Abstract：
OBJECTIVES:To evaluate whether fall risk in older adults is associated with the use of selective serotonin receptor inhibitor (SSRI) monotherapy among geriatric outpatients, and whether this association is moderated by the presence of depressive disorder and/or frailty. METHODS:Prospective cohort study with a 12-month follow-up and including 811 community-dwelling adults aged 60 or older from a university-based Geriatric Outpatient Unit. Major depressive disorder (MDD) was diagnosed according to DSM-5 criteria; subsyndromal depression as not meeting MDD criteria, but a Geriatric Depression Scale 15-item score ≥ 6 points. Frailty was evaluated with the FRAIL questionnaire. The association between SSRI use, depression, or both as well as the association between SSRI use, frailty, or both with falls were estimated through a generalized estimating equation (GEE) adjusted for relevant confounders. RESULTS:At baseline, 297 patients (36.6%) used a SSRI (82 without remitted depression) and 306 (37.7%) were classified as physically frail. Frailty was more prevalent among SSRI users (44.8% versus 33.7%, p =.004). After 12 months, 179 participants had at least one fall (22.1%). SSRI use, depression as well as frailty were all independently associated with falls during follow-up. Nonetheless, patients with concurrent of SSRI usage and non-remitted depression had no higher risk compared to either remitted SSRI users or depressed patients without SSRIs. In contrast, concurrence of SSRI use and frailty increases the risk of falling substantially above those by SSRI usage or frailty alone. CONCLUSION:SSRI usage was independently associated with falls. Especially in frail-depressed patients, treatment strategies for depression other than SSRIs should be considered.
journal_name
Aging Ment Healthjournal_title
Aging & mental healthauthors
Lin SM,Borges MK,de Siqueira ASS,Biella MM,Jacob-Filho W,Cesari M,Voshaar RCO,Aprahamian Idoi
10.1080/13607863.2019.1675143subject
Has Abstractpub_date
2021-02-01 00:00:00pages
219-224issue
2eissn
1360-7863issn
1364-6915journal_volume
25pub_type
杂志文章abstract：:The present paper discusses recruitment of older African-Americans for a psycho-physiological study using the matching model of recruitment proposed by Levkoff, Levy, and Weitzman (2000). The hallmark of the model by Levkoff et al. is that there must be a match between research and minority communities' perspectives i...
journal_title：Aging & mental health
pub_type： 杂志文章,评审
doi：10.1080/13607860500409781
更新日期：2006-05-01 00:00:00
abstract：:Purposes: Responding to the growing needs of the largest aging population in the world, China has been experimenting interventions introduced from other countries to serve its older citizens. Using the life review approach, this study aimed to understand stress and coping experiences of a group of rural older adults l...
journal_title：Aging & mental health
pub_type： 杂志文章,随机对照试验
doi：10.1080/13607863.2019.1612322
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVES:Self-perceptions of aging have been shown to predict mental and physical health and even longevity. This study examined the aging perceptions of patients with rheumatic disease and compared them with the general Dutch population. METHODS:Consecutive patients visiting a rheumatology clinic completed the Pers...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607863.2011.651438
更新日期：2012-01-01 00:00:00
abstract：OBJECTIVE:Late-life suicide is a complex clinical and public health problem. METHOD:In this article, some of the key complexities inherent in studying late-life suicide are discussed in the service of promoting high-quality late-life suicide prevention science. RESULTS:We discuss the following research issues: the re...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607863.2015.1065791
更新日期：2016-01-01 00:00:00
abstract：:There is little evidence to indicate how far psychiatric day hospitals for older people can identify and address the needs of older people who attend. The current practice of Care Programme Approach (CPA) in which multidisciplinary team members, patients and their families meet, may provide a suitable forum for needs ...
