Abstract：
BACKGROUND:The colonic mucosa is highly dependent upon the presence of luminal nutrients. This dependence is most marked in the distal colon. The major luminal nutrients are short chain fatty acids that are produced as a by-product of colonic fermentation of carbohydrates. Butyrate appears to be the short chain fatty acid most avidly metabolized by the colonic mucosa. It has been suggested that ulcerative colitis is, at least in part, related to an energy deficiency state of the colonic mucosa which may be secondary to impaired short chain fatty acid production, uptake or utilization. The objective of this study was to determine if butyrate given as enema therapy is effective in the treatment of active distal ulcerative colitis. METHODS:Thirty-eight patients with distal ulcerative colitis were randomly assigned to receive nightly butyrate (n = 19) or saline/placebo (n = 19) enemas. Butyrate enemas consisted of 60 mL of 80 mM sodium butyrate titrated to a pH of 7.0. Patients were assessed clinically and endoscopically at baseline and at 3 and 6 weeks follow-up. Pre- and post-treatment mucosal biopsies were assessed histologically. Response to therapy was determined by changes in a 12-point clinical disease activity index score based on patient symptoms, endoscopic mucosal appearance and physicians' global assessment. RESULTS:Clinical improvement was noted in seven of 19 (37%) butyrate-treated patients and nine of 19 (47%) placebo-treated patients (P = 0.51). Clinical remission was achieved in three patients in each group (16%). No toxicity was observed in either treatment arm. CONCLUSIONS:The results suggests that once nightly 60 mL butyrate enemas (80 mmol/L) are not efficacious in the treatment of distal ulcerative colitis.
journal_name
Aliment Pharmacol Therjournal_title
Alimentary pharmacology & therapeuticsauthors
Steinhart AH,Hiruki T,Brzezinski A,Baker JPdoi
10.1046/j.1365-2036.1996.d01-509.xsubject
Has Abstractpub_date
1996-10-01 00:00:00pages
729-36issue
5eissn
0269-2813issn
1365-2036journal_volume
10pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract：BACKGROUND:Diagnosis of inflammatory bowel disease (IBD) is based on clinical presentation, colonoscopy and histology. Differentiation of Crohn's disease (CD) and ulcerative colitis (UC) can be difficult in some patients. Endoscopic ultrasound (EUS) provides high resolution images of the gastrointestinal wall (GI) and ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/apt.12671
更新日期：2014-04-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.2009.03930.x
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1365-2036.2011.04902.x
更新日期：2012-01-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1046/j.1365-2036.1998.00414.x
更新日期：1998-11-01 00:00:00
abstract：BACKGROUND:Sulfasalazine is accepted therapy for active ulcerative colitis, but side-effects and intolerance are common. Balsalazide is an azo-bonded pro-drug which also releases 5-aminosalicylic acid into the colon, but uses an inert carrier molecule. AIM:To compare the safety and efficacy of sul- fasalazine, 3 g, wi...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1046/j.1365-2036.2002.01151.x
更新日期：2002-01-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2036.11.s1.11.x
更新日期：1997-04-01 00:00:00
abstract：BACKGROUND:Functional dyspepsia is a problem that is difficult to treat in clinical practice. AIM:To evaluate the efficacy and safety of rebamipide (a cytoprotective drug) in functional dyspepsia. METHODS:Patients with functional dyspepsia (n=557) were divided a priori into two studies by Helicobacter pylori status, ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1046/j.1365-2036.2001.01074.x
更新日期：2001-10-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1365-2036.2008.03814.x
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Alimentary pharmacology & therapeutics
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doi：10.1111/apt.13516
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Alimentary pharmacology & therapeutics
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更新日期：1991-10-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,meta分析,评审
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章
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更新日期：2012-12-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,随机对照试验
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journal_title：Alimentary pharmacology & therapeutics
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
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更新日期：2003-03-15 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
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更新日期：2014-03-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：1988-12-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2002-03-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,meta分析
doi：10.1111/apt.14672
更新日期：2018-06-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
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更新日期：2002-07-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
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更新日期：1999-02-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2004-02-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/apt.12305
更新日期：2013-06-01 00:00:00
