Evolution of nicotinic acetylcholine receptor subunits.

abstract：:The mammalian family Talpidae (moles, shrew moles, desmans) is characterized by diverse ecomorphologies associated with terrestrial, semi-aquatic, semi-fossorial, fossorial, and aquatic-fossorial lifestyles. Prominent specializations involved with these different lifestyles, and the transitions between them, pose outs...

journal_title：Molecular biology and evolution

authors： He K,Shinohara A,Helgen KM,Springer MS,Jiang XL,Campbell KL

更新日期：2017-01-01 00:00:00

abstract：:Cytochrome c oxidase (COX) consists of 13 subunits, 3 encoded in the mitochondrial genome and 10 in the nucleus. Little is known of the role of the nuclear-encoded subunits, some of which exhibit tissue-specific isoforms. Subunit VIa is unique in having tissue-specific isoforms in all mammalian species examined. We ex...

journal_title：Molecular biology and evolution

authors： Schmidt TR,Jaradat SA,Goodman M,Lomax MI,Grossman LI

更新日期：1997-06-01 00:00:00

abstract：:The evolutionary expansion of CAG repeats in human triplet expansion disease genes is intriguing because of their deleterious phenotype. In the past, this expansion has been suggested to reflect a broad genomewide expansion of repeats, which would imply that mutational and evolutionary processes acting on repeats diff...

journal_title：Molecular biology and evolution

authors： Hancock JM,Worthey EA,Santibáñez-Koref MF

更新日期：2001-06-01 00:00:00

abstract：:A major limitation on ability to reconstruct bacterial evolution is the lack of dated ancestors that might be used to evaluate and calibrate molecular clocks. Vertically transmitted symbionts that have cospeciated with animal hosts offer a firm basis for calibrating sequence evolution in bacteria, since fossils of the...

journal_title：Molecular biology and evolution

authors： Clark MA,Moran NA,Baumann P

更新日期：1999-11-01 00:00:00

abstract：:A recent genomewide screen identified 13 transposable elements that are likely to have been adaptive during or after the spread of Drosophila melanogaster out of Africa. One of these insertions, Bari-Juvenile hormone epoxy hydrolase (Bari-Jheh), was associated with the selective sweep of its flanking neutral variation...

journal_title：Molecular biology and evolution

authors： González J,Macpherson JM,Petrov DA

更新日期：2009-09-01 00:00:00

abstract：:An attempt to use phylogenetic invariants for tree reconstruction was made at the end of the 80s and the beginning of the 90s by several researchers (the initial idea due to Lake [1987] and Cavender and Felsenstein [1987]). However, the efficiency of methods based on invariants is still in doubt (Huelsenbeck 1995; Jin...

journal_title：Molecular biology and evolution

authors： Casanellas M,Fernández-Sánchez J

更新日期：2007-01-01 00:00:00

abstract：:Microbial species play important roles in different environments and the production of high-quality genomes from metagenome data sets represents a major obstacle to understanding their ecological and evolutionary dynamics. Metagenome-Assembled Genomes Orchestra (MAGO) is a computational framework that integrates and s...

journal_title：Molecular biology and evolution

authors： Murovec B,Deutsch L,Stres B

更新日期：2020-02-01 00:00:00

abstract：:Gene conversion is considered to play important roles in the formation of genomic makeup such as homogenization of multigene families and diversification of alleles. We devised two statistical tests on quartets for detecting gene conversion events. Each "quartet" consists of two pairs of orthologous sequences supposed...

journal_title：Molecular biology and evolution

authors： Ezawa K,OOta S,Saitou N,SMBE Tri-National Young Investigators.

更新日期：2006-05-01 00:00:00

abstract：:The most frequent measure of phylogenetic uncertainty for splits is bootstrap support. Although large bootstrap support intuitively suggests that a split in a tree is well supported, it has not been clear how large bootstrap support needs to be to conclude that there is significant evidence that a hypothesized split i...

journal_title：Molecular biology and evolution

authors： Susko E

更新日期：2010-07-01 00:00:00

abstract：:This paper discusses the optimization principle in phylogenetic analysis, in the case of distance data. We argue that the use of this principle cannot be called into question, except for computing time reasons. We show that the minimum-evolution criterion is not perfectly suited for distance data estimated from sequen...

