Polymyxin B for Gram Negative Multidrug Resistant Bacteria in a Hispanic Population.

Abstract:

OBJECTIVE:This study intends to determine the prevalence of multidrug resistant (MDR) infections by A. baumannii, K. pneumoniae and P. aeruginosa in a tertiary care teaching hospital intensive care unit (ICU) in San Juan, PR, estimate the mortality rate and compare the morbidity and mortality differences among those treated with and without polymyxin B. METHODS:We selected adults patients admitted to the ICU who had positive cultures from January 2012 to June 2013. Sample consisted of 25 patients with age ranges from 27-78 years, 13 women and 12 men. RESULTS:The median age at death was 60 years. Polymyxin B nephrotoxicity was identified on 15% of the patients. Variables related to higher survival were younger age, female sex, use of polymyxin B, and the use of daptomycin. The use of vancomycin and vasopressors were associated with worse outcome. Mortality associated to single MDR bacteria was 88% for A. baumannii, 84% for K. pneumoniae and 67% for P. aeruginosa. All patients with more than one MDR infection died in the ICU. CONCLUSION:The use of polymyxin B was associated with an ICU mortality reduction. Unexpectedly we found a significantly improved survival in patients who received polymyxin B in combination with daptomycin, which awaits prospective confirmation.

journal_name

P R Health Sci J

authors

De León-Borrás R,Sánchez-Sergentón C,Mayor-Becerra A,Laureano-Cuadrado AF

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

15-21

issue

1

eissn

0738-0658

issn

2373-6011

journal_volume

38

pub_type

杂志文章
  • Prevalence of osteopenia and osteoporosis in a normal female Puerto Rican population.

    abstract::The World Health Organization criteria for the diagnosis of Osteopenia and Osteopoposis was applied to a control group of 33 females ages 50 to 59 years and 24 females ages 60 to 69 years. The general exclusion criteria for the selection of subjects included early menopause and diseases, use of drugs and toxic habits ...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Haddock L

    更新日期:1997-09-01 00:00:00

  • A preliminary report on pelvic floor reconstruction through colpocleisis from 2001 to 2007 at the University Hospital of the Puerto Rico Medical Center.

    abstract:OBJECTIVE:Describe the pre-, intra-, and postoperative experience of colpocleisis in a group of patients at the University Hospital of the Puerto Rico Medical Center. METHODS:A chart review was done on a subgroup of patients, 70 years or older, on which colpocleisis was performed between January 2001 and December 2007...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Marrero C,Aponte A,Torres R,Santos F,Rivera J

    更新日期:2010-12-01 00:00:00

  • Incidental adreno-cortical adenoma, why surgery? a case report.

    abstract:INTRODUCTION:Incidental adrenal tumors are commonly benign, but reports demonstrate that if the characteristics of the tumor are not clear, on images surgery is the procedure of choice. Our objective through this case is to show that laparoscopic adrenalectomy is a safe approach for adrenal incidental tumor regardless ...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Solís-López DR,Rodríguez-Hernández Z,Solís-López DH

    更新日期:2010-06-01 00:00:00

  • Evaluation of pediatric patients with vascular malformations managed with endovascular and radiosurgical techniques using a modified Rankin Disability Scale.

    abstract:BACKGROUND:Pre- and postoperative evaluation of the pediatric patient with a cerebrovascular malformation can be cumbersome. This may be due to several factors, including age and ability to verbalize. Functional evaluation scales have been devised, yet application to a retrospective study, where information can be limi...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Feliciano CE,Rodríguez-Mercado R

    更新日期:2008-03-01 00:00:00

  • Pituitary--adrenal response to capture in Cayo Santiago--derived group M rhesus monkeys.

    abstract::113 rhesus monkeys, representing 4 age classes, 3 matrilines, and immigrant adult males in a 161-member Cayo Santiago-derived troop living in a 2-acre enclosure, were sampled for levels of plasma ACTH and cortisol during a period of capture and brief cage confinement for routine veterinary examination. ACTH levels sho...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Suomi SJ,Scanlan JM,Rasmussen KL,Davidson M,Boinski S,Higley JD,Marriott B

    更新日期:1989-04-01 00:00:00

  • Breast Asymmetry in Women Requesting Plastic Surgery of the Breast.

