Cholesterol lowering effect of dietary weight loss and orlistat treatment--efficacy and limitations.

abstract：BACKGROUND:Butyrate, propionate and acetate are short chain fatty acids (SCFA), important for maintaining a healthy colon and are considered as protective in colorectal carcinogenesis. However, they may also regulate immune responses and the composition of the intestinal microbiota. Consequently, their importance in a ...

journal_title：Alimentary pharmacology & therapeutics

authors： Gill PA,van Zelm MC,Muir JG,Gibson PR

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Intravenous esomeprazole may be beneficial for patients who cannot take oral medications. AIM:To compare intravenous esomeprazole with oral esomeprazole for effects on maximal acid output during pentagastrin stimulation in patients with gastro-oesophageal reflux disease symptoms. METHODS:In four separate o...

journal_title：Alimentary pharmacology & therapeutics

authors： Metz DC,Miner PB,Heuman DM,Chen Y,Sostek M

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Restriction of dietary FODMAP intake can alleviate symptoms in patients with irritable bowel syndrome. Because many FODMAPs have prebiotic actions, there is concern that their dietary restriction leads to dysbiosis with health consequences, and their intake is being encouraged by addition to foods and via su...

journal_title：Alimentary pharmacology & therapeutics

authors： Gibson PR,Halmos EP,Muir JG

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Proton pump inhibitor (PPI) therapy is known to suppress gastric acid secretion. Thus PPI therapy may decrease gastric volume and gastric contents available for gastro-oesophageal reflux by decreasing acid secretion. AIM:To determine the effect of PPI therapy on the gastric volume after a standard meal. ME...

journal_title：Alimentary pharmacology & therapeutics

authors： Babaei A,Bhargava V,Aalam S,Scadeng M,Mittal RK

更新日期：2009-04-15 00:00:00

abstract：:Alginate-based raft-forming formulations have been marketed word-wide for over 30 years under various brand names, including Gaviscon. They are used for the symptomatic treatment of heartburn and oesophagitis, and appear to act by a unique mechanism which differs from that of traditional antacids. In the presence of g...

journal_title：Alimentary pharmacology & therapeutics

authors： Mandel KG,Daggy BP,Brodie DA,Jacoby HI

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Proton pump inhibitors (PPIs) provide the most effective pharmacotherapy for treating acid-related disorders. However, PPIs do not completely control acid over 24 h with once-daily dosing. AIMS:To discuss limitations inherent in the pharmacokinetics (PK) and pharmacodynamics of conventional PPI formulations...

journal_title：Alimentary pharmacology & therapeutics

authors： Metz DC,Vakily M,Dixit T,Mulford D

更新日期：2009-05-01 00:00:00

abstract：:The bioavailability of three pure 5-aminosalicylic (5-ASA) preparations (Asacol, Claversal, and Pentasa) was studied in 8 ileostomy patients and 12 normal subjects after 6 days of treatment with 2000 mg 5-ASA. The local bioavailability, reflected by the 5-ASA concentration was thereby measured at two clinically releva...

journal_title：Alimentary pharmacology & therapeutics

authors： Christensen LA,Fallingborg J,Abildgaard K,Jacobsen BA,Sanchez G,Hansen SH,Bondesen S,Hvidberg EF,Rasmussen SN

更新日期：1990-10-01 00:00:00

abstract：:The mode of transmission of Helicobacter pylori is largely unknown and is a matter of circumstantial evidence and speculation rather than fact. However, the principle evidence is of two sorts: the epidemiological data, providing evidence of possible risk factors associated with transmission, and the identification of ...

journal_title：Alimentary pharmacology & therapeutics

authors： Vaira D,Holton J,Ricci C,Menegatti M,Gatta L,Berardi S,Tampieri A,Miglioli M

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Abnormal gall-bladder motility has been reported in diabetics. The objective was to evaluate the effect of chronic D2-dopamine receptor inhibition on gall-bladder emptying in diabetic patients. METHODS:Under double-blind placebo-controlled conditions and according to a crossover design, patients were random...

journal_title：Alimentary pharmacology & therapeutics

authors： Mansi C,Savarino V,Vigneri S,Sciabà L,Perilli D,Mele MR,Celle G

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Efficacy and safety of antiviral combination therapy in patients with Crohn's disease (CD) and chronic hepatitis C (CHC) is presently not established and consequently CHC is rarely treated in CD patients. AIM:To analyse the efficacy and tolerability of antiviral interferon/ribavirin therapy in patients with...

journal_title：Alimentary pharmacology & therapeutics

authors： Scherzer TM,Staufer K,Novacek G,Steindl-Munda P,Schumacher S,Hofer H,Ferenci P,Vogelsang H

