Abstract:
:Cardiovascular disease (CVD) is the major cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Recent major publications, such as the Action to Control Cardiovascular Risk in Diabetes trial, the Advance in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation trial, and the Veterans Affairs Diabetes Trial, found that intensive glucose control in patients with T2DM did not reduce CVD outcomes. However, in this article, we review observational studies and clinical trials that, on aggregate, indicate how glucose lowering appears to reduce risks of CVD in certain subgroups, but can be harmful in other individuals. Based on available evidence, we suggest that younger patients with a shorter duration of T2DM, without CVD, and with few comorbid conditions may experience the greatest cardiovascular benefit from intensive glucose control. In contrast, more aggressive glucose lowering in older patients with a longer duration of T2DM, a history of CVD, and/or multiple comorbidities does not translate to reduced cardiovascular events, and may cause harm. The target goal and therapeutic strategy for intensive glucose control should be established for each individual after a careful review of his or her medical and psychosocial history, and should not reflect a "one-size-fits-all" approach.
journal_name
Postgrad Medjournal_title
Postgraduate medicineauthors
Chokrungvaranon N,Deer J,Reaven PDdoi
10.3810/pgm.2011.11.2501subject
Has Abstractpub_date
2011-11-01 00:00:00pages
114-23issue
6eissn
0032-5481issn
1941-9260journal_volume
123pub_type
杂志文章,评审abstract::Preview The number of cardiac drugs is growing every day, and their indications are changing as more is learned about each one. Choosing the appropriate drug for each patient is made difficult by these complexities, especially when a patient has already had a heart attack. The authors review the latest trials of the m...
journal_title:Postgraduate medicine
pub_type: 杂志文章
doi:10.1080/00325481.1993.11945746
更新日期:1993-11-01 00:00:00
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journal_title:Postgraduate medicine
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journal_title:Postgraduate medicine
pub_type: 杂志文章
doi:10.1080/00325481.1985.11699151
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journal_title:Postgraduate medicine
pub_type: 杂志文章
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更新日期:1976-12-01 00:00:00
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journal_title:Postgraduate medicine
pub_type: 杂志文章
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更新日期:1987-05-01 00:00:00
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journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
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更新日期:2013-09-01 00:00:00
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journal_title:Postgraduate medicine
pub_type: 杂志文章
doi:10.1080/00325481.1984.11698794
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journal_title:Postgraduate medicine
pub_type: 杂志文章
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更新日期:1991-09-01 00:00:00
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journal_title:Postgraduate medicine
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2016-11-01 00:00:00
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journal_title:Postgraduate medicine
pub_type: 杂志文章
doi:10.1080/00325481.1995.11945953
更新日期:1995-01-01 00:00:00
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journal_title:Postgraduate medicine
pub_type: 杂志文章
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更新日期:1978-02-01 00:00:00
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journal_title:Postgraduate medicine
pub_type: 杂志文章
doi:10.1080/00325481.1978.11714844
更新日期:1978-05-01 00:00:00
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journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
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更新日期:2005-12-01 00:00:00
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journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
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更新日期:2004-09-01 00:00:00
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journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
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更新日期:2012-03-01 00:00:00
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更新日期:2016-06-01 00:00:00
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journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
doi:10.3810/pgm.1998.03.416
更新日期:1998-03-01 00:00:00
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journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
doi:10.3810/pgm.2000.02.890
更新日期:2000-02-01 00:00:00
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doi:10.1080/00325481.1980.11715409
更新日期:1980-03-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1975-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2009-05-01 00:00:00
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journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
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更新日期:2018-03-01 00:00:00
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journal_title:Postgraduate medicine
pub_type: 杂志文章
doi:10.1080/00325481.1990.11704612
更新日期:1990-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1080/00325481.1991.11701146
更新日期:1991-12-01 00:00:00
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journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
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更新日期:1998-01-01 00:00:00
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journal_title:Postgraduate medicine
pub_type: 杂志文章,评审
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更新日期:2019-01-01 00:00:00
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journal_title:Postgraduate medicine
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:Postgraduate medicine
pub_type: 杂志文章
doi:10.1080/00325481.1975.11714014
更新日期:1975-04-01 00:00:00