Management of neuropathic pain following spinal cord injury: now and in the future.


OBJECTIVE:To provide an overview of our current understanding of the problem of neuropathic pain following spinal cord injury (SCI) and to suggest possible therapeutic options in the near future. METHODS:Original research articles, reviews and book chapters on the subject of pain and SCI. RESULTS:Neuropathic pain following SCI has presented a challenge not only for traditional concepts of how pain occurs but also for more recent conceptualizations. We have made substantial progress in identifying the common types of pain that occur following SCI, determining the prevalence and characteristics of pain, investigating some of the pathophysiological changes in the nervous system that may contribute to the presence of neuropathic SCI pain and examining the effectiveness of some treatments. However major challenges remain. We still need to reach consensus on an SCI pain taxonomy; our understanding of mechanisms and the relative contribution of changes in the periphery, spinal cord and brain is incompletely understood; there are few studies that indicate effective treatment options, particularly for neuropathic SCI pain; and treatment of the biological and psychological contributors to pain is often fragmented. CONCLUSION:Recent studies suggest the potential usefulness of new treatment approaches such as selective pharmacological agents, application of novel neurostimulation techniques and the use of cognitive approaches to modify the pain experience. Our increasing understanding of the problem combined with the promise of these new approaches offers hope for improved management of neuropathic pain following SCI in the near future.


Spinal Cord


Spinal cord


Siddall PJ




Has Abstract


2009-05-01 00:00:00














  • Soluble complement receptor type 1 inhibits complement system activation and improves motor function in acute spinal cord injury.

    abstract:STUDY DESIGN:Spinal cord injured rat model, treated with soluble complement receptor type 1 (sCR1). SETTING:Experimental Animal Department of China Medical University, Shenyang, China. OBJECTIVES:Soluble CR1 is a powerful inhibitor of complement activation. In this study, we investigate the effectiveness of sCR1 on s...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Li LM,Li JB,Zhu Y,Fan GY

    更新日期:2010-02-01 00:00:00

  • Static respiratory pressures in patients with post-traumatic tetraplegia.

    abstract::The purpose of this study was to examine ventilatory muscle strength as represented by static respiratory pressures in 30 tetraplegic patients with a complete lesion between the fifth and the eighth cervical vertebrae. The Inspiratory/Expiratory Pressure Meter was used to obtain maximum static expiratory mouth pressur...

    journal_title:Spinal cord

    pub_type: 临床试验,杂志文章


    authors: Gounden P

    更新日期:1997-01-01 00:00:00

  • Descriptive study of earthquake-related spinal cord injury in Nepal.

    abstract:STUDY DESIGN:Descriptive study. OBJECTIVES:To describe the epidemiological features of spinal cord injury (SCI) following the 2015 earthquakes in Nepal. SETTING:Spinal Injury Rehabilitation Centre, Kavre, Nepal. METHODS:Data were collected from the medical records of all earthquake-related patients seen from 25 Apri...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Groves CC,Poudel MK,Baniya M,Rana C,House DR

    更新日期:2017-07-01 00:00:00

  • Neurological issues.

    abstract::The case histories of two patients who had had a spinal cord injury (SCI) were selected by the senior author and sent to four experts in the field of SCI. Based on the 1992 American Spinal Injury Association (ASIA) and International Medical Society of Paraplegia (IMSOP) standards, the four participants plus the senior...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Donovan WH,Brown DJ,Ditunno JF Jr,Dollfus P,Frankel HL

    更新日期:1997-05-01 00:00:00

  • Patient preferences for next generation neural prostheses to restore bladder function.

    abstract:STUDY DESIGN:A survey administered to 66 individuals with spinal cord injury (SCI) implementing a choice-based conjoint (CBC) analysis. Six attributes with three levels each were defined and used to generate choice sets with treatment scenarios. Patients were asked to choose the scenario that they preferred most. OBJE...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Sanders PM,Ijzerman MJ,Roach MJ,Gustafson KJ

    更新日期:2011-01-01 00:00:00

  • Changes in renal function during acute spinal cord injury: implications for pharmacotherapy.

    abstract:STUDY DESIGN:Laboratory investigation in rats submitted to experimental spinal cord injury (SCI). OBJECTIVE:To characterize changes in renal function during acute SCI. METHODS:Sprague Dawley rats were subjected to severe spinal cord contusion at T8 level or to laminectomy as control. Twenty-four hours after spine sur...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Rodríguez-Romero V,Cruz-Antonio L,Franco-Bourland RE,Guízar-Sahagún G,Castañeda-Hernández G

