matsumoto M,Tamaoka H,Ishikawa H,Kikuchi M

    更新日期:1998-11-01 00:00:00

  • Preclinical pharmacokinetics and distribution to tissue of AG1343, an inhibitor of human immunodeficiency virus type 1 protease.

    abstract::AG1343, a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) protease (Ki = 2 nM), was designed by protein structure-based drug design techniques. AG1343 has potent antiviral activity (95% effective dose = 0.04 microgram/ml) against a number of HIV-1 strains in acute and chronic models of infection. As pa...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Shetty BV,Kosa MB,Khalil DA,Webber S

    更新日期:1996-01-01 00:00:00

  • Concentration-dependent synergy and antagonism within a triple antifungal drug combination against Aspergillus species: analysis by a new response surface model.

    abstract::Triple antifungal combinations are used against refractory invasive aspergillosis without an adequate understanding of their pharmacodynamic interactions. We initially studied the in vitro triple combination of voriconazole, amphotericin B, and caspofungin against Aspergillus fumigatus, A. flavus, and A. terreus by a ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Meletiadis J,Stergiopoulou T,O'Shaughnessy EM,Peter J,Walsh TJ

    更新日期:2007-06-01 00:00:00

  • Effect of 3'-azido-3'-deoxythymidine on human immunodeficiency virus type 1 replication in human fetal brain macrophages.

    abstract::We investigated whether cells derived from the fetal central nervous system can support productive infection by a human immunodeficiency virus type 1 (HIV-1) isolate termed UHC-1, produced by a cellular clone derived from HIV-1 strain HIV-IIIB chronically infected U-937 promonocytic cells, and what the effect of nucle...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Geleziunas R,Arts EJ,Boulerice F,Goldman H,Wainberg MA

    更新日期:1993-06-01 00:00:00

  • Evaluation of susceptibility of gram-positive and -negative bacteria to human defensins by using radial diffusion assay.

    abstract::Defensins are small cationic bactericidal peptides present abundantly in the granules of polymorphonuclear neutrophils (PMNs). Human PMNs contain four defensins termed HNP-1 to HNP-4. We used a new assay system in agar plates, the radial diffusion assay, to evaluate the effects of human defensins against gram-positive...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Takemura H,Kaku M,Kohno S,Hirakata Y,Tanaka H,Yoshida R,Tomono K,Koga H,Wada A,Hirayama T,Kamihira S

    更新日期:1996-10-01 00:00:00