Abstract：
STUDY DESIGN:Narrative review. OBJECTIVES:To discuss how electrophysiology may contribute to future clinical trials in spinal cord injury (SCI) in terms of: (1) improvement of SCI diagnosis, patient stratification and determination of exclusion criteria; (2) the assessment of adverse events; and (3) detection of therapeutic effects following an intervention. METHODS:An international expert panel for electrophysiological measures in SCI searched and discussed the literature focused on the topic. RESULTS:Electrophysiology represents a valid method to detect, track, and quantify readouts of nerve functions including signal conduction, e.g., evoked potentials testing long spinal tracts, and neural processing, e.g., reflex testing. Furthermore, electrophysiological measures can predict functional outcomes and thereby guide rehabilitation programs and therapeutic interventions for clinical studies. CONCLUSION:Objective and quantitative measures of sensory, motor, and autonomic function based on electrophysiological techniques are promising tools to inform and improve future SCI trials. Complementing clinical outcome measures, electrophysiological recordings can improve the SCI diagnosis and patient stratification, as well as the detection of both beneficial and adverse events. Specifically composed electrophysiological measures can be used to characterize the topography and completeness of SCI and reveal neuronal integrity below the lesion, a prerequisite for the success of any interventional trial. Further validation of electrophysiological tools with regard to their validity, reliability, and sensitivity are needed in order to become routinely applied in clinical SCI trials.
journal_name
Spinal Cordjournal_title
Spinal cordauthors
Hubli M,Kramer JLK,Jutzeler CR,Rosner J,Furlan JC,Tansey KE,Schubert Mdoi
10.1038/s41393-019-0331-zsubject
Has Abstractpub_date
2019-11-01 00:00:00pages
909-923issue
11eissn
1362-4393issn
1476-5624pii
10.1038/s41393-019-0331-zjournal_volume
57pub_type
杂志文章,评审相关文献
SPINAL CORD文献大全abstract：STUDY DESIGN:Quasi-experimental translational study with pre- and post-measures. OBJECTIVES:To determine the effects of the Spinal Cord Injury and Physical Activity in the Community (SCIPA Com) intervention on leisure-time physical activity (LTPA) and associated outcomes among participants with spinal cord injury (SCI...
journal_title：Spinal cord
pub_type： 杂志文章,多中心研究
doi：10.1038/sc.2015.235
更新日期：2016-10-01 00:00:00
abstract：STUDY DESIGN:Systematic review and meta-analysis. OBJECTIVE:To determine the risk factors predictive of dysphagia after a spinal cord injury (SCI). SETTING:None. METHODS:A comprehensive literature search was performed in five scientific databases for English articles that identified risk factors for dysphagia after ...
journal_title：Spinal cord
pub_type： 杂志文章,meta分析
doi：10.1038/s41393-018-0170-3
更新日期：2018-12-01 00:00:00
abstract：:Ejaculatory failure and poor fertility are major problems for patients with spinal cord injury, who wish to father children. Artificial ejaculation in conjunction with assisted reproductive techniques has been proposed as a possible solution to this situation. In this paper, we presented the case of a tetraplegic man ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3100381
更新日期：1997-03-01 00:00:00
abstract：STUDY DESIGN:A randomized, prospective, double-blind, placebo-controlled clinical trial. OBJECTIVES:To determine the effect of indomethacin on the prevention of heterotopic ossification (HO) following spinal cord injury (SCI). SETTING:County Hospital, Miami, Florida, USA. METHODS:Sixteen patients were treated with s...
