Abstract:
BACKGROUND:Adipose and adipose derived regenerative cells (ADRCs) play an increasing role in androgenetic alopecia. OBJECTIVES:The authors sought to evaluate the safety and feasibility of fat grafts enriched with ADRCs in early androgenetic alopecia. METHODS:Seventy-one patients were treated: 16 with Puregraft fat and 1.0 × 106 ADRCs/cm2 scalp; 22 with Puregraft fat and 0.5 × 106 ADRCs/cm2 scalp, 24 with Puregraft fat alone, and 9 with saline control. Treatments were delivered into the skin and subcutaneous layer of the scalp. A total of 40 cm2 of scalp was treated and macrophotography and global photography were obtained at baseline and at 6, 24, and 52 weeks. RESULTS:A total of 71 patients tolerated the procedures well. No unanticipated associated adverse events were reported. When evaluating all patients at 24 weeks, there were no statistical differences between any of the treatment groups with respect to nonvellus (terminal) hair counts or width. There were increases (mean change from baseline) in terminal hair count for the low-dose ADRC group in the Norwood Hamilton 3 subgroup at week 6 (13.90 ± 16.68), week 12 (11.75 ± 19.42), week 24 (16.56 ± 14.68), and week 52 (2.78 ± 16.15). For this subgroup, the difference in hair count between the low-dose ADRC group and no-fat saline control was statistically significant (P = 0.0318) at week 24. CONCLUSIONS:Puregraft fat and ADRCs are safe and well tolerated. In early male hair loss, this therapy demonstrated a statistically significant increase in terminal hair counts relative to the control population at 24 weeks and represents a promising approach for early androgenetic alopecia. LEVEL OF EVIDENCE: 2:
journal_name
Aesthet Surg Jjournal_title
Aesthetic surgery journalauthors
Kuka G,Epstein J,Aronowitz J,Glasgold MJ,Rogal JG,Brown W,Geronemus RG,Daniels EJ,Washenik Kdoi
10.1093/asj/sjaa037subject
Has Abstractpub_date
2020-05-16 00:00:00pages
NP328-NP339issue
6eissn
1090-820Xissn
1527-330Xpii
5722400journal_volume
40pub_type
杂志文章abstract:Background:Multiple processing and handling methods of autologous fat yield to variations in graft retention and viability, which results in unpredictable clinical outcomes. Objectives:This study aims to understand the skin effects of fat graft preparations that contain a varying ratio of free-lipid and stem-cell-bear...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjy111
更新日期:2018-11-12 00:00:00
abstract::Gluteal augmentation with fat has become one of the most common cosmetic procedures worldwide. Gluteal augmentation is designed to increase the volume and contour of the gluteal region. Intramuscular lipoinjection has been linked to multiple reports of severe complications, including death due to macro fat embolism (M...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjz151
更新日期:2019-08-22 00:00:00
abstract::Fat grafting is a common procedure in aesthetic and reconstructive plastic surgery, but variable graft retention limits its utility. Unpredictable clinical outcomes with fat grafting can be explained in part by the lack of standardized protocols for harvesting, processing, and transplanting adipose tissue (AT). Histor...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,评审
doi:10.1093/asj/sju059
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Within the plastic surgery community, it is widely believed that waiting a minimum of 6 to 12 months after patient cessation of systemic retinoid therapy is necessary before proceeding with elective surgery. OBJECTIVE:The authors investigate partial- and full-thickness wound healing after treatment with sys...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X12462383
更新日期:2012-11-01 00:00:00
abstract::According to the author, cohesive gel implants produce a more predictable breast shape with no wrinkles, less silicone bleed, less capsular contracture, and possibly greater durability than other implant types. Here he describes his technique for inserting these devices for breast augmentation and implant replacement....