journal_title：Aging & mental health
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1080/1360786031000101166
更新日期：2003-05-01 00:00:00
abstract：OBJECTIVES:The steeling effect suggests that early-life adversity can have a beneficial impact later in life. However, little is known about its underlying mechanisms and long-term outcomes . The study aimed to examine the role of early-life adversity (ELA) on successful aging, and whether this relationship can be expl...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607863.2018.1433635
更新日期：2019-05-01 00:00:00
abstract：OBJECTIVE:The US population of older adults is growing, with an increase in diseases like cancer. As cancer rates increase, there is a concomitant increase in adverse correlates, such as cognitive impairment and depressive symptomatology. In order to develop appropriate interventions, it is vital to assess relationship...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607863.2017.1363868
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVE:This study aims to identify the relationship among social functioning, polypharmacy and depression among older patients in Hong Kong. METHOD:Three out of 18 elderly health centres were selected using the cluster sampling method. 457 elders were randomly selected from all the patients aged 65 and over attendi...
journal_title：Aging & mental health
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1080/13607863.2011.562174
更新日期：2011-08-01 00:00:00
abstract：OBJECTIVES:The increasing number of older adults with dementia is a large and growing public health problem. Alzheimer's disease, the prevailing form of dementia, is projected to quadruple worldwide. To date, the care and social integration of individuals with dementia is complicated by limited collaborations between b...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607863.2013.837149
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVES:Limited health literacy has been shown to be associated with poor health status. However, research to date has not elucidated the factors that mediate the relationship between low literacy and poor health outcomes. The purpose of this study was to examine the mediating effect of self-efficacy on the relation...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607861003801011
更新日期：2010-09-01 00:00:00
abstract：OBJECTIVES:To examine the effect of personal (coping strategies and locus of control) and social resources (family and friendship support) on adjustment to chronic vision impairment in older adults at baseline (rehabilitation service application), 6 months, and 18 months later. METHOD:313 community dwelling, English s...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607860902860912
更新日期：2009-05-01 00:00:00
abstract：:Objective: The well documented demographic shift to an aging population means that more people will in future be in need of long term residential care. Previous research has reported an increased risk of mental health issues and suicidal ideation among older people living in residential care settings. However, there i...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607863.2018.1501666
更新日期：2019-11-01 00:00:00
abstract：:This paper reports on the evaluation of the Enriched Opportunities Programme in improving well-being, diversity of activity, health, and staff practice in nursing home care for people with dementia. Participants were 127 residents with a diagnosis of dementia or enduring mental health problems in three specialist nurs...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607860600963679
更新日期：2007-07-01 00:00:00
abstract：OBJECTIVES:Neuroticism predicts falls in older people. In addition, concern about falling and depressive symptoms are associated with fall risk. This study examined whether concern about falling and depressive symptoms mediate the association between neuroticism and falls. METHOD:Cross-sectional data on 314 community-...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607863.2020.1841735
更新日期：2020-11-06 00:00:00
abstract：:While it is clear that families remain involved in the lives of loved ones following placement in a nursing home, little research has examined whether visiting and the provision of care has effects on the emotional stress and psychological well-being of family members. Utilizing pre-placement and post-placement data f...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607860310001613356
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVES:In old age, the will-to-live (WTL) is one of the most important indicators of subjective well-being (SWB). However, few studies to date have focused on WTL. In these studies, WTL has mainly been evaluated via indirect questions concerning factors that may influence peoples' WTL, or by measures directed to pa...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607863.2015.1081149
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVES:To document the reliability, construct and nomological validity of the perceived Social Stigmatisation (STIG) scale in the older adult population. DESIGN:Cross-sectional survey. SETTING:Primary medical health services clinics. PARTICIPANTS:Probabilistic sample of older adults aged 65 years and over waitin...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607863.2014.944092
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVES:This qualitative study aimed to illuminate former family caregivers' experiences of aspects that facilitate and hinder the process of relinquishing the care of a person with dementia to a nursing home. METHOD:Ten narrative interviews with former family caregivers were performed and subjected to qualitative ...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607863.2014.908456
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:There is an increased evidence of an association between inflammatory mediators, particularly serum IL-6, depression and cognitive impairment in the elderly. This study aims at exploring the relation of peripheral IL-6 to cognitive functions in elderly patients with major depressive disorder (MDD). OBJECTIV...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607863.2017.1293005
更新日期：2018-05-01 00:00:00
abstract：:Objectives: Humans often hold structured generalizations about themselves, which include attributes of qualities or characteristics they consider as important to their personal self-definitions. In this regard, holding one's age as an important defining personal category (high age awareness) was demonstrated to be con...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607863.2019.1566815
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVES:The primary objective of this work is to report the observed changes in psychological well-being in a sample of long-term medically hospitalized patients, after attending a cognitive stimulation program. The secondary aim is to determine if the observed changes were related to previous cognitive level. METH...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607863.2015.1099033
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVES:To investigate changes of cognitive performances in female elderly patients with osteoporosis and to determine whether any impairments can be attributed to dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. METHODS:This cross-sectional study included 277 postmenopausal women, who were divided i...