journal_title：Spinal cord
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.sc.3101166
更新日期：2001-07-01 00:00:00
abstract：STUDY DESIGN:Prospective repeated measures. OBJECTIVES:Evaluate intra-rater agreement of repeated motor and sensory scores at individual spinal levels. SETTING:Non-profit pediatric rehabilitation center. METHODS:Fifty-eight youth with complete spinal cord injury undergoing two neurological exams. Agreement between e...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2008.66
更新日期：2009-01-01 00:00:00
abstract：STUDY DESIGN:Propensity score-matched, retrospective cohort study. OBJECTIVES:To determine the risk of developing Alzheimer's disease (AD) in patients with spinal cord injury (SCI). SETTING:The present study used Taiwan's National Health Insurance Research Database. METHODS:A total of 9257 patients who had ⩾2 ambula...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-017-0009-3
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVE:To compare self-reported health, independence, and depression in two samples of people with spinal cord injury (SCI), one which receives regular, comprehensive outpatient health care follow-up and one that does not. DESIGN:Exploratory study of self-reported secondary conditions in 235 individuals with SCI wh...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3100957
更新日期：2000-02-01 00:00:00
abstract：STUDY DESIGN:Prospective, observational OBJECTIVES: To evaluate agreement between a reference method (doubly labelled water, DLW) of total energy expenditure (TEE) and published equations for estimating energy requirements in acute spinal cord injury (SCI). SETTING:Victoria, Australia METHODS: Twenty participants (18 ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-019-0253-9
更新日期：2019-07-01 00:00:00
abstract：STUDY DESIGN:Case report of a 7-month-old boy, who developed acute transverse myelitis after diphtheria-tetanus-pertussis immunization. OBJECTIVES:To describe the clinical course of acute transverse myelitis in an infant and to review the literature regarding the association of acute transverse myelitis and vaccinatio...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101879
更新日期：2006-11-01 00:00:00
abstract：STUDY DESIGN:This was a psychometric study. OBJECTIVES:To determine the validity of the Spanish version of the World Health Organization Quality of Life instrument (WHOQOL-BREF) for its use in persons with traumatic spinal cord injury and, as secondary objectives, to correlate the results with variables such as functi...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-018-0139-2
更新日期：2018-10-01 00:00:00
abstract：STUDY DESIGN:A combination of review of case notes and outpatient follow-up. OBJECTIVE:To evaluate the effectiveness of the modified Girdlestones-Taylor procedure in patients with spinal cord injury (SCI). SETTING:Princess Royal Spinal Injuries Centre (PRSIC), Northern General Hospital, Sheffield, UK. METHODS:Nine p...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101924
更新日期：2006-12-01 00:00:00
abstract：STUDY DESIGN:A case report of Neisseria sicca/subflava discitis in a healthy elderly female. OBJECTIVE:To report a rare case, which is usually seen exclusively in children. SETTING:Stoke on Trent, England. METHOD:Case report, a 65-year-old female with a 6 month history of back and bilateral leg pain. X-rays showed c...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101497
更新日期：2003-10-01 00:00:00
abstract：STUDY DESIGN:Prospective cross-sectional study. OBJECTIVES:To investigate residual urine volumes after intermittent catheterization (IC) in men with spinal cord injury (SCI) and the effect of residual urine on the rate of symptomatic urinary tract infections (UTIs). SETTING:Single SCI rehabilitation center in Switzer...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2013.81
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND CONTEXT:Spondyloarthropathy has been described radiographically in patients following paralysis from spinal cord trauma. Onset of these findings after cauda equina syndrome have not been reported previously. Furthermore, the magnetic resonance documentation of its early evolution has not been recorded. PURP...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2014.190
更新日期：2015-03-01 00:00:00
abstract：STUDY DESIGN:Literature review. OBJECTIVES:Upper extremity (UE) joint degeneration, particularly at the shoulder, detrimentally influences functional independence, quality of life, cardiovascular disease risk, and life expectancy of individuals following spinal cord injury (SCI). This review (1) describes UE use for t...
journal_title：Spinal cord
pub_type： 杂志文章,评审
doi：10.1038/sj.sc.3101070
更新日期：2000-11-01 00:00:00
abstract：STUDY DESIGN:Intervention study. OBJECTIVES:The present study aimed at examining whether spinal and/or peripheral alterations are in the origin of neuromuscular fatigue development induced by intermittent neuromuscular electrical stimulation (NMES) in subjects with complete spinal cord injury (SCI). SETTING:Neurologi...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2013.172
更新日期：2014-03-01 00:00:00
abstract：STUDY DESIGN:A survey administered to 66 individuals with spinal cord injury (SCI) implementing a choice-based conjoint (CBC) analysis. Six attributes with three levels each were defined and used to generate choice sets with treatment scenarios. Patients were asked to choose the scenario that they preferred most. OBJE...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2010.65
更新日期：2011-01-01 00:00:00
abstract：:It is important to consider a differential diagnosis between paralysis on an organic basis and paralysis and disability due to psychological mechanisms in people with physical impairment secondary to trauma, without evidence of organic etiology. We review the most dramatic type of conversion disorder (CD)-'Conversion ...
