Abstract：
OBJECTIVES:To clarify the clinical and prognostic significance of cortactin and phosphorylated cortactin in patients with sarcomatoid renal cell carcinoma (SRCC). METHODS:We retrospectively reviewed the data from 31 patients with SRCC and 33 with conventional renal cell carcinoma matched for clinicopathologic features. The immunoreactive score for cortactin, pY421 cortactin, and pY466 cortactin were measured using immunohistochemistry. The relationships between each immunoreactive score and the clinicopathologic features and survival were investigated. RESULTS:The immunoreactive score of p421 cortactin, but not that of cortactin and pY466 cortactin, was significantly greater in SRCC than in conventional renal cell carcinoma (P < .001). The expression of pY421 cortactin in SRCC correlated with the pT stage and metastasis (P < .001). The expression of pY466 cortactin showed a similar trend with pT stage (P = .043) but not with metastasis. Although both of pY421 cortactin and pY466 cortactin were identified as useful predictors for survival in univariate analyses, only pY421 cortactin expression was considered an independent predictor in patients with SRCC (odds ratio 4.53, 95% confidence interval 1.07-19.12, P = .040) in the multivariate analysis model, including pT stage and metastasis. CONCLUSIONS:Our results have demonstrated that phosphorylation of cortactin is a key process in malignant aggressiveness, and its expression is a useful predictor of cause-specific survival and could be a useful potential therapeutic target in patients with SRCC.
journal_name
Urologyjournal_title
Urologyauthors
Matsuo T,Miyata Y,Watanabe S,Ohba K,Hayashi T,Kanda S,Sakai Hdoi
10.1016/j.urology.2011.03.019subject
Has Abstractpub_date
2011-08-01 00:00:00pages
476.e9-15issue
2eissn
0090-4295issn
1527-9995pii
S0090-4295(11)00298-6journal_volume
78pub_type
杂志文章相关文献
UROLOGY文献大全abstract：OBJECTIVES:An analysis of differentially expressed genes (DEGs) between bladder transitional cell carcinoma (TCC) and the surrounding urothelium to help identify what lies behind the mechanism of multifocal tumor development has not yet been performed. We sought to find a new DEG related to the development of bladder T...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2008.02.019
更新日期：2008-10-01 00:00:00
abstract：:Evidence relating to the perception and view of patients and physicians on natural orifice transluminal endoscopic surgery (NOTES) and laparoendoscopic single-site surgery (LESS) was scrutinized. A comprehensive literature search was performed through PubMed. A total of 18 studies were included in the analysis. Patien...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/j.urology.2012.04.002
更新日期：2012-09-01 00:00:00
abstract：:In this case report we describe a case of persistant Müllerian duct syndrome together with transverse testicular ectopia. These 2 entities are discussed to assess the relationship between them and the lack of necessity for magnetic resonance imaging in cases of undescended testes, and relevant literature is reviewed. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2010.03.043
更新日期：2010-12-01 00:00:00
abstract：:A retrospective study was made of 200 patients undergoing transurethral prostatectomy. Half of these patients received bilateral vasectomies. The vasectomized patients had a 5-percent incidence of epididymitis as compared with a 2-percent incidence in the nonvasectomized patients. Vasectomy failed to provide adequate ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(79)90281-4
更新日期：1979-02-01 00:00:00
abstract：:The presence of gas in the portal venous system is considered an ominous sign often mandating immediate exploratory laparotomy; however, there are numerous reports of benign incidences of this finding. This report describes a case of portal venous gas after extracorporeal shockwave lithotripsy. The patient had the rar...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.10.067
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVE:To compare quality of life (QOL) outcomes after conversion from laparoscopic radical prostatectomy (LRP) to robot-assisted radical prostatectomy (RALP) as the routine procedure for surgical treatment of localized cancer of the prostate (CaP). METHODS:In November 2007, we changed the routine operative techniq...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2013.01.017
更新日期：2013-04-01 00:00:00
