Abstract:
:Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL)-a new category of anaplastic large cell lymphoma associated with textured breast implants-has a distinct variation in incidence and is especially rare in Asia. We report the first case of BIA-ALCL in Korea and present its histological and genetic characteristics. A 44-year-old female patient presented with a typical clinical course and symptoms, including breast augmentation with textured breast implants, late-onset peri-implant effusion, and CD30 +ALK - histology, followed by bilateral implant removal and total capsulectomy. For histological analysis, we performed immunohistochemistry of the bilateral breast capsules. For transcriptome analysis, we identified highly upregulated gene sets using RNA-seq and characterized the lymphoma immune cell components. In the lymphoma-associated capsule, CD30 + cells infiltrated not only the lymphoma lesion but also the peritumoral lesion. The morphologies of the myofibroblasts and vessels in the peritumoral lesion were similar to those in the tumoral lesion. We observed strong activation of the JAK/STAT3 pathway and expression of programmed death ligand-1 (PD-L1) in the lymphoma. Unlike the molecular profiles of BIA-ALCL samples from Caucasian patients-all of which contained activated CD4 + T cells-the Asian patient's profile was characterized by more abundant CD8 + T cells. This study contributes to a better understanding of the pathogenesis and molecular mechanisms of BIA-ALCL in Asian patients that will ultimately facilitate the development of clinical therapies.
journal_name
Aesthet Surg Jjournal_title
Aesthetic surgery journalauthors
Kim IK,Hong KY,Lee CK,Choi BG,Shin H,Lee JH,Kim MK,Gu MJ,Choi JE,Kim TGdoi
10.1093/asj/sjaa398subject
Has Abstractpub_date
2020-12-26 00:00:00eissn
1090-820Xissn
1527-330Xpii
6052959pub_type
杂志文章abstract:BACKGROUND:The demand for minimally invasive cosmetic procedures has continued to rise, yet few studies have examined this patient population. OBJECTIVES:This study sought to define the demographics, social characteristics, and motivations of patients seeking minimally invasive facial cosmetic procedures. METHODS:A p...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjv094
更新日期:2015-11-01 00:00:00
abstract::Although the principles of burn management are still primarily focused on survival, as advances are realized in resuscitation, nutrition, and wound management, the functional and aesthetic outcomes following burn injury have become increasingly important. Acellular dermal matrix materials, which allow surgeons to mini...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,评审
doi:10.1177/1090820X11418202
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Severe blepharoptosis with poor LF has traditionally been managed with exogenous frontalis suspension but complications such as lagophthalmos, infection, rejection were often reported. OBJECTIVES:The function-preserving frontalis orbicularis oculi muscle (FOOM) flap was designed to correct severe blepharopt...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjaa429
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND:A well-defined supratarsal crease has often been considered attractive, representing a significant component in a beautiful upper eyelid. Approximately 50% of East and Southeast Asian women are born with either a minimal or absent supratarsal eyelid crease. Among people of Chinese descent, the creation of a ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X14523020
更新日期:2014-03-01 00:00:00
abstract::BotulinumtoxinA (BoNT-A) is now widely established for the main approved indication of reducing glabellar lines, and is also widely used off-label to improve the appearance of wrinkles and lines in other parts of the face. The number of aesthetic procedures continues to increase as the patient population becomes more ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,评审
doi:10.1093/asj/sjx005
更新日期:2017-05-01 00:00:00
abstract::Gluteal augmentation with fat has become one of the most common cosmetic procedures worldwide. Gluteal augmentation is designed to increase the volume and contour of the gluteal region. Intramuscular lipoinjection has been linked to multiple reports of severe complications, including death due to macro fat embolism (M...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjz151
更新日期:2019-08-22 00:00:00
abstract:BACKGROUND:Although the anatomy of the individual pectoralis major and minor muscles has been described previously, never before has the anatomic relationship between these muscles been investigated. OBJECTIVE:The authors identify the anatomic relationship of the costal origins of the pectoralis major and minor muscle...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X13519643
更新日期:2014-02-01 00:00:00
abstract::According to the authors, prophylactic antibiotics should not be used routinely in aesthetic surgery, but only when indicated by empirically-based criteria. Here they provide literature-based guidelines, advocate for new double-blinded studies, and advise aesthetic surgeons to decide on prophylactic antibiotic treatme...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2005.10.005
更新日期:2006-01-01 00:00:00
abstract::Young aesthetic surgeons may wonder, "Why care about aesthetic medicine?" The answer is based on the "five principles" of aesthetic medicine: patient acquisition, patient retention, patient optimization, patient education, and patient conversion. The explosion in new nonsurgical technologies and treatments combined wi...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjy273
更新日期:2019-06-21 00:00:00
abstract:BACKGROUND:Many strategies have been developed to lower the high complications rate associated with a full abdominoplasty. The dissection technique may have a role to achieve this goal. OBJECTIVES:The present study compares two different dissection techniques to perform a full abdominoplasty with Scarpa fascia preserv...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjaa428
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:The suspension of orbicularis oculi during lower blepharoplasty presents a logical surgical addition for further support of the lid, as well as further improvement to its contour profile. It has traditionally been performed as an extension of the skin-muscle flap procedure, but more recently, and aggressivel...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjw052
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:It would be useful if existing tools or outcomes measures could predict which patients are at greater risk of revision surgery following rhinoplasty. OBJECTIVE:We aim to determine if a single question assessing nasal self-esteem could be used to predict which patients are at greatest risk of revision surger...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjaa252
更新日期:2020-08-28 00:00:00
abstract:BACKGROUND:Despite its popularity for facial rejuvenation, blepharoplasty has been associated with several adverse effects. One of the most common is eyelid displacement after lower transcutaneous blepharoplasty. The tarsal sling procedure affixes the external portion of the septum (the lateral canthal ligament) to the...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sju018
