Science to practice: Can contrast-enhanced US of targeted microbubbles be used to monitor and quantify inflammation in patients with inflammatory bowel disease?

Abstract:

:Deshpande et al (1) have shown that P-selectin-targeted microbubbles (MBs) can be used to monitor the expression of this molecule as a marker of inflammation in a murine model of inflammatory bowel disease (IBD). If these results can be reproduced in future clinical trials, contrast material–enhanced ultrasound (US) of targeted MBs (US molecular imaging) will enable accurate monitoring of inflammation and, specifically, response to IBD therapy, which should improve clinical outcomes.

journal_name

Radiology

journal_title

Radiology

authors

Forsberg F

doi

10.1148/radiol.11112145

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

1-2

issue

1

eissn

0033-8419

issn

1527-1315

pii

262/1/1

journal_volume

262

pub_type

评论,杂志文章
  • Survival outcomes of breast cancer patients who receive neoadjuvant chemotherapy: association with dynamic contrast-enhanced MR imaging with computer-aided evaluation.

    abstract:PURPOSE:To retrospectively evaluate whether dynamic contrast agent-enhanced (DCE) magnetic resonance (MR) imaging parameters assessed by a computer-aided evaluation program are associated with recurrence-free and overall survival in breast cancer patients who received neoadjuvant chemotherapy (NAC). MATERIALS AND METH...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.13121801

    authors: Yi A,Cho N,Im SA,Chang JM,Kim SJ,Moon HG,Han W,Park IA,Noh DY,Moon WK

    更新日期:2013-09-01 00:00:00

  • Artificial multiple sclerosis lesions on simulated FLAIR brain MR images: echo time and observer performance in detection.

    abstract::The institutional review board approved the described HIPAA-compliant study, which was performed to prospectively evaluate observer performance in the detection of artificial multiple sclerosis (MS) lesions that were randomly distributed supra- and infratentorially on simulated fluid-attenuated inversion-recovery (FLA...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2383050211

    authors: Pikus L,Woo JH,Wolf RL,Herskovits EH,Moonis G,Jawad AF,Krejza J,Melhem ER

    更新日期:2006-04-01 00:00:00

  • Noninvasive assessment of acute ureteral obstruction with diffusion-weighted MR imaging: a prospective study.

    abstract:PURPOSE:To prospectively assess the potential of noninvasive diffusion-weighted magnetic resonance (MR) imaging to depict changes in microperfusion and diffusion in patients with acute unilateral ureteral obstruction. MATERIALS AND METHODS:The local ethics committee approved the study protocol. Informed consent was ob...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2523082090

    authors: Thoeny HC,Binser T,Roth B,Kessler TM,Vermathen P

    更新日期:2009-09-01 00:00:00

  • Characteristics of triangular fibrocartilage defects in symptomatic and contralateral asymptomatic wrists.

    abstract:PURPOSE:To characterize triangular fibrocartilage (TFC) defects in symptomatic and contralateral asymptomatic wrists. MATERIALS AND METHODS:Communicating and noncommunicating defects of the TFC were depicted on bilateral wrist arthrograms in 56 patients with unilateral wrist pain and without associated lesions of the ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.216.3.r00se06840

    authors: Zanetti M,Linkous MD,Gilula LA,Hodler J

    更新日期:2000-09-01 00:00:00

  • Does multi-detector row CT pulmonary angiography reduce the incremental value of indirect CT venography compared with single-detector row CT pulmonary angiography?

    abstract:PURPOSE:To compare retrospectively the incremental value of indirect computed tomographic (CT) venography performed after multi-detector row CT pulmonary angiography and single-detector row CT pulmonary angiography for the diagnosis of venous thromboembolism (VTE). MATERIALS AND METHODS:The institutional ethics commit...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2401050350

    authors: Ghaye B,Nchimi A,Noukoua CT,Dondelinger RF

    更新日期:2006-07-01 00:00:00

  • Unenhanced dynamic MR angiography: high spatial and temporal resolution by using true FISP-based spin tagging with alternating radiofrequency.

    abstract:PURPOSE:To present an unenhanced four-dimensional time-resolved dynamic magnetic resonance (MR) angiography technique with true fast imaging with steady-state precession-based spin tagging with alternating radiofrequency (STAR), also called TrueSTAR. MATERIALS AND METHODS:This study received Institutional Review Board...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.10091543

    authors: Yan L,Wang S,Zhuo Y,Wolf RL,Stiefel MF,An J,Ye Y,Zhang Q,Melhem ER,Wang DJ

