当前位置： SCI文献检索 > DISABILITY AND REHABILITATION期刊下所有文献 > Developing and validating equations to predict [Formula: see text]O2 peak from the 6MWT in Childhood ALL Survivors.

Developing and validating equations to predict [Formula: see text]O2 peak from the 6MWT in Childhood ALL Survivors.

Abstract：

:Introduction: The 6-Minute Walking Test (6MWT) is a safe, standardized and well utilized method to assess the functional capacity. Recently, it was reported that the published prediction equations cannot accurately predict a valid maximal oxygen consumption ([Formula: see text]O2 peak) value in cancer survivors. Thus, the aim of this study was to establish and to validate a new equation based on the 6MWT to predict [Formula: see text]O2 peak in childhood acute lymphoblastic leukemia (ALL) survivors.Methods: A total of 200 childhood ALL survivors were enrolled in this study, among which 168 participants underwent a cardiopulmonary exercise test and a 6MWT to assess their functional capacity and their cardiorespiratory fitness. In addition, participants completed a physical activity questionnaire. Participants were randomly divided in two groups to establish the equations (n = 118 (70%)) and to validate it (n = 50 (30%)). Multiple linear regression analyses were used to determine a new prediction equation for [Formula: see text]O2 peak from 6MWT using clinical and specific variables related to the disease. The accuracy in between [Formula: see text]O2 peak measured and [Formula: see text]O2 peak predicted were assessed using the Bland and Altman method.Results: The new establish clinical [Formula: see text]O2 peak equation is: [Formula: see text]O2 peak (mL.kg-1.min-1) = (-0.283*age(years)) - (0.099*weight(kg)) + (0.071*6MWD(meters)) -(0.135*HR end(bpm)) + 22.789 with a mean bias of 2.67 mL.kg-1.min-1 (95% CI (-9.64 to 14.98)). The new establish disease-specific [Formula: see text]O2 peak equation is: [Formula: see text]O2 peak (mL.kg-1.min-1) = (-0.236*age(years)) - (0.094*weight(kg)) -(0.120*HR end(bpm)) + (0.067*6MWD(meters)) + (0.065*MVLPA(min/day)) - (0.204*DT(years)) + 25.145 with a mean bias of 2.51 mL.kg-1.min-1 (95% CI (-9.98 to 15.01)).Conclusion: This is the first study that predicted [Formula: see text]O2 peak from a 6MWT using clinical and specific variables related to the disease of childhood ALL survivors. The availability of these newly established [Formula: see text]O2 peak equations makes them an accurate tool to provide a better follow-up and better adapted physical training for survivors. We invite researchers to use our assessment procedures for their further studies.IMPLICATIONS FOR REHABILITATIONIt is critical to understand the cardiorespiratory fitness of the childhood ALL survivorsThe maximal oxygen consumption (i.e., [Formula: see text]O2 peak) is recognized as the gold standard to measure the patient's cardiorespiratory fitness in the field of exercise physiologyThis study is novel and reports the validation of two new VO2 peak equations, from 6MWT, by using clinical and disease-specific variables of childhood ALL survivorsThe availability of such validated equations can better facilitate the follow-up of survivors' cardiorespiratory fitness, by relevant health care professionals and exercise physiologists.

journal_name

Disabil Rehabil

journal_title

Disability and rehabilitation

authors

Labonté J,Caru M,Lemay V,Alos N,Drouin S,Bertout L,Andelfinger G,Krajinovic M,Laverdière C,Sinnett D,Curnier D

doi

10.1080/09638288.2020.1725159

subject

Has Abstract

pub_date

2020-02-11 00:00:00

pages

1-8

eissn

0963-8288

issn

1464-5165

pub_type

杂志文章

在线工具

Developing and validating equations to predict [Formula: see text]O2 peak from the 6MWT in Childhood ALL Survivors.