Abstract:
BACKGROUND:There is an increased evidence of an association between inflammatory mediators, particularly serum IL-6, depression and cognitive impairment in the elderly. This study aims at exploring the relation of peripheral IL-6 to cognitive functions in elderly patients with major depressive disorder (MDD). OBJECTIVES:(1) Assessment of serum IL-6 levels and cognitive functions in elderly patients suffering from major depression and comparing them to healthy age-matched control subjects; (2) correlation between serum IL-6 levels and clinical characteristics of depression and cognitive functions in these patients. SUBJECTS AND METHODS:The study is an observational, case-control study. It consisted of 80 subjects, 40 with the diagnosis of MDD according to the Diagnostic and Statistical Manual of Mental Disorders (DSM IV-TR) with early onset (first episode before the age of 60) and 40 community-dwelling subjects. They were subjected to the Structured Clinical Interview according to DSM-IV, Montreal Cognitive Assessment, Montgomery Asberg Depression Rating Scale, and serum IL-6 assay using ELISA. RESULTS:In the depression group, subjects had lower scores in cognitive testing, than the control group (p = 0.001). Serum IL-6 was found to have a negative correlation with cognitive testing in these patients even after controlling for the severity of depressive status and Body Mass Index (BMI) (p = 0.025). CONCLUSIONS:MDD in elderly subjects is associated with decline in cognitive functions that may be related to peripheral IL-6 levels.
journal_name
Aging Ment Healthjournal_title
Aging & mental healthauthors
Ali NS,Hashem AHH,Hassan AM,Saleh AA,El-Baz HNdoi
10.1080/13607863.2017.1293005subject
Has Abstractpub_date
2018-05-01 00:00:00pages
655-661issue
5eissn
1360-7863issn
1364-6915journal_volume
22pub_type
杂志文章abstract:OBJECTIVES:There is very often a lengthy delay between first noticing symptoms of dementia and making first contact with Health Care Professionals (HCPs). This article identifies influences on the decision to contact HCPs for the first time. METHOD:Qualitative thematic analysis of 20 case studies of carer experience. ...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2011.651794
更新日期:2012-01-01 00:00:00
abstract::This study examined severity of depression, age of onset, and thought suppression as predictors of treatment outcome. Measures were taken pre-treatment, post-treatment, and at six-month follow-up in 34 depressed older adults receiving the treatment protocol described in Lynch, Morse, Mendelson & Robins (Dialectical be...
journal_title:Aging & mental health
pub_type: 临床试验,杂志文章
doi:10.1080/13607860512331334040
更新日期:2005-01-01 00:00:00
abstract::When diagnosis of dementia occurs earlier in the disease process, more time is available for treatment aimed at maintaining patient function and delaying decline, and for family education about the disease and its management. Primary care providers often, however, face challenges in making timely diagnoses. Nineteen p...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860410001725018
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVES:To examine the effect of personal (coping strategies and locus of control) and social resources (family and friendship support) on adjustment to chronic vision impairment in older adults at baseline (rehabilitation service application), 6 months, and 18 months later. METHOD:313 community dwelling, English s...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860902860912
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVES:To evaluate whether fall risk in older adults is associated with the use of selective serotonin receptor inhibitor (SSRI) monotherapy among geriatric outpatients, and whether this association is moderated by the presence of depressive disorder and/or frailty. METHODS:Prospective cohort study with a 12-month...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2019.1675143
更新日期:2021-02-01 00:00:00
abstract::The present paper discusses recruitment of older African-Americans for a psycho-physiological study using the matching model of recruitment proposed by Levkoff, Levy, and Weitzman (2000). The hallmark of the model by Levkoff et al. is that there must be a match between research and minority communities' perspectives i...
journal_title:Aging & mental health
pub_type: 杂志文章,评审
doi:10.1080/13607860500409781
更新日期:2006-05-01 00:00:00
abstract::The purpose of this study was to consider the contribution of intergenerational exchange to mental health. Using data from a national sample of Jewish Israelis age 60 and over with children (n = 1799), reciprocal and non-reciprocal exchange patterns were identified and examined in relation to respondents' scores on a ...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860410001669723
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVES:Demonstrations of the effectiveness of interventions requires evidence that the model can be implemented with fidelity. Caregiving interventions that are tailored to the individual or family require flexibility, which adds some challenges to the assessment of fidelity. This paper outlines the components nece...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2019.1647134
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVES:Neuroticism predicts falls in older people. In addition, concern about falling and depressive symptoms are associated with fall risk. This study examined whether concern about falling and depressive symptoms mediate the association between neuroticism and falls. METHOD:Cross-sectional data on 314 community-...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2020.1841735
更新日期:2020-11-06 00:00:00
abstract:BACKGROUND:In Hong Kong, older Chinese adults generally have a low level of education. This study examined the effect of education on very mild Alzheimer's disease (AD), as quantified by Clinical Dementia Rating (CDR) scale (CDR 0.5 versus 0), in a Chinese community. The Cantonese version of the Mini-Mental State Exami...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2012.743962
更新日期:2013-01-01 00:00:00
abstract::Objectives: Hong Kong - Vigilance and Memory Test (HK-VMT) is developed to distinguish early cognitive impairment in the pre-symptomatic phase from normal cognitive ageing in older adults. The objectives were to validate HK-VMT to differentiate mild cognitive impairment (MCI) and healthy control (HC), and to explore t...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2018.1523878
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:To assess the concurrent and the construct validity of the Euro-D in older Thai persons. METHOD:Eight local psychiatrists used the major depressive episode section of the Mini International Neuropsychiatric Interview to interview 150 consecutive psychiatric clinic attendees. A trained interviewer administer...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860903046479
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVES:This study aimed at exploring the Internet's role in supporting subjective well-being in later life by applying a functional approach, namely, simultaneously but separately examining each of the principal online functions common among older adults (interpersonal communication, information, task performance a...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2016.1232370
