Neural and muscular mechanisms of electrically induced fatigue in patients with spinal cord injury.

Abstract:

STUDY DESIGN:Intervention study. OBJECTIVES:The present study aimed at examining whether spinal and/or peripheral alterations are in the origin of neuromuscular fatigue development induced by intermittent neuromuscular electrical stimulation (NMES) in subjects with complete spinal cord injury (SCI). SETTING:Neurological Rehabilitation Center CMN Propara, Montpellier, France. METHODS:Thirteen volunteers with complete SCI participated in the study. The right triceps surae muscle was fatigued using a 30-Hz NMES protocol (2 s ON-2 s OFF) composed of three series of five trains. Spinal excitability (assessed by the H-reflex), muscle excitability (assessed by the M-wave), muscle contractile properties (assessed by mechanical response parameters) and torque evoked by NMES were tested before and after each five-train series. RESULTS:NMES-evoked torque significantly decreased throughout the protocol (P<0.001). This decrease was accompanied by a significant increase in M-wave amplitude (P<0.001), whereas H-reflex and the Hmax/Mmax ratio were not significantly modified. The amplitude of the mechanical response was significantly decreased at the end of the protocol (P<0.05). CONCLUSION:The results indicate significant fatigue development, which was attributed to impaired cross-bridge force-generating capacity, without modification of spinal excitability nor muscle excitability.

journal_name

Spinal Cord

journal_title

Spinal cord

authors

Papaiordanidou M,Varray A,Fattal C,Guiraud D

doi

10.1038/sc.2013.172

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

246-50

issue

3

eissn

1362-4393

issn

1476-5624

pii

sc2013172

journal_volume

52

pub_type

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