journal_title：Spinal cord
pub_type： 杂志文章,评审
doi：10.1038/sj.sc.3101308
更新日期：2002-07-01 00:00:00
abstract：OBJECTIVES:To report the simultaneous occurrence of generalised spinal cord atrophy, Chiari-I malformation, and syringomyelia. SETTING:Vienna, Austria. CASE DESCRIPTION:An 83-year old woman presented with predominantly lower limb and distal tetraparesis, diffuse wasting, spasticity of both lower limbs, contractures, ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101138
更新日期：2001-03-01 00:00:00
abstract：STUDY DESIGN:Intra-rater reliability study, cross-sectional design. OBJECTIVES:To determine reliability of the International Standards for Neurological Classification of Spinal Cord Injury (ISCSCI) motor and sensory exam in children. SETTING:Nonprofit pediatric hospital. METHODS:In all, 74 subjects had two trials of...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101987
更新日期：2007-06-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to investigate the pharmacological effects of long-term oral tadalafil treatment on the corpus cavernosum function in rats subjected to experimental spinal cord transection (SCT). METHODS:Thirty young adult, male Sprague–Dawley rats were randomly divided into five groups (n¼ 6, eac...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2013.61
更新日期：2013-09-01 00:00:00
abstract：STUDY DESIGN:Cohort cross-sectional study. OBJECTIVE:To investigate the relationship between cardiac vagal activity and left ventricular filling at rest and during vagal stimulation, via the cold face test (CFT), in individuals with spinal cord injury (SCI). SETTING:University-based laboratory at Brock University, St...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-018-0224-6
更新日期：2019-05-01 00:00:00
abstract：STUDY DESIGN:A cross-sectional study with comparison group. OBJECTIVES:To examine the effect of rugby training on the blood antioxidant capacity in able-bodied and wheelchair rugby players with tetraplegia. SETTING:Poland. METHODS:Four groups of subjects participated in the study: sedentary able-bodied males (group ...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sc.2011.134
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVE:To draw attention to inadequate care received by some spinal cord injury patients after discharge from the regional spinal injury center. SETTING:Regional Spinal Injuries Centre, Southport, UK. METHODS:Presence of the urethral stricture was not recognised in a 69-year-old male with T-3 paraplegia, who atten...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101576
更新日期：2004-08-01 00:00:00
abstract：STUDY DESIGN:A qualitative study with an emergent design using semi-structured interviews in focus groups. OBJECTIVES:To explore the expectations, experiences and desires among individuals who are prescribed drugs for spinal cord injury (SCI) neuropathic pain (NP). SETTING:SCI rehabilitation centre. METHODS:Eighteen...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-020-00553-w
更新日期：2020-09-25 00:00:00
abstract：OBJECTIVE:To determine the long-term mortality rate and the types of morbidity among all people with spinal cord injuries (SCI) that occurred during the 1948 Israel War of Independence. METHOD:Chart review and telephone interviews for collecting demographic data, injury characteristics, marital status, physical activi...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101043
更新日期：2000-09-01 00:00:00
abstract：STUDY DESIGN:Cross-sectional study by mail survey of participation in productive activities of individuals who sustained a spinal cord injury (SCI) in Quebec from 1970 to 1993. OBJECTIVES:To determine the level of productivity outcomes of a representative sample and to determine the relationship between the productivi...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3100918
更新日期：1999-10-01 00:00:00
abstract：STUDY DESIGN:Cross-sectional study. OBJECTIVE:To determine the prevalence and potential risk factors of vitamin D deficiency and insufficiency among Malaysian children with spina bifida. SETTING:Four Malaysian tertiary hospitals. METHODS:Children with spina bifida were assessed for potential demographic, disease sev...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/s41393-020-0441-7
更新日期：2020-09-01 00:00:00
abstract：STUDY DESIGN:Multicenter, open, prospective, before-after study. OBJECTIVE:To assess the efficacy and safety of sildenafil therapy for erectile dysfunction in patients with spinal cord injury, and the association between the response to sildenafil and factors such as causes and levels of spinal cord injury, grade of A...
journal_title：Spinal cord
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/sj.sc.3101210
更新日期：2001-12-01 00:00:00
abstract：STUDY DESIGN:A controlled, descriptive and comparative, questionnaire based study. OBJECTIVES:To describe the bowel function of spinal cord injured (SCI) patients and compare this with a general community control group. SETTING:Christchurch, New Zealand. METHODOLOGY:A postal questionnaire was sent out to past SCI pa...
journal_title：Spinal cord
pub_type： 杂志文章
doi：10.1038/sj.sc.3101058
更新日期：2000-12-01 00:00:00
