Pituitary response to a new analog of luteinizing hormone releasing factor during the menstrual cycle.

Abstract:

:A new analog of luteinizing-hormone-releasing factor, (Des-Gly-NH-2-10, Pro-ethylamide-9)-LHRF, was tested in healthy women with regular menstrual cycles. This synthetic nonapeptide amide was injected intravenously in a dose of 200 mug into 15 normal female volunteers in the follicular, preovulatory, and luteal phases of the menstrual cycle, and the serum LH and FSH responses were compared with those to the same dose of the synthetic decapeptide LHRF in 15 controls. The new analog exhibited significantly higher activity than the synthetic decapeptide LHRF in the release of LH in the follicular (P smaller than 0.05), preovulatory (P smaller than 0.01), and luteal phases (P smaller than 0.05). In contrast, no statistical significance in the magnitude of FSH response was demonstrated in any phase of the menstrual cycle. The serum LH and FSH response to the nonapeptide amide suggested a longer physiologic half-life of the new LHRF analog. The results are similar to a previous report in men with normal gonadal function, and a clinical usefulness for the new analog is expected.

journal_name

Obstet Gynecol

authors

Nakano R,Takekida H,Kotsuji F,Tojo S

subject

Has Abstract

pub_date

1975-03-01 00:00:00

pages

263-6

issue

3

eissn

0029-7844

issn

1873-233X

journal_volume

45

pub_type

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