当前位置： SCI文献检索 > ALIMENTARY PHARMACOLOGY & THERAPEUTICS期刊下所有文献 > The emergence of non-hypervascular hypointense nodules on Gd-EOB-DTPA-enhanced MRI in patients with chronic hepatitis C.

The emergence of non-hypervascular hypointense nodules on Gd-EOB-DTPA-enhanced MRI in patients with chronic hepatitis C.

Abstract：

BACKGROUND:Intrahepatic non-hypervascular hypointense nodules (NHHNs) detected during the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging (EOB-MRI) have the potential to transition into typical hypervascular hepatocellular carcinoma (HCC). However, the incidence and risk factors for the emergence of these nodules in patients with chronic hepatitis C virus (HCV) infection are unknown. AIM:To investigate the incidence and risk factors for NHHNs in patients with chronic HCV infection in a longitudinal follow-up study METHODS: EOB-MRI was performed in 608 patients with chronic HCV infection and no history of HCC. The characteristics of patients with and without NHHNs were compared. In patients without NHHNs at baseline, the incidence of NHHN emergence and associated risk factors were analysed. RESULTS:NHHNs were detected at baseline in 93 of 608 patients (15.3%). Among 515 patients without NHHNs at baseline, the 1-year, 3-year and 5-year incidence of NHHN emergence was 1.8%, 9.8% and 16.4%, respectively. Only FIB-4 index was independently associated with the emergence of NHHNs in multivariate analyses. Whereas NHHNs emerged in 24.1% of patients with FIB-4 index ≥ 3.25 at 5 years, none emerged in patients with FIB-4 index < 1.45. CONCLUSION:In patients with chronic HCV infection, advanced liver fibrosis is an important risk factor for the presence or emergence of NHHNs.

journal_name

Aliment Pharmacol Ther

journal_title

Alimentary pharmacology & therapeutics

authors

Toyoda H,Tada T,Yasuda S,Mizuno K,Sone Y,Kaneoka Y,Maeda A,Akita T,Tanaka J,Kumada T

doi

10.1111/apt.15490

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

1232-1238

issue

11-12

eissn

0269-2813

issn

1365-2036

journal_volume

50

pub_type

杂志文章

相关文献

ALIMENTARY PHARMACOLOGY & THERAPEUTICS文献大全
  • Systematic review with meta-analysis: recurrence of Crohn's disease after total colectomy with permanent ileostomy.

    abstract：BACKGROUND:Subtotal or total colectomy or proctocolectomy with permanent ileostomy (TC-PI) may be a treatment option for medically refractory colonic Crohn's disease (CD). AIM:To perform a systematic review and meta-analysis to evaluate the rate, risk factors and outcomes of CD recurrence after TC-PI. METHODS:In a sy...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,meta分析,评审

    doi：10.1111/apt.13886

    authors： Fumery M,Dulai PS,Meirick P,Farrell AM,Ramamoorthy S,Sandborn WJ,Singh S

    更新日期：2017-02-01 00:00:00

  • Efficacy of a standard United Kingdom oral rehydration solution (ORS) and a hypotonic ORS assessed by human intestinal perfusion.

    abstract：:Human triple-lumen intestinal perfusion was used to compare water and solute absorption from the oral rehydration solution (ORS) most widely used in the United Kingdom and a new experimental hypotonic ORS (HYPO-ORS). HYPO-ORS (osmolality 210 mOsm/kg) promoted significantly greater water absorption than UK-ORS (7.03 +/...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1111/j.1365-2036.1989.tb00249.x

    authors： Hunt JB,Elliott EJ,Farthing MJ

    更新日期：1989-12-01 00:00:00

  • Ascitic cholesterol is superior to serum-ascites albumin gradient in the detection of non-portal hypertensive ascites and the diagnosis of mixed ascites.

    abstract：BACKGROUND:The diagnostic value of ascitic cholesterol in the differential diagnosis of ascites is controversial. AIM:To investigate the diagnostic performance of ascitic cholesterol in the differential diagnosis of ascites. METHODS:Consecutive patients with new-onset ascites were enrolled prospectively. The pertinen...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1111/apt.15042

    authors： Du L,Zhu S,Lu Z,Xu T,Bai T,Xu D,Wei X,Li J,Xu K,Ye J,Hou X,Song Y

    更新日期：2019-01-01 00:00:00

  • Effect of ursodeoxycholic acid administration in patients with acute viral hepatitis: a pilot study.