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/S1090-820X(03)00210-3
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Excessive concavity of the lower lateral crura can cause significant aesthetic problems for the nasal tip and can be associated with significant functional problems, such as insufficiencies in the external nasal valve. OBJECTIVES:The aim of this study was to develop a novel technique for the improvement of ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjaa018
更新日期:2020-09-14 00:00:00
abstract:BACKGROUND:A well-defined supratarsal crease has often been considered attractive, representing a significant component in a beautiful upper eyelid. Approximately 50% of East and Southeast Asian women are born with either a minimal or absent supratarsal eyelid crease. Among people of Chinese descent, the creation of a ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X14523020
更新日期:2014-03-01 00:00:00
abstract:Background:Seroma is the most common complication of abdominoplasty. Certain modifications to abdominoplasty may reduce the risk of seroma. Objectives:The authors evaluated the incidence of seroma for 3 abdominoplasty techniques: preservation of Scarpa's fascia, placement of progressive tension (or quilting) sutures, ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,meta分析
doi:10.1093/asj/sjx051
更新日期:2017-10-16 00:00:00
abstract:BACKGROUND:Previously, the problem created by overly convex, wide, and robust lower lateral cartilages (LLC) required an external or endonasal approach with delivery. Although this method has proven invaluable, it may not be indicated in all patients with large tips, specifically those with overly convex LLC or with th...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X10391779
更新日期:2011-01-01 00:00:00
abstract::Volume enhancement/restoration addresses a key component of facial aging and plays an increasingly central role in facial rejuvenation. Advancing our understanding of the structure and morphology of facial aging-and the changes that can be induced with currently-available fillers-will optimize treatment and provide a ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X11434523
更新日期:2012-02-01 00:00:00
abstract::Perioperative hyperglycemia is a well-known risk factor for surgical morbidity such as wound healing, infection, and prolonged hospitalization. This association has been reported for a number of surgical subspecialties, including plastic surgery. Specialty-specific guidelines have become increasingly available in the ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,评审
doi:10.1093/asj/sjw064
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Fat necrosis is a frequent complication (up to 62.5%) of microsurgical breast reconstruction using the deep inferior epigastric perforator (DIEP) flap. This could have important clinical and psychological repercussions, deteriorating the results and increasing reconstruction costs. OBJECTIVES:The aim of thi...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjy256
更新日期:2019-03-14 00:00:00
abstract:BACKGROUND:To obtain an ideal outcome in breast augmentation procedures, breast implants may be overfilled to reduce wrinkles and improve longevity. Determination of the optimal volume for saline-filled breast implants remains problematic for plastic surgeons. OBJECTIVE:We sought to evaluate the effect of overfilling ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2005.11.003
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Adipose-derived stromal cells (ADSCs) may play a pivotal role by differentiating into multilineage cells or by secreting growth factors or cytokines in cell-assisted lipotransfer, which participates in adipose tissue regeneration. The angiogenic potential of various ADSCs from different anatomical regions re...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjy252
更新日期:2019-04-08 00:00:00
abstract:Background:Lower eyelid blepharoplasty has continued to evolve with ongoing debate regarding optimal techniques. Despite large case series publishing excellent results and minimal complications, the true longevity of these procedures remains unclear. Objectives:The aim of this study was to determine how thoroughly the...
