Abstract:
:The institutional review board approved the described HIPAA-compliant study, which was performed to prospectively evaluate observer performance in the detection of artificial multiple sclerosis (MS) lesions that were randomly distributed supra- and infratentorially on simulated fluid-attenuated inversion-recovery (FLAIR) magnetic resonance (MR) images obtained at different echo times (TEs). MR parametric maps were derived from mixed multi-echo inversion-recovery images obtained in a 40-year-old healthy male volunteer and in a patient with MS, both of whom gave informed consent. Pseudo-randomly distributed artificial MS lesions of varying size, number, and location were equally represented on the FLAIR images (11 000/100-200/2600 [repetition time msec/TE msec/inversion time msec]). Twelve images obtained in both regions at each of 11 TEs spaced 10 msec apart were rated by seven neuroradiologists by using a four-point scale. Observer performance in the detection of MS lesions on the FLAIR images, as estimated by using areas under the alternative free-response receiver operating characteristic curve, was highest and most consistent at the 100-msec TE, both supratentorially (93.0% +/- 8.6 [standard error of the mean]) and infratentorially (87.4% +/- 10.0).
journal_name
Radiologyjournal_title
Radiologyauthors
Pikus L,Woo JH,Wolf RL,Herskovits EH,Moonis G,Jawad AF,Krejza J,Melhem ERdoi
10.1148/radiol.2383050211subject
Has Abstractpub_date
2006-04-01 00:00:00pages
238-45issue
1eissn
0033-8419issn
1527-1315pii
2383050211journal_volume
239pub_type
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