abstract：:Various parasympathomimetic drugs are discussed, including the choline esters, bethanechol, carbachol, methacholine chloride, and furtrethonium. Other cholinomimetic agents include muscarine, muscarone, arecholine, and pilocarpine. Anticholinesterase agents inhibit or inactivate acetylcholinesterase enzyme and thus re...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/0090-4295(77)90052-8
更新日期：1977-07-01 00:00:00
abstract：:Genital prolapse is usually seen as a benign condition warranting treatment only when bothersome. We report the case of a 77-year-old woman who presented with massive incarcerated pelvic organ prolapse, which led to bladder necrosis, cystectomy with bilateral cutaneous ureterostomy, and death from medical complication...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2016.09.010
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVE:To introduce a grading system (kidney, ureter, and bladder [KUB]) to identify encrusted stents that may require multiple surgeries, multimodal surgery, and operative time > 180 minutes for successful removal. METHODS:One hundred ten retained encrusted ureteral stents were retrospectively scored using the KUB...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2016.06.050
更新日期：2016-11-01 00:00:00
abstract：:We report a case of human penile ossification with roentgenologic and histologic confirmation. The English literature is reviewed, and the pathogenesis of such a rare lesion is presented. Penile ossification appears to be an acquired metaplastic process occurring in an area of fibrosis. ...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/0090-4295(90)80163-h
更新日期：1990-04-01 00:00:00
abstract：:Transcaval ureter is a rare congenital anomaly characterized by an inferior cava vein duplication producing a vascular ring around the right ureter, usually determining hydroureteronephrosis. The knowledge of this vascular anomaly on imaging examinations permits to avoid erroneous diagnosis of retroperitoneal masses o...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2015.03.029
更新日期：2015-07-01 00:00:00
abstract：OBJECTIVE:To characterize the interactions between the cholinergic and prostaglandin signaling systems within the urothelium-lamina propria of the guinea pig and elucidate the role of muscarinic receptors in these interactions. METHODS:The urothelium-lamina propria was isolated from guinea pig bladders, cut into strip...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2011.08.029
更新日期：2012-01-01 00:00:00
abstract：:We describe a case of an unusual variation of the double retroaortic left renal vein discovered during routine donor examination of the abdomen by multidetector computed tomography. A 53-year-old man underwent evaluation in our department as a potential renal donor for his brother who had end-stage renal failure. Mult...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2009.01.050
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVES:Laser tissue soldering (LTS) in the urinary tract provides an immediate leak-free seal and may avoid complications seen with conventional repair (such as fistula and stricture). We have begun a Phase I clinical trial investigating the use of LTS in performing urologic reconstructive surgery. METHODS:Ten pat...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/s0090-4295(99)80206-4
更新日期：1995-08-01 00:00:00
abstract：OBJECTIVES:Prostatic structure and secretory activity are thought to be influenced by autonomic innervation of the prostate. Prostatic denervation is especially likely in patients with spinal cord injury (SCI) at the level of the cauda equina or the conus medullaris, where the peripheral nerve supply to the prostate ma...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/s0090-4295(00)00548-3
更新日期：2000-07-01 00:00:00
abstract：:Seventy women with stress urinary incontinence underwent simultaneous voiding-urethrocystometry using microtip transducers and an 8-channel recorder, before and three to twelve months after either the modified Burch (48/70) or the modified Pereyra (22/70) retropubic urethropexy. Increase in urethral resistance (p less...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(89)90372-5
更新日期：1989-10-01 00:00:00
abstract：OBJECTIVE:To describe the prevalence and risk factors for incomplete bladder emptying after midurethral slings (MUS) in a large multicenter trial. METHODS:Five hundred ninety-seven women were randomized to retropubic (RMUS) or transobturator midurethral slings as part of the Trial of MidUrethral Slings study. Demograp...