journal_title：Molecular biology and evolution

authors： Gascuel O

更新日期：2000-03-01 00:00:00

abstract：:Selection on codon usage bias is well documented in a number of microorganisms. Whether codon usage is also generally shaped by natural selection in large organisms, despite their relatively small effective population size (Ne), is unclear. In animals, the population genetics of codon usage bias has only been studied ...

journal_title：Molecular biology and evolution

authors： Galtier N,Roux C,Rousselle M,Romiguier J,Figuet E,Glémin S,Bierne N,Duret L

更新日期：2018-05-01 00:00:00

abstract：:DNA cytosine methylation is central to many biological processes, including regulation of gene expression, cellular differentiation, and development. This DNA modification is conserved across animals, having been found in representatives of sponges, ctenophores, cnidarians, and bilaterians, and with very few known ins...

journal_title：Molecular biology and evolution

authors： Kyger R,Luzuriaga-Neira A,Layman T,Milkewitz Sandberg TO,Singh D,Huchon D,Peri S,Atkinson SD,Bartholomew JL,Yi SV,Alvarez-Ponce D

更新日期：2021-01-23 00:00:00

abstract：:Inactivation of the X chromosome in the male germ line has been suggested to contribute to the excess of gene movement off the X chromosome and the paucity of X-linked male-biased genes that have been observed in Drosophila species. Recent experimental work has demonstrated the transcriptional inactivation of the X ch...

journal_title：Molecular biology and evolution

authors： Kemkemer C,Hense W,Parsch J

更新日期：2011-05-01 00:00:00

abstract：:Malaria is a deadly disease that causes nearly one million deaths each year. To develop methods to control and eradicate malaria, it is important to understand the genetic basis of Plasmodium falciparum adaptations to antimalarial treatments and the human immune system while taking into account its demographic history...

journal_title：Molecular biology and evolution

authors： Chang HH,Park DJ,Galinsky KJ,Schaffner SF,Ndiaye D,Ndir O,Mboup S,Wiegand RC,Volkman SK,Sabeti PC,Wirth DF,Neafsey DE,Hartl DL

更新日期：2012-11-01 00:00:00

abstract：:Gene expression changes contribute to complex trait variations in both individuals and populations. However, the evolution of gene expression underlying complex traits over macroevolutionary timescales remains poorly understood. Snake venoms are proteinaceous cocktails where the expression of each toxin can be quantif...

journal_title：Molecular biology and evolution

authors： Barua A,Mikheyev AS

更新日期：2019-09-01 00:00:00

abstract：:Polymerase chain reaction (PCR) products corresponding to 803 bp of the cytochrome oxidase subunits I and II region of mitochondrial DNA (mtDNA COI-II) were deduced to consist of multiple haplotypes in three Sitobion species. We investigated the molecular basis of these observations. PCR products were cloned, and six ...

journal_title：Molecular biology and evolution

authors： Sunnucks P,Hales DF

更新日期：1996-03-01 00:00:00

abstract：:Direct sequencing of the mitochondrial displacement loop (D-loop) of shrews (genus Sorex) for the region between the tRNA(Pro) and the conserved sequence block-F revealed variable numbers of 79-bp tandem repeats. These repeats were found in all 19 individuals sequenced, representing three subspecies and one closely re...

journal_title：Molecular biology and evolution

authors： Stewart DT,Baker AJ

更新日期：1994-01-01 00:00:00

abstract：:The assumption of a molecular clock for dating events from sequence information is often frustrated by the presence of heterogeneity among evolutionary rates due, among other factors, to positively selected sites. In this work, our goal is to explore methods to estimate infection dates from sequence analysis. One such...

journal_title：Molecular biology and evolution

authors： Wróbel B,Torres-Puente M,Jiménez N,Bracho MA,García-Robles I,Moya A,González-Candelas F

更新日期：2006-06-01 00:00:00

abstract：:The occurrence of a fish-specific genome duplication (FSGD) in the lineage leading to teleost fishes is widely accepted, but the consequences of this event remain elusive. Teleosts, and the cichlid fishes from the species flocks in the East African Great Lakes in particular, evolved a unique complexity and diversity o...

journal_title：Molecular biology and evolution

authors： Braasch I,Salzburger W,Meyer A

更新日期：2006-06-01 00:00:00

abstract：:Gene unscrambling in spirotrichous ciliates involves massive genome-wide DNA deletion and rearrangement events during development. During each sexual cycle, the somatic nucleus (macronucleus) regenerates from the germ line nucleus (micronucleus). Development of the polyploid somatic genome requires programmed DNA dele...

