Review article: treatment algorithms to maximize remission and minimize corticosteroid dependence in patients with inflammatory bowel disease.

abstract：:Forty-two patients with peptic ulceration of the duodenum, stomach or oesophagus, who had not responded to 3 or more months of high-dose treatment with ranitidine (450 or 600 mg/day), were treated with oral lansoprazole at 30-60 mg daily. In 40 patients (95.2%) the ulcers healed within 2-12 weeks. In the remaining 2 p...

journal_title：Alimentary pharmacology & therapeutics

authors： Brunner G,Arnold R,Hennig U,Fuchs W

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is associated with colorectal neoplasia. Yet, NAFLD ranges from simple steatosis to steatohepatitis with advanced fibrosis. AIM:To investigate the risk of colorectal neoplasia according to the presence and severity of NAFLD. METHODS:A total of 26 540 asymptomatic a...

journal_title：Alimentary pharmacology & therapeutics

authors： Ahn JS,Sinn DH,Min YW,Hong SN,Kim HS,Jung SH,Gu S,Rhee PL,Paik SW,Son HJ,Gwak GY

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Lubiprostone (8 μg b.d.) received US Food and Drug Administration (FDA) approval in 2008 for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) in women aged ≥18 years. In 2012, the FDA issued new guidance for IBS-C clinical trials, recommending a composite endpoint incorporating both...

journal_title：Alimentary pharmacology & therapeutics

authors： Chang L,Chey WD,Drossman D,Losch-Beridon T,Wang M,Lichtlen P,Mareya S

更新日期：2016-11-01 00:00:00

abstract：:Despite implementation of screening and surveillance strategies, a significantly large number of patients with Barrett's oesophagus remain undiagnosed. In those who are identified, the management options include acid reduction therapies with proton pump inhibitors or anti-reflux surgery. Endoscopic ablative therapies ...

journal_title：Alimentary pharmacology & therapeutics

authors： Jankowski J,Sharma P

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is a systemic disorder that predominantly affects the bowels but is also associated with venous thromboembolism (VTE). AIM:To provide a quantitative assessment of the association of IBD with venous thromboembo...

journal_title：Alimentary pharmacology & therapeutics

authors： Yuhara H,Steinmaus C,Corley D,Koike J,Igarashi M,Suzuki T,Mine T

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Some patients requiring acid suppression may be unable to take oral medications. AIM:To compare the gastric acid inhibition effects of lansoprazole 30 mg administered either intravenous or orally in erosive oesophagitis patients. METHODS:The study included 87 Helicobacter pylori-negative patients with eros...

journal_title：Alimentary pharmacology & therapeutics

authors： Kovacs TO,Lee CQ,Chiu YL,Pilmer BL,Metz DC

更新日期：2004-10-15 00:00:00

abstract：BACKGROUND:Tumour necrosis factor (TNF)-antagonists have an established role in the treatment of inflammatory bowel diseases (IBDs), however, subtherapeutic drug levels and the formation of anti-drug antibodies (ADAs) may decrease their efficacy. AIM:The evidence supporting the use of therapeutic drug monitoring (TDM)...

journal_title：Alimentary pharmacology & therapeutics

authors： Khanna R,Sattin BD,Afif W,Benchimol EI,Bernard EJ,Bitton A,Bressler B,Fedorak RN,Ghosh S,Greenberg GR,Marshall JK,Panaccione R,Seidman EG,Silverberg MS,Steinhart AH,Sy R,Van Assche G,Walters TD,Sandborn WJ,Feagan BG

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Ingestion of capsaicin reduces symptoms in functional dyspepsia but induces upper abdominal symptoms initially. AIMS:To evaluate the effects of one week of oral dosing with capsaicin on mechanonociception and chemonociception. METHODS:Healthy subjects ingested capsules containing 0.5 mg capsaicin t.d.s (n ...

journal_title：Alimentary pharmacology & therapeutics

authors： Hammer J

更新日期：2006-08-15 00:00:00

abstract：BACKGROUND:Hypoxia may contribute to impairment of liver function and thus interfere with results of liver tests. In patients with cirrhosis, cytochrome P-450 mediated metabolism of substrates is facilitated in the presence of supplemental oxygen. It has not been studied how this relates to liver function and haemoglob...

journal_title：Alimentary pharmacology & therapeutics

authors： Zipprich A,Meiss F,Steudel N,Sziegoleit U,Fleig WE,Kleber G

更新日期：2003-06-15 00:00:00

abstract：BACKGROUND:The efficacy of cyclosporin in the management of ulcerative colitis is recognized. Not all patients respond to this treatment. Existing clinical and laboratory parameters are of little use in identifying those most likely to respond. AIMS:To determine whether in-vitro sensitivity to cyclosporin as measured ...