journal_title:Aesthetic surgery journal
pub_type: 历史文章,杂志文章,评审
doi:10.1093/asj/sjy186
更新日期:2018-11-12 00:00:00
abstract:BACKGROUND:Macrolane is a stabilized, hyaluronic acid-based gel that has been available since 2007 as a minimally invasive, nonpermanent option for breast enhancement. However, numerous controversies pertaining to its side effects have highlighted the need for studies involving larger groups of patients. OBJECTIVES:Th...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjv042
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:The transaxillary approach for breast augmentation has gained popularity because of the absence of scarring on the breast. However, the effects of this procedure on breast cancer detection and treatment (which rely heavily on the results of axillary status studies) remain under debate. Specifically, sentinel...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X11404399
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Previous anatomic studies have provided valuable information on the two-dimensional (2-D) course of the angular segment of the facial artery in the midface and its arterial connections. The third dimension (ie, the depth of the artery) is less well characterized. OBJECTIVE:The objective of the present study...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjaa176
更新日期:2020-06-27 00:00:00
abstract::Efforts to improve lipoplasty results through the application of focused energy continue to arouse interest. The author's initial experience with power-assisted lipoplasty indicates that this technique is safe, fast, and capable of producing results equal or superior to those achieved through use of traditional lipopl...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1067/maj.2001.113641
更新日期:2001-01-01 00:00:00
abstract::The authors have created a strategy for rejuvenation of the peribuccal region based on the concept that the repeated contraction of certain fascicles of the mimetic muscles, and not gravity, is the primary cause of structural aging. Treatment is based on a 4-stage strategy, with interventions including botulinum toxin...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2006.08.001
更新日期:2006-09-01 00:00:00
abstract::Endoscopic forehead rejuvenation offers the advantages of greater patient acceptance and lower complication rates. The author describes technical modifications that make the endoscopic approach effective in a wide range of patients. Particular attention is paid to the problem of asymmetry. When the preoperative differ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1067/maj.2001.115258
更新日期:2001-03-01 00:00:00
abstract::The hairline and frontal hair volume are frequently overlooked aspects of attractive facial proportion and overall facial aesthetics. The author contends that patient benefit from hair restoration surgery is significant, and these procedures should be routinely considered as part of a complete facial rejuvenation. ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2004.08.007
更新日期:2004-11-01 00:00:00
abstract::Rhinoplasty utilizes cartilage harvested from the nasal septum as autologous graft material. Traditional dogma espouses preservation of the "L-strut" of dorsal and caudal septum, which is less resistant to axial loading than virgin septum. Considering the 90° angle between dorsal and caudal limbs, the traditional L-st...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,评审
doi:10.1093/asj/sjy301
更新日期:2019-11-13 00:00:00
abstract::Full and high cheekbones are considered a desirable component of facial attractiveness. The aging process can result in a loss of facial volume and changes in facial contours. Cheek augmentation can replace lost facial volume, rejuvenate facial appearance, enhance cheek prominence, and improve facial symmetry. A new, ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2009.03.004
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Transaxillary augmentation mammaplasty (TAM) is an option for patients who wish to avoid a visible breast incision from breast augmentation (BA). OBJECTIVES:The authors compared TAM outcome data for gel and saline implants and evaluated patient satisfaction using the BREAST-Q patient-reported outcome measur...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X14530552
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Given the wide application of autologous fat grafting, a new emphasis on fat processing techniques has emerged in an effort to limit unpredictable degrees of resorption often seen with this procedure. With the growing interest in regenerative medicine, approaches to supplement fat grafts with adipose-derived...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X13487371
更新日期:2013-07-01 00:00:00
abstract::Reduced scarring, improved shape, long-term shape retention, and good nipple sensation are advantages of medial pedicle vertical breast reduction. This technique precludes the concept of the skin brassiere as holding breast shape and discards the 5-cm vertical rule and the chasing of dogears. The author provides a det...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1067/maj.2002.123052
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:The size and weight of hypertrophied breast can cause both physical and psychological problems. Although the majority of these problems can be solved with breast reduction surgery, the particular problem of development of brassiere strap grooves on the shoulders due to the weight of the breasts cannot be cor...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjv007
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:The advantages of dual-plane, partially submuscular breast implants are well documented. Standard conversion techniques to dual-plane positioning use marionette sutures and internal capsulorrhaphy sutures from the lower edge of the pectoralis major muscle to the anterior capsule or breast fascia within the s...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2008.12.005
更新日期:2009-01-01 00:00:00
abstract::As injectable products have been introduced and as clinicians have gained experience with them, applications and techniques for injection have evolved, with better cosmetic results, enhanced patient safety, and greatly improved patient satisfaction. Within the past four years, several consensus recommendation panels h...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X10378697
更新日期:2010-07-01 00:00:00