Prevention of learning deficit in a Down syndrome model.

Abstract:

OBJECTIVE:To evaluate whether peptides given to adult mice with Down syndrome prevent learning deficits, and to delineate the mechanisms behind the protective effect. METHODS:Ts65Dn mice were treated for 9 days with peptides D-NAPVSIPQ (NAP)+D-SALLRSIPA (SAL) or placebo, and wild-type animals were treated with placebo. Beginning on treatment day 4, the mice were tested for learning using the Morris watermaze. Probe tests for long-term memory were performed on treatment day 9 and 10 days after treatment stopped. Open-field testing was performed before and after the treatment. Calibrator-normalized relative real-time polymerase chain reaction (PCR) with glyceraldehyde-3-phosphate dehydrogenase (GAPD) standardization was performed on the whole brain and hippocampus for activity-dependent neuroprotective protein, vasoactive intestinal peptide (VIP), glial fibrillary acidic protein (GFAP), NR2B, NR2A, and γ-aminobutyric acid type A (GABAA)-α5. Statistics included analysis of variance and the Fisher protected least significant difference, with P<.05 significant. RESULTS:The Ts65Dn plus placebo animals did not learn over the 5-day period compared with the controls (P<.001). The Ts65Dn +(D-NAP+D-SAL) learned significantly better than the Ts65Dn plus placebo (P<.05), and they retained learning similar to controls on treatment day 9, but not after 10 days of no treatment. Treatment with D-NAP+D-SAL prevented the Ts65Dn hyperactivity. Adult administration of D-NAP+D-SAL prevented changes in activity-dependent neuroprotective protein, intestinal peptide, and NR2B with levels similar to controls (all P<.05). CONCLUSION:Adult treatment with D-NAP+D-SAL prevented learning deficit in Ts65Dn, a model of Down syndrome. Possible mechanisms of action include reversal of vasoactive intestinal peptide and activity-dependent neuroprotective protein dysregulation, as well as increasing expression of NR2B, thus facilitating learning.

journal_name

Obstet Gynecol

authors

Incerti M,Toso L,Vink J,Roberson R,Nold C,Abebe D,Spong CY

doi

10.1097/AOG.0b013e3182051ca5

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

354-361

issue

2 Pt 1

eissn

0029-7844

issn

1873-233X

pii

00006250-201102000-00023

journal_volume

117

pub_type

杂志文章
  • Human papillomavirus detection in cervical lesions nondiagnostic for cervical intraepithelial neoplasia: correlation with Papanicolaou smear, colposcopy, and occurrence of cervical intraepithelial neoplasia.

    abstract::Human papillomavirus (HPV) is associated with cervical intraepithelial neoplasia (CIN) and carcinomas. The present study involved women who had an abnormal Papanicolaou smear and whose cervix contained acetowhite area(s) that lacked the histologic features of CIN. Sequences homologous to HPV DNA, determined by Souther...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Nuovo GJ,Blanco JS,Leipzig S,Smith D

    更新日期:1990-06-01 00:00:00

  • Delayed hemorrhage of a persistent ectopic pregnancy following laparoscopic salpingostomy and methotrexate therapy.

    abstract::This report describes the first known case of delayed hemorrhage of a persistent ectopic pregnancy following surgical and medical therapy. A 2.5-cm ampullary pregnancy without cardiac activity was removed by laparoscopic salpingostomy. The serum beta-hCG level before laparoscopy was 1542 mIU/mL, increasing to 3163 mIU...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Dumesic DA,Hafez GR

    更新日期:1991-11-01 00:00:00

  • Alcohol, indomethacin, and salbutamol. A comparative trial of their use in preterm labor.

    abstract::In a comparative trial, ethanol effectively arrested preterm labor for 48 hours for more in 32% of cases, a beta-adrenergic agent (salbutamol) in 60% of cases (not statistically significant), and a combination of ethanol and indomethacin in 70% of cases (statistically significant, P less than 0.5). Labor was delayed f...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Spearing G

    更新日期:1979-02-01 00:00:00

  • Mechanisms of placentofetal blood flow.

    abstract::The average length of the umbilical cord at delivery is 21 +/- 1 in., but lengths vary from 10 to 50 in. When distended and carrying blood between the fetus and the placenta, the cord is longer; the distended areteries and vein are spiraled about each other. No physiologic data explain the manner by which blood flows ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Reynolds SR

    更新日期:1978-02-01 00:00:00

  • Differences in postpartum weight retention between black and white mothers.