journal_title：Urology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.urology.2013.05.060
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:To identify key anatomic structures that should be preserved to decrease postoperative anejaculation after Aquablation. METHODS:We conducted a case-control study design using patient data and operative video logs from Aquablation clinical trials. Cases were sexually active participants with functional baseli...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2021.01.023
更新日期：2021-01-19 00:00:00
abstract：OBJECTIVE:To offer recommendations on identification of disease progression, treatment management strategies, and suggestions on timing of initiating and discontinuing specific castration-resistant prostate cancer (CRPC) treatments. MATERIALS AND METHODS:The Prostate Cancer Radiographic Assessments for Detection of Ad...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/j.urology.2016.12.033
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVE:To explore the roles of stem cell factor (SCF) on the loss of interstitial cells (ICCs) in the bladder of diabetic rats, which have not been investigated. METHODS:The rats were assigned to 3 groups: normal control rats, diabetic rats, and SCF-treated diabetic rats. The diabetic rat model was created using a ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2011.08.019
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the efficacy of the Memokath stent in managing recurrent bulbar urethral strictures. MATERIALS AND METHODS:This is an investigative pilot stage 2A study in patients with a recurrent bulbar urethral stricture who underwent a Memokath stent implant from January 2014 to January 2016 in a single high...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.04.039
更新日期：2017-09-01 00:00:00
abstract：:A procedure for congenital or acquired crural venous leakage is described. A 3-in.-long inguinoscrotal incision is made about 1 in. lateral to the penis. The suspensory ligament is incised, and the penis is detached from the pubic bone. The deep dorsal vein is resected to expose the hilum of the penis. The entrance of...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(99)00244-7
更新日期：1999-10-01 00:00:00
abstract：OBJECTIVES:To assess the capacity of several clinical and needle biopsy pathologic parameters to predict insignificant and advanced prostate carcinoma (CaP) in radical prostatectomy tissue from men enrolled in a prostate-specific antigen screening program. METHODS:We captured multiple clinical variables and measures o...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2004.04.008
更新日期：2004-09-01 00:00:00
abstract：OBJECTIVE:To measure past active surveillance (AS) adoption rates, institute the best practice, and measure the AS adoption rates following implementation. We report our findings over a 3-year period. METHODS:Patient prostate needle biopsy and treatment data from the period August 2011 to August 2014 were retrieved fr...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2015.11.053
更新日期：2016-07-01 00:00:00
abstract：OBJECTIVES:To evaluate, in a screening population, the impact of tumor volume and prostate volume on prostate-specific antigen (PSA) velocity (PSAV) and to find predictors of biochemical failure after radical prostatectomy. Longitudinal PSA changes in men with prostate cancer have been reported to be significantly diff...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2006.06.020
更新日期：2006-11-01 00:00:00
abstract：OBJECTIVE:To report our experience with different approaches for management of pouch stones in children with ileal-based urinary reservoir. PATIENTS AND METHODS:Charts of children who underwent ileal-based urinary reservoirs between 2000 and 2009 were retrospectively reviewed. Patients who were diagnosed with reservoi...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2014.09.021
更新日期：2015-01-01 00:00:00
abstract：:Infective penile gangrene is a rare but known complication of circumcision. The causes may vary from neutropenia, diabetes mellitus, and human immunodeficiency virus infection to lymphoproliferative malignancy. Penile mycosis leading to penile gangrene is a rare entity. Only 1 case has been reported in an adult. Juven...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2013.03.073
更新日期：2013-09-01 00:00:00
abstract：OBJECTIVE:To study the combination of thermal magnetic resonance imaging (MRI) and novel hypothermic cooling, via an endorectal cooling balloon (ECB), to assess the effective dispersion and temperature drop in pelvic tissue to potentially reduce inflammatory cascade in surgical applications. METHODS:Three male subject...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.07.006
更新日期：2017-10-01 00:00:00
abstract：:Smooth muscle tone in the enlarged prostate is directly related to stimulation of the alpha-adrenergic receptors present in prostatic tissue. Variations in tone produce corresponding alterations in the degree of prostatic obstruction. Such variations can explain the spontaneous symptomatic variations seen clinically i...
journal_title：Urology
pub_type： 杂志文章,评审
doi：
更新日期：1988-12-01 00:00:00
abstract：:Seminal vesicle cysts are usually congenital and frequently accompanied by upper urinary tract abnormalities due to mesonephric duct maldevelopment. Zinner syndrome, first described in 1914, refers to a triad of features consisting of seminal vesicle cysts, ejaculatory duct obstruction, and unilateral (mostly ipsilate...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2020.09.024
更新日期：2020-09-28 00:00:00