journal_title：Alimentary pharmacology & therapeutics

authors： McCormack G,O'Donoghue D,Baird A

更新日期：2001-05-01 00:00:00

abstract：:Trospium chloride is a muscarinergic antagonist acting on oesophageal smooth muscle and on ganglionic and/or myenteric neurons. The effect of this drug on oesophageal motility was tested in 16 healthy male subjects in a double-blind randomized cross-over examination of trospium chloride or placebo following phentolami...

journal_title：Alimentary pharmacology & therapeutics

authors： Frieling T,Enck P,Dohmann R,Wienbeck M,Lübke HJ

更新日期：1993-02-01 00:00:00

abstract：AIM:To update previous overviews of placebo-controlled double-blind trials assessing the efficacy and tolerance of smooth muscle relaxants in irritable bowel syndrome. METHODS AND TRIALS: A total of 23 randomized clinical trials were selected for meta-analyses of their efficacy and tolerance. Six drugs were analysed: c...

journal_title：Alimentary pharmacology & therapeutics

authors： Poynard T,Regimbeau C,Benhamou Y

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:The basis for individual variation in gastroduodenal vulnerability to NSAIDs is not well understood. AIM:To assess whether a gene expression signature is associated with susceptibility to gastroduodenal ulcerations. METHODS:Twenty-five Helicobacter pylori negative adults were treated for 7 days with naprox...

journal_title：Alimentary pharmacology & therapeutics

authors： Desai JC,Goo T,Fukata M,Sanyal S,Dikman A,Miller K,Cohen L,Brooks A,Wang Q,Abreu MT,Aisenberg J

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Serum hepatitis B virus (HBV) RNA may reflect intrahepatic HBV replication. Novel anti-viral drugs have shown potent HBV RNA decline without concomitant hepatitis B surface antigen (HBsAg) decrease. How this relates to off-treatment response is yet unclear. AIM:To study the degree of on-treatment viral anti...

journal_title：Alimentary pharmacology & therapeutics

authors： Brakenhoff SM,de Man RA,Boonstra A,van Campenhout MJH,de Knegt RJ,van Bömmel F,van der Eijk AA,Berg T,Hansen BE,Janssen HLA,Sonneveld MJ

更新日期：2021-01-01 00:00:00

abstract：:Functional dyspepsia is highly variable in its clinical presentation and multifactorial in its underlying causes. Since many of the symptoms included in the definition of dyspepsia are intuitively suggestive of different pathogenic mechanisms, it has been proposed that patients with functional dyspepsia be divided int...

journal_title：Alimentary pharmacology & therapeutics

authors： Stanghellini V

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Mild impairments of cognition or 'Brain fog' are often reported by patients with coeliac disease but the nature of these impairments has not been systematically investigated. AIM:This longitudinal pilot study investigated relationships between cognitive function and mucosal healing in people with newly diag...

journal_title：Alimentary pharmacology & therapeutics

authors： Lichtwark IT,Newnham ED,Robinson SR,Shepherd SJ,Hosking P,Gibson PR,Yelland GW

更新日期：2014-07-01 00:00:00

abstract：AIM:To identify optimal antibiotics for second-line quadruple therapy of Helicobacter pylori after failed 1-week triple therapy. METHODS:One hundred patients were enrolled in this study after the failure of 1-week triple therapy. They were randomized to receive 1-week quadruple therapy consisting of amoxicillin, omepr...

journal_title：Alimentary pharmacology & therapeutics

authors： Chi CH,Lin CY,Sheu BS,Yang HB,Huang AH,Wu JJ

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Anti-TNFα biologics induce and maintain remission in inflammatory bowel disease (IBD). Also, they have been reported to induce or unmask idiopathic inflammatory demyelinating disease of the central nervous system (IIDD). AIM:To determine if anti-TNFα biologics increased the risk of IIDD in a large cohort of...

journal_title：Alimentary pharmacology & therapeutics

authors： De Felice KM,Novotna M,Enders FT,Faubion WA,Tremaine WJ,Kantarci OH,Raffals LE

更新日期：2015-01-01 00:00:00

abstract：:The aetiology of Crohn's disease is unknown and therefore no curative treatments are available for the disease. The natural history of Crohn's disease is characterized by recurrent flare-ups of symptoms. Several drug treatments are effective in inducing clinical remission. However, no drug treatments are available in ...

journal_title：Alimentary pharmacology & therapeutics

authors： Biancone L,Tosti C,Fina D,Fantini M,De Nigris F,Geremia A,Pallone F

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) infection is associated with the appearance of liver steatosis. AIM:To search for a correlation between the number of HCV infected hepatocytes and the presence, amount and distribution of steatosis. METHODS:A total of 124 frozen liver biopsies from HCV patients (genotype 3 = 21) wer...