    abstract:OBJECTIVE:To determine whether the overall retention of weight gained during pregnancy and the factors affecting postpartum weight retention differ by race. METHODS:Data from the 1988 National Maternal and Infant Health Survey were analyzed to examine postpartum weight retention of 20 lb or more among 990 black and 11...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Parker JD,Abrams B

    更新日期:1993-05-01 00:00:00

  • Amniotic fluid optical density and neonatal respiratory outcome.

    abstract::A simple, rapid, economical, and accurate test to assess fetal pulmonary maturity on a 24-hour basis, 7 days a week, is urgently needed. A 15-minute test has been developed that correlates well with fetal pulmonary maturity. Optical density (OD) readings at 650 nm of greater than or equal to 0.15 in pigment-free, cent...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Cetrulo CL,Sbarra AJ,Selvaraj RJ,Kappy KA,Herschel MJ,Knuppel RJ,Ingardia CJ,Kennedy JL,Mitchell GW

    更新日期:1980-02-01 00:00:00

  • Parental chromosome translocations and fetal loss.

    abstract::The authors report on the incidence of translocations detected among 300 Greek couples referred for cytogenetic investigation because of repeated abortion, stillbirth, and/or the birth of children with multiple congenital anomalies. Translocations were detected in 16 cases, ie, 1 of 19 couples. However, the incidence ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Tsenghi C,Metaxotou C,Kalpini-Mavrou A,Strataki-Benetou M,Matsaniotis N

    更新日期:1981-10-01 00:00:00

  • Previous tubal ligation is a risk factor for hysterectomy after rollerball endometrial ablation.

    abstract:OBJECTIVE:To determine risk factors for hysterectomy, pelvic pain, and continued menorrhagia after rollerball endometrial ablation. METHODS:All women having rollerball endometrial ablations between 1990 and 2000 were sent standardized questionnaires on pre- and postablation symptoms, satisfaction with the ablation, an...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(02)02185-3

    authors: Mall A,Shirk G,Van Voorhis BJ

    更新日期:2002-10-01 00:00:00

  • Plasma free and protein-bound testosterone in hirsutism.

    abstract::Blood samples were obtained from 145 preovulatory and postovulatory hirsute women and the plasma was analyzed for total testosterone (T), T index, and free T concentration as well as the fraction of free T percentage and that bound by testosterone-estradiol binding globulin. Fifty-six patients were subjected to a 2-we...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Wu CH

    更新日期:1982-08-01 00:00:00

  • Cesarean delivery and the long-term risk of offspring obesity.

    abstract:OBJECTIVE:To examine the association between the mode of delivery and the risk of offspring obesity by age 21 years using a large community-based birth cohort study in Australia. METHODS:We followed-up a subsample of 2,625 offspring for whom we had measured physical assessments, including height and weight at 21 years...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000000016

    authors: Mamun AA,Sutharsan R,O'Callaghan M,Williams G,Najman J,McIntyre HD,Callaway L

    更新日期:2013-12-01 00:00:00

  • A comparison of the accuracy of the TDx-FLM assay, lecithin-sphingomyelin ratio, and phosphatidylglycerol in the prediction of neonatal respiratory distress syndrome.

    abstract:OBJECTIVE:To ascertain whether the TDx-FLM assay is a better predictor of neonatal respiratory distress syndrome (RDS) than the lecithin-sphingomyelin ratio (L/S) and phosphatidylglycerol (PG). METHODS:Amniotic fluid samples of 140 women requiring assessment of fetal lung maturity and delivering within 72 hours of amn...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Hagen E,Link JC,Arias F

    更新日期:1993-12-01 00:00:00

  • Hospital variation in postpartum tubal sterilization rates in California and Texas.

    abstract:OBJECTIVE:To estimate variation across hospitals in the rate of postpartum sterilization. METHODS:All hospitals with deliveries in California and Texas in 2009 were included. Proportion of live singleton deliveries with postpartum sterilization was calculated by hospital, insurance status (Medicaid compared with priva...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/aog.0b013e318278f241

    authors: Potter JE,Stevenson AJ,White K,Hopkins K,Grossman D

    更新日期:2013-01-01 00:00:00

  • Early recognition of ectopic pregnancy in an infertility population.

    abstract::On an infertility service, 170 patients were evaluated for possible ectopic pregnancy using tests for beta-human chorionic gonadotropin levels, ultrasound, and clinical examination. Thirty-four (20%) of those evaluated underwent laparoscopy, of whom 31 (91%) were found to have ectopic pregnancies. Only three of the ec...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Dinsmoor M,Gibson M