    更新日期:2010-07-01 00:00:00

  • Rapid change in caliber of the nonobstructed common duct.

    abstract::A case of a postcholecystectomy patient is presented in which an initially grossly dilated common hepatic duct returned to normal size within several minutes. We have tried to explain this phenomenon using known facts abut bile duct elasticity and bile flow, and conclude that such rapid size change probably only occur...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.140.1.7244220

    authors: Glazer GM,Filly RA,Laing FC

    更新日期:1981-07-01 00:00:00

  • Pneumatosis coli secondary to acute appendicitis. Case report.

    abstract::An unusual case of pneumatosis coli is presented. The patient had acute inflammatory disease with gangrene of the appendix associated with air within the wall of the contiguous right colon. ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/120.1.90

    authors: DiDonato LR

    更新日期:1976-07-01 00:00:00

  • Lymphomas: initial reactivation.

    abstract::A total of 299 patients with Stage IA-Stage IIB nodal lymphoma treated by irradiation were evaluated for initial reactivation. The abdomen was the major site of reactivation for patients with supradiaphragmatic Hodgkin's disease. The non-Hodgkin's lymphomas reactivated in a variable fashion. Reactivation was prompt fo...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/117.3.695

    authors: Knapp WT,Fayos JV

    更新日期:1975-12-01 00:00:00

  • Enhancement of vascular permeability with low-frequency contrast-enhanced ultrasound in the chorioallantoic membrane model.

    abstract:PURPOSE:To characterize the effect of low-frequency contrast material-enhanced ultrasound on the vascular endothelium and to determine the parameters and techniques required to deliver a therapeutic agent by using the chorioallantoic membrane (CAM) model. MATERIALS AND METHODS:All in vivo animal procedures were conduc...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2431060167

    authors: Stieger SM,Caskey CF,Adamson RH,Qin S,Curry FR,Wisner ER,Ferrara KW

    更新日期:2007-04-01 00:00:00

  • Intraosseous venous drainage anomaly in patients with pretibial varices: imaging findings.

    abstract:PURPOSE:To determine a set of distinctive imaging findings seen in symptomatic patients with pretibial varices. MATERIALS AND METHODS:Medical records and imaging studies of patients who presented with pretibial varices over an 8-year period were collected from four institutions. Findings in six symptomatic patients wi...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.202.3.9051030

    authors: Boutin RD,Sartoris DJ,Rose SC,Plecha EJ,Bundens WP,Haghighi P,Harter LP,Resnick D

    更新日期:1997-03-01 00:00:00

  • CT fluoroscopy--guided interventional procedures: techniques and radiation dose to radiologists.

    abstract:PURPOSE:To determine the radiation dose to radiologists who perform computed tomographic (CT) fluoroscopic interventional procedures by using a quick-check method and a low-milliampere technique. MATERIALS AND METHODS:Two hundred twenty CT fluoroscopy--guided interventional procedures were performed in 189 patients. P...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.220.1.r01jl29161

    authors: Paulson EK,Sheafor DH,Enterline DS,McAdams HP,Yoshizumi TT

    更新日期:2001-07-01 00:00:00

  • Hepatic perfusion disorder associated with focal liver lesions: contrast-enhanced US patterns--correlation study with contrast-enhanced CT.

    abstract:PURPOSE:To retrospectively compare the detection and characterization of hepatic perfusion disorder (HPD) associated with focal liver lesions (FLLs) at contrast material-enhanced ultrasonography (US) by using contrast-enhanced computed tomography (CT) as the reference standard. MATERIALS AND METHODS:The study was appr...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.11101454

    authors: Zhou X,Luo Y,Peng YL,Cai W,Lu Q,Lin L,Sha XX,Li YZ,Zhu M

    更新日期:2011-07-01 00:00:00

  • Prostaglandins and angioplasty. An experimental study in canine arteries.

    abstract::To prevent platelet aggregation following percutaneous transluminal angioplasty (PTA), cyclooxygenase inhibitors such as acetylsalicylic acid (ASA) and indomethacin are recommended. However, ASA blocks both the proaggregating effects of thromboxane (TXA2) and the antiaggregating and vasodilating effects of prostacycli...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.149.3.6227930

    authors: Zollikofer CL,Cragg AH,Einzig S,Castaneda-Zuniga WR,Castaneda F,Rysavy JA,Bruhlmann WF,Shebuski RJ,Amplatz K

    更新日期:1983-12-01 00:00:00

  • Intravenous versus superior mesenteric artery vasopressin infusions for the treatment of variceal bleeding.

