Abstract：
:Renal cell carcinoma is the most common cancer of the kidney and is among the tumors that are the most resistant to systemic therapy. Until recently, long term survival of this disease when it was not confined to the kidney was dismal, with the use of drugs such as interleukin-2 resulting in a 5-year survival rate of less than 10% for patients with advanced disease. Nearly 30% of patients present with metastatic disease, and recurrence develops in approximately 40% of patients with localized tumors. Since December 2005, the Food and Drug Administration (FDA) has approved 6 novel drugs that target advanced disease. These molecularly targeted drugs, representing the next generation of anticancer agents, inhibit angiogenesis and tumor growth factors. Small molecule tyrosine kinase inhibitors are the prototype of cancer therapy in this century, causing fewer toxic effects in the normal cells and with targeted inhibition of malignant cell proliferation. These therapies have emerged from the understanding of the molecular genetics and biology of this tumor. Further elucidation of the mechanisms of action of these drugs and those in development will lead to more effective therapies and increase the understanding of the best ways to combine them.
journal_name
P R Health Sci Jjournal_title
Puerto Rico health sciences journalauthors
Cáceres W,Cruz-Chacón Asubject
Has Abstractpub_date
2011-06-01 00:00:00pages
73-7issue
2eissn
0738-0658issn
2373-6011journal_volume
30pub_type
杂志文章,评审abstract：OBJECTIVE:To determine the frequency of pediatric brain tumors treated at the University Pediatric Hospital of Puerto Rico over a 6-year period and examine the demographic data and tumor histology of patients in different age groups. METHODS:A retrospective study was undertaken at the University Pediatric Hospital. We...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:To test the hypothesis that fermentable fiber prevents Salmonella typhimurium infection-associated symptoms by enhancing innate and adaptive immune system in neonatal pigs. METHODS:Two-d-old piglets (n=120) were randomized to receive either a nutritionally complete sow milk replacer formula (CON), or supplem...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:This study intends to determine the prevalence of multidrug resistant (MDR) infections by A. baumannii, K. pneumoniae and P. aeruginosa in a tertiary care teaching hospital intensive care unit (ICU) in San Juan, PR, estimate the mortality rate and compare the morbidity and mortality differences among those tr...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2019-03-01 00:00:00
abstract：:Surveillance for emerging diseases is critically dependent on four factors: reporting methods, case definition, laboratory diagnosis, and knowledge of the disease among health-care professionals. The dengue hemorrhagic fever (DHF) surveillance system in Puerto Rico collects patient data from three sources: dengue case...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：:Although regeneration in the peripheral nervous system (PNS) after injury is robust, regeneration in the central nervous system (CNS) is abortive. The results from differences in the balance of regeneration inhibiting and promoting factors, which in the CNS is skewed toward inhibition while in the PNS it is skewed tow...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章,评审
doi：
更新日期：2000-09-01 00:00:00
abstract：:A young male adult with significant aortic coarctation was initially referred to our clinics due to uncontrolled blood pressures. On evaluation the diagnosis of aortic coarctation was evident and confirmed with Magnetic Resonance Angiography (MRA). After discussing treatment options with the patient and his parents th...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
abstract：:Atrial fibrillation (AF) is the most common sustained arrhythmia in adults. It is a significant public health problem in the United States where it affects 2.2 million Americans and almost 10% of the population older than 80 years. It should be emphasized that the prevalence of AF increases with advancing age and with...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章,评审
doi：
更新日期：2004-12-01 00:00:00
abstract：:A retrospective review was performed from November 2011 through June 2012 in 49 stable patients receiving ambulatory hemodialysis at the dialysis unit of the University Hospital in San Juan. Measurements of serum phosphate, serum calcium (corrected to albumin levels), intact parathyroid hormone (PTH), and pulse pressu...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVE:To compare the effectiveness of intravenous immunoglobulin (IVIG) alone, high dose methylprednisolone (HDMP) alone and the combination of IVIG and HDMP in the treatment of childhood immune thrombocytopenic purpura (ITP). BACKGROUND:Acute ITP in children is a self-limited disease with a benign course and low ...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：OBJECTIVE:Present evidence-based recommendations on the use of biochemical markers of bone turnover in the management of osteoporosis. METHODS:The English literature from 1999 to 2005 was reviewed by using data sources from MEDLINE. RESULTS:Measurement of biochemical markers of bone turnover helps us identify a high ...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章,评审
doi：
更新日期：2007-06-01 00:00:00
abstract：:This brief celebration of the work of Francisco Guerra (1916-2011) highlights his role as mentor for an international community, his study of local events in the context of global developments, and his contributions to the understanding of the medical history of Puerto Rico. A selective review of Francisco Guerra's me...