    abstract：BACKGROUND:Ursodeoxycholic acid (UDCA) is able to improve biochemical markers of cholestasis, with a parallel decrease in transaminases, in various cholestatic liver diseases. AIM:To evaluate the effects of UDCA administration on acute viral hepatitis-related cholestasis and the course of acute viral hepatitis. METHO...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2036.1999.00592.x

    authors： Fabris P,Tositti G,Mazzella G,Zanetti AR,Nicolin R,Pellizzer G,Benedetti P,de Lalla F

    更新日期：1999-09-01 00:00:00

  • Helicobacter pylori second-line rescue therapy with levofloxacin- and bismuth-containing quadruple therapy, after failure of standard triple or non-bismuth quadruple treatments.

    abstract：BACKGROUND:The most commonly used second-line Helicobacter pylori eradication regimens are bismuth-containing quadruple therapy and levofloxacin-containing triple therapy, both offering suboptimal results. Combining bismuth and levofloxacin may enhance the efficacy of rescue eradication regimens. AIMS:To evaluate the ...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1111/apt.13128

    authors： Gisbert JP,Romano M,Gravina AG,Solís-Muñoz P,Bermejo F,Molina-Infante J,Castro-Fernández M,Ortuño J,Lucendo AJ,Herranz M,Modolell I,Del Castillo F,Gómez J,Barrio J,Velayos B,Gómez B,Domínguez JL,Miranda A,Martorano M

    更新日期：2015-04-01 00:00:00

  • The cost effectiveness of Helicobacter pylori population screening-economic evaluation alongside a randomised controlled trial with 13-year follow-up.

    abstract：BACKGROUND:Helicobacter pylori eradication improves dyspeptic symptoms in 8%-10%, prevents peptic ulcer and may reduce the risk of gastric cancer. Availability of a high quality diagnostic test and an effective treatment makes population screening and eradication of Helicobacter pylori an attractive option. AIM:To eva...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/apt.15193

    authors： Høgh MB,Kronborg C,Hansen JM,Schaffalitzky de Muckadell OB

    更新日期：2019-04-01 00:00:00

  • Systematic review: combination therapies for treatment-naïve chronic hepatitis B.

    abstract：BACKGROUND:There is a renewed interest in use of combination therapies in treatment-naïve chronic hepatitis B (CHB) because of limitations of monotherapies. AIM:To discuss the current status of combination therapies in treatment-naïve CHB. METHODS:PubMed search was done using 'combination', 'sequential' and 'chronic ...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2036.2008.03695.x

    authors： Kumar M,Sarin SK

    更新日期：2008-06-01 00:00:00

  • Clinical trial: the effects of adding ranitidine at night to twice daily omeprazole therapy on nocturnal acid breakthrough and acid reflux in patients with systemic sclerosis--a randomized controlled, cross-over trial.

    abstract：BACKGROUND:Gastro-oesophageal reflux disease (GERD) is an important problem in systemic sclerosis due to impaired salivation and oesophageal function. AIM:To determine the efficacy of adding ranitidine at bedtime to control nocturnal acid breakthrough (NAB) and GERD in patients with systemic sclerosis already prescrib...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2036.2007.03469.x

    authors： Janiak P,Thumshirn M,Menne D,Fox M,Halim S,Fried M,Brühlmann P,Distler O,Schwizer W

    更新日期：2007-11-01 00:00:00

  • Vedolizumab in the treatment of chronic, antibiotic-dependent or refractory pouchitis.

    abstract：BACKGROUND:The most common complication after ileal pouch anal anastomosis in up to 50% of patients is an acute pouchitis. The majority of patients respond to antibiotic treatment. However, 10%-15% develops chronic antibiotic-dependent or refractory pouchitis which is usually hard to treat. AIM:To evaluate the effecti...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,多中心研究

    doi：10.1111/apt.14479

    authors： Bär F,Kühbacher T,Dietrich NA,Krause T,Stallmach A,Teich N,Schreiber S,Walldorf J,Schmelz R,Büning C,Fellermann K,Büning J,Helwig U,German IBD Study Group.