    abstract::The effects of 30-minute intravenous and superior mesenteric artery (SMA) infusions of vasopressin in dosages of 2.75 mU and 14 mU per min per kg were compared in five dogs that had cirrhosis and portal hypertension induced by fractionated intraportal polyvinyl alcohol injections. A reduction in portal pressure of app...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.142.3.6977790

    authors: Burgener FA,Gutierrez OH

    更新日期:1982-03-01 00:00:00

  • Simulated aggressive skull base erosion in response to benign sinonasal disease.

    abstract::Benign sinonasal masses and slow-growing neoplasms tend to remodel the nasal vault and facial bones, and this is particularly true of nasal polyps and inverted papillomas. However, when such benign masses press against the floor of the anterior cranial fossa and the walls of the sphenoid sinuses, simulated aggressive ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.180.3.1871290

    authors: Som PM,Lawson W,Lidov MW

    更新日期:1991-09-01 00:00:00

  • Protein-losing enteropathy: diagnosis with (99m)Tc-labeled human serum albumin scintigraphy.

    abstract:PURPOSE:To investigate the diagnostic value of technetium 99m-labeled human serum albumin (HSA) scintigraphy in a group of patients suspected of having protein-losing enteropathy (PLE). MATERIALS AND METHODS:After intravenous injection of 740 MBq of freshly prepared (99m)Tc HSA, serial images of the abdomen were obtai...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.219.1.r01ap2986

    authors: Chiu NT,Lee BF,Hwang SJ,Chang JM,Liu GC,Yu HS

    更新日期:2001-04-01 00:00:00

  • Choledochal cysts: roentgenographic techniques.

    abstract::Twenty-four cases of choledochal cysts were reviewed. Only 7 cases were definitely diagnosed preoperatively: 3 by 131I rose bengal scanning, 2 by intravenous cholangiography, 1 by oral cholecystography, and 1 by 99mTc sulfur colloid scanning followed by angiography. The highest percentage of definitive positive examin...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/114.1.113

    authors: Rosenfield N,Griscom NT

    更新日期:1975-01-01 00:00:00

  • Exercise radionuclide ventriculography: practical considerations and sensitivity of coronary artery disease detection.

    abstract::Eighty-nine patients were evaluated for coronary artery disease (CAD) with exercise radionuclide ventriculography (ERV) and contrast coronary angiography. In 70 patients with documented lesions the ERV was abnormal in 65 for a sensitivity of 93%. In patients with normal coronary arteries, the ERV was abnormal in none ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/132.3.697

    authors: Brady TJ,Thrall JH,Clare JM,Rogers WL,Lo K,Pitt B

    更新日期:1979-09-01 00:00:00

  • T1 Shortening in the Globus Pallidus after Multiple Administrations of Gadobutrol: Assessment with a Multidynamic Multiecho Sequence.

    abstract::Purpose To determine the association between the administration of the macrocyclic contrast medium gadobutrol and T1 relaxation time in the brains of patients with normal renal function by using multidynamic multiecho (MDME) magnetic resonance (MR) imaging sequences. Materials and Methods The institutional review boar...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2017162852

    authors: Kang KM,Choi SH,Hwang M,Yun TJ,Kim JH,Sohn CH

    更新日期:2018-04-01 00:00:00

  • Biofunctionalized Hybrid Magnetic Gold Nanoparticles as Catalysts for Photothermal Ablation of Colorectal Liver Metastases.

    abstract::Purpose To demonstrate that anti-MG1 conjugated hybrid magnetic gold nanoparticles (HNPs) act as a catalyst during photothermal ablation (PTA) of colorectal liver metastases, and thus increase ablation zones. Materials and Methods All experiments were performed with approval of the institutional animal care and use co...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2017161497

    authors: White SB,Kim DH,Guo Y,Li W,Yang Y,Chen J,Gogineni VR,Larson AC

    更新日期:2017-12-01 00:00:00

  • Dose efficiency of screen-film systems used in pediatric radiography.

    abstract::Twenty-one screen-film systems were examined using contrast-detail-dose methods in order to determine which were most dose-efficient for use in pediatric radiography. With a given screen, dose efficiency in the noise-limited region (contrast approximately equal to 0.05) was more or less constant (within the range of e...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.152.1.6729110

    authors: Cohen G,Wagner LK,McDaniel DL,Robinson LH

    更新日期:1984-07-01 00:00:00

  • Rheumatoid arthritis of the cervical spine: early and progressive radiographic features.

