Fluoroquinolone resistance among Mycobacterium tuberculosis strains from Karachi, Pakistan: data from community-based field clinics.

abstract：:Two morphotypes of Hafnia alvei differed in their susceptibilities to beta-lactam antibiotics. Both produced an inducible Bush group 1 beta-lactamase. Hyperinducibility of this enzyme was associated with reduced susceptibility in one morphotype. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Thomson KS,Sanders CC,Washington JA 2nd

更新日期：1993-06-01 00:00:00

abstract：:Omadacycline is a first-in-class aminomethylcycline antibiotic with microbiological activity against Gram-positive and Gram-negative aerobes and anaerobes and atypical bacteria that is being developed for the treatment of acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneu...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun H,Ting L,Machineni S,Praestgaard J,Kuemmell A,Stein DS,Sunkara G,Kovacs SJ,Villano S,Tanaka SK

更新日期：2016-11-21 00:00:00

abstract：:Previous studies have shown that the proton pump inhibitor omeprazole has antimalarial activity in vitro. The interactions of omeprazole with commonly used antimalarial drugs were assessed in vitro. Omeprazole and quinine combinations were synergistic; however, chloroquine and omeprazole combinations were antagonistic...

journal_title：Antimicrobial agents and chemotherapy

authors： Skinner-Adams T,Davis TM

更新日期：1999-05-01 00:00:00

abstract：:The effect of SM-1213 [1,2-O-isopropylidene-3-O-3'-(N', N'-dimethylamino-n-propyl)-D-glucofuranose] on the candidastatic and candidacidal capacity of guinea pig peritoneal exudate cells was investigated. Phagocytes treated with SM-1213 demonstrated an enhanced ability to inhibit intracellular hyphal formation and elon...

journal_title：Antimicrobial agents and chemotherapy

authors： Morrison CJ,Gordon P,Hashimoto T

更新日期：1984-07-01 00:00:00

abstract：:Invasive pulmonary aspergillosis (IPA) is a devastating disease of immunocompromised patients. Pharmacodynamic (PD) examination of antifungal drug therapy in IPA is one strategy that may improve outcomes. The current study explored the PD target of posaconazole in an immunocompromised murine model of IPA against 10 A....

journal_title：Antimicrobial agents and chemotherapy

authors： Lepak AJ,Marchillo K,Vanhecker J,Andes DR

更新日期：2013-01-01 00:00:00

abstract：:The multidrug resistance profiles of Klebsiella pneumoniae carbapenemase (KPC) producers have led to increased clinical polymyxin use. Combination therapy with polymyxins may improve treatment outcomes, but it is uncertain which combinations are most effective. Clinical successes with intravenous minocycline-based com...

journal_title：Antimicrobial agents and chemotherapy

authors： Huang D,Yu B,Diep JK,Sharma R,Dudley M,Monteiro J,Kaye KS,Pogue JM,Abboud CS,Rao GG

更新日期：2017-06-27 00:00:00

abstract：:A reverse-phase, high-pressure liquid chromatographic method for the rapid and quantitative determination of ketoconazole has been developed. Drug levels from 0.5 to 10 microgram/ml can be determined in either yeast nitrogen base medium or human serum by using an octadecylsilane column. A retention time of 4.9 +/- 0.1...

journal_title：Antimicrobial agents and chemotherapy

authors： Andrews FA,Peterson LR,Beggs WH,Crankshaw D,Sarosi GA

更新日期：1981-01-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) produces two polyproteins, Pr55(Gag) and Pr160(Gag-Pol), that are cleaved into mature functional subunits by the virally encoded protease. Drugs that inhibit this protease are an important part of anti-HIV therapy. We studied the ordered accumulation of Gag and Gag-Pol proce...

journal_title：Antimicrobial agents and chemotherapy

authors： Speck RR,Flexner C,Tian CJ,Yu XF

更新日期：2000-05-01 00:00:00

abstract：:Laboratory-based in vitro antimicrobial susceptibility testing is the foundation for guiding anti-infective therapy and monitoring antimicrobial resistance trends. We used whole-genome sequencing (WGS) technology to identify known antimicrobial resistance determinants among strains of nontyphoidal Salmonella and corre...

journal_title：Antimicrobial agents and chemotherapy

authors： McDermott PF,Tyson GH,Kabera C,Chen Y,Li C,Folster JP,Ayers SL,Lam C,Tate HP,Zhao S

更新日期：2016-08-22 00:00:00

abstract：:In both scid and BALB/c mouse-Leishmania donovani models, hexadecyphosphocholine (miltefosine) and AmBisome had similar levels of activity. In contrast, sodium stibogluconate (Pentostam) was significantly less active against L. donovani in scid mice than in BALB/c mice. The in vitro anti-leishmanial activity of miltef...

journal_title：Antimicrobial agents and chemotherapy

authors： Escobar P,Yardley V,Croft SL

更新日期：2001-06-01 00:00:00

abstract：:The genetic basis of erythromycin resistance in cutaneous propionibacteria was determined by comparing the nucleotide sequences of the peptidyl transferase region in the 23S rRNAs from 9 susceptible and 26 resistant clinical isolates as well as 4 laboratory-selected erythromycin-resistant mutants of a susceptible stra...