    更新日期：2018-03-01 00:00:00

  • Childhood coeliac disease: towards an improved serological mass screening strategy.

    abstract：BACKGROUND:In 1997-1998, 6127 asymptomatic children aged 2-4 years were screened for coeliac disease (CD) by anti-endomysium (EmA) testing in the Netherlands. After 6 (+/-2) months, biopsies were performed in 57 seropositive children; 31(54%) had villous atrophy, but 26 (46%), all HLA-DQ2/DQ8 positive, had normal histo...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,多中心研究

    doi：10.1111/j.1365-2036.2009.04226.x

    authors： Hogen Esch CE,Csizmadia GD,van Hoogstraten IM,Schreurs MW,Mearin ML,von Blomberg BM

    更新日期：2010-04-01 00:00:00

  • Review article: impact of night-time reflux on lifestyle - unrecognized issues in reflux disease.

    abstract：:Gastro-oesophageal reflux disease (GERD), manifesting with symptoms including heartburn and regurgitation, affects people during both daytime and nocturnal hours. Night-time GERD has been reported to have a greater impact on a patient's life than daytime GERD due to prolonged oesophageal acid exposure time per reflux ...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2036.2004.02237.x

    authors： Shaker R,Brunton S,Elfant A,Golopol L,Ruoff G,Stanghellini V

    更新日期：2004-12-01 00:00:00

  • Rifaximin in the treatment of recurrent Clostridium difficile infection.

    abstract：BACKGROUND:Clostridium difficile can cause severe antibiotic-associated colitis. Conventional treatments with metronidazole and vancomycin improve symptoms, but after discontinuation of treatment, C. difficile infection (CDI) recurs in a number of patients. Rifaximin is a rifamycin-based non-systemic antibiotic that ha...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1111/apt.12111

    authors： Mattila E,Arkkila P,Mattila PS,Tarkka E,Tissari P,Anttila VJ

    更新日期：2013-01-01 00:00:00

  • Serum pepsinogen and gastrin levels in HIV-positive patients: relationship with CD4+ cell count and Helicobacter pylori infection.

    abstract：BACKGROUND:The relationship between serum parameters of gastric function and Helicobacter pylori infection in human immunodeficiency virus (HIV)-positive patients is almost unknown. AIMS:To investigate in HIV-infected patients: (i) the relationship between serum gastrin and serum pepsinogens over the progressive phase...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1046/j.1365-2036.2002.01234.x

    authors： Fabris P,Pilotto A,Bozzola L,Tositti G,Soffiati G,Manfrin V,de Lalla F

    更新日期：2002-04-01 00:00:00

  • The impact of eosinophilia and hepatic necrosis on prognosis in patients with drug-induced liver injury.

    abstract：BACKGROUND:Drug-induced liver injury may be immunologically mediated or metabolically induced. Peripheral eosinophilia and liver eosinophilia in suspected drug-induced liver injury generally supports the role of drug aetiology. AIM:To assess the importance of eosinophilia and hepatic necrosis on outcome in patients wi...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1111/j.1365-2036.2007.03330.x

    authors： Björnsson E,Kalaitzakis E,Olsson R

    更新日期：2007-06-15 00:00:00

  • A randomized trial of high-dose interferon alpha-2b, with or without ribavirin, in chronic hepatitis C patients who have not responded to standard dose interferon.

    abstract：BACKGROUND:Conventional interferon monotherapy fails to achieve virological clearance in most hepatitis C-infected patients. The use of high-dose induction regimens may improve the initial clearance of virus, while the addition of ribavirin appears to improve the rates of sustained response once clearance is achieved. ...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2036.2002.01201.x

    authors： Malik AH,Kumar KS,Malet PF,Ostapowicz G,Adams G,Wood M,Yarbrough K,Jones A,Lee WM

    更新日期：2002-03-01 00:00:00

  • Hepatitis B virus RNA decline without concomitant viral antigen decrease is associated with a low probability of sustained response and hepatitis B surface antigen loss.

    abstract：BACKGROUND:Serum hepatitis B virus (HBV) RNA may reflect intrahepatic HBV replication. Novel anti-viral drugs have shown potent HBV RNA decline without concomitant hepatitis B surface antigen (HBsAg) decrease. How this relates to off-treatment response is yet unclear. AIM:To study the degree of on-treatment viral anti...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1111/apt.16172

    authors： Brakenhoff SM,de Man RA,Boonstra A,van Campenhout MJH,de Knegt RJ,van Bömmel F,van der Eijk AA,Berg T,Hansen BE,Janssen HLA,Sonneveld MJ