    abstract:OBJECTIVE:Breast asymmetries have a high prevalence among women requesting breast augmentation. However, the prevalence of breast asymmetries in women undergoing other types of breast surgeries is not known. METHODS:The breast measurements of consecutively women evaluated for plastic surgery of the breast, but without...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Cruz NI

    更新日期:2018-12-01 00:00:00

  • Tooth-Loss Experience and Associated Variables among Adult Mexicans 60 Years and Older.

    abstract:OBJECTIVE:This study was conducted to determine the experience of tooth loss, as well as its associated variables, in a sample of adult Mexicans, aged 60 years and older. MATERIALS AND METHODS:This cross-sectional study was part of a larger project to measure diverse oral health indicators in a convenience sample: it ...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Islas-Granillo H,Borges-Yañez A,Medina-Solis CE,Lucas-Rincón SE,Navarrete-Hernández Jde J,Villalobos-Rodelo JJ,Casanova-Rosado JF,Maupomé G

    更新日期:2016-06-01 00:00:00

  • Inflammation in Osteoarthritis.

    abstract::Advances in the understanding of chondrocytes and the synovial membrane as targets of and participants in the inflammatory process in articular joints have provided insights into the role of inflammation in cartilage and subchondral bone injury in rheumatic diseases. Reports that describe the inflammatory cellular inf...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章,评审

    doi:

    authors: Vilá S

    更新日期:2017-09-01 00:00:00

  • Risk stratification in the patient with non ST segment elevation acute coronary syndrome.

    abstract::Patients hospitalized with unstable angina (UA) or with a non-ST segment elevation myocardial infarct (NSTEMI) are at increased risk of suffering refractory angina, recurrent myocardial infarct (MI), and death. These patients need to be evaluated more aggressively. According to the last published guidelines (2002) of ...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章,评审

    doi:

    authors: Escabí-Mendoza J,Rosales-Alvarez C

    更新日期:2005-12-01 00:00:00

  • Longitudinal Observations on the Mineral Metabolism of Dialysis Patients at the University Hospital.

    abstract::A retrospective review was performed from November 2011 through June 2012 in 49 stable patients receiving ambulatory hemodialysis at the dialysis unit of the University Hospital in San Juan. Measurements of serum phosphate, serum calcium (corrected to albumin levels), intact parathyroid hormone (PTH), and pulse pressu...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Colón C,Watts E,Rebollo NP,Ocasio I,Cangiano JL

    更新日期:2015-06-01 00:00:00

  • Prevalence of Dental Caries in 12-Year-Olds in San Pedro de Macorís, DR.

    abstract:OBJECTIVE:Dental caries is one of the most prevalent chronic diseases in children. Currently, no data are available on dental caries prevalence in the Dominican Republic. The purpose of this study was to estimate the prevalence of dental caries in schoolattending 12-year-olds in San Pedro de Macorís, Dominican Republic...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Diaz-Nicolas J,Silva-Vetri MG,Rivas-Tumanyan S,Toro MJ,Elías-Boneta AR

    更新日期:2020-06-01 00:00:00

  • Head and Neck Microvascular Reconstruction in Puerto Rico: Developing a Two-team approach to Microvascular Reconstructive Surgery.

    abstract::Hypopharyngeal carcinoma as a subsite of head and neck cancer, carries with it the lowest 5-year relative survival rate. Treatment of hypopharyngeal cancer relies on single therapy or multimodality treatment: surgery, radiation and/or chemotherapy. When surgical intervention is chosen, the type of operation depends on...

    journal_title:Puerto Rico health sciences journal

    pub_type:

    doi:

    authors: Hernández G,González-Castro J,Giráldez-Rodríguez L

    更新日期:2020-03-01 00:00:00

  • Comparison of Atmospheric Fungal Spore Concentrations between Two Main Cities in the Caribbean Basin.

    abstract:OBJECTIVE:Fungal spores are ubiquitous in the atmosphere worldwide, but their distribution is not homogeneous at different locations. Most studies have compared airborne fungal spores ecology in temperate zones, but less is known about the tropics. METHODS:This study compared, through statistical analysis of archived ...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Rivera-Mariani FE,Almaguer M,Aira MJ,Bolaños-Rosero B

