Lidocaine metabolism pathophysiology, drug interactions, and surgical implications.

Abstract:

:A thorough understanding of the pathophysiology of lidocaine metabolism is an important prerequisite to minimizing the risk of morbidity and mortality associated with lipoplasty. Although the tumescent technique has greatly improved the safety of large-volume lipoplasty through decreased blood loss and reduced anesthetic needs, it has introduced the possibility for lidocaine toxicity. Because lidocaine is metabolized by the cytochrome P450 system, the potential for drug interactions is heightened. These drug interactions are implicated as a cause of lidocaine toxicity. A comprehensive review of the patient's preoperative, intraoperative, and postoperative medication profile is critical to perioperative patient safety.

journal_name

Aesthet Surg J

authors

Bill TJ,Clayman MA,Morgan RF,Gampper TJ

doi

10.1016/j.asj.2004.05.001

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

307-11

issue

4

eissn

1090-820X

issn

1527-330X

pii

S1090-820X(04)00127-X

journal_volume

24

pub_type

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