Abstract:
Background:Multiple processing and handling methods of autologous fat yield to variations in graft retention and viability, which results in unpredictable clinical outcomes. Objectives:This study aims to understand the skin effects of fat graft preparations that contain a varying ratio of free-lipid and stem-cell-bearing stromal vascular fractions (SVF). Methods:Lipoaspirates from consenting patients were processed into emulsified fat and then SVF and adipocyte fractions (free-lipid). SVF enriched with 0%, 5%, and 15% free-lipid were grafted along the dorsum of athymic rats. The xenografts were collected 45 days after grafting and then prepped for immunostaining. Results:Xenografts resulted in viable tissue mass under the panniculus carnosus of rats as confirmed with human specific markers. A low percentage of human cells was also detected in the lower reticular dermis. Although grafts with SVF formed adipocytes of normal architecture, grafts formed with free-lipid alone resulted in large lipid vacuoles in varying sizes. Among graft preparations, SVF with 10% free-lipid resulted in much-developed adipocyte architecture with collagen and elastin. Compared with SVF alone grafts, SVF with free-lipid had higher CD44 expression, suggesting a localized immune response of adipocytes. Conclusions:Current studies suggest that SVF enriched with approximately 10% free-lipid provides the best conditions for fat graft differentiation into viable fat tissue formation as well as collagen and elastin production to provide mechanical support for overlaying skin in an athymic rat model. Additionally, application of this therapeutic modality in a simple clinical setting may offer a practical way to concentrate SVF with free-lipid in a small volume for the improvement of clinical defects. Level of Evidence 5:
journal_name
Aesthet Surg Jjournal_title
Aesthetic surgery journalauthors
Akgul Y,Constantine R,Bartels M,Scherer P,Davis K,Kenkel JMdoi
10.1093/asj/sjy111subject
Has Abstractpub_date
2018-11-12 00:00:00pages
1363-1373issue
12eissn
1090-820Xissn
1527-330Xpii
4990840journal_volume
38pub_type
杂志文章abstract::Arm contour improvement is a desired goal of the massive weight loss and the aging population who want to maintain the arm aesthetics. Brachioplasty is a growing and safe procedure to improve the arm contour and different approaches and innovative treatment options have been described since the 1930s. This paper revie...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,评审
doi:10.1093/asj/sjx218
更新日期:2018-07-13 00:00:00
abstract:BACKGROUND:A significant proportion of patients seeking labiaplasty are nulliparous and may experience later changes to their labia following vaginal delivery. OBJECTIVES:In the present study, we report the long-term outcomes of a single surgeon's patient cohort who had vaginal delivery after labiaplasty. METHODS:A r...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjaa027
更新日期:2020-01-29 00:00:00
abstract:BACKGROUND:Transaxillary augmentation mammaplasty (TAM) is an option for patients who wish to avoid a visible breast incision from breast augmentation (BA). OBJECTIVES:The authors compared TAM outcome data for gel and saline implants and evaluated patient satisfaction using the BREAST-Q patient-reported outcome measur...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X14530552
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Several growth factors and hyaluronic acid are implicated in fetal scarless healing. Whether these factors can be applied to an adult scar to improve scar characteristics is unknown. OBJECTIVES:This study compared the efficacy and safety of SKN2017B, a proprietary topical cream consisting of selective synth...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/asj/sjy185
更新日期:2019-02-15 00:00:00
abstract:BACKGROUND:Many strategies have been developed to lower the high complications rate associated with a full abdominoplasty. The dissection technique may have a role to achieve this goal. OBJECTIVES:The present study compares two different dissection techniques to perform a full abdominoplasty with Scarpa fascia preserv...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjaa428
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:Comparative studies have shown little statistical difference in outcomes following rhinoplasty, demonstrating near equivalent results across all surgical techniques. Cross-study comparisons of these trials are difficult because variation in outcome reporting prevents statistical pooling and analysis. OBJECT...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjz138
更新日期:2020-01-29 00:00:00
abstract:BACKGROUND:Adipocyte viability is affected by fat preparation and processing methods, but rigorous and objective studies of these relationships are lacking. OBJECTIVES:The authors conducted a comprehensive evaluation of variables affecting adipocyte viability prior to injection of fat at the recipient site. METHODS:L...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjw106
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:The acute columellar-labial angle is associated with a long upper lip and can promote disharmony in the adult face. The different alloplastic or biologic materials used to correct this defect all have some disadvantages. OBJECTIVE:The authors propose the concomitant treatment of the acute columellar-labial ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2008.10.003
更新日期:2008-11-01 00:00:00
abstract:Background:Improvement in the retention rate of transplanted fat is currently a topic of interest. The retention of transplanted fat relies heavily on the reestablishment of blood supply and the function of the adipose-derived stem cells (ADSCs), which may both be impeded by mechanical force. However, the effect of mec...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjy104
更新日期:2018-08-16 00:00:00
abstract:Background:Low satisfaction rates and severe complications are two major limitations for temporal hollowing augmentation using autologous fat grafting. Despite fat compartments in temporal region have been reported, its clinical applied anatomy for fat grafting have not been the subject of studies that show its benefit...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjw257
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Bacterial biofilm on surfaces of mammary implants is a predisposing factor for several outcomes. Since Gram-positive bacteria are potential agents of biomaterial-associated infections (BAIs), their abilities to form biofilm on breast implants should be elucidated. OBJECTIVES:To evaluate biofilm formation on...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjaa416
更新日期:2020-12-30 00:00:00
abstract::The authors recommend this brachioplasty technique for patients who have lost a significant amount of weight. The sinusoidal-shaped scar helps to avoid problems such as linear scar contracture, wound tension, and widened or hypertrophic scars. ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2004.04.010
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Breast augmentation through incisions in the axillae is an option for patients who wish to avoid scars on the breasts. The axillary approach also preserves the mammary parenchyma and lactiferous ducts. The utility of video-assisted endoscopy during this procedure as a means to improve safety and aesthetic ou...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,随机对照试验
