Abstract：
INTRODUCTION:Decompression sickness (DCS) results from a decrease in ambient pressure leading to supersaturation of tissues with inert gas and bubble formation. Perfluorocarbons (PFCs) are able to dissolve vast amounts of non-polar gases. Intravenous (IV) PFC emulsions reduce both morbidity and mortality associated with DCS, but the mechanism of this protective effect has not yet been demonstrated. METHODS:Juvenile Dorper-cross sheep (n = 31) were anaesthetised and instrumented for physiological monitoring, IV fluid administration and blood sampling. Animals were compressed in air in a hyperbaric chamber to 608 kPa for 30 minutes and then rapidly decompressed. Upon decompression, animals were randomly assigned to receive 6 mmol per L of PFC or saline over 10 minutes beginning immediately after chamber exit. Arterial and mixed venous bloods were drawn at 5, 10, 15, 30, 60 and 90 minutes to examine pH, partial pressures of oxygen and carbon dioxide, oxygen saturation and electrolytes. RESULTS:Compared to saline, PFC administration increased arterial oxygen content (16.33 ± 0.28 vs. 14.68 ± 0.26 ml per dL, P < 0.0001), mixed venous oxygen content (12.56 ± 0.28 vs. 11.62 ± 0.26 ml per dL, P = 0.0167), oxygen delivery (14.83 ± 0.28 vs. 13.39 ± 0.26 mmol per L kg, P = 0.0003) and tissue oxygen consumption (3.30 ± 0.15 vs. 2.78 ± 0.13 mmol per L kg, P = 0.0149) but did not increase extraction ratio (0.22 ± 0.012 vs. 0.21 ± 0.011, P = 0.5343). CONCLUSIONS:It is likely that the improved oxygenation explains, at least in part, the previously-observed therapeutic effects of PFCs in DCS.
journal_name
Diving Hyperb Medjournal_title
Diving and hyperbaric medicineauthors
Smith CR,Parsons JT,Zhu J,Spiess BDsubject
Has Abstractpub_date
2012-03-01 00:00:00pages
10-7issue
1eissn
1833-3516issn
2209-1491journal_volume
42pub_type
杂志文章abstract：:It is increasingly common for recreational scuba divers to use breathing mixtures enriched with additional oxygen ('nitrox' or 'enriched air nitrogen') and for technical divers to be exposed to elevated partial pressures of oxygen for prolonged periods of time. The National Oceanic and Atmospheric Administration oxyge...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2008-06-01 00:00:00
abstract：:Sphenoid sinus mucocele is a rare cystic lesion. It grows gradually and causes visual disturbances, ocular motility abnormalities and headache due to cavernous sinus compression. Sudden change in sinus cavity volume by a barotrauma may compress a mucocele and precipitate symptoms that may easily be confused with decom...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：10.28920/dhm50.2.168-172
更新日期：2020-06-30 00:00:00
abstract：:We present a case of cerebral venous gas embolism. Our patient made a complete neurological recovery after hyperbaric oxygen therapy (HBOT). The principles of HBOT, compressing and eliminating air bubbles and decreasing Β-2 integrin function, thus improving microcirculation, can only be beneficial in a situation where...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2012-06-01 00:00:00
abstract：INTRODUCTION:In-water resuscitation has recently been proposed in the European resuscitation guidelines. Initiation of mechanical ventilation underwater might be considered when an immediate ascent to the surface is impossible or dangerous. The present study evaluated the feasibility of such ventilation underwater. ME...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2013-06-01 00:00:00
abstract：INTRODUCTION:Running out of air, buoyancy problems and rapid ascents are known risk factors for diving morbidity and mortality. The effects of the diving environment and equipment and the influence of individual diver characteristics on these risks were studied. METHODS:Between 1995 and 2004, Project Dive Exploration ...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2009-12-01 00:00:00
abstract：:In an emergency, life support can be provided during recompression or hyperbaric oxygen therapy using very basic equipment, provided the equipment is hyperbaric-compatible and the clinicians have appropriate experience. For hyperbaric critical care to be provided safely on a routine basis, however, a great deal of pre...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章,评审
doi：
更新日期：2015-03-01 00:00:00
abstract：:Two cases are presented of divers suffering epileptic seizure and loss of consciousness as a result of probable cerebral arterial gas embolism (CAGE). Both cases had apparently problem-free dives with no obvious provocation for CAGE, though one case may have been having repeated embolisms for some time in their diving...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2008-03-01 00:00:00
abstract：:Vomiting and aspiration of gastric contents into the airways and lungs is a common and well-known clinicopathological entity. This phenomenon might also occur in underwater diving, where it can lead to life-threatening or fatal situations. This article presents two incidents involving diving-related vomiting with asso...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：10.28920/dhm48.1.36-39
更新日期：2018-03-31 00:00:00
abstract：:Divers from many countries travel to explore various diving sites worldwide. In 2005, the Divers Alert Network (DAN) wrote guidelines for recreational diving and diabetes mellitus, but there is no up-to-date consensus or adoption of international guidelines on diabetes and diving. There are also large differences betw...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2012-12-01 00:00:00
abstract：:Firstly I would like to thank SPUMS members for making me a Life Member of SPUMS; I was surprised and greatly honoured by the award. I also want to confirm and expand on the findings on carbon dioxide absorbents reported by David Harvey et al. For about 35 years, I was the main player in deciding which absorbent went ...