    更新日期:2013-07-01 00:00:00

  • Patellar tendon reflex as a predictor of improving motor paralysis in complete paralysis due to cervical cord injury.

    abstract:STUDY DESIGN:A retrospective study. OBJECTIVE:We have encountered several cases of complete sensorimotor paralysis in which patellar tendon reflex (PTR) was demonstrated approximately 3 days after injury and improvement of motor paralysis was subsequently achieved. We considered that PTR apparent in the early stage af...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Morishita K,Kasai Y,Ueta T,Shiba K,Akeda K,Uchida A

    更新日期:2009-08-01 00:00:00

  • Spinal cord decompression: an endoscopically assisted approach for metastatic tumors.

    abstract:STUDY DESIGN:The paper describes a technique for complete vertebrectomy and spinal cord decompression, followed by a formal anterior column reconstruction, using endoscopic instruments. This procedure is indicated for patients with radioresistant metastasis of the thoracic spine, particularly those involving the upper ...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: McLain RF

    更新日期:2001-09-01 00:00:00

  • Syringomyelia associated with syphilitic spinal meningitis: real complication or possible association?

    abstract:STUDY DESIGN:The study has been designed as a case report. OBJECTIVE:The objective of this study was to report a rare case of syringomyelia in a patient with syphilitic spinal meningitis. SETTING:The Neurology Department, University Hospital Mohamed VI Marrakesh, Morocco. CASE REPORT:A 40-year-old Moroccan male pres...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Mebrouk Y,Chraa M,McMaughey C,Kissani N

    更新日期:2011-06-01 00:00:00

  • Employment status, hours working, and gainful earnings after spinal cord injury: relationship with pain, prescription medications for pain, and nonprescription opioid use.

    abstract:STUDY DESIGN:Cross-sectional self-report assessment. Econometric modeling. OBJECTIVES:Identify the relationship of multiple pain indicators, prescription pain medication, nonprescription opioid use, and multiple indicators of quality employment among those with spinal cord injury (SCI). SETTING:Data were collected at...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Krause JS,Dismuke-Greer CE,Reed KS,Li C

    更新日期:2020-03-01 00:00:00

  • Comparison of ambulatory versus video urodynamics in patients with spinal cord injury.

    abstract:OBJECTIVE:To compare the data obtained through video urodynamics (VUD) with those obtained through one voiding cycle ambulatory urodynamics monitoring (AUM) in patients with spinal cord injury (SCI). METHODS:A comparative study was conducted in 69 patients with SCI (mean age±s.d. 44±16.9 years), 51 men and 18 women, w...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Vírseda-Chamorro M,Salinas-Casado J,de la Marta-García M,Esteban-Fuertes M,Méndez S

    更新日期:2014-07-01 00:00:00

  • Epidural spinal cord stimulation for the control of spasticity in spinal cord injury patients lacks long-term efficacy and is not cost-effective.

    abstract::Epidural spinal cord stimulation has been used to decrease spasticity and spasms in spinal cord injury patients. However, the long-term benefits of this procedure have not been determined. We therefore conducted a retrospective study of the possible long-term efficacy of the epidural spinal cord stimulator for the rel...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Midha M,Schmitt JK

    更新日期:1998-03-01 00:00:00

  • Pelvic organ prolapse and urogynecological assessment in women with spinal cord injury.

    abstract:STUDY DESIGN:Observational cross-sectional study. OBJECTIVES:Due to weakened pelvic floor muscles, the risk of pelvic organ prolapse (POP) may increase after a spinal cord injury (SCI); hence, the aim of this study was to investigate the occurrence of POP after SCI and to evaluate the need for urogynecological consult...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Elmelund M,Biering-Sørensen F,Bing MH,Klarskov N

    更新日期:2019-01-01 00:00:00

  • Mediating effects of social support and self-concept on depressive symptoms in adults with spinal cord injury.

    abstract:STUDY DESIGN:Cross-sectional, correlational design. OBJECTIVES:To examine the effects of individual demographics, activities of daily living, social support, and self-concept on depressive symptoms in people with spinal cord injury (SCI). SETTING:A convenience sample of 135 adults with SCI was recruited from medical ...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Huang CY,Chen WK,Lu CY,Tsai CC,Lai HL,Lin HY,Guo SE,Wu LM,Chen CI

    更新日期:2015-05-01 00:00:00

  • Symptomatic postoperative spinal epidural hematoma after spine tumor surgery: Incidence, clinical features, and risk factors.

