Abstract:
:It is now rare to find biological, or genetic investigations that do not rely on the tools, data, and thinking drawn from the genomic sciences. Much of this revolution is powered by contemporary sequencing approaches that readily deliver large, genome-wide data sets that not only provide genetic insights but also uniquely report molecular outcomes from experiments that biophysicists are increasingly using for potentiating structural and mechanistic investigations. In this perspective, I describe a path of how biophysical thinking greatly contributed to this revolution in ways that parallel advancements in computer science through discussion of several key inventions, described as "foundational devices." These discussions also point at the future of how biophysics and the genomic sciences may become more finely integrated for empowering new measurement paradigms for biological investigations.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Schwartz DCdoi
10.1016/j.bpj.2019.07.038subject
Has Abstractpub_date
2019-12-03 00:00:00pages
2047-2053issue
11eissn
0006-3495issn
1542-0086pii
S0006-3495(19)30627-7journal_volume
117pub_type
杂志文章,评审abstract::We studied the cold unfolding of myoglobin with Fourier transform infrared spectroscopy and compared it with pressure and heat unfolding. Because protein aggregation is a phenomenon with medical as well as biotechnological implications, we were interested in both the structural changes as well as the aggregation behav...
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journal_title:Biophysical journal
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