更新日期：2008-09-15 00:00:00

abstract：BACKGROUND:The gamma-aminobutyric acid receptor type B agonist, baclofen, inhibits transient lower oesophageal sphincter relaxations by influencing a vagal pathway. Although post-prandial proximal gastric function, which is vagally mediated, is important in the occurrence of transient lower oesophageal sphincter relaxa...

journal_title：Alimentary pharmacology & therapeutics

authors： Lee KJ,Vos R,Janssens J,Tack J

更新日期：2003-07-15 00:00:00

abstract：BACKGROUND:Coeliac disease (CD), originally thought to be largely confined to Northern Europe and Australasia and uncommon in North America and the Middle East, is now recognised to be equally common in all these countries. It is still thought to be rare in the Orient and Sub-Saharan Africa. AIM:To assess geographical...

journal_title：Alimentary pharmacology & therapeutics

authors： Kang JY,Kang AH,Green A,Gwee KA,Ho KY

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Previous epidemiological studies suggest that patients diagnosed with nonalcoholic fatty liver disease (NAFLD) who drink light to moderate amounts of alcohol (up to ~30 g per day) have less severe histological lesions compared with nondrinkers. However, while the cross-sectional nature of current evidence pr...

journal_title：Alimentary pharmacology & therapeutics

authors： Sookoian S,Flichman D,Castaño GO,Pirola CJ

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:The outbreak of coronavirus disease 2019 (COVID-19) is a critical challenge for public health. The effect of COVID-19 on liver injury has not been fully established. AIMS:To evaluate the dynamic changes in liver function and the relationship between liver damage and prognosis in patients with COVID-19. MET...

journal_title：Alimentary pharmacology & therapeutics

authors： Huang H,Chen S,Li H,Zhou XL,Dai Y,Wu J,Zhang J,Shao L,Yan R,Wang M,Wang J,Tu Y,Ge M

更新日期：2020-09-01 00:00:00

abstract：:The efficacy of a nitroimidazole-containing regimen for the treatment of Helicobacter pylori infection is decreased by nitroimidazole resistance. Nitroimidazoles are meta- bolized by H. pylori by several nitro-reductases of which an oxygen-insensitive NADPH nitroreductase encoded by the rdxA gene is the most important...

journal_title：Alimentary pharmacology & therapeutics

authors： Van Der Wouden EJ,Thijs JC,Van Zwet AA,Kleibeuker JH

更新日期：2000-01-01 00:00:00

abstract：:An analysis carried out in 1994 by the WHO International Agency for Research on Cancer (IARC) resulted in Helicobacter pylori being designated as a Group 1 carcinogen and thus clearly having an association with the development of gastric cancer. In the case of H. pylori, the evaluation was made solely on the basis of ...

journal_title：Alimentary pharmacology & therapeutics

authors： Asaka M,Kudo M,Kato M,Sugiyama T,Takeda H

更新日期：1998-02-01 00:00:00

abstract：:Haemochromatosis was first recognized as a disease entity over a century ago and its hereditary nature recognized over 60 years ago. However it was only in late 1996 that the haemochromatosis gene was cloned and a single C282Y mutation confirmed as being the cause of all HLA-linked iron overload in Caucasian populatio...

journal_title：Alimentary pharmacology & therapeutics

authors： George DK,Powell LW

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:The treatment of acute coronary syndromes involves a combination of antiplatelet therapies. Proton pump inhibitors are frequently recommended for patients receiving clopidogrel in addition to aspirin, to minimise the risk of bleeding. Several studies have shown that proton pump inhibitors can affect the plat...

journal_title：Alimentary pharmacology & therapeutics

authors： Disney BR,Watson RD,Blann AD,Lip GY,Anderson MR

更新日期：2011-04-01 00:00:00

abstract：:Despite implementation of screening and surveillance strategies, a significantly large number of patients with Barrett's oesophagus remain undiagnosed. In those who are identified, the management options include acid reduction therapies with proton pump inhibitors or anti-reflux surgery. Endoscopic ablative therapies ...

journal_title：Alimentary pharmacology & therapeutics

authors： Jankowski J,Sharma P

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Bismuth compounds prevent gastric injury from the short-term administration of nonsteroidal anti-inflammatory drugs. We studied the mechanisms underlying the gastroprotective actions of bismuth subsalicylate against indomethacin-induced injury in rats. METHODS:An in vivo microscopic technique was used in wh...

journal_title：Alimentary pharmacology & therapeutics

authors： Tanaka S,Guth PH,Carryl OR,Kaunitz JD

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:No validated patient-reported outcome (PRO) measure exists for functional dyspepsia (FD) assessment. Verbal descriptions of different upper abdominal symptoms may be poorly distinguishable to patients. AIM:To investigate whether understanding of FD symptoms is enhanced by pictograms symbolising the nature o...

