Abstract：
:Few studies have comprehensively investigated the association of 2 key kidney disease measures, estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (ACR), with cancer incidence. In 8,935 participants at the baseline (1996-1998) from the Atherosclerosis Risk in Communities study, we quantified the associations of eGFR (based on creatinine and cystatin C) and ACR with cancer risk using Cox regression models adjusted for potential confounders. Due to changing guidelines for prostate cancer screening during the follow-up period, we investigated overall cancer, overall nonprostate cancer, and site-specific cancer. During a median follow-up of 14.7 years, 2,030 incident cancer cases occurred. In demographically adjusted models, low eGFR and high ACR were associated with cancer incidence (both overall and overall nonprostate cancer). These associations were attenuated after adjusting for other shared risk factors, with a significant association remaining only for ACR (≥103 compared with 5 mg/g) and overall nonprostate cancer. For site-specific cancer, only high ACR showed a significant association with lung and urinary tract cancers. Of these, the association between ACR and lung cancer appeared most robust in several sensitivity analyses. Kidney disease measures, particularly high ACR, were independently associated with cancer risk. The association between ACR and lung cancer was uniquely robust, warranting future studies to explore potential mechanisms.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Mok Y,Ballew SH,Sang Y,Coresh J,Joshu CE,Platz EA,Matsushita Kdoi
10.1093/aje/kwaa043subject
Has Abstractpub_date
2020-09-01 00:00:00pages
942-950issue
9eissn
0002-9262issn
1476-6256pii
5812657journal_volume
189pub_type
杂志文章abstract：:Semen quality has been suggested to be a biological marker of long-term morbidity and mortality; however, few studies have been conducted on this subject. We identified 5,370 men seen for infertility at Frederiksberg Hospital, Denmark, during 1977-2010, and 4,712 of these men were followed in the Danish National Patie...
journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：2017-10-15 00:00:00
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journal_title：American journal of epidemiology
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更新日期：2003-08-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章,评审
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更新日期：1992-05-15 00:00:00
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journal_title：American journal of epidemiology
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更新日期：1998-05-15 00:00:00
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journal_title：American journal of epidemiology
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更新日期：2009-09-01 00:00:00
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更新日期：2007-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a113937
更新日期：1984-11-01 00:00:00
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更新日期：2014-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：1980-01-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：1998-11-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：1994-11-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
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更新日期：2018-11-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a010267
更新日期：2000-04-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a009113
更新日期：1997-02-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章
doi：10.1093/oxfordjournals.aje.a116513
更新日期：1992-08-15 00:00:00
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journal_title：American journal of epidemiology
pub_type： 传,历史文章,面试
doi：10.1093/aje/kwt027
更新日期：2013-04-01 00:00:00
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journal_title：American journal of epidemiology
pub_type： 杂志文章,评审
doi：10.1093/oxfordjournals.aje.a112243
更新日期：1976-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-12-01 00:00:00
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更新日期：1979-12-01 00:00:00
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更新日期：1991-11-15 00:00:00
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更新日期：2013-10-01 00:00:00
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更新日期：1993-09-01 00:00:00
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更新日期：2020-05-05 00:00:00
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更新日期：1980-02-01 00:00:00
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更新日期：1979-07-01 00:00:00
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更新日期：2017-06-15 00:00:00
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更新日期：2010-05-15 00:00:00
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更新日期：2018-08-01 00:00:00
abstract：:An analysis of the familial aggregation of blood pressure (BP) was conducted to provide estimates of the role of genes and household environment in determining the phenotypic resemblance between biologically related family members. The biological model used for this analysis parameterizes the correlations between fami...
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更新日期：1979-10-01 00:00:00