journal_title：Puerto Rico health sciences journal
pub_type： 传,历史文章,杂志文章
doi：
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:The present study was performed to detect cancer risk of the midwifes and nurses playing central role in raising awareness in the society using Gail's model. MATERIALS AND METHODS:Sample of the present cross sectional study consists of 750 volunteer midwifes and nurses in 2016. Breast cancer risk was calcula...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2018-06-01 00:00:00
abstract：:Genital human papillomavirus (HPV) infection is one of the most commonly diagnosed sexually transmitted infections world-wide. Over the last two decades, research has established a strong causal link between specific types of HPV infection and cancer, particularly cervical, anal, vulvar/vaginal, penile, and oropharyng...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章,评审
doi：
更新日期：2010-09-01 00:00:00
abstract：OBJECTIVE:To determine the IgE reactivity against recombinant protein Blo t 1 from the dust mite Blomia tropicalis (Bt) using serum from patients with positive skin test to this mite and to investigate the cross-reactivity between Bt and Dermatophagoides pteronyssinus. BACKGROUND:Dust mites have an important role as i...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
abstract：BACKGROUND:Suicidal behavior among adolescents is not a well-explored public health problem. Health policy decision-making on suicidal behavior needs reliable information on the prevalence of suicidal ideation (SI) and its associated risk factors to produce health promotion and prevention programs. METHODS:The Global ...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2008-12-01 00:00:00
abstract：INTRODUCTION:Neoplasms of the heart are extremely rare and difficult to diagnose. In this study, we intend to describe the experience at the Cardiovascular Center of Puerto Rico and the Caribbean (CCPRC) dealing with benign cardiac neoplasms. METHODS:A retrospective review of the archival material at our institution w...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2008-12-01 00:00:00
abstract：:Although injection drug use (IDU) is the major risk category for HIV infection in Puerto Rico and injection drug users start their drug injection careers very young, there is little information related to drug injection patterns of young IDUs. In this paper we report on factors found to be associated with HIV seroposi...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
abstract：:113 rhesus monkeys, representing 4 age classes, 3 matrilines, and immigrant adult males in a 161-member Cayo Santiago-derived troop living in a 2-acre enclosure, were sampled for levels of plasma ACTH and cortisol during a period of capture and brief cage confinement for routine veterinary examination. ACTH levels sho...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：OBJECTIVE:Colorectal cancer (CRC) is among the most common cancers in Puerto Rico. Few studies have correlated clinical and pathological variables with the overall survival of CRC patients in Puerto Rico. We report the clinical and pathological characteristics of patients who underwent surgical resection at a community...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:Low back pain is one of the most frequent work related injuries in all occupations. Back school programs are therapeutic interventions directed towards treatment, prevention and rehabilitation of backaches. The purpose of this study was to (1) evaluate the test-retest reliability of the modified version of t...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2009-03-01 00:00:00
abstract：OBJECTIVE:to estimate the prevalence of pit and fissure sealants on first permanent molars in twelve year olds living in Puerto Rico and to further evaluate dental sealant prevalence by (1) urban/rural and public/private school status as well as (2) gender; DESIGN:population-based, cross-sectional study. SETTING:publ...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2006-06-01 00:00:00
abstract：:Post-mortem medical examiner samples may be useful for sentinel surveillance of disorders usually detected by antibody determinations on specimens from ill patients or from surveys. We found anti-dengue IgM positivity in 3% (23/780) and anti-dengue IgG positivity in 77% (597/777) of sera obtained at the Puerto Rico me...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
abstract：:Cayo Santiago has provided the opportunity to study primate biology in a free-ranging neutral environment free of provocative human influences. Rarely, if ever, does such a situation occur in natural rhesus habitats in Asia. This Cayo Santiago advantage has permitted fine-scale analyses of the details of behavior, eco...
journal_title：Puerto Rico health sciences journal
pub_type： 历史文章,杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：:Four hundred and sixty six non-institutionalized seniors, 65 years of age and over comprise the sample. The questions pertaining to the specific topic are made up of 17 items: 9 related to background information and 8 relating to nutritional practices. It is part of a larger study of the socio-demographic characterist...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：:The World Health Organization criteria for the diagnosis of Osteopenia and Osteopoposis was applied to a control group of 33 females ages 50 to 59 years and 24 females ages 60 to 69 years. The general exclusion criteria for the selection of subjects included early menopause and diseases, use of drugs and toxic habits ...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：:Endothelial cell proliferation and differentiation into blood capillaries (i.e., angiogenesis) are essential for growth and development, wound healing, osetogenesis, etc. But abnormal angiogenesis during tumor progression could lead to serious consequences. Angiogenesis is a complex biochemical process, and is often d...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:Atherosclerosis is the most frequent cause of ischemic heart disease and cerebrovascular disorders. The condition is the leading cause of death in Western societies. At the core of this condition is the atherosclerotic plaque. It is within the structure of this lesion that multiple biochemical and cellular processes i...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
abstract：:Seventy two partial subperiosteal implants were inserted in 52 patients. Thirty six of these implants had a classical design in which the submerged structure had thick primary and secondary connectors. Thirty six implants had a newly designed submerged structure consisting of long and thin primary connectors with groo...
journal_title：Puerto Rico health sciences journal
pub_type： 临床试验,杂志文章
doi：
更新日期：1994-09-01 00:00:00
abstract：:Small island exigencies and a legacy of colonial jurisprudence set the stage for this three-year study in 2001-2003 of abortion practice on several islands of the northeast Caribbean: St. Martin, St. Maarten, Anguilla, Antigua and St Kitts. Based on in-depth interviews with 26 physicians, 16 of whom were performing ab...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVE:Due to advances in the care of people living with HIV/AIDS (PLWHA), life expectancy significantly increased, putting this group vulnerable to age-related comorbidities, such as cancer. The objective of this study was to describe the knowledge of cancer screening (cervical, breast, anal, colon, prostate) and o...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2016-09-01 00:00:00