    更新日期：2021-01-01 00:00:00

  • Ranitidine bismuth citrate with clarithromycin versus omeprazole with amoxycillin in the cure of Helicobacter pylori infection.

    abstract：AIM:To compare the efficacy of ranitidine bismuth citrate plus clarithromycin (RBC-C) vs. omeprazole plus amoxycillin (OME-AMO) in the cure of Helicobacter pylori infection. METHODS:In this double-blind, multicentre, parallel-group study 122 H. pylori-positive patients with active duodenal ulcer or gastritis, with con...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1046/j.1365-2036.1997.00254.x

    authors： Kolkman JJ,Tan TG,Oudkerk Pool M,Van Kleef WA,Geraedts AA,Timmerman RJ,Crobach LF,Nicolai JJ,Wolff AA,Van Der Laan J

    更新日期：1997-12-01 00:00:00

  • Clinical response after transjugular intrahepatic portosystemic stent shunt insertion for refractory ascites in cirrhosis.

    abstract：BACKGROUND:Transjugular intrahepatic portosystemic stent shunts (TIPSS) have been used successfully to reduce portal pressure in the context of variceal haemorrhage. Recent interest has focused on the possible use of TIPSS to manage refractory ascites. AIM:To study the effect of TIPSS insertion in 18 patients with ref...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1046/j.1365-2036.1996.60202000.x

    authors： Forrest EH,Stanley AJ,Redhead DN,McGilchrist AJ,Hayes PC

    更新日期：1996-10-01 00:00:00

  • Sequential treatment for Helicobacter pylori does not share the risk factors of triple therapy failure.

    abstract：BACKGROUND:Predicting factors for the outcome of conventional Helicobacter pylori triple therapy have been identified. Of these, the presence of the CagA gene is a strong predictor of successful treatment. Our preliminary data show that this factor becomes irrelevant when sequential therapy is used. AIM:To identify pr...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2036.2004.01818.x

    authors： De Francesco V,Zullo A,Margiotta M,Marangi S,Burattini O,Berloco P,Russo F,Barone M,Di Leo A,Minenna MF,Stoppino V,Morini S,Panella C,Francavilla A,Ierardi E

    更新日期：2004-02-15 00:00:00

  • Treatment of left-sided ulcerative colitis with butyrate enemas: a controlled trial.

    abstract：BACKGROUND:The colonic mucosa is highly dependent upon the presence of luminal nutrients. This dependence is most marked in the distal colon. The major luminal nutrients are short chain fatty acids that are produced as a by-product of colonic fermentation of carbohydrates. Butyrate appears to be the short chain fatty a...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1046/j.1365-2036.1996.d01-509.x

    authors： Steinhart AH,Hiruki T,Brzezinski A,Baker JP

    更新日期：1996-10-01 00:00:00

  • Randomised clinical trial: identification of responders to short-term treatment with esomeprazole for dyspepsia in primary care - a randomised, placebo-controlled study.

    abstract：BACKGROUND:Response to proton pump inhibitor (PPI) treatment in dyspepsia is unpredictable. AIM:To identify symptoms associated with response to esomeprazole in order to target patients for empirical treatment. METHODS:Eight hundred and five uninvestigated, primary care patients with upper GI symptoms that were consi...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1365-2036.2010.04501.x

    authors： Meineche-Schmidt V,Christensen E,Bytzer P

    更新日期：2011-01-01 00:00:00

  • Use of proton pump inhibitors and the risk of cholangitis: a nationwide cohort study.

    abstract：BACKGROUND:Proton pump inhibitor (PPI) use may alter the gut microbiome and increase the risk of cholangitis. However, the association of PPI use with the risk of incident cholangitis has not been evaluated. AIM:To evaluate whether PPI use was associated with a higher risk of cholangitis. METHODS:This cohort study in...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1111/apt.15466

    authors： Min YW,Kang D,Shin JY,Kang M,Park JK,Lee KH,Lee JK,Lee KT,Rhee PL,Kim JJ,Guallar E,Cho J,Lee H

    更新日期：2019-10-01 00:00:00

  • The impact of past alcohol use on treatment response rates in patients with chronic hepatitis C.

    abstract：BACKGROUND:Studies have shown that past alcohol consumption reduces response rates in patients with chronic hepatitis C treated with interferon monotherapy. AIM:To clarify the importance of alcohol consumption on response rates in patients undergoing treatment with pegylated interferon and ribavirin. METHODS:In a sin...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1111/j.1365-2036.2005.02631.x

    authors： Chang A,Skole K,Gautam M,Schmutz J,Black M,Thomas R,Horwitz B,Friedenberg FK

