Does systemic isotretinoin inhibit healing in a porcine wound model?

Abstract:

BACKGROUND:Within the plastic surgery community, it is widely believed that waiting a minimum of 6 to 12 months after patient cessation of systemic retinoid therapy is necessary before proceeding with elective surgery. OBJECTIVE:The authors investigate partial- and full-thickness wound healing after treatment with systemic isotretinoin in a porcine model. METHODS:Following institutional approval, 2 Hanford miniature pigs were obtained. One pig received isotretinoin at a dose of 2 mg/kg/d, administered orally along with pig feed over a 60-day period; the other (control) pig received only pig feed over the same time period. After the treatment period ended, a total of 24 full-thickness wounds and 24 partial-thickness wounds were made on each pig. The wounds were evaluated by photographic and histological analysis at 7, 14, and 28 days. RESULTS:The average full-thickness wound size in the control animal was 0.4346 cm(2) at 14 days and 0.0689 cm(2) at 28 days. The average full-thickness wound size in the isotretinoin-treated animal was 0.4685 cm(2) at 14 days and 0.0363 cm(2) at 28 days. The differences were not statistically significant between the 2 animals at either time point. On histological analysis, the healing characteristics of partial- and full-thickness wounds were similar at 7, 14, and 28 days for both animals. CONCLUSIONS:Invasive surgery might be safely performed even in the presence of recent isotretinoin therapy. This finding challenges the current practice of waiting longer than 6 months after completion of therapy to perform surgery.

journal_name

Aesthet Surg J

authors

Larson DL,Flugstad NA,O'Connor E,Kluesner KA,Plaza JA

doi

10.1177/1090820X12462383

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

989-98

issue

8

eissn

1090-820X

issn

1527-330X

pii

1090820X12462383

journal_volume

32

pub_type

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