Effects of midazolam on small bowel motility in humans.

abstract：BACKGROUND:Depression is associated with substantial morbidity and mortality in cirrhosis, but is underdiagnosed and undertreated. AIMS:Using the Mini International Neuropsychiatric Interview (MINI) as a gold-standard, to determine prevalence, predictors, and outcomes of depression, and to develop a screening nomogram...

journal_title：Alimentary pharmacology & therapeutics

authors： Buganza-Torio E,Mitchell N,Abraldes JG,Thomas L,Ma M,Bailey RJ,Tandon P

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Interferon (IFN-alpha)-based regimens have been used with varying success in the treatment of chronic hepatitis C (CHC) for over two decades. The effect of such treatments on the natural course of CHC has been evaluated in small clinical trials with conflicting results. AIM:To investigate the natural course...

journal_title：Alimentary pharmacology & therapeutics

authors： Manesis EK,Papatheodoridis GV,Touloumi G,Karafoulidou A,Ketikoglou J,Kitis GE,Antoniou A,Kanatakis S,Koutsounas SJ,Vafiadis I,HEPNET.Greece Cohort Study.

更新日期：2009-05-15 00:00:00

abstract：BACKGROUND:Anti-tumour necrosis factor α (anti-TNF) agents have been implicated in drug-induced liver injury. There is minimal data on this occurrence in inflammatory bowel disease (IBD) patients. AIM:To identify the characteristics of liver enzyme elevations following anti-TNF therapy initiation in IBD. METHODS:A re...

journal_title：Alimentary pharmacology & therapeutics

authors： Shelton E,Chaudrey K,Sauk J,Khalili H,Masia R,Nguyen DD,Yajnik V,Ananthakrishnan AN

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:The long-term time trends of multiple gastrointestinal diseases are characterised by a striking rise and fall. These temporal changes provide important clues about disease aetiology. AIM:To highlight the importance of Helicobacter pylori infection in shaping the temporal trends of many common gastrointestin...

journal_title：Alimentary pharmacology & therapeutics

authors： Sonnenberg A

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:The presence of the gastric pathogen, Helicobacter pylori influences acid suppression by proton pump inhibitors and treatment outcome in patients with gastro-oesophageal reflux disease. AIM:To determine the influence of H. pylori infection on effectiveness of rabeprazole in primary and secondary care patien...

journal_title：Alimentary pharmacology & therapeutics

authors： Wit NJ,Boer WA,Geldof H,Hazelhoff B,Bergmans P,Tytgat GN,Smout AJ

更新日期：2004-08-15 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease affects 10-35% of the adult population worldwide; there is no consensus on its treatment. Omega-3 fatty acids have proven benefits for hyperlipidaemia and cardiovascular disease, and have recently been suggested as a treatment for non-alcoholic fatty liver disease. AIMS:To ...

journal_title：Alimentary pharmacology & therapeutics

authors： Masterton GS,Plevris JN,Hayes PC

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:In rheumatoid arthritis and psoriasis female sex has been shown to be associated with discontinuation of anti-tumour necrosis factor-α (TNF-α) therapy. AIM:To retrospectively assess the association between sex and TNF-α drug persistence in patients with inflammatory bowel disease (IBD). METHODS:All IBD pat...

journal_title：Alimentary pharmacology & therapeutics

authors： Schultheiss JPD,Brand EC,Lamers E,van den Berg WCM,van Schaik FDM,Oldenburg B,Fidder HH

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Therapy with adalimumab has been shown to be effective in Crohn's disease (CD) patients who have lost response or are intolerant to infliximab. AIM:To determine the efficacy of adalimumab in CD patients who discontinued infliximab through a systematic review. METHODS:Electronic searches of EMBASE and MEDLI...

journal_title：Alimentary pharmacology & therapeutics

authors： Ma C,Panaccione R,Heitman SJ,Devlin SM,Ghosh S,Kaplan GG

更新日期：2009-11-15 00:00:00

abstract：:Long-term studies have confirmed unequivocally the clinical efficacy of continuous therapy with H2-receptor antagonists in reducing the incidence of ulcer recurrence. However, studies have also reported varying relapse rates as a result of differences in study design, particularly the frequency of endoscopy and hence ...

journal_title：Alimentary pharmacology & therapeutics

authors： Dammann HG,Walter TA

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:The eradication rates following standard triple therapy for Helicobacter pylori infection are declining worldwide. Recent studies have shown that sequential therapy for H. pylori infection yields high cure rates. AIM:To compare the efficacy and tolerability of a sequential regimen as first-line treatment of...

journal_title：Alimentary pharmacology & therapeutics

authors： Park HG,Jung MK,Jung JT,Kwon JG,Kim EY,Seo HE,Lee JH,Yang CH,Kim ES,Cho KB,Park KS,Lee SH,Kim KO,Jeon SW

