Spinal cord injury and Alzheimer's disease risk: a population-based, retrospective cohort study.

Abstract:

STUDY DESIGN:Propensity score-matched, retrospective cohort study. OBJECTIVES:To determine the risk of developing Alzheimer's disease (AD) in patients with spinal cord injury (SCI). SETTING:The present study used Taiwan's National Health Insurance Research Database. METHODS:A total of 9257 patients who had ⩾2 ambulatory visits with a diagnosis of SCI in 2001 were included in the SCI group. The non-SCI group consisted of 37,028 propensity score-matched patients without a diagnosis of SCI. The cumulative incidence of AD was estimated for each of the two patient groups using the Kaplan-Meier method. Stratified Cox proportional hazard regression was then employed to assess the influence of SCI on the risk of AD. RESULTS:During the follow-up period, 25 subjects in the SCI group and 57 in the non-SCI group developed AD. The cumulative incidence of AD in the SCI group was higher than in the non-SCI group (P = 0.0168); and the hazard ratio of AD for the SCI group, as compared to the non-SCI group, was 1.71 (95% CI 1.06-2.76, P = 0.0273). CONCLUSIONS:This study suggests that patients with SCI have an increased risk of developing AD.

journal_name

Spinal Cord

journal_title

Spinal cord

authors

Yeh TS,Ho YC,Hsu CL,Pan SL

doi

10.1038/s41393-017-0009-3

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

151-157

issue

2

eissn

1362-4393

issn

1476-5624

pii

10.1038/s41393-017-0009-3

journal_volume

56

pub_type

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