A Multicenter Evaluation of Paradoxical Adipose Hyperplasia Following Cryolipolysis for Fat Reduction and Body Contouring: A Review of 8,658 Cycles in 2,114 Patients.

Abstract:

BACKGROUND:Paradoxical adipose hyperplasia (PAH) is a rare, moderate-to-severe adverse event associated with cryolipolysis (Coolsculpting, CS). OBJECTIVES:Describe the incidence, diagnoses and treatment of PAH, following CS for nonsurgical fat reduction. METHODS:A multicenter evaluation of all patients who underwent CS treatment between January 2015 and December 2019 at eight Canadian medical centers was conducted. Data abstracted included: symptoms, management strategy, outcome, operator characteristics, device characteristics, patient characteristics, body region and CS treatment details. Incidence of PAH was calculated based on the number of treatment cycles. RESULTS:Findings revealed incidence rates between 0.05% and 0.39%, which are slightly higher than the manufacturer's quoted rate of 0.025% (1 per 4000 cycles). Incidence rates at all sites were dramatically reduced by over 75% with the implementation of newer models of CS units. Of patients who developed PAH, 55% were male and 77.8% were of European ethnic origin. The majority of cases (76.9%) were associated with older models of the CS units. CONCLUSIONS:Development of PAH may be related to a combination of factors, including older models of the CS unit and applicators, as well as individual characteristics that predispose certain patients.

journal_name

Aesthet Surg J

authors

Nikolis A,Enright KM

doi

10.1093/asj/sjaa310

subject

Has Abstract

pub_date

2020-11-20 00:00:00

eissn

1090-820X

issn

1527-330X

pii

5995602

pub_type

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