更新日期：2012-01-01 00:00:00

abstract：AIM:To study the effect of prokinetic treatment with cisapride in patients with constipation-predominant irritable bowel syndrome. PATIENTS AND METHODS:Ninety-six patients were randomly assigned to treatment with either cisapride 5 mg three times daily or placebo three times daily for a period of 12 weeks. The dosage ...

journal_title：Alimentary pharmacology & therapeutics

authors： Schütze K,Brandstätter G,Dragosics B,Judmaier G,Hentschel E

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Guidelines recommend that patients with gastro-oesophageal reflux disease are adequately treated with acid-suppressive therapy before undergoing anti-reflux surgery. Little is known of the use of acid-suppressive drugs before anti-reflux surgery. AIM:To determine the use of proton pump inhibitors and H2 -re...

journal_title：Alimentary pharmacology & therapeutics

authors： Lødrup A,Pottegård A,Hallas J,Bytzer P

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Subtotal or total colectomy or proctocolectomy with permanent ileostomy (TC-PI) may be a treatment option for medically refractory colonic Crohn's disease (CD). AIM:To perform a systematic review and meta-analysis to evaluate the rate, risk factors and outcomes of CD recurrence after TC-PI. METHODS:In a sy...

journal_title：Alimentary pharmacology & therapeutics

authors： Fumery M,Dulai PS,Meirick P,Farrell AM,Ramamoorthy S,Sandborn WJ,Singh S

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Recent studies in adults have shown that polymeric (whole protein) diets are as effective as semi-elemental and elemental formulae for the induction of remission in small bowel Crohn's disease. Whole protein diets are more palatable and cheaper. There have been no studies confirming efficacy in children. PA...

journal_title：Alimentary pharmacology & therapeutics

authors： Beattie RM,Schiffrin EJ,Donnet-Hughes A,Huggett AC,Domizio P,MacDonald TT,Walker-Smith JA

更新日期：1994-12-01 00:00:00

abstract：:The effects of treatment with the Chinese herbal medicine Liu-Jun-Zi-Tang (TJ-43) on gastric emptying and gastrointestinal symptoms were investigated in 42 patients with chronic idiopathic dyspepsia. By random allocation, 22 patients received oral treatment with 2.5 g TJ-43 three times daily, and 20 patients received ...

journal_title：Alimentary pharmacology & therapeutics

authors： Tatsuta M,Iishi H

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Differentiating symptoms of irritable bowel syndrome from those of organic intestinal disease is a common clinical problem. Several neutrophil-derived proteins have been proposed as a marker of inflammatory bowel disease. AIM:To compare the diagnostic value of faecal calprotectin, lactoferrin and polymorpho...

journal_title：Alimentary pharmacology & therapeutics

authors： Schröder O,Naumann M,Shastri Y,Povse N,Stein J

更新日期：2007-10-01 00:00:00

abstract：AIM:To assess the pathophysiology and treatment of neurogenic dysphagia. METHODS:46 patients with brain damage, 46 with neurodegenerative diseases and eight healthy volunteers were studied by videofluoroscopy while swallowing 3-20 mL liquid (20.4 mPa s), nectar (274.4 mPa s) and pudding (3931.2 mPa s) boluses. RESULT...

journal_title：Alimentary pharmacology & therapeutics

authors： Clavé P,de Kraa M,Arreola V,Girvent M,Farré R,Palomera E,Serra-Prat M

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Lubiprostone (8 μg b.d.) received US Food and Drug Administration (FDA) approval in 2008 for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) in women aged ≥18 years. In 2012, the FDA issued new guidance for IBS-C clinical trials, recommending a composite endpoint incorporating both...

journal_title：Alimentary pharmacology & therapeutics

authors： Chang L,Chey WD,Drossman D,Losch-Beridon T,Wang M,Lichtlen P,Mareya S

更新日期：2016-11-01 00:00:00

abstract：AIM:To compare the efficacy of ranitidine bismuth citrate plus clarithromycin (RBC-C) vs. omeprazole plus amoxycillin (OME-AMO) in the cure of Helicobacter pylori infection. METHODS:In this double-blind, multicentre, parallel-group study 122 H. pylori-positive patients with active duodenal ulcer or gastritis, with con...

journal_title：Alimentary pharmacology & therapeutics

authors： Kolkman JJ,Tan TG,Oudkerk Pool M,Van Kleef WA,Geraedts AA,Timmerman RJ,Crobach LF,Nicolai JJ,Wolff AA,Van Der Laan J

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:Few studies have evaluated interferon and ribavirin therapy in hepatitis C virus-infected patients with persistently normal alanine aminotransferase (ALT) levels. AIM:To determine the efficacy and safety of combination therapy in this population, and to evaluate the impact of treatment on health-related qua...

journal_title：Alimentary pharmacology & therapeutics

authors： Bini EJ,Mehandru S

更新日期：2006-03-15 00:00:00

abstract：BACKGROUND:Ingested peanut agglutinin stimulates colonic proliferation in humans. In rats, ingested peanut agglutinin stimulates hormone release and proliferation in the small and large intestines. Peanut agglutinin is absorbed into the circulation but little is known about the systemic effect of this lectin. Therefore...

