Abstract:
:Inactivation of the X chromosome in the male germ line has been suggested to contribute to the excess of gene movement off the X chromosome and the paucity of X-linked male-biased genes that have been observed in Drosophila species. Recent experimental work has demonstrated the transcriptional inactivation of the X chromosome during spermatogenesis, but it is not known if some regions of the X escape inactivation. To test this, we analyzed the expression of 112 precisely-mapped, testis-specific reporter gene insertions along the X chromosome. All of the reporter gene insertions showed low levels of expression that were significantly less than those of autosomal insertions, suggesting that the X chromosome is globally inactivated in the male germ line. There was no evidence for regions of the X chromosome escaping inactivation, including cytological region 19, which appears to be a hot spot for newly evolved, testis-expressed genes.
journal_name
Mol Biol Evoljournal_title
Molecular biology and evolutionauthors
Kemkemer C,Hense W,Parsch Jdoi
10.1093/molbev/msq355subject
Has Abstractpub_date
2011-05-01 00:00:00pages
1561-3issue
5eissn
0737-4038issn
1537-1719pii
msq355journal_volume
28pub_type
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