    更新日期:1986-12-01 00:00:00

  • Maternal Pulse Pressure and the Risk of Postepidural Complications: A Randomized Controlled Trial.

    abstract:OBJECTIVE:To test the hypothesis that increasing the intravenous fluid bolus volume at the time of epidural placement in women with narrow pulse pressure would reduce postepidural fetal heart rate (FHR) abnormalities, hypotension, and resuscitative obstetric interventions. METHODS:We performed a single-center randomiz...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/AOG.0000000000002326

    authors: Lappen JR,Myers SA,Bolen N,Mercer BM,Chien EKS

    更新日期:2017-12-01 00:00:00

  • Gestational weight gain and gestational diabetes mellitus: perinatal outcomes.

    abstract:OBJECTIVE:To examine the association between gestational weight gain and perinatal outcome in women with gestational diabetes mellitus (GDM). METHODS:This is a retrospective cohort study of women with nonanomalous singleton pregnancies with GDM enrolled in the Sweet Success California Diabetes and Pregnancy Program be...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0b013e31818b5dd9

    authors: Cheng YW,Chung JH,Kurbisch-Block I,Inturrisi M,Shafer S,Caughey AB

    更新日期:2008-11-01 00:00:00

  • A 12-month comparative study of raloxifene, estrogen, and placebo on the postmenopausal endometrium.

    abstract:OBJECTIVE:To determine the effects of a selective estrogen receptor modulator, raloxifene, on postmenopausal endometrium. METHODS:Healthy postmenopausal women (n = 415) were randomly assigned to one of the following four groups: 60 or 150 mg/day raloxifene hydrochloride, 0.625 mg/day conjugated equine estrogens, or pl...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/s0029-7844(99)00502-5

    authors: Goldstein SR,Scheele WH,Rajagopalan SK,Wilkie JL,Walsh BW,Parsons AK

    更新日期:2000-01-01 00:00:00

  • Laparoscopy in 100 women with chronic pelvic pain.

    abstract::Laparoscopy was used to evaluate 100 women who consistently reported pelvic pain in the same location for a minimum of six months. These findings were compared with those of 50 asymptomatic women who underwent laparoscopy for tubal ligation. Overall, 83% of the group with pelvic pain had abnormal pelvic organs as comp...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Kresch AJ,Seifer DB,Sachs LB,Barrese I

    更新日期:1984-11-01 00:00:00

  • Treatment of vaginal condylomata acuminata by weekly topical application of 5-fluorouracil.

    abstract::Twenty nonpregnant women with condylomata acuminata of the vagina were studied to assess the effectiveness of weekly topical 5-fluorouracil application. All patients were instructed to insert an applicator one-third full of 5% 5-fluorouracil cream (approximately 1.5 g) deeply into the vagina at bedtime once each week ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Krebs HB

    更新日期:1987-07-01 00:00:00

  • Posttraumatic stress disorder and pregnancy complications.

    abstract:OBJECTIVE:To assess the associations between specific pregnancy complications and posttraumatic stress disorder based on neurobiologic and behavioral characteristics, using Michigan Medicaid claims data from 1994-1996. METHODS:Two thousand, two hundred nineteen female recipients of Michigan Medicaid who were of childb...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(00)01097-8

    authors: Seng JS,Oakley DJ,Sampselle CM,Killion C,Graham-Bermann S,Liberzon I

    更新日期:2001-01-01 00:00:00

  • Pituitary response to a new analog of luteinizing hormone releasing factor during the menstrual cycle.

    abstract::A new analog of luteinizing-hormone-releasing factor, (Des-Gly-NH-2-10, Pro-ethylamide-9)-LHRF, was tested in healthy women with regular menstrual cycles. This synthetic nonapeptide amide was injected intravenously in a dose of 200 mug into 15 normal female volunteers in the follicular, preovulatory, and luteal phases...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Nakano R,Takekida H,Kotsuji F,Tojo S

    更新日期:1975-03-01 00:00:00

  • Presenting symptoms of women with depression in an obstetrics and gynecology setting.

    abstract:OBJECTIVE:To describe the presenting symptoms of women with depression in two obstetrics and gynecology clinics, determine depression diagnosis frequency, and examine factors associated with depression diagnosis. METHODS:Data were extracted from charts of women screening positive for depression in a clinical trial tes...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0b013e31829999ee

    authors: Cerimele JM,Vanderlip ER,Croicu CA,Melville JL,Russo J,Reed SD,Katon W

    更新日期:2013-08-01 00:00:00

  • Fetal heart rate patterns and fetal distress in fetuses with congenital anomalies.