journal_title：Antimicrobial agents and chemotherapy

authors： Ross JI,Eady EA,Cove JH,Jones CE,Ratyal AH,Miller YW,Vyakrnam S,Cunliffe WJ

更新日期：1997-05-01 00:00:00

abstract：:The report describes the establishment and characterization of a mouse xenograft transplantation model for the study of papillomavirus infection of bovine skin. Calf scrotal skin was inoculated with bovine papillomavirus type 2 before grafting it to the dorsum of severe combined immunodeficient mice. The grafted skin ...

journal_title：Antimicrobial agents and chemotherapy

authors： Pawellek A,Hewlett G,Kreuter J,Rübsamen-Waigmann H,Weber O

更新日期：2001-04-01 00:00:00

abstract：:We studied the activity of voriconazole against 400 clinical strains of Aspergillus from the pre-voriconazole (1999 to 2002) and post-voriconazole (2003 to 2007) periods. Although the mean MICs of strains from the post-voriconazole period were slightly higher (0.39 versus 0.57 microg/ml; P < 0.001), all strains were s...

journal_title：Antimicrobial agents and chemotherapy

authors： Guinea J,Recio S,Peláez T,Torres-Narbona M,Bouza E

更新日期：2008-09-01 00:00:00

abstract：:We tested the hypothesis that the bacterial load at the infection site could impact considerably on the pharmacokinetic/pharmacodynamic (PK/PD) parameters of fluoroquinolones. Using a rat lung infection model, we measured the influence of different marbofloxacin dosage regimens on selection of resistant bacteria after...

journal_title：Antimicrobial agents and chemotherapy

authors： Kesteman AS,Ferran AA,Perrin-Guyomard A,Laurentie M,Sanders P,Toutain PL,Bousquet-Mélou A

更新日期：2009-11-01 00:00:00

abstract：:We report the sequence of a 630-bp fragment of a gene associated with resistance to high levels of vancomycin in a clinical isolate of Enterococcus faecalis which retained susceptibility to teicoplanin. This gene was similar to the recently sequenced vanB and partially homologous with vanA, but it showed less-marked s...

journal_title：Antimicrobial agents and chemotherapy

authors： Gold HS,Unal S,Cercenado E,Thauvin-Eliopoulos C,Eliopoulos GM,Wennersten CB,Moellering RC Jr

更新日期：1993-08-01 00:00:00

abstract：:The new fluoroquinolone trovafloxacin was tested against a ciprofloxacin-sensitive, methicillin-resistant Staphylococcus aureus strain in the rabbit model of endocarditis. Trovafloxacin was more effective than vancomycin (CFU/g of vegetation, 2.65 +/- 1.87 versus 4.54 +/- 2.80 [mean +/- standard deviation]; P < 0.05) ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kim YS,Liu Q,Chow LL,Chambers HF,Täuber MG

更新日期：1998-12-01 00:00:00

abstract：:Anidulafungin is an echinocandin with activity against Candida species and Aspergillus species. Adult dosages under study are 50 mg/day for esophageal candidiasis and 100 mg/day for invasive candidiasis and aspergillosis. Little is known, however, about the safety and pharmacokinetics of anidulafungin in children. A m...

journal_title：Antimicrobial agents and chemotherapy

authors： Benjamin DK Jr,Driscoll T,Seibel NL,Gonzalez CE,Roden MM,Kilaru R,Clark K,Dowell JA,Schranz J,Walsh TJ

更新日期：2006-02-01 00:00:00

abstract：:Unlike mammalian cells, malarial parasites lack the enzymes to salvage preformed pyrimidines. For this reason, a combination of a thymidylate synthase inhibitor and the nucleoside thymidine should provide selective antimalarial activity even in the absence of any known active site differences between malarial and mamm...

journal_title：Antimicrobial agents and chemotherapy

authors： Rathod PK,Reshmi S

更新日期：1994-03-01 00:00:00

abstract：:Mefloquine is widely used in combination with artemisinin derivatives for the treatment of falciparum malaria. Mefloquine resistance in Plasmodium falciparum has been related to increased copy numbers of multidrug-resistant gene 1 (pfmdr1). We studied the ex vivo dynamics of pfmdr1 gene amplification in culture-adapte...

journal_title：Antimicrobial agents and chemotherapy

authors： Preechapornkul P,Imwong M,Chotivanich K,Pongtavornpinyo W,Dondorp AM,Day NP,White NJ,Pukrittayakamee S

更新日期：2009-04-01 00:00:00

abstract：:Mecillinam is an amidino penicillinate derivative with a broad spectrum of activity against many gram-negative bacilli. Moreover, marked in vitro synergy against these organisms occurs when mecillinam is combined with other beta-lactam antibiotics. The purpose of this study was to determine the pharmacokinetic disposi...

