Serum interleukin-6 is related to lower cognitive functioning in elderly patients with major depression.

Abstract:

BACKGROUND:There is an increased evidence of an association between inflammatory mediators, particularly serum IL-6, depression and cognitive impairment in the elderly. This study aims at exploring the relation of peripheral IL-6 to cognitive functions in elderly patients with major depressive disorder (MDD). OBJECTIVES:(1) Assessment of serum IL-6 levels and cognitive functions in elderly patients suffering from major depression and comparing them to healthy age-matched control subjects; (2) correlation between serum IL-6 levels and clinical characteristics of depression and cognitive functions in these patients. SUBJECTS AND METHODS:The study is an observational, case-control study. It consisted of 80 subjects, 40 with the diagnosis of MDD according to the Diagnostic and Statistical Manual of Mental Disorders (DSM IV-TR) with early onset (first episode before the age of 60) and 40 community-dwelling subjects. They were subjected to the Structured Clinical Interview according to DSM-IV, Montreal Cognitive Assessment, Montgomery Asberg Depression Rating Scale, and serum IL-6 assay using ELISA. RESULTS:In the depression group, subjects had lower scores in cognitive testing, than the control group (p = 0.001). Serum IL-6 was found to have a negative correlation with cognitive testing in these patients even after controlling for the severity of depressive status and Body Mass Index (BMI) (p = 0.025). CONCLUSIONS:MDD in elderly subjects is associated with decline in cognitive functions that may be related to peripheral IL-6 levels.

journal_name

Aging Ment Health

journal_title

Aging & mental health

authors

Ali NS,Hashem AHH,Hassan AM,Saleh AA,El-Baz HN

doi

10.1080/13607863.2017.1293005

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

655-661

issue

5

eissn

1360-7863

issn

1364-6915

journal_volume

22

pub_type

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