    更新日期：2005-10-15 00:00:00

  • Relationship between the Fibrotest and portal hypertension in patients with liver disease.

    abstract：BACKGROUND:The best technique to estimate portal hypertension (PHT) is to measure the hepatic venous pressure gradient (HVPG), which is an invasive method. AIM:To assess the relationship between the Fibrotest (Biopredictive, Paris, France) and the presence and degree of PHT in patients with liver disease, and to deter...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1111/j.1365-2036.2007.03378.x

    authors： Thabut D,Imbert-Bismut F,Cazals-Hatem D,Messous D,Muntenau M,Valla DC,Moreau R,Poynard T,Lebrec D

    更新日期：2007-08-01 00:00:00

  • Clinical features and treatment of nonalcoholic fatty liver disease across the Asia Pacific region-the GO ASIA initiative.

    abstract：BACKGROUND:The Gut and Obesity Asia (GO ASIA) workgroup was formed to study the relationships between obesity and gastrointestinal diseases in the Asia Pacific region. AIM:To study factors associated with nonalcoholic steatohepatitis (NASH) and advanced fibrosis, and medical treatment of biopsy-proven nonalcoholic fat...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1111/apt.14506

    authors： Chan WK,Treeprasertsuk S,Imajo K,Nakajima A,Seki Y,Kasama K,Kakizaki S,Fan JG,Song MJ,Yoon SK,Dan YY,Lesmana L,Ho KY,Goh KL,Wong VW

    更新日期：2018-03-01 00:00:00

  • Review article: anti-inflammatory mechanisms of action of Saccharomyces boulardii.

    abstract：BACKGROUND:Saccharomyces boulardii, a well-studied probiotic, can be effective in inflammatory gastrointestinal diseases with diverse pathophysiology, such as inflammatory bowel disease (IBD), and bacterially mediated or enterotoxin-mediated diarrhoea and inflammation. AIM:To discuss the mechanisms of action involved ...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2036.2009.04102.x

    authors： Pothoulakis C

    更新日期：2009-10-15 00:00:00

  • Review article: treatment algorithms to maximize remission and minimize corticosteroid dependence in patients with inflammatory bowel disease.

    abstract：BACKGROUND:Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases of the intestine, which frequently require surgery for complications or failure of medical therapy. AIM:To seek evidence and provide direction for clinicians on optimal strategies to enable steroid free remission in inflammat...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2036.2008.03753.x

    authors： Panaccione R,Rutgeerts P,Sandborn WJ,Feagan B,Schreiber S,Ghosh S

    更新日期：2008-09-15 00:00:00

  • Fatty liver indices in the multiethnic United States National Health and Nutrition Examination Survey.

    abstract：BACKGROUND:Validated non-invasive measures of fatty liver are needed that can be applied across populations and over time. A fatty liver index (FLI) including body mass index, waist circumference, triglycerides and gamma glutamyltransferase (GGT) activity was developed in an Italian municipality, but has not been valid...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1111/apt.13012

    authors： Ruhl CE,Everhart JE

    更新日期：2015-01-01 00:00:00

  • Review article: the diagnosis and treatment of haematinic deficiency in gastrointestinal disease.

    abstract：:Deficiency of any of the vitamins and minerals essential for normal erythropoiesis (haematinics), including iron, copper, cobalt, vitamins A, B12, B6, C, E, folic acid, riboflavin and nicotinic acid, may be associated with defective erythropoiesis and anaemia. Iron, vitamin B12 and folate are the haematinics for which...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2036.1998.00368.x

    authors： Pawson R,Mehta A

    更新日期：1998-08-01 00:00:00

  • Review article: liver transplantation for the pulmonary disorders of portal hypertension.

    abstract：BACKGROUND:Liver transplantation is potentially a life-saving therapeutic intervention for patients with portopulmonary hypertension and hepatopulmonary syndrome. However, due to limited data, listing criteria for patients with these conditions have not been clearly established. Indeed, this has led some to speculate t...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,评审

    doi：10.1111/apt.12140

    authors： Houlihan DD,Holt A,Elliot C,Ferguson JW

    更新日期：2013-01-01 00:00:00