journal_title：Molecular biology and evolution

authors： Wong LC,Landweber LF

更新日期：2006-04-01 00:00:00

abstract：:Hepcidin is a small bioactive peptide with dual roles as an antimicrobial peptide and as the principal hormonal regulator of iron homeostasis in human and mouse. Hepcidin homologs of very similar structures are found in lower vertebrates, all comprise approximately 20-25 amino acids with 8 highly conserved cysteines f...

journal_title：Molecular biology and evolution

authors： Xu Q,Cheng CH,Hu P,Ye H,Chen Z,Cao L,Chen L,Shen Y,Chen L

更新日期：2008-06-01 00:00:00

abstract：:Many methods exist for detecting introgression between nonsister species, but the most commonly used require either a single sequence from four or more taxa or multiple sequences from each of three taxa. Here, we present a test for introgression that uses only a single sequence from three taxa. This test, denoted D3, ...

journal_title：Molecular biology and evolution

authors： Hahn MW,Hibbins MS

更新日期：2019-12-01 00:00:00

abstract：:Enzyme function is strongly affected by temperature, and orthologs from species adapted to different thermal environments often show temperature compensation in kinetic properties. Antarctic notothenioid fishes live in a habitat of constant, extreme cold (-1.86 +/- 2 degrees C), and orthologs of the enzyme A4-lactate ...

journal_title：Molecular biology and evolution

authors： Fields PA,Houseman DE

更新日期：2004-12-01 00:00:00

abstract：:Reconstructing phylogenies from intraspecific data (such as human mitochondrial DNA variation) is often a challenging task because of large sample sizes and small genetic distances between individuals. The resulting multitude of plausible trees is best expressed by a network which displays alternative potential evolut...

journal_title：Molecular biology and evolution

authors： Bandelt HJ,Forster P,Röhl A

更新日期：1999-01-01 00:00:00

abstract：:This study describes the origin and structural features of a mammalian gene, CGIN1 (Cousin of GIN1). CGIN1 proteins contain an NYN domain, retroviral RNase H and integrase domains, and a domain of unknown function (CGIN1 domain) that is also present in two other genes (N4BP1 and KIAA0323). We suggest that CGIN1 derive...

journal_title：Molecular biology and evolution

authors： Marco A,Marín I

更新日期：2009-10-01 00:00:00

abstract：:The distribution of fitness effects of mutations is a factor of fundamental importance in evolutionary biology. We determined the distribution of fitness effects of 510 mutants that each carried between 1 and 10 mutations (synonymous and nonsynonymous) in the hisA gene, encoding an essential enzyme in the l-histidine ...

journal_title：Molecular biology and evolution

authors： Lundin E,Tang PC,Guy L,Näsvall J,Andersson DI

更新日期：2018-03-01 00:00:00

abstract：:The field of ancient DNA (aDNA) is casting new light on many evolutionary questions. However, problems associated with the postmortem instability of DNA may complicate the interpretation of aDNA data. For example, in population genetic studies, the inclusion of damaged DNA may inflate estimates of diversity. In this p...

journal_title：Molecular biology and evolution

authors： Axelsson E,Willerslev E,Gilbert MT,Nielsen R

更新日期：2008-10-01 00:00:00

abstract：:Standard methods of phylogenetic reconstruction are based on models that assume homogeneity of nucleotide composition among taxa. However, this assumption is often violated in biological data sets. In this study, we examine possible effects of nucleotide heterogeneity among lineages on the phylogenetic reconstruction ...

journal_title：Molecular biology and evolution

authors： Herbeck JT,Degnan PH,Wernegreen JJ

更新日期：2005-03-01 00:00:00

abstract：:In numerous species, individual dispersal is restricted in space so that "continuous" populations evolve under isolation by distance. A method based on individual genotypes assuming a lattice population model was recently developed to estimate the product Dsigma2, where D is the population density and sigma2 is the av...

journal_title：Molecular biology and evolution

authors： Leblois R,Estoup A,Rousset F

更新日期：2003-04-01 00:00:00

abstract：:Although many phylogenetic studies have focused on developing hypotheses about relationships, advances in data collection and computation have increased the feasibility of collecting large independent data sets to rigorously test controversial hypotheses or carefully assess artifacts that may be misleading. One such r...

journal_title：Molecular biology and evolution

authors： Wang N,Braun EL,Kimball RT

更新日期：2012-02-01 00:00:00