journal_title：Antimicrobial agents and chemotherapy

authors： Gambertoglio JG,Barriere SL,Lin ET,Conte JE Jr

更新日期：1980-12-01 00:00:00

abstract：:Enfuvirtide is the first fusion and entry inhibitor approved for use for the treatment of human immunodeficiency virus (HIV) type 1 infection and as such represents a novel class of agents. For the population of patients experienced with three antiretroviral classes, enfuvirtide provides an additional option for treat...

journal_title：Antimicrobial agents and chemotherapy

authors： DeJesus E,Gottlieb MS,Gathe JC Jr,Greenberg ML,Guittari CJ,Zolopa AR

更新日期：2008-12-01 00:00:00

abstract：:The Pseudomonas R factor RP1 determines an inducible tetracycline resistance similar to that described for Escherichia coli R factors. The level of RP1-determined resistance measured by minimal inhibitory concentration testing is dependent on the host bacteria and corresponds to the magnitude of decrease in tetracycli...

journal_title：Antimicrobial agents and chemotherapy

authors： Shipley PL,Olsen RH

更新日期：1974-08-01 00:00:00

abstract：:The association of an IS440-sul3 platform with Tn21 class 1 integrons carried by IncI1 plasmids encoding extended-spectrum β-lactamases (ESBLs; mainly SHV-12 and CTX-M-14) among worldwide Escherichia coli clones of phylogroups A (ST10, ST23, and ST46), B1 (ST155, ST351, and ST359), and D/B2 (ST131) is reported. An in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Curiao T,Cantón R,Garcillán-Barcia MP,de la Cruz F,Baquero F,Coque TM

更新日期：2011-05-01 00:00:00

abstract：:Replication complexes of hepatitis C virus synthesized two major species of viral RNA in vitro, double stranded and single stranded. NS5B nonnucleoside inhibitors inhibited dose dependently the synthesis of single-stranded RNA but not double-stranded RNA. Moreover, replication complexes carrying a mutation resistant t...

journal_title：Antimicrobial agents and chemotherapy

authors： Yang W,Sun Y,Phadke A,Deshpande M,Huang M

更新日期：2007-01-01 00:00:00

abstract：:In the sequence upstream from qnrB (but not qnrA or qnrS) is a LexA binding site. qnrB was shown to be under SOS control by demonstrating that quinolone susceptibility decreased with increasing temperature in a strain with a recA441(Ts) allele, whereas qnrB expression increased in response to ciprofloxacin or mitomyci...

journal_title：Antimicrobial agents and chemotherapy

authors： Wang M,Jacoby GA,Mills DM,Hooper DC

更新日期：2009-02-01 00:00:00

abstract：:Bacterial sepsis is a major cause of morbidity and mortality in neonates, especially those involving methicillin-resistant Staphylococcus aureus (MRSA). Guidelines by the Infectious Diseases Society of America recommend the vancomycin 24-h area under the concentration-time curve to MIC ratio (AUC24/MIC) of >400 as the...

journal_title：Antimicrobial agents and chemotherapy

authors： Tseng SH,Lim CP,Chen Q,Tang CC,Kong ST,Ho PC

更新日期：2018-03-27 00:00:00

abstract：:The in vitro activity of TR-700 (torezolid) was evaluated against a collection of 660 staphylococcal blood isolates. TR-700 showed excellent activity against all the staphylococci tested. The MIC(50) and MIC(90) values of TR-700, linezolid, daptomycin, and vancomycin against methicillin-resistant Staphylococcus aureus...

journal_title：Antimicrobial agents and chemotherapy

authors： Betriu C,Morales G,Rodríguez-Avial I,Culebras E,Gómez M,López-Fabal F,Picazo JJ

更新日期：2010-05-01 00:00:00

abstract：:We report the emergence of five carbapenem-resistant K1 hypervirulent Klebsiella pneumoniae (hvKP) strains which caused fatal infections in hospital patients in Zhejiang Province, China, upon entry through surgical wounds. Genotyping results revealed the existence of three genetically related strains which exhibited a...

journal_title：Antimicrobial agents and chemotherapy

authors： Zhang R,Lin D,Chan EW,Gu D,Chen GX,Chen S

更新日期：2015-11-16 00:00:00

abstract：:Two new fluorinated oxazolidinones, U-100592 and U-100766, were evaluated against more than 659 gram-positive and -negative organisms and compared with glycopeptides, erythromycin, clindamycin, clinafloxacin, and chloramphenicol. U-100592 and U-100766 were usually equally potent, but the MICs at which 90% of the isola...

journal_title：Antimicrobial agents and chemotherapy

authors： Jones RN,Johnson DM,Erwin ME

更新日期：1996-03-01 00:00:00

abstract：:R plasmids identified in Pseudomonas aeruginosa strains isolated in our laboratories were classified by their incompatibility characters by using intraspecies conjugation in P. aeruginosa. The fertility factor, FP2, was compatible with R plasmids belonging to all groups, and was classified in a new group. From these d...

journal_title：Antimicrobial agents and chemotherapy

authors： Sagai H,Hasuda K,Iyobe S,Bryan LE,Holloway BW,Mitsuhashi S

更新日期：1976-10-01 00:00:00