journal_title：Diving and hyperbaric medicine
pub_type： 评论,信件
doi：
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Colorectal cancer is the third most common form of cancer and colorectal surgery is the treatment of choice in local disease. Anastomotic leakage following colorectal surgery is a major complication with a high incidence and mortality. Adjuvant hyperbaric oxygen treatment (HBOT) may be associated with reduct...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章,meta分析
doi：10.28920/dhm48.3.173-185
更新日期：2018-09-30 00:00:00
abstract：:Exposure to hyperoxia is associated with oxidative stress and is known to cause inflammation in the lung and the airways. Exhaled nitric oxide concentration (FENO) is a marker of some inflammatory processes in the lung and airways, and is reduced immediately after a single session of hyperbaric oxygen (HBO) exposure. ...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2009-06-01 00:00:00
abstract：:Divers are exposed to circulatory stress that directly affects the endothelial lining of blood vessels, and even asymptomatic dives are associated with inflammatory responses, microparticle release and endothelial dysfunction. As humans age, there is a relative increase in the risk of cardiovascular disease, attribute...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章,评审
doi：
更新日期：2015-12-01 00:00:00
abstract：:The South Pacific Underwater Medicine Society (SPUMS) diving medical for recreational scuba divers was last reviewed in 2011. From 2011 to 2019, considerable advancements have occurred in cardiovascular risk assessment relevant to divers. The SPUMS 48th (2019) Annual Scientific Meeting theme was cardiovascular risk as...
journal_title：Diving and hyperbaric medicine
pub_type： 指南
doi：10.28920/dhm50.3.273-277
更新日期：2020-09-30 00:00:00
abstract：INTRODUCTION:We have previously shown that hyperbaric oxygen treatment (HBOT) increased insulin sensitivity in men who were obese or overweight, both with and without type 2 diabetes. The aim of this study was to test whether this insulin-sensitising effect is seen in hyperbaric air (HA). METHODS:Men with type 2 diabe...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章,随机对照试验
doi：10.28920/dhm50.4.386-390
更新日期：2020-12-20 00:00:00
abstract：INTRODUCTION:Scuba diving involves risks, and candidates in Australia usually have a medical evaluation prior to undertaking a diving course. Hyperbaric physicians act as secondary referral practitioners for these assessments. This study aimed to identify reasons for these secondary referrals, and document the assessme...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
abstract：:Recreational scuba diving is a popular leisure activity with the number of divers reaching several millions worldwide. Scuba diving represents a huge challenge for integrative physiology. In mammalian evolution, physiological reflexes developed to deal with lack of oxygen, rather than with an excess, which makes adapt...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章,评审
doi：
更新日期：2013-09-01 00:00:00
abstract：:Inner-ear decompression sickness (DCS) is an incompletely understood and increasingly recognized condition in compressed-air divers. Previous reports show a high association of inner-ear DCS with persistent foramen ovale (PFO), suggesting that a moderate-to-severe right-to-left shunt might represent a major predisposi...
journal_title：Diving and hyperbaric medicine
pub_type： 信件
doi：
更新日期：2015-06-01 00:00:00
abstract：:Cerebral arterial gas embolism (CAGE) from breath-holding or inadequate exhalation during ascent is a well-recognised complication of scuba diving. It does not usually occur with breath-hold (BH) diving in those with normal lungs, as the volume of gas in the lungs on surfacing cannot exceed what it was on leaving the ...