    abstract::One hundred thirty-three cervical spine radiographs of 50 patients with rheumatoid arthritis were examined. The patients were a representative random sample chosen from among 675 patients followed up for more than 10 years. The frequency of occurrence for each radiographic finding was correlated with the duration of r...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.165.1.3628760

    authors: Wolfe BK,O'Keeffe D,Mitchell DM,Tchang SP

    更新日期:1987-10-01 00:00:00

  • Cholelithiasis in children.

    abstract::Review of 367 cases of cholelithiasis in children from the literature and our experience showed that 81% of these patients has no evidence of hemolytic anemia. Oral cholecystograms were diagnostic of cholelithiasis in approximately 70% of these cases. Plain film studies were found to be of diagnostic value as a high p...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/117.2.391

    authors: Harned RK,Babbitt DP

    更新日期:1975-11-01 00:00:00

  • Electrocardiographic Pad for Efficient Cardiac MR Gating.

    abstract:PURPOSE:To assess feasibility and reliability of electrocardiographic (ECG)-gated cardiac magnetic resonance (MR) imaging with a simplified reusable electrode design that does not touch the skin. MATERIALS AND METHODS:In this institutional review board-approved, HIPAA-compliant study, a silicon positioner held four EC...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2015142318

    authors: Thimmappa ND,Cooper MA,Nguyen TD,Dutruel SP,Kawaji K,Weinsaft JW

    更新日期:2016-02-01 00:00:00

  • Prostate cancer: sextant localization with MR imaging, MR spectroscopy, and 11C-choline PET/CT.

    abstract:PURPOSE:To retrospectively compare sensitivity and specificity of magnetic resonance (MR) imaging, three-dimensional (3D) MR spectroscopy, combined MR imaging and 3D MR spectroscopy, and carbon 11 (11C)-choline positron emission tomography (PET)/computed tomography (CT) for intraprostatic tumor sextant localization, wi...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2443061063

    authors: Testa C,Schiavina R,Lodi R,Salizzoni E,Corti B,Farsad M,Kurhanewicz J,Manferrari F,Brunocilla E,Tonon C,Monetti N,Castellucci P,Fanti S,Coe M,Grigioni WF,Martorana G,Canini R,Barbiroli B

    更新日期:2007-09-01 00:00:00

  • Intrahepatic amebic abscesses: indications for and results of percutaneous catheter drainage.

    abstract::Medical therapy is standard for intrahepatic amebic abscess and generally is effective. However, we have encountered a group of patients in whom percutaneous aspiration and drainage was indicated due to uncertainty of diagnosis or clinical deterioration of the patient. Twenty such patients underwent percutaneous drain...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.156.3.4023220

    authors: vanSonnenberg E,Mueller PR,Schiffman HR,Ferrucci JT Jr,Casola G,Simeone JF,Cabrera OA,Gosink BB

    更新日期:1985-09-01 00:00:00

  • Acute knee trauma: value of a short dedicated extremity MR imaging examination for prediction of subsequent treatment.

    abstract:PURPOSE:To assess the predictive value of a short magnetic resonance (MR) imaging examination, in addition to or instead of radiography, performed in patients with acute knee trauma to identify those who require additional treatment versus those who do not and can be discharged without further follow-up. MATERIALS AND...

    journal_title:Radiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1148/radiol.2341031062

    authors: Oei EH,Nikken JJ,Ginai AZ,Krestin GP,Verhaar JA,van Vugt AB,Hunink MG

    更新日期:2005-01-01 00:00:00

  • Percutaneous abscess drainage in Crohn disease: technical success and short- and long-term outcomes during 14 years.

    abstract:PURPOSE:To determine technical success with percutaneous abscess drainage (PAD) in patients with Crohn disease during 14 years. MATERIALS AND METHODS:Medical records of 32 patients with Crohn disease who underwent PAD from 1985 to 1999 were reviewed. Results of abscess drainage and nature of subsequent surgical proced...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2223010554

    authors: Gervais DA,Hahn PF,O'Neill MJ,Mueller PR

    更新日期:2002-03-01 00:00:00

  • Solid renal cortical tumors: differentiation with CT.

    abstract:PURPOSE:To retrospectively determine if solid renal cortical tumors can be differentiated on computed tomographic (CT) images on the basis of their morphologic features and enhancement patterns. MATERIALS AND METHODS:Institutional review board approval was obtained and the informed consent requirement was waived for t...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2442060927

    authors: Zhang J,Lefkowitz RA,Ishill NM,Wang L,Moskowitz CS,Russo P,Eisenberg H,Hricak H

    更新日期:2007-08-01 00:00:00