    更新日期:2020-09-01 00:00:00

  • Burnout and its related Demographic Factors among the Medical Staff working in Hospitals associated with Bushehr University of Medical Sciences.

    abstract:OBJECTIVE:Burnout exerts a significant negative influence on job performance, especially in such difficult jobs as those to be found in the health care industry. This research aimed to evaluate the association between 3 dimensions of burnout and demographic factors among the medical staff working in all of the hospital...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Gashmard R,Bagherzadeh R,Pouladi S,Akaberian S

    更新日期:2015-12-01 00:00:00

  • Peripartum Cardiomyopathy: Experience at a Tertiary Care Center in Puerto Rico.

    abstract:OBJECTIVE:Peripartum cardiomyopathy is a rare type of heart failure to which only pregnant women are susceptible. In Puerto Rico there is a paucity of information regarding this condition. In this report we describe our experience with peripartum cardiomyopathy. METHODS:This was a descriptive retrospective study. We c...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Osterman-Pla AD,López-Cepero R,Jiménez L,Romaguera J,Aranda J

    更新日期:2016-12-01 00:00:00

  • Comparison of the endocervical brush and the endocervical curettage for the evaluation of the endocervical canal.

    abstract:OBJECTIVE:To evaluate and compare the efficacy in obtaining an adequate endocervical sampling using the endocervical brush and the endocervical curettage. METHODS:Analysis of the cytology and histology of samples obtained from patients referred to the University of Puerto Rico School of Medicine Tertiary Care Center A...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Martin D,Umpierre SA,Villamarzo G,Sánchez O,Sánchez J,Carrodeguas J,Adamsons K

    更新日期:1995-09-01 00:00:00

  • [To the northernmost part of the airlift bridge: the Puerto Ricans in the United States].

    abstract::This article examines the available data on the health status of Puerto Rican women in the United States. Statistics on reproductive health, cancer and AIDS indicate that the health status of these women is lower than that of both their U.S. and island counterparts. Usually, the health of immigrants lies somewhere bet...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Ramírez de Arellano AB

    更新日期:1998-03-01 00:00:00

  • Symposium review: drug discovery, development and clinical research in academia.

    abstract::The development of new drugs for the pharmacological treatment of diseases is a costly and time-consuming process. The pharmaceutical industry has traditionally played the main role in the discovery, development, manufacturing and marketing of new drugs. However, in recent years, the role of academia in the process of...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Vlaar CP,Hernández L

    更新日期:2009-09-01 00:00:00

  • Occult aspiration of a chicken wishbone as a cause of hemoptysis.

    abstract::Aspiration of foreign bodies is more common in children than adults. The clinical and radiological findings between these two age groups are different. It is a clinical diagnosis often overlooked in adults. We hereby present an elderly male patient who was referred to us due to a one year history of hemoptysis. He was...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Mercado JA,Rodríguez W

    更新日期:1999-03-01 00:00:00

  • A profile of knowledge and attitudes toward tobacco usage of first and fourth year medical students at the University of Puerto Rico.

    abstract::A questionnaire entitled "Attitude toward tobacco usage among health professionals in Puerto Rico" was administered to medical students completing their first and fourth years respectively at the University of Puerto Rico Medical School. Percent of each group currently smoking was found to be 18.5 and 10.8 with an ave...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Preston AM,Matos FV,Flores MI

    更新日期:1987-08-01 00:00:00

  • University of Puerto Rico - School of Pharmacy: one hundred years of history and service.

    abstract::The University of Puerto Rico School of Pharmacy was initially established as the Department of Pharmacy at the Río Piedras Campus on September 22, 1913, being the first healthcare program founded in Puerto Rico. The history of the School of Pharmacy reveals a remarkable evolution over a 100 years period in order to r...

    journal_title:Puerto Rico health sciences journal

    pub_type: 历史文章,杂志文章

    doi:

    authors: Maldonado-Dávila WT

    更新日期:2013-12-01 00:00:00

  • Effectiveness of a back school program in the application of body mechanics principles.

    abstract:BACKGROUND:Low back pain is one of the most frequent work related injuries in all occupations. Back school programs are therapeutic interventions directed towards treatment, prevention and rehabilitation of backaches. The purpose of this study was to (1) evaluate the test-retest reliability of the modified version of t...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Berríos-López Y,Cádiz-Blackman J,Vélez-Hernández Y,Venegas HL,Ortiz A