journal_title：Diving and hyperbaric medicine
pub_type：
doi：10.28920/dhm49.4.304-305
更新日期：2019-12-20 00:00:00
abstract：INTRODUCTION:After a maximal apnoea, breath-hold divers must restore O2 levels and clear CO2 and lactic acid produced. High intensity interval training (HIIT) and inspiratory muscle training (IMT) could be employed with the aim of increasing recovery capacity. This study aimed to evaluate the relative effects of IMT ve...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章,随机对照试验
doi：10.28920/dhm50.4.318-324
更新日期：2020-12-20 00:00:00
abstract：INTRODUCTION:Various prescribed and over-the-counter medications may theoretically be incompatible with the diving environment. Anecdotally, it is known divers regularly take medications around the time of their diving activities for different health conditions, possibly ignoring the recommendations not to do so. As pa...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2011-03-01 00:00:00
abstract：INTRODUCTION:This study identified pre-existing medical conditions among scuba diving fatalities in Australia from 2001 to 2013, inclusive, and assessed whether these conditions likely contributed to the deaths. METHODS:The National Coronial Information System (NCIS) was searched for scuba diving-related cases during ...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：10.28920/dhm50.2.98-104
更新日期：2020-06-30 00:00:00
abstract：:Gas micronuclei are gas-filled voids in liquids from which bubbles can form at low gas supersaturation. If water is depleted of gas micronuclei, high gas supersaturation is required for bubble formation. This high gas supersaturation is required in part to overcome the Laplace pressure at the point of transition from ...
journal_title：Diving and hyperbaric medicine
pub_type： 信件
doi：10.28920/dhm49.1.64
更新日期：2019-03-31 00:00:00
abstract：:Dear Editor, By focussing on the details of the Watson case, I believe Bryan Walpole has missed the thrust of my earlier letter. I agree this was a complex case, which is why I deliberately avoided the murky specifics in order to consider the 'big-picture' ramifications of the judgement. My concerns relate to the pote...
journal_title：Diving and hyperbaric medicine
pub_type： 信件
doi：
更新日期：2011-12-01 00:00:00
abstract：:Livedoid vasculopathy is a painful, ulcerating condition of the lower legs, ankles and feet with the typical histological feature of hyalinising vascular change of dermal blood vessels with minimal inflammation. Therapeutic interventions have been diverse and varyingly successful. We report a biopsy-proven case in a 2...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
abstract：:Commercial or occupational breath-hold (BH) harvest divers along the coast and islands of Japan are collectively called Ama divers. Repetitive BH diving by Ama divers may place them at risk of developing neurological decompression sickness (DCS). We report a 74-year-old Ama diver who demonstrated right hemiparesis dur...
journal_title：Diving and hyperbaric medicine
pub_type：
doi：10.28920/dhm48.4.262-263
更新日期：2018-12-24 00:00:00
abstract：INTRODUCTION:In studies of decompression procedures, ultrasonically detected venous gas emboli (VGE) are commonly used as a surrogate outcome if decompression sickness (DCS) is unlikely to be observed. There is substantial variability in observed VGE grades, and studies should be designed with sufficient power to detec...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2014-03-01 00:00:00
abstract：:Divers suspected of suffering decompression illness (DCI) in locations remote from a recompression chamber are sometimes treated with in-water recompression (IWR). There are no data that establish the benefits of IWR compared to conventional first aid with surface oxygen and transport to the nearest chamber. However, ...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章,评审
doi：10.28920/dhm48.2.84-95
更新日期：2018-06-30 00:00:00
abstract：BACKGROUND:Since 2009, the United Kingdom diving incident data show an increasing number of fatalities in the over-50s age group. Previous studies also suggest some divers take cardiac medications. Since 2001, diving medicals have not been mandatory for UK sport divers. Instead, an annual medical self-certification for...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2015-09-01 00:00:00
abstract：:It has been shown that a single bout of exercise performed 20 hours prior to hyperbaric exposure reduces bubble formation and increases survival in rats. Heat shock proteins (HSPs) are stress proteins expressed in cells that are exposed to different stressors. HSPs are known to protect cells, by binding to proteins an...
journal_title：Diving and hyperbaric medicine
pub_type： 杂志文章
doi：
更新日期：2008-12-01 00:00:00
