Abstract:
:For a machine to function, it must first be assembled. The morphogenesis of the simplest icosahedral virus would require only 60 copies of a single capsid protein to coalesce. If the capsid protein's structure could be entirely dedicated to this endeavor, the morphogenetic mechanism would be relatively uncomplicated. However, capsid proteins have had to evolve other functions, such as receptor recognition, immune system evasion, and the incorporation of other structure proteins, which can detract from efficient assembly. Moreover, evolution has mandated that viruses obtain additional proteins that allow them to adapt to their hosts or to more effectively compete in their respective niches. Consequently, genomes have increased in size, which has required capsids to do likewise. This, in turn, has lead to more complex icosahedral geometries. These challenges have driven the evolution of scaffolding proteins, which mediate, catalyze, and promote proper virus assembly. The mechanisms by which these proteins perform their functions are discussed in this review.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Prevelige PE,Fane BAdoi
10.1007/978-1-4614-0980-9_14subject
Has Abstractpub_date
2012-01-01 00:00:00pages
325-50eissn
0065-2598issn
2214-8019journal_volume
726pub_type
杂志文章,评审abstract::Despite the abundance and ecological importance of sea urchins in eastern Australia, it is not known how they may contribute to ambient noise. The sounds of feeding of two temperate and two tropical species were recorded in captivity. Most sound was produced between 2.3 and 9.2 kHz, but there were differences between ...
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journal_title:Advances in experimental medicine and biology
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journal_title:Advances in experimental medicine and biology
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journal_title:Advances in experimental medicine and biology
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abstract::Age is a critical determinant of the ability of most arthropod vectors to transmit a range of human pathogens. This is due to the fact that most pathogens require a period of extrinsic incubation in the arthropod host before pathogen transmission can occur. This developmental period for the pathogen often comprises a ...
journal_title:Advances in experimental medicine and biology
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更新日期:2008-01-01 00:00:00
abstract::Neonates supported on extracorporeal membrane oxygenation (ECMO) are at high risk of brain injury due to haemodynamic instability. In order to monitor cerebral and peripheral (muscle) haemodynamic and oxygenation changes in this population we used a dual-channel near-infrared spectroscopy (NIRS) system. In addition, t...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
abstract::Reactive oxygen species (ROS) likely play a role in the hypoxic ventilatory response. We determined whether hypoxic responses were influenced by alterations in cellular redox status induced by reductions in superoxide dismutase-1 (SOD-1) activity, a cytosolic anti-oxidant enzyme. Using whole-body, continuous-flow plet...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
abstract::It is now well recognized that a main actor in the continuous interaction between the nervous and immune systems is the pineal hormone MLT. T-helper cells bear G-protein coupled MLT cell membrane receptors and, perhaps, MLT nuclear receptors. Activation of MLT receptors enhances the release of T-helper cell type 1 (Th...
journal_title:Advances in experimental medicine and biology
pub_type: 杂志文章,评审
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