Abstract：
:The development of new drugs for the pharmacological treatment of diseases is a costly and time-consuming process. The pharmaceutical industry has traditionally played the main role in the discovery, development, manufacturing and marketing of new drugs. However, in recent years, the role of academia in the process of drug discovery and development, and its eventual translation into clinical applications has steadily increased. At the occasion of their 95th anniversary, the School of Pharmacy at the University of Puerto Rico organized a symposium titled "Drug Discovery, Development and Clinical Research in Academia". This article presents a summary of the symposium presentations and the potential role of academic drug discovery and development as a complement to the pharmaceutical manufacturing industry in Puerto Rico.
journal_name
P R Health Sci Jjournal_title
Puerto Rico health sciences journalauthors
Vlaar CP,Hernández Lsubject
Has Abstractpub_date
2009-09-01 00:00:00pages
268-73issue
3eissn
0738-0658issn
2373-6011journal_volume
28pub_type
杂志文章abstract：OBJECTIVE:Dental caries is one of the most prevalent chronic diseases in children. Currently, no data are available on dental caries prevalence in the Dominican Republic. The purpose of this study was to estimate the prevalence of dental caries in schoolattending 12-year-olds in San Pedro de Macorís, Dominican Republic...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVE:This study was conducted to determine the experience of tooth loss, as well as its associated variables, in a sample of adult Mexicans, aged 60 years and older. MATERIALS AND METHODS:This cross-sectional study was part of a larger project to measure diverse oral health indicators in a convenience sample: it ...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2016-06-01 00:00:00
abstract：:Patients hospitalized with unstable angina (UA) or with a non-ST segment elevation myocardial infarct (NSTEMI) are at increased risk of suffering refractory angina, recurrent myocardial infarct (MI), and death. These patients need to be evaluated more aggressively. According to the last published guidelines (2002) of ...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章,评审
doi：
更新日期：2005-12-01 00:00:00
abstract：OBJECTIVE:This study aimed to assess the role of gender on HIV/AIDS stigma among 507 medical students in Puerto Rico. METHODS:A secondary data analysis was performed with baseline measurements of a controlled randomized study. RESULTS:Unadjusted analyses showed that the overall multivariate test for gender was signif...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVE:to estimate the prevalence of pit and fissure sealants on first permanent molars in twelve year olds living in Puerto Rico and to further evaluate dental sealant prevalence by (1) urban/rural and public/private school status as well as (2) gender; DESIGN:population-based, cross-sectional study. SETTING:publ...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2006-06-01 00:00:00
abstract：:The therapy of chronic myeloid leukemia (CML), characterized by the presence of the Philadelphia chromosome in the clonal hematopoietic stem cells, has changed dramatically in the last year with the development of a specific inhibitor of the BCR-ABL tyrosine kinase. This medication, STI571 or imatinib, was recently ap...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章,评审
doi：
更新日期：2002-09-01 00:00:00
abstract：:Hypokalemic periodic paralysis (hypoKPP) is a clinical entity characterized by recurrent skeletal muscle paralysis due to a decrease in serum potassium levels; hypoKPP can have either a primary (familial) or a secondary cause. One of the secondary causes of hypoKPP is distal renal tubular acidosis (dRTA). Distal renal...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2017-12-01 00:00:00
abstract：OBJECTIVE:To describe the respiratory pathogens found in the bronchoalveolar lavage of a Puerto Rican population infected with the human immunodeficiency virus (HIV). BACKGROUND:Empirical treatment is an accepted strategy for management of HIV-related pneumonia, but it is usually recommended for countries that have kn...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2005-09-01 00:00:00
abstract：OBJECTIVE:Peripartum cardiomyopathy is a rare type of heart failure to which only pregnant women are susceptible. In Puerto Rico there is a paucity of information regarding this condition. In this report we describe our experience with peripartum cardiomyopathy. METHODS:This was a descriptive retrospective study. We c...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2016-12-01 00:00:00
abstract：OBJECTIVE:To evaluate and compare the efficacy in obtaining an adequate endocervical sampling using the endocervical brush and the endocervical curettage. METHODS:Analysis of the cytology and histology of samples obtained from patients referred to the University of Puerto Rico School of Medicine Tertiary Care Center A...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：:Extracts from higher plants were evaluated for inhibitory activity against avian myeloblastosis virus reverse transcriptase. The assay may serve as a useful prescreen for potential anti-HIV bioactives. ...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：BACKGROUND:Pre- and postoperative evaluation of the pediatric patient with a cerebrovascular malformation can be cumbersome. This may be due to several factors, including age and ability to verbalize. Functional evaluation scales have been devised, yet application to a retrospective study, where information can be limi...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2008-03-01 00:00:00
abstract：:Folate deficiency is one of today's most common vitamin deficiencies in women. Women who consume a low level of folate during pregnancy are at risk for poor pregnancy outcomes including neural tube defects (NTD). However, other factors such as heredity, social class, maternal age, birth order, maternal diet, length of...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章,评审
doi：
更新日期：1997-12-01 00:00:00
abstract：OBJECTIVE:Present evidence-based recommendations on the use of biochemical markers of bone turnover in the management of osteoporosis. METHODS:The English literature from 1999 to 2005 was reviewed by using data sources from MEDLINE. RESULTS:Measurement of biochemical markers of bone turnover helps us identify a high ...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章,评审
