Abstract:
OBJECTIVE:Present evidence-based recommendations on the use of biochemical markers of bone turnover in the management of osteoporosis. METHODS:The English literature from 1999 to 2005 was reviewed by using data sources from MEDLINE. RESULTS:Measurement of biochemical markers of bone turnover helps us identify a high bone turnover rate. Elevated levels of these markers points towards a pathology and at an accelerated loss of bone mass. Its main utility is in documenting the response to therapy. They have a limited role in the follow-up of patients with osteoporosis. To be useful, bone markers must be measured at baseline and periodically after the beginning of therapy. A fall of on fifty (50%) percent in the levels of resorption markers between the third and sixth month of therapy predicts a good response. Bone markers can not be used to establish the diagnosis of osteoporosis. Neither do they measure bone mass. Markers are not capable of predicting future loss of bone mass in an individual nor do they correlate with the occurrence of previous fractures. The greatest limitation of these measurements is not being able to measure bone remodeling in the individual subject. Bone resorption markers are more frequently used than those of formation. The levels of the markers can identify the failures to the therapy and responses to therapy. Lack of reduction in the resorption markers could indicate lack of compliance with therapy, problems of absorption of the medication or lack in response to treatment. There may be problems with the measurement and the interpretation of results of bone remodeling markers. Variability between individuals and intra-individual variability exist as well as inter-assay and intra-assay variability. CONCLUSION:Biochemical markers of bone turnover along with measurements of bone density can help optimize the management of osteoporosis. The use of the bone markers is not recommended in a routine form, but they can be of utility in situations of poor compliance with the therapy or when there are difficulties in the management of the treatment of osteoporosis.
journal_name
P R Health Sci Jjournal_title
Puerto Rico health sciences journalauthors
Allende-Vigo MZsubject
Has Abstractpub_date
2007-06-01 00:00:00pages
91-5issue
2eissn
0738-0658issn
2373-6011journal_volume
26pub_type
杂志文章,评审abstract::The objective of this study was to identify the knowledge about sexuality (including STD/HIV/AIDS), the sexual practices more frequents and sexuality education sources in a group of students with visual impairments. A self administered questionnaire was utilized in 50 students with visual impairment. Descriptive stati...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:2001-09-01 00:00:00
abstract::Rat gene 33 (g33) mRNA has a widespread tissue distribution. Insulin and various agents such as glucocorticoids, phorbol esters and plant lectins regulate G33 expression in rat hepatoma cells. The regulation of g33 by insulin and a phorbol ester was examined in two Chinese Hamster ovary (CHO) cell lines, CHO-T cells (...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract:INTRODUCTION:Incidental adrenal tumors are commonly benign, but reports demonstrate that if the characteristics of the tumor are not clear, on images surgery is the procedure of choice. Our objective through this case is to show that laparoscopic adrenalectomy is a safe approach for adrenal incidental tumor regardless ...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:2010-06-01 00:00:00
abstract::Advances in the understanding of chondrocytes and the synovial membrane as targets of and participants in the inflammatory process in articular joints have provided insights into the role of inflammation in cartilage and subchondral bone injury in rheumatic diseases. Reports that describe the inflammatory cellular inf...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章,评审
doi:
更新日期:2017-09-01 00:00:00
abstract::This brief celebration of the work of Francisco Guerra (1916-2011) highlights his role as mentor for an international community, his study of local events in the context of global developments, and his contributions to the understanding of the medical history of Puerto Rico. A selective review of Francisco Guerra's me...
journal_title:Puerto Rico health sciences journal
pub_type: 传,历史文章,杂志文章
doi:
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:Puerto Rican children could have a higher prevalence of obesity, compared to US children or even to US Hispanic children. Obese youths are more likely to have risk factors for cardiovascular conditions, such as hypertension. Although BMI provides a simple, convenient measurement of obesity, it does not measur...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:2016-03-01 00:00:00
abstract::Cayo Santiago has provided the opportunity to study primate biology in a free-ranging neutral environment free of provocative human influences. Rarely, if ever, does such a situation occur in natural rhesus habitats in Asia. This Cayo Santiago advantage has permitted fine-scale analyses of the details of behavior, eco...