journal_title：Alimentary pharmacology & therapeutics

authors： Jordinson M,Fitzgerald AJ,Goodlad RA,Brynes A,Grant G,Pignatelli M,Calam J

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Previous data have indicated low bone formation as a mechanism of osteoporosis in inflammatory bowel disease. Fluoride can stimulate bone formation. AIM:To assess the effect of fluoride supplementation on lumbar spine bone mineral density in osteoporotic patients with inflammatory bowel disease treated in p...

journal_title：Alimentary pharmacology & therapeutics

authors： Abitbol V,Mary JY,Roux C,Soulé JC,Belaiche J,Dupas JL,Gendre JP,Lerebours E,Chaussade S,Groupe D'etudes Thérapeutiques des Affections Inflammatoires Digestives (GETAID).

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori eradication has become the standard treatment for duodenal ulcer. However, there is no relevant evidence for antibacterial treatment of the white scar stage of duodenal ulcer (duodenal ulcer scar) in patients with no past history of duodenal ulcer. AIM:To investigate whether H. pylori er...

journal_title：Alimentary pharmacology & therapeutics

authors： Kim JS,Kim SG,Choi IJ,Park MJ,Kim BG,Jung HC,Song IS

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Bodybuilding supplements can cause a profound cholestatic syndrome. AIM:To describe the drug-Induced liver injury network's experience with liver injury due to bodybuilding supplements. METHODS:Liver injury pattern, severity and outcomes, potential genetic associations, and exposure to anabolic steroids by...

journal_title：Alimentary pharmacology & therapeutics

authors： Stolz A,Navarro V,Hayashi PH,Fontana RJ,Barnhart HX,Gu J,Chalasani NP,Vega MM,Bonkovsky HL,Seeff LB,Serrano J,Avula B,Khan IA,Cirulli ET,Kleiner DE,Hoofnagle JH,DILIN Investigators.

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:While current medications used to treat patients with chronic hepatitis C virus (HCV) effectively produce sustained viral response (SVR), postponement of therapy is often times attributed to patient perceptions of unfavourable outcomes. However, an instrument to assess patient perceptions of therapy (i.e. tr...

journal_title：Alimentary pharmacology & therapeutics

authors： Szeinbach SL,Baran RW,Dietz B,Gazzouola Rocca L,Littlefield D,Yawn BP

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Alterations in serotonergic (5-HT) metabolism and/or intestinal integrity have been associated with irritable bowel syndrome (IBS). AIMS:To assess the effects of the precursor of 5-HT, 5-hydroxytryptophan (5-HTP), on mucosal 5-HT availability and intestinal integrity, and to assess potential differences bet...

journal_title：Alimentary pharmacology & therapeutics

authors： Keszthelyi D,Troost FJ,Jonkers DM,van Eijk HM,Lindsey PJ,Dekker J,Buurman WA,Masclee AA

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Pneumatic dilation has re-emerged as a first line treatment for achalasia, but conclusions are limited by the relatively small numbers of patients studied and the lack of long term follow-up. AIM:To summarise and analyse 29 available studies evaluating pneumatic dilation for achalasia with focus on efficacy...

journal_title：Alimentary pharmacology & therapeutics

authors： Katzka DA,Castell DO

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Cannabinoid (CB) receptors have been located in brain areas involved in the triggering of TLESRs as well as in the nodose ganglion from which vagal afferents emanate. The distribution of CB(1) receptors has been investigated in the human gastrointestinal mucosa, as expression of inflammatory process. AIM:To...

journal_title：Alimentary pharmacology & therapeutics

authors： Calabrese C,Spisni E,Liguori G,Lazzarini G,Valerii MC,Strillacci A,Gionchetti P,Pagotto U,Campieri M,Rizzello F

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:The gastric juice concentration of vitamin C is reduced in subjects with elevated intragastric pH. This is probably because of the fact that the vitamin is unstable at non-acidic pH and undergoes irreversible denaturation. AIM:To determine whether elevation of intragastric pH reduces the bioavailability of ...

journal_title：Alimentary pharmacology & therapeutics

authors： Henry EB,Carswell A,Wirz A,Fyffe V,McColl KE

更新日期：2005-09-15 00:00:00

abstract：AIM:To demonstrate the pharmacodynamic comparability between oral 40 mg pantoprazole delayed-release granules and tablets. METHODS:This was a multicentre, randomized, open-label, 2-period, 2-sequence, 9-week crossover study in patients aged 18-65 years with gastro-oesophageal reflux disease and documented erosive oeso...

journal_title：Alimentary pharmacology & therapeutics

authors： Hogan D,Pratha V,Riff D,Ducker S,Schwartz H,Soffer E,Wang W,Rath N,Comer GM

更新日期：2007-07-15 00:00:00