    abstract:STUDY DESIGN:Case-control study. OBJECTIVES:The objective of this study was to provide some useful information concerning the incidence, clinical features, and risk factors for symptomatic postoperative spinal epidural hematoma (SPSEH) in an isolated cohort of patients undergoing spine tumor surgery. SETTING:Hospital...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Gao X,Li L,Cao J,Zhao Y,Liu Y,Yang J,Dong L,Wan W,Liu T,Xiao J

    更新日期:2019-08-01 00:00:00

  • Content comparison of the Spinal Cord Injury Model System Database to the ICF Generic Sets and Core Sets for spinal cord injury.

    abstract:STUDY DESIGN:Mapping of the National Spinal Cord Injury Model System (SCIMS) Database (NSCID) to the International Classification of Functioning, Disability and Health (ICF). OBJECTIVES:To link the content of the latest two versions of the NSCID to the ICF; more specifically (1) to compare the content of the current N...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Maritz R,Pongpipatpaiboon K,Melvin JL,Graves DE,Prodinger B

    更新日期:2019-12-01 00:00:00

  • Neurogenic heterotopic ossification of the hands in a patient with spinal cord injury: a case report.

    abstract:STUDY DESIGN:The study was designed as a case report. OBJECTIVE:The objective of this study was to report an unusual case of bilateral neurogenic heterotopic ossification of the hands in a patient with spinal cord injury. SETTING:Physical Medicine and Rehabilitation department in Sale, Morocco. METHODS:A 47-year-old...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Bendeddouche I,Aissaoui N,Hajjaj-Hassouni N

    更新日期:2011-10-01 00:00:00

  • Neural and muscular mechanisms of electrically induced fatigue in patients with spinal cord injury.

    abstract:STUDY DESIGN:Intervention study. OBJECTIVES:The present study aimed at examining whether spinal and/or peripheral alterations are in the origin of neuromuscular fatigue development induced by intermittent neuromuscular electrical stimulation (NMES) in subjects with complete spinal cord injury (SCI). SETTING:Neurologi...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Papaiordanidou M,Varray A,Fattal C,Guiraud D

    更新日期:2014-03-01 00:00:00

  • Attentional requirements of postural control in people with spinal cord injury: the effect of dual task.

    abstract:STUDY DESIGN:Cross-sectional study. OBJECTIVES:To investigate the attentional requirements for maintaining standing balance in people with spinal cord injury (SCI) using a dual-task paradigm and to compare standing balance performance between SCI and able-bodied (AB) controls. SETTING:LaboratoryMethods:Nine adults wi...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Tse CM,Carpenter MG,Liu-Ambrose T,Chisholm AE,Lam T

    更新日期:2017-10-01 00:00:00

  • MRI in acute and subacute post-traumatic spinal cord injury: pictorial review.

    abstract:STUDY DESIGN:Pictorial review. OBJECTIVES:To illustrate MRI signs of acute and subacute injury with emphasis on evidence-based links to clinical outcome and implications for treatment. METHODS:Description of important aspects of MRI techniques and illustration of critical MRI signs important in the assessment of spin...

    journal_title:Spinal cord

    pub_type: 杂志文章,评审


    authors: Chandra J,Sheerin F,Lopez de Heredia L,Meagher T,King D,Belci M,Hughes RJ

    更新日期:2012-01-01 00:00:00

  • Sequential treatment of chronic constipation in paraplegic subjects.

    abstract::Chronic constipation is the main gastrointestinal complaint of spinal cord injury (SCI) patients, and has a significant effect on patients' lives, concerning nursing dependence, morbidity and complications. Many therapies have been proposed to treat chronic severe constipation, most of them with limited effect or bein...

    journal_title:Spinal cord

    pub_type: 临床试验,杂志文章


    authors: Badiali D,Bracci F,Castellano V,Corazziari E,Fuoco U,Habib FI,Scivoletto G

    更新日期:1997-02-01 00:00:00

  • Delayed post-traumatic syringohydromyelia after an uncomplicated fracture of the spine: case report and literature review.

    abstract::A patient who had had a traffic accident resulting with a compression fracture of the L1 vertebra but with no neurological deficits, developed urinary incontinence and weakness in his lower extremities 25 years after the spinal injury. An MRI scan of the spine revealed gliosis of the conus medullaris at the level of t...

    journal_title:Spinal cord

    pub_type: 杂志文章,评审


    authors: Güler-Uysal F,Orkun S,Cila A,Ozgirgin N

    更新日期:1996-05-01 00:00:00

  • The short-term effect of hippotherapy on spasticity in patients with spinal cord injury.