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Anatomical structures of the nose (including muscles) are elevated, sutured, or reshaped during rhinoplasty. Electromyography and electroneurography are the objective electrophysiologic tests performed for the direct measurement of nasal muscle function. OBJECTIVES:The authors investigate the predictive val...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X11398478
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Canthopexies can be performed to modify the eye slant, both when the lateral canthus is lower than the medial one (congenital defect) or in case the patient asks for an almond-shaped eye (cosmetic indication). OBJECTIVES:This peculiar type of canthopexy can be defined as "dynamic canthopexy," meaning that t...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjz077
更新日期:2019-11-13 00:00:00
abstract::Wound-closing technology continues to evolve with the advent of barbed sutures, which appear to address some of the limitations of traditional sutures (numerous knots and time-consuming insertion, among other things). Advantages of knotless suture devices, specifically in body contouring, have been discussed in the li...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,评审
doi:10.1177/1090820X13499577
更新日期:2013-09-01 00:00:00
abstract::Reduced scarring, improved shape, long-term shape retention, and good nipple sensation are advantages of medial pedicle vertical breast reduction. This technique precludes the concept of the skin brassiere as holding breast shape and discards the 5-cm vertical rule and the chasing of dogears. The author provides a det...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1067/maj.2002.123052
更新日期:2002-03-01 00:00:00
abstract:Background:The nipple-areola complex (NAC) is important aesthetically and functionally for both sexes. Methods for positioning the NAC in males are less well established in the literature compared to females but are just as important. Objectives:This study aims to determine the normal parameters for the male NAC, to r...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjx245
更新日期:2018-06-13 00:00:00
abstract:BACKGROUND:Nowadays, corporal perception has evolved among different ethnic groups and a tendency to change from a slim to an athletic shape has been influenced by geography, culture, race, gender, and social media. Although exercise improves health status, physical appearance does as well in the long term. Patients of...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjaa133
更新日期:2020-05-26 00:00:00
abstract::Endoscopic forehead rejuvenation offers the advantages of greater patient acceptance and lower complication rates. The author describes technical modifications that make the endoscopic approach effective in a wide range of patients. Particular attention is paid to the problem of asymmetry. When the preoperative differ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1067/maj.2001.115258
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:Rhinoplasty in the elderly requires different surgical approaches due to the morphological and structural changes affecting the nose over time. OBJECTIVES:In this study, the authors aimed to evaluate the age-related cellular and architectural changes of nasal cartilages and soft tissue attachments. METHODS...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjy245
更新日期:2019-08-22 00:00:00
abstract:Background:Improvement in the retention rate of transplanted fat is currently a topic of interest. The retention of transplanted fat relies heavily on the reestablishment of blood supply and the function of the adipose-derived stem cells (ADSCs), which may both be impeded by mechanical force. However, the effect of mec...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjy104
更新日期:2018-08-16 00:00:00
abstract::According to the author, cohesive gel implants produce a more predictable breast shape with no wrinkles, less silicone bleed, less capsular contracture, and possibly greater durability than other implant types. Here he describes his technique for inserting these devices for breast augmentation and implant replacement....
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/S1090-820X(03)00210-3
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Until 2001, body contouring surgery after massive weight loss was uncoordinated, with few patients achieving compete rehabilitation. OBJECTIVE:The authors report a 5-year, retrospective, 75-case clinical review to determine the effectiveness, reliability, and safety of single and multistage total body lift ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2008.03.001
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Comparative studies have shown little statistical difference in outcomes following rhinoplasty, demonstrating near equivalent results across all surgical techniques. Cross-study comparisons of these trials are difficult because variation in outcome reporting prevents statistical pooling and analysis. OBJECT...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjz138
更新日期:2020-01-29 00:00:00
abstract::The author presents guidelines and new instruments for transplanting autologous fat. He describes this procedure as effective, predictable, and reliable when performed with careful donor-zone preparation, atraumatic fat extraction, anaerobic sterility, and precise placement in a properly prepared receiving zone. (Aest...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1067/maj.2003.44
更新日期:2003-05-01 00:00:00
abstract:Background:Congenital, traumatic, or developmental bony vault deformities may require additional interventions rather than classical osteotomies to correct the surface structure or angulations of the nasal bones in rhinoplasty. Objectives:The aim of the study was to determine the effects of the additional osteotomies ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjy107
更新日期:2019-01-01 00:00:00
abstract::Posterior neck lift, which combines anterior platysmaplasty and anterior and lateral neck lift, is a good alternative to a full or lower face lift for patients with minimal or no jowl sagging. It may be combined with neck lipoplasty, serial platysma notching, expanded polytetrafluoroethylene neck sling, and chemical p...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2004.01.005
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Bacterial biofilm on surfaces of mammary implants is a predisposing factor for several outcomes. Since Gram-positive bacteria are potential agents of biomaterial-associated infections (BAIs), their abilities to form biofilm on breast implants should be elucidated. OBJECTIVES:To evaluate biofilm formation on...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjaa416
更新日期:2020-12-30 00:00:00
abstract:Background:Multiple processing and handling methods of autologous fat yield to variations in graft retention and viability, which results in unpredictable clinical outcomes. Objectives:This study aims to understand the skin effects of fat graft preparations that contain a varying ratio of free-lipid and stem-cell-bear...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjy111
更新日期:2018-11-12 00:00:00