journal_title：Alimentary pharmacology & therapeutics

authors： Tack J,Carbone F,Holvoet L,Vanheel H,Vanuytsel T,Vandenberghe A

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Proton pump inhibitors (PPIs) are the most commonly used first-line therapy for patients with eosinophilic oesophagitis (EoE). However, many aspects related to PPIs in EoE are still unknown. AIMS:To assess the effectiveness of PPI therapy for EoE in real-world practice. METHODS:This cross-sectional study c...

journal_title：Alimentary pharmacology & therapeutics

authors： Laserna-Mendieta EJ,Casabona S,Guagnozzi D,Savarino E,Perelló A,Guardiola-Arévalo A,Barrio J,Pérez-Martínez I,Lund Krarup A,Alcedo J,de la Riva S,Rey-Iborra E,Santander C,Arias Á,Lucendo AJ,EUREOS EoE CONNECT Research group

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Misoprostol is known to be effective in stimulating intestinal transit both in healthy individuals and in patients with chronic constipation when evaluated in short-term trials. The aim of this study was to determine the utility of misoprostol in the long-term management of patients with chronic refractory c...

journal_title：Alimentary pharmacology & therapeutics

authors： Roarty TP,Weber F,Soykan I,McCallum RW

更新日期：1997-12-01 00:00:00

abstract：:The 24-hour intragastric pH of 12 patients with an acute duodenal ulcer was recorded with the aim of comparing the effects of two different times of administration of 300 mg ranitidine: post evening meal, or bedtime. This double-blind crossover trial involved 3 centres. Twenty-four-hour gastric pH was measured under s...

journal_title：Alimentary pharmacology & therapeutics

authors： Cortot A,Guillemot F,Moreau J,Soule JC,Veyrac M,Alberola B,Pappo M

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Combined treatment using an acid-inhibiting drug with antibiotics can cure Helicobacter pylori infection. However, eradication rates are highly variable, especially if a proton pump inhibitor is used with amoxycillin. Therefore it is important to define factors/predictors of the clinical outcome. METHODS:In...

journal_title：Alimentary pharmacology & therapeutics

authors： Treiber G,Ammon S,Klotz U

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:Little is known about the distinctive characteristics of subjects with frequent (at least weekly) and occasional gastro-oesophageal reflux symptoms. AIM:To compare the characteristics and disease management of subjects complaining of at least weekly and less frequent gastro-oesophageal reflux symptoms. MET...

journal_title：Alimentary pharmacology & therapeutics

authors： Bretagne JF,Honnorat C,Richard-Molard B,Caekaert A,Barthélemy P

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Gastroprotective strategies are recommended for nonsteroidal anti-inflammatory drug (NSAID) users at risk of upper gastrointestinal (UGI) complications. AIM:To compare the use of gastroprotective strategies in NSAID users in three countries, and the subsequent impact of rofecoxib withdrawal. METHODS:We con...

journal_title：Alimentary pharmacology & therapeutics

authors： Valkhoff VE,van Soest EM,Masclee GM,de Bie S,Mazzaglia G,Molokhia M,Kuipers EJ,Sturkenboom MC

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Grey Zone (GZ) is an ill-defined situation including patients falling between inactive carrier (IC) state and HBeAg-negative chronic hepatitis B (HBeAg-negative CHB). AIMS:To assess the long-term outcomes of GZ patients compared to IC in the absence of treatment. METHODS:Retrospective analysis of 287 IC an...

journal_title：Alimentary pharmacology & therapeutics

authors： Bonacci M,Lens S,Mariño Z,Londoño MC,Rodríguez-Tajes S,Mas A,García-López M,Pérez-Del-Pulgar S,Sánchez-Tapias JM,Forns X

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:The sequential organ failure assessment (SOFA) score is an effective triage marker following single time point paracetamol (acetaminophen) overdose, but has not been evaluated following staggered (multiple supratherapeutic doses over >8 h, resulting in cumulative dose of >4 g/day) overdoses. AIM:To evaluate...

journal_title：Alimentary pharmacology & therapeutics

authors： Craig DG,Zafar S,Reid TW,Martin KG,Davidson JS,Hayes PC,Simpson KJ

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Aim of this work was to improve standardization of the 13C-urea breath test (13C-UBT) by evaluating the effect of drug administration, feeding and colonic ureolysis on the UBT results. METHODS:Three different studies were performed. First, a 13C-UBT was performed in 41 Helicobacter pylori infected subjects ...

journal_title：Alimentary pharmacology & therapeutics

authors： Perri F,Maes B,Geypens B,Ghoos Y,Hiele M,Rutgeerts P

更新日期：1995-12-01 00:00:00