journal_title:Puerto Rico health sciences journal
pub_type: 历史文章,杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract:INTRODUCTION:Neoplasms of the heart are extremely rare and difficult to diagnose. In this study, we intend to describe the experience at the Cardiovascular Center of Puerto Rico and the Caribbean (CCPRC) dealing with benign cardiac neoplasms. METHODS:A retrospective review of the archival material at our institution w...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:2008-12-01 00:00:00
abstract::Breastfeeding mothers need orientation and help in order to succeed with breastfeeding. Lack of support from health professionals and societal barriers result in a median duration of breastfeeding in Puerto Rico of only 3 weeks. A telephone warm line at our breastfeeding clinic tries to provide some much-needed suppor...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of hypothyroidism in an adult female population in Puerto Rico and to determine the relationship between hypothyroidism, bone mineral density and vertebral and non-vertebral fractures in this population. METHODS:Data from the 400 subjects' database of the Latin American Vertebral ...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:2013-06-01 00:00:00
abstract::Genital human papillomavirus (HPV) infection is one of the most commonly diagnosed sexually transmitted infections world-wide. Over the last two decades, research has established a strong causal link between specific types of HPV infection and cancer, particularly cervical, anal, vulvar/vaginal, penile, and oropharyng...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章,评审
doi:
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To compare the effectiveness of intravenous immunoglobulin (IVIG) alone, high dose methylprednisolone (HDMP) alone and the combination of IVIG and HDMP in the treatment of childhood immune thrombocytopenic purpura (ITP). BACKGROUND:Acute ITP in children is a self-limited disease with a benign course and low ...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:The recent FDA approval of non-prescription sales of Plan B, an emergency contraceptive method to those 18 years old and over, gives a prominent role to pharmacists in providing timely access to emergency contraception (EC). While this decision affects Puerto Rico, no studies on non-prescription EC in Puerto...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:To describe the general knowledge and choices of postpartum contraception among pregnant teens who, at the time of the study, ranged in age from 13 to 19 years old and were receiving prenatal care at a hospital-based prenatal clinic. METHODS:Questionnaires to obtain information regarding demographic characte...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:2014-09-01 00:00:00
abstract::As part of the January, 1988 trapping of the Cayo Santiago rhesus colony a number of morphometric measurements and serum were collected to examine metabolic and hormonal changes associated with spontaneous obesity. Measurements included body weights, crown-rump lengths, abdominal and scapular skinfolds and circumferen...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract::Thymidine kinase is a key enzyme responsible for the activation of several anticancer and antiviral drugs. As the first enzyme in the salvage pathway of thymidine, it is regulated by the feedback inhibition exerted by the end-product of the pathway, namely thymidine 5'-triphosphate. 5'-Aminothymidine is a non-toxic an...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章,评审
doi:
更新日期:1994-03-01 00:00:00
abstract::The type of glass used to fabricate patch pipettes influences the kinetic properties of single-channel currents activated by acetylcholine in Xenopus myocytes. In patches formed with hard glass pipettes, the opening rate decreased in a time-dependent manner. Such decrease was most pronounced for the low conductance ch...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:1988-08-01 00:00:00
abstract::Prenatal sonographic evaluation is of utmost importance in the detection of congenital anomalies. At the Ultrasound Section of our Radiology service, we incidentally detected fetal intracranial neoplasms in two different patients using non-invasive imaging. Our presumptive diagnosis in both cases was a teratoma, the m...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:Dental caries is one of the most prevalent chronic diseases in children. Currently, no data are available on dental caries prevalence in the Dominican Republic. The purpose of this study was to estimate the prevalence of dental caries in schoolattending 12-year-olds in San Pedro de Macorís, Dominican Republic...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:Bladder cancer is, in Poland, the fourth most common malignancy in men and the eighth most common in women. Radical cystectomy often seems to be the only method of treatment. This mutilating procedure may affect the quality of life of the patient. The aim of our study was to analyze the impact of factors infl...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Suicidal behavior among adolescents is not a well-explored public health problem. Health policy decision-making on suicidal behavior needs reliable information on the prevalence of suicidal ideation (SI) and its associated risk factors to produce health promotion and prevention programs. METHODS:The Global ...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:2008-12-01 00:00:00
abstract::Aspiration of foreign bodies is more common in children than adults. The clinical and radiological findings between these two age groups are different. It is a clinical diagnosis often overlooked in adults. We hereby present an elderly male patient who was referred to us due to a one year history of hemoptysis. He was...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:1999-03-01 00:00:00
abstract::Alzheimer's Disease. The untold story. After considering the potential relationship between amyloid deposits and myxedematous infiltrations, the hypothesis is formulated that Alzheimer's disease may be due to functional hypothyroidism and may thus respond to thyroid therapy. ...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:1993-06-01 00:00:00
abstract::Insulin-dependent diabetes mellitus (IDDM) is a chronic health condition that affects 18 of every 100,000 Puerto Rican youth. Few research studies have been performed on the problems that youth with diabetes encounter and how they are related to adherence to treatment and adequate metabolic control. Adequate metabolic...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:2006-12-01 00:00:00
abstract::The therapy of chronic myeloid leukemia (CML), characterized by the presence of the Philadelphia chromosome in the clonal hematopoietic stem cells, has changed dramatically in the last year with the development of a specific inhibitor of the BCR-ABL tyrosine kinase. This medication, STI571 or imatinib, was recently ap...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章,评审
doi:
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:Burnout exerts a significant negative influence on job performance, especially in such difficult jobs as those to be found in the health care industry. This research aimed to evaluate the association between 3 dimensions of burnout and demographic factors among the medical staff working in all of the hospital...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:2015-12-01 00:00:00
abstract::Patterns of stress-responsiveness were studied in 19 adolescent male rhesus monkeys (Macaca mulatta) who are part of the free-ranging colony on Cayo Santiago, PR. Morphometric and blood samples were obtained as each male was captured and after holding overnight. Subject heart rate was recorded on Day 2, using surface ...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract::Candida is the fourth most common cause of nosocomial bloodstream infections (BSI), being Candida albicans the most common species. This study evaluated the distribution of Candida spp isolates at a tertiary care medical center. The associated factors and outcome of patients with candidemia at the Puerto Rico Medical ...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Plant materials represent promising sources of anti-cancer agents. We developed and tested a novel extract from the ubiquitous plant Convolvulus arvensis. MATERIALS AND METHODS:Convolvulus arvensis components were extracted in boiling water, and small molecules were removed by high-pressure filtration. The ...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:The present study was performed to detect cancer risk of the midwifes and nurses playing central role in raising awareness in the society using Gail's model. MATERIALS AND METHODS:Sample of the present cross sectional study consists of 750 volunteer midwifes and nurses in 2016. Breast cancer risk was calcula...
journal_title:Puerto Rico health sciences journal
pub_type: 杂志文章
doi:
更新日期:2018-06-01 00:00:00