doi:10.1093/asj/sju076
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Excessive concavity of the lower lateral crura can cause significant aesthetic problems for the nasal tip and can be associated with significant functional problems, such as insufficiencies in the external nasal valve. OBJECTIVES:The aim of this study was to develop a novel technique for the improvement of ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjaa018
更新日期:2020-09-14 00:00:00
abstract:BACKGROUND:In 1971, Ribeiro isolated a segment in the inferior pole of the ptotic breast, nourished by muscular perforating vessels, and moved it cranially to the posterior region of the remaining detached breast tissue, where it was fixed to the pectoral fascia. This maneuver created a flap with autologous implant fun...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjz188
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Safety and efficacy of botulinum toxin A for glabellar line (GL) treatment are well established. Currently approved formulations require reconstitution before injection. OBJECTIVES:The authors sought to assess 6-month efficacy, safety, and patient satisfaction of new ready-to-use abobotulinumtoxinA solution...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,随机对照试验
doi:10.1093/asj/sjz003
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The size and weight of hypertrophied breast can cause both physical and psychological problems. Although the majority of these problems can be solved with breast reduction surgery, the particular problem of development of brassiere strap grooves on the shoulders due to the weight of the breasts cannot be cor...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjv007
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Running parallel with-and perhaps driven by-the huge increase in demand for cosmetic surgery, office-based anesthesia (OBA) is the fastest growing segment of anesthesia practice. Despite this, only 2% of anesthesiology residencies provide exposure to OBA, and many practicing anesthesiologists are not convinc...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2008.07.012
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Free tissue transfer with lower abdominal flaps for autologous breast reconstruction is not suitable for all patients. The latissimus dorsi (LD) musculocutaneous flap is an alternative, effective method for both immediate and delayed breast reconstruction. OBJECTIVES:The authors assess their experience with...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X12437783
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:The long-acting preparation of bupivacaine, liposomal bupivacaine (EXPAREL, Pacira Pharmaceuticals, Inc., San Diego, CA), was approved by the Food and Drug Administration in October 2011 and has been shown to be safe in breast augmentation. It remains to be established if liposomal bupivacaine provides super...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,随机对照试验
doi:10.1093/asj/sjv149
更新日期:2016-02-01 00:00:00
abstract::There is a perfect storm developing in 21st century healthcare; rising complexity and patient expectations in the context of fiscal restraint. Evidence-based medicine (EBM) may be the best-kept secret in dealing with the "storm." Such an approach prefers management pathways that deliver better outcomes at less relativ...
journal_title:Aesthetic surgery journal
pub_type: 历史文章,杂志文章,评审
doi:10.1093/asj/sjv204
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Temple hollowing with soft tissue volume loss is well recognized in HIV lipoatrophy. Similar changes occur as part of aging, with skeletalization of the orbital rim and clipping of the eyebrow tail. OBJECTIVES:The authors report their initial experience treating temple volume loss and orbitofacial asymmetry...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X10374099
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:New microfat preparations provide material suitable for use as a regenerative filler for different facial areas. To support the development of new robust techniques for regenerative purposes, the cellular content of the sample should be considered. OBJECTIVES:To evaluate the stromal vascular fraction (SVF) ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjy142
更新日期:2020-05-16 00:00:00
abstract:BACKGROUND:Despite multiple advantages of fat grafting for calf augmentation and re-shaping over traditional silicone calf implants, few reports have been published. OBJECTIVES:To report our technique and results with autologous fat grafting for calf augmentation and reshaping. METHODS:A retrospective review of the s...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjv166
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:As a consumer-driven industry, cosmetic plastic surgery is subject to ebbs and flows as the economy changes. There have been many predictions about the short, intermediate, and long-term impact on cosmetic plastic surgery as a result of difficulties in the current economic climate, but no studies published i...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X10372209
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:The pedicled latissimus dorsi (LD) flap serves an important function in breast reconstruction, but its utility is limited by its inability to provide sufficient breast volume. OBJECTIVES:The purpose of this preliminary report was to review the techniques and outcomes of utilizing fat-grafted, volume-enhance...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjv173
更新日期:2016-02-01 00:00:00
abstract::Recent technical advances in fat grafting and the development of surgical devices such as liposuction cannulae have made fat grafting a relatively safe and effective procedure. However, new guidelines issued by the American Society of Plastic Surgeons in 2009 announced that fat grafting to the breast is not a strongly...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,评审
doi:10.1177/1090820X10373063
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:It would be useful if existing tools or outcomes measures could predict which patients are at greater risk of revision surgery following rhinoplasty. OBJECTIVE:We aim to determine if a single question assessing nasal self-esteem could be used to predict which patients are at greatest risk of revision surger...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjaa252
更新日期:2020-08-28 00:00:00
abstract::In this review, the authors provide a 20-year review and comparison of implant options and describe the evolution of breast implant surface textures; compare available implant surfaces; present long-term safety data from the 10-year US-based Core clinical studies; list the key benefits and risks associated with smooth...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,评审
doi:10.1093/asj/sjx157
更新日期:2017-12-13 00:00:00
abstract:BACKGROUND:A device to assist in the delivery of dermal filler may achieve reductions in patient discomfort and adverse events, as well physician fatigue. It may also increase the accuracy of material placement. OBJECTIVES:The authors assess the safety and performance of the Artiste Assisted Injection System (Nordson ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,随机对照试验
doi:10.1177/1090820X13487372
更新日期:2013-07-01 00:00:00