    abstract::Over a 3-year period at the Long Beach Women's Hospital, where electronic FHR (fetal heart rate) monitoring was routine, there were 8622 live births, including 41 infants born with major congenital malformations. The neonatal death rate in these malformed infants was 44%; 17 were delivered by cesarean section, 11 of w...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Garite TJ,Linzey EM,Freeman RK,Dorchester W

    更新日期:1979-06-01 00:00:00

  • Absorption kinetics of misoprostol with oral or vaginal administration.

    abstract:OBJECTIVE:To compare the pharmacokinetics of vaginal and oral administration of the prostaglandin E1 analogue, misoprostol. METHODS:Twenty women received 400-micrograms doses of misoprostol either orally or as tablets placed in the vagina. Serum levels of principal metabolite, misoprostol acid, were measured at 7.5, 1...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/S0029-7844(97)00111-7

    authors: Zieman M,Fong SK,Benowitz NL,Banskter D,Darney PD

    更新日期:1997-07-01 00:00:00

  • Screening for human immunodeficiency virus and other sexually transmitted diseases among U.S. women with prenatal care.

    abstract:OBJECTIVE:To estimate prenatal sexually transmitted disease-human immunodeficiency virus (HIV) screening rates among insured women with prenatal care and the association of chlamydia and gonorrhea screening with Pap testing. METHODS:We estimated prenatal screening rates for syphilis, hepatitis B, HIV, chlamydia, and g...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000000756

    authors: Ross CE,Tao G,Patton M,Hoover KW

    更新日期:2015-05-01 00:00:00

  • Maternal smoking and fetal erythropoietin levels.

    abstract:OBJECTIVE:To determine the influence of maternal smoking on fetal erythropoietin concentrations in health term pregnancies and test the correlation between cotinine, a biomarker of maternal smoking, and erythropoietin levels in fetuses. METHODS:We invited women with healthy term pregnancies to participate in the study...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(99)00622-5

    authors: Gruslin A,Perkins SL,Manchanda R,Fleming N,Clinch JJ

    更新日期:2000-04-01 00:00:00

  • Obstetric Care Consensus No. 2: Levels of maternal care.

    abstract::In the 1970s, studies demonstrated that timely access to risk-appropriate neonatal and obstetric care could reduce perinatal mortality. Since the publication of the Toward Improving the Outcome of Pregnancy report, more than three decades ago, the conceptual framework of regionalization of care of the woman and the ne...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/01.AOG.0000460770.99574.9f

    authors:

    更新日期:2015-02-01 00:00:00

  • Evaluation of Early Pregnancy Concerns in an Early Pregnancy Unit Compared With an Emergency Department.

    abstract:OBJECTIVE:To assess total time for evaluation of women with first-trimester pregnancy concerns in an early pregnancy unit compared with an emergency department (ED) within a single safety net hospital system. METHODS:We performed a retrospective cohort study at Denver Health Medical Center from May 1, 2017, to April 3...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000004080

    authors: VanArendonk SH,Rockhill K,Stickrath EH,Alston MJ

    更新日期:2020-11-01 00:00:00

  • Economic burden of hospitalizations for preterm labor in the United States.

    abstract:OBJECTIVE:To determine patient factors associated with hospital care costs for preterm labor and to develop a clinically applicable cost model for evaluating economic consequences of interventions to reduce preterm-labor hospitalizations. METHODS:Maryland state hospital discharge data from 1993-1996 were used to ident...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(00)00863-2

    authors: Nicholson WK,Frick KD,Powe NR

    更新日期:2000-07-01 00:00:00

  • Hormone replacement therapy after transcervical resection of the endometrium.

    abstract:OBJECTIVE:To determine if women who have undergone transcervical resection of the endometrium can be treated safely with estrogens alone. METHODS:Sixty-two postmenopausal women who had undergone endometrial resection were recruited into a double-blind, randomized study. Twenty-one had menopausal symptoms at the primar...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0029-7844(96)00308-0

    authors: Istre O,Holm-Nielsen P,Bourne T,Forman A

    更新日期:1996-11-01 00:00:00

  • Bias in the Peer Review Process: Can We Do Better?

    abstract::Peer review is the major method used by the scientific community to evaluate manuscripts and decide what is suitable for publication. However, this process in its current design is not bulletproof and is prone to reviewer and editorial bias. Its lack of objectivity and transparency raise concerns that manuscripts migh...

    journal_title:Obstetrics and gynecology

    pub_type: 社论

    doi:10.1097/AOG.0000000000003260

    authors: Tvina A,Spellecy R,Palatnik A

    更新日期:2019-06-01 00:00:00