journal_title：Aging & mental health
pub_type： 杂志文章,多中心研究
doi：10.1080/13607863.2015.1033680
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVES:Although high volumes of literature have been written on interventions in dementia home care, only a poor efficiency has been proved. Nevertheless, caregivers often express strong feelings of satisfaction about the proposed support. In this meta-analytic review, a quantitative analysis of the effect of the d...
journal_title：Aging & mental health
pub_type： 杂志文章,meta分析,评审
doi：10.1080/13607860902845533
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVES:Carers of people with dementia face barriers in accessing therapy for mental health difficulties. Computerised cognitive behavioural therapy (cCBT) packages can be effective in treating a range of presentations; however, tailored packages for carers' unique needs are lacking. Our aim was to design a cCBT pac...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607863.2017.1348475
更新日期：2018-10-01 00:00:00
abstract：:Objectives: This study aims to identify heterogeneous depressive symptom trajectories among the widowed elderly in China, to explore predictive variables of latent class membership, and to detect between-classes differences in life satisfaction across time.Method: Data of 198 individuals widowed between 2011 and 2013 ...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607863.2019.1603285
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVES:This study aimed (1) to determine whether octogenarian and centenarian care recipients' self-report on physical, social, and emotional status are different from caregivers' reports, (2) to assess associations between octogenarian and centenarian care recipients' poor physical, social, and emotional status an...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607863.2016.1206512
更新日期：2017-11-01 00:00:00
abstract：:Objectives: Explorations of relationships between loneliness and depression have focused on loneliness as a uni-dimensional construct. We hypothesised that reciprocal relationships may exist between depressive symptomatology and social and emotional subtypes of loneliness.Methods: Using data from 373 adults aged over ...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607863.2018.1517728
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVES:Falls and the fall-related psychological concerns associated with these events pose a serious public health problem among aging adults. The measurement of fall-related psychological concerns can serve as important endpoints for fall prevention programs, yet there is some confusion regarding the best method o...
journal_title：Aging & mental health
pub_type： 杂志文章,评审
doi：10.1080/13607860802148855
更新日期：2008-11-01 00:00:00
abstract：OBJECTIVES:Gerontopsychiatric nursing home residents are residents with a chronic mental condition (not dementia), in combination with one or more physical disorders. Psychiatric and behavioral problems are common within this population. The objective of this study is to examine these behaviors and their relationship t...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607863.2019.1695738
更新日期：2021-02-01 00:00:00
abstract：:Medication adherence is a substantial problem in the elderly. It may be even more important among elderly persons with memory problems, since other factors that lead to non-adherence may be compounded with the memory problems themselves. The objective was to determine whether a model that integrates research on medica...
journal_title：Aging & mental health
pub_type： 杂志文章
doi：10.1080/13607860500410011
更新日期：2006-07-01 00:00:00