doi：
更新日期：2007-06-01 00:00:00
abstract：OBJECTIVE:People with type 1 diabetes (T1D) may experience significant changes in their daily routines due to this condition, which frequently results in depressive symptoms and the deterioration of their quality of life. We examined the factors associated with suicidal ideation (SI) and diabetes-related quality of lif...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2018-03-01 00:00:00
abstract：:Human physiology depends on countless biochemical reactions, numerous of which are co-dependent and interrelated. The speed and level of completion of reactions usually depend on the availability of precursors and enzymes. The enzymatic activity depends on the bioavailability of micronutrient cofactors such as vitamin...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2015-03-01 00:00:00
abstract：:Small island exigencies and a legacy of colonial jurisprudence set the stage for this three-year study in 2001-2003 of abortion practice on several islands of the northeast Caribbean: St. Martin, St. Maarten, Anguilla, Antigua and St Kitts. Based on in-depth interviews with 26 physicians, 16 of whom were performing ab...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2008-03-01 00:00:00
abstract：:Deficient mydriasis of diverse etiology renders extracapsular cataract extraction and posterior chamber intraocular lens implantation technically difficult. Several techniques are available to improve surgical results when this problem is present. We have used multiple sphincterotomies in 6 patients with narrow pupils...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：1993-06-01 00:00:00
abstract：:This is a case report of a patient who developed a nodule in one foot, which upon biopsy, was diagnosed as tungiasis, a cutaneous infestation caused by a human flea. The natural life cycle, clinical and pathological expressions are discussed. ...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2007-12-01 00:00:00
abstract：:The University of Puerto Rico School of Pharmacy was initially established as the Department of Pharmacy at the Río Piedras Campus on September 22, 1913, being the first healthcare program founded in Puerto Rico. The history of the School of Pharmacy reveals a remarkable evolution over a 100 years period in order to r...
journal_title：Puerto Rico health sciences journal
pub_type： 历史文章,杂志文章
doi：
更新日期：2013-12-01 00:00:00
abstract：:The objective of this study was to identify the knowledge about sexuality (including STD/HIV/AIDS), the sexual practices more frequents and sexuality education sources in a group of students with visual impairments. A self administered questionnaire was utilized in 50 students with visual impairment. Descriptive stati...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2001-09-01 00:00:00
abstract：:Candida is the fourth most common cause of nosocomial bloodstream infections (BSI), being Candida albicans the most common species. This study evaluated the distribution of Candida spp isolates at a tertiary care medical center. The associated factors and outcome of patients with candidemia at the Puerto Rico Medical ...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2010-03-01 00:00:00
abstract：:Atrial fibrillation (AF) is the most common sustained arrhythmia in adults. It is a significant public health problem in the United States where it affects 2.2 million Americans and almost 10% of the population older than 80 years. It should be emphasized that the prevalence of AF increases with advancing age and with...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章,评审
doi：
更新日期：2004-12-01 00:00:00
abstract：:In studying the process of protein synthesis of a silk-producing organism we have found that several macromolecules must be synthesized in order for the process to occur. Through time course studies, we have found that small RNAs may play a paramount role in directing the finely orchestrated process. Alanine tRNA, U1 ...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：:This is the case of an 11-year-old girl who presented with a right adnexal mass and vague abdominal symptoms since seven months prior to her hospital admission for surgery. CT-scan and sonographic images were those of a benign lesion, probably ovarian torsion or infarction. Serum tumoral markers were normal. A right s...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：:Atherosclerosis is the most frequent cause of ischemic heart disease and cerebrovascular disorders. The condition is the leading cause of death in Western societies. At the core of this condition is the atherosclerotic plaque. It is within the structure of this lesion that multiple biochemical and cellular processes i...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
abstract：:This paper examines the characteristics of youngsters in drug treatment who volunteer for AIDS testing in comparison to those who do not. HIV Antibodies testing was offered on a voluntary basis to a sample of 250 Puerto Rican youngsters enrolled in three ambulatory drug treatment centers in 1991. Sixty-six percent of ...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：1997-03-01 00:00:00
abstract：:This brief celebration of the work of Francisco Guerra (1916-2011) highlights his role as mentor for an international community, his study of local events in the context of global developments, and his contributions to the understanding of the medical history of Puerto Rico. A selective review of Francisco Guerra's me...
journal_title：Puerto Rico health sciences journal
pub_type： 传,历史文章,杂志文章
doi：
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:Due to advances in the care of people living with HIV/AIDS (PLWHA), life expectancy significantly increased, putting this group vulnerable to age-related comorbidities, such as cancer. The objective of this study was to describe the knowledge of cancer screening (cervical, breast, anal, colon, prostate) and o...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVE:This study aimed to assess the demographic, behavioral, and clinical factors associated with HIV and syphilis infection among a sample of men attending a sexually transmitted infection clinic during 2009 to 2010 in San Juan, Puerto Rico (PR). METHODS:A sample of 350 clinical records from men visiting the cli...
journal_title：Puerto Rico health sciences journal
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