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:With the process of population aging and urbanization, a vast amount of studies have confirmed the increasing urban-rural cognition gaps, while less is known about the extent to which cognition gaps can be explained by urban-rural difference and urbanization status. This study aimed to examine the role of ur...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2021.1872490
更新日期:2021-01-20 00:00:00
abstract::This study examines the effectiveness of a peer counselling program in Hong Kong for the elderly with depression living in the community, and its impact on the peer counsellors. Thirty depressed elderly subjects participated in the program, which was found to have improved their perceived health status and level of de...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860600735861
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:Self-perceptions of aging have been shown to predict mental and physical health and even longevity. This study examined the aging perceptions of patients with rheumatic disease and compared them with the general Dutch population. METHODS:Consecutive patients visiting a rheumatology clinic completed the Pers...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2011.651438
更新日期:2012-01-01 00:00:00
abstract::Research suggests that the use of creative, artistic activities in later life may positively impact the psychological well-being of older adults. Social robots have been utilized in research with older adults, however, few studies have integrated participatory arts (e.g. theatre) into social robotic platforms for the ...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2019.1699016
更新日期:2019-12-18 00:00:00
abstract:OBJECTIVES:The aim of this study is to determine the prevalence of psychosis in mild cognitive impairment (MCI, Petersen's criteria) and patients with Alzheimer's dementia, and to characterize the associated behavioral and psychological signs and symptoms of dementia (BPSD). METHOD:A cross-sectional analysis of baseli...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2014.967170
更新日期:2015-01-01 00:00:00
abstract::This study investigates general and social self-efficacy as possible mediators of the relationship between quantity and quality of social relations and depressive symptomatology. Mediation models were examined using a regionally representative sample of middle-aged (35-59) and older adults (60+). Hierarchical regressi...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860500310690
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVES:In many countries veterans from World War II are growing old. Research has shown that war experiences continue to impact those who have been involved in war for a long time. The present study targets old injured war veterans from World War II in Finland. The aim of this study was to produce knowledge of the ...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2014.954525
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:This study examines: (1) the effect of widowed persons' frequency of contact with friends and relatives on their depressive and grief symptoms six months following spousal loss and (2) the extent to which the effects of social contact are contingent upon the degree of emotional support received from these re...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2010.519325
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVES:To identify caregiver profiles of persons with mild to moderate dementia and to investigate differences between identified caregiver profiles, using baseline data of the international prospective cohort study Actifcare. METHODS:A latent class analysis was used to discover different caregiver profiles based ...
journal_title:Aging & mental health
pub_type: 杂志文章,多中心研究
doi:10.1080/13607863.2016.1255716
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:Cognitive behavioral therapy (CBT) for depression and anxiety for older adults living in residential aged care facilities (RACFs) needs to accommodate the care needs of residents and the circumstances of RACFs. This systematic review examines the delivery and content characteristics of these interventions, i...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2019.1686457
更新日期:2021-02-01 00:00:00
abstract::This cross-sectional study investigated the relationship between apathy and quality of life (QOL) in nursing home residents (n = 227). In all, 92 residents could be assessed with the Mini Mental State Examination (MMSE), the Geriatric Depression Scale (GDS) and the Philadelphia Geriatric Centre Morale Scale (PGCMS), a...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860412331336797
更新日期:2005-03-01 00:00:00
abstract::The experience of feeling unforgiven for past transgressions may contribute to depressive symptoms in later life. This article tests a model in which feeling unforgiven by God and by other people have direct effects on depressive symptoms while self-unforgiveness and rumination mediate this relationship. The sample co...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860903483136
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVES:Having a broadened perspective on one's future has been associated with better affective well-being, including reduced reports of depressive symptoms. However, research is limited regarding which aspect of future time perspective is associated with depressive symptoms, and whether these findings are consiste...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2020.1855107
更新日期:2020-12-21 00:00:00
abstract:OBJECTIVES:In old age, the will-to-live (WTL) is one of the most important indicators of subjective well-being (SWB). However, few studies to date have focused on WTL. In these studies, WTL has mainly been evaluated via indirect questions concerning factors that may influence peoples' WTL, or by measures directed to pa...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2015.1081149
更新日期:2017-03-01 00:00:00
abstract::To examine the psychometric properties of the 20-item Centre for Epidemiological Studies - Depression scale (CES-D). Data were collected from 400 community-dwelling older adults aged 65 years and above, residing in Chennai, India. The instruments including the CES-D scale were translated into Tamil language. The sampl...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2012.751580
更新日期:2013-01-01 00:00:00
abstract::This study explores the associations of loneliness with depressive symptoms in a five-year follow-up and describes how the six dimensions of perceived togetherness explain loneliness and depressive symptoms at baseline. The data were collected on 207 residents of Jyväskylä, central Finland, who at baseline in 1990 wer...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860500193138
更新日期:2005-11-01 00:00:00
abstract::The quality of written prescriptions has not been examined in a psychiatric setting. The aim of this study was to examine the quality of drug prescribing by medical staff for elderly patients hospitalized with dementia in comparison with the quality of prescribing for elderly patients hospitalized for functional psych...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860220126817
更新日期:2002-05-01 00:00:00