journal_title：Alimentary pharmacology & therapeutics

authors： Grassi A,Ballardini G,Susca M,Bianchini F,Bonoli S,Bianchi FB,Lenzi M

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Recently, the therapeutic landscape with regard to anti-HCV therapy has changed dramatically. The new directly acting anti-virals (DAAs) have demonstrated improved sustained virological response (SVR) compared with pegylated-interferon and ribavirin. AIM:To examine and present the latest data with regard to...

journal_title：Alimentary pharmacology & therapeutics

authors： Joshi D,Carey I,Agarwal K

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Bismuth compounds prevent gastric injury from the short-term administration of nonsteroidal anti-inflammatory drugs. We studied the mechanisms underlying the gastroprotective actions of bismuth subsalicylate against indomethacin-induced injury in rats. METHODS:An in vivo microscopic technique was used in wh...

journal_title：Alimentary pharmacology & therapeutics

authors： Tanaka S,Guth PH,Carryl OR,Kaunitz JD

更新日期：1997-06-01 00:00:00

abstract：:The treatment of non-alcoholic fatty liver disease may be worthwhile to prevent progression to advanced liver failure, but no therapy is definitely evidence-based. Weight loss or lifestyle modifications remain the primary line of intervention, particularly in overweight or obese subjects. In adult non-alcoholic fatty ...

journal_title：Alimentary pharmacology & therapeutics

authors： Marchesini G,Natale S,Manini R,Agostini F

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Epidemiological studies of microscopic colitis have shown varying but increasing incidence rates. AIM:To assess the incidence of microscopic colitis in Sweden. METHODS:Nationwide cohort study performed in 1995-2015 based on biopsy reports. Age-specific and age-standardised incidence rates were calculated. ...

journal_title：Alimentary pharmacology & therapeutics

authors： Bergman D,Clements MS,Khalili H,Agréus L,Hultcrantz R,Ludvigsson JF

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Misoprostol is known to be effective in stimulating intestinal transit both in healthy individuals and in patients with chronic constipation when evaluated in short-term trials. The aim of this study was to determine the utility of misoprostol in the long-term management of patients with chronic refractory c...

journal_title：Alimentary pharmacology & therapeutics

authors： Roarty TP,Weber F,Soykan I,McCallum RW

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:Patients with thalassaemia major depend on blood transfusions. In Italy, up to 80% of thalassaemia patients bear HCV antibodies due to HCV contaminated transfusions before 1990. Thalassaemia patients with HCV infection have high risk of developing HCC. Treatment based on Pegylated-IFN (Peg-IFN) and Ribavirin...

journal_title：Alimentary pharmacology & therapeutics

authors： Mangia A,Sarli R,Gamberini R,Piga A,Cenderello G,Piazzolla V,Santoro R,Caruso V,Quarta A,Ganga R,Copetti M,Forni G

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Dermatitis herpetiformis forms part of the same spectrum of gluten-sensitive disorders as coeliac disease yet may have different risks of morbidity and mortality. AIMS:To quantify the risks of fracture, malignancy and mortality in people with dermatitis herpetiformis compared with the general population. M...

journal_title：Alimentary pharmacology & therapeutics

authors： Lewis NR,Logan RF,Hubbard RB,West J

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Although a few adult cases of fulminant-type autoimmune hepatitis have been reported, their clinical features and prognosis have remained uncertain. AIM:To assess the clinical features and prognosis of patients with fulminant-type autoimmune hepatitis. METHODS:Eleven patients (10%) diagnosed with fulminant...

journal_title：Alimentary pharmacology & therapeutics

authors： Miyake Y,Iwasaki Y,Terada R,Onishi T,Okamoto R,Sakai N,Sakaguchi K,Shiratori Y

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Optimal management approach is not well defined for subjects who fail initial first- and second-line Helicobacter pylori eradication attempts and are dealt on a case-by-case basis by the specialists. AIM:To evaluate the efficacy and safety of standard and 'rescue' eradication therapies at primary and second...

journal_title：Alimentary pharmacology & therapeutics

authors： Qasim A,Sebastian S,Thornton O,Dobson M,McLoughlin R,Buckley M,O'Connor H,O'Morain C

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The new tablet formulation of omeprazole (Losec MUPS), is thought to have a stronger acid inhibition than the previously marketed capsules. METHODS:The effects of the proton pump inhibitors lansoprazole and omeprazole tablets on pentagastrin-stimulated acid secretion were compared in Helicobacter pylori-neg...

journal_title：Alimentary pharmacology & therapeutics

authors： Müller P,Göksu MA,Fuchs W,Schlüter F,Simon B

更新日期：2000-09-01 00:00:00