    更新日期:2009-03-01 00:00:00

  • Insulin and phorbol ester regulation of gene 33 expression in CHO cells.

    abstract::Rat gene 33 (g33) mRNA has a widespread tissue distribution. Insulin and various agents such as glucocorticoids, phorbol esters and plant lectins regulate G33 expression in rat hepatoma cells. The regulation of g33 by insulin and a phorbol ester was examined in two Chinese Hamster ovary (CHO) cell lines, CHO-T cells (...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Romero N,Jiménez BD,Cadilla CL

    更新日期:1999-09-01 00:00:00

  • The Zika Virus Infection in Pregnancy: Review and Implications for Research and Care of Women and Infants in Affected Areas.

    abstract::The world has encountered a new and serious epidemic which has disproportionately affected fetuses and infants. What makes the Zika virus (ZIKV) epidemic such a threat in our times, is that a whole generation can be affected by birth defects caused by a seemingly innocuous maternal infection, which in most cases go un...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章,评审

    doi:

    authors: Zorrilla CD,Rivera-Viñas JI,De La Vega-Pujols A,Garcia-Garcia I,Rabionet SE,Mosquera AM

    更新日期:2018-12-01 00:00:00

  • Efficacy of Hydromer-Coated and Antibiotic- Impregnated Shunt Systems in Reducing Early Shunt Infections in the Pediatric Population.

    abstract:OBJECTIVE:Shunt infection is the most common complication following a Cerebrospinal fluid (CSF) diversion procedure with devastating consequences. This study analyzes the efficacy of different shunt systems in reducing early shunt infections in the pediatric population. METHODS:Retrospective case study analysis of 177...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Mayol M,Estronza S,Sosa IJ,Vigo JA,Pastrana EA

    更新日期:2019-12-01 00:00:00

  • [Multiple sphincterotomies in the surgical treatment of cataracts in narrow pupils].

    abstract::Deficient mydriasis of diverse etiology renders extracapsular cataract extraction and posterior chamber intraocular lens implantation technically difficult. Several techniques are available to improve surgical results when this problem is present. We have used multiple sphincterotomies in 6 patients with narrow pupils...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Mendicute J,Seminario M,Eder F,Müller-Thyssen A,Genua I,Lamsfus JM

    更新日期:1993-06-01 00:00:00

  • [Ethical aspects of human lactation and breastfeeding].

    abstract::Breastfeeding has experienced a surge in Puerto Rico thanks to the efforts of many women, as well as governmental, non-governmental and private organizations. Among the aspects which can affect the initiation, establishment and maintenance of successful breastfeeding one finds potential ethical conflicts among health ...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Parrilla Rodríguez AM,Gorrín Peralta JJ

    更新日期:2000-06-01 00:00:00

  • The role of Cayo Santiago in primate field studies.

    abstract::Cayo Santiago has provided the opportunity to study primate biology in a free-ranging neutral environment free of provocative human influences. Rarely, if ever, does such a situation occur in natural rhesus habitats in Asia. This Cayo Santiago advantage has permitted fine-scale analyses of the details of behavior, eco...

    journal_title:Puerto Rico health sciences journal

    pub_type: 历史文章,杂志文章

    doi:

    authors: Southwick CH

    更新日期:1989-04-01 00:00:00

  • Update in atrial fibrillation.

    abstract::Atrial fibrillation (AF) is the most common sustained arrhythmia in adults. It is a significant public health problem in the United States where it affects 2.2 million Americans and almost 10% of the population older than 80 years. It should be emphasized that the prevalence of AF increases with advancing age and with...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章,评审

    doi:

    authors: Gutiérrez A,López JE

    更新日期:2004-12-01 00:00:00

  • [Alzheimer's disease: the untold story].

    abstract::Alzheimer's Disease. The untold story. After considering the potential relationship between amyloid deposits and myxedematous infiltrations, the hypothesis is formulated that Alzheimer's disease may be due to functional hypothyroidism and may thus respond to thyroid therapy. ...

    journal_title:Puerto Rico health sciences journal

    pub_type: 杂志文章

    doi:

    authors: Picó-Santiago G

    更新日期:1993-06-01 00:00:00