    abstract:STUDY DESIGN:Assessment of spasticity before and after hippotherapy treatment. OBJECTIVE:To evaluate the short-term effect of hippotherapy on spasticity of spinal cord injured patients (SCIs). SETTING:Swiss Paraplegic Centre, Nottwil. METHODS:32 patients with spinal cord injury with various degrees of spasticity had...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Lechner HE,Feldhaus S,Gudmundsen L,Hegemann D,Michel D,Zäch GA,Knecht H

    更新日期:2003-09-01 00:00:00

  • Spontaneous spinal subdural hematoma with spontaneous resolution.

    abstract:STUDY DESIGN:Single patient case report. OBJECTIVES:To present and discuss a case of spontaneous spinal subdural hematoma that was not associated with coagulation abnormality. SETTING:Seoul National University Hospital, Seoul, Korea. METHODS:Clinical and radiological magnetic resonance imaging follow-up of the patie...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Kang HS,Chung CK,Kim HJ

    更新日期:2000-03-01 00:00:00

  • Amenorrhoea in newly spinal cord injured women: an effect of hyperprolactinaemia?

    abstract:STUDY DESIGN:Prospective, single centre study. OBJECTIVES:Previous studies have suggested a relationship between stress reaction and elevated levels of prolactine. The aim of the present study was to investigate if there was a relationship between s-prolactine and menstrual cycle status following spinal cord injury (S...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Rutberg L,Fridén B,Karlsson AK

    更新日期:2008-03-01 00:00:00

  • "Challenges and facilitators-navigating in the landscape of spinal cord injury neuropathic pain"-a qualitative study on the use of prescribed drugs.

    abstract:STUDY DESIGN:A qualitative study with an emergent design using semi-structured interviews in focus groups. OBJECTIVES:To explore the expectations, experiences and desires among individuals who are prescribed drugs for spinal cord injury (SCI) neuropathic pain (NP). SETTING:SCI rehabilitation centre. METHODS:Eighteen...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Norrbrink C,Sörling K,Hultling C,von Kieseritzky F,Wahman K

    更新日期:2020-09-25 00:00:00

  • The effect of autonomic nervous system dysfunction on oxygen consumption during daily living activities in patients with spinal cord injury.

    abstract:STUDY DESIGN:Case-control study. OBJECTIVES:To investigate the level of autonomic nervous system dysfunction in patients with spinal cord injury and to determine its effect on the basal metabolic rate and oxygen consumption during daily living activities. SETTING:Turkish Armed Forces Rehabilitation Center, Ankara, Tu...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Yilmaz B,Göktepe S,Yaşar E,Kesikburun S,Adıgüzel E

    更新日期:2017-03-01 00:00:00

  • Controversy over the pharmacological treatments of storage symptoms in spinal cord injury patients: a literature overview.

    abstract:STUDY DESIGN:Our aim was to locate research and communicate the evidence found from scientific studies pertaining to the treatment of neurogenic detrusor overactivity (NDO) in the chronic stage of spinal cord injury (SCI). OBJECTIVE:To address the controversy over the traditional (antimuscarinics) and the 'new' treatm...

    journal_title:Spinal cord

    pub_type: 杂志文章,评审


    authors: del Popolo G,Mencarini M,Nelli F,Lazzeri M

    更新日期:2012-01-01 00:00:00

  • The characteristics of posttraumatic syringomyelia.

    abstract:STUDY DESIGN:Retrospective cross-sectional study. OBJECTIVES:To investigate the characteristics of posttraumatic symptomatic syringomyelia after spinal cord injury (SCI). SETTING:Swiss Paraplegic Centre, Nottwil, Switzerland. METHODS:The patient database was screened for patients diagnosed with posttraumatic syringo...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Krebs J,Koch HG,Hartmann K,Frotzler A

    更新日期:2016-06-01 00:00:00

  • Bowel dysfunction following spinal cord injury: a description of bowel function in a spinal cord-injured population and comparison with age and gender matched controls.

    abstract:STUDY DESIGN:A controlled, descriptive and comparative, questionnaire based study. OBJECTIVES:To describe the bowel function of spinal cord injured (SCI) patients and compare this with a general community control group. SETTING:Christchurch, New Zealand. METHODOLOGY:A postal questionnaire was sent out to past SCI pa...

    journal_title:Spinal cord

    pub_type: 杂志文章


    authors: Lynch AC,Wong C,Anthony A,Dobbs BR,Frizelle FA

    更新日期:2000-12-01 00:00:00