Abstract：
OBJECTIVES:To explore current evidence of the physiological embedding of stress to discuss whether adverse childhood experiences (ACE) causing chronic or acute stress responses may alter fundamental biological functions. METHODS:A non-systematic review of the literature was carried out using keyword searches in Pubmed and the web of science from May to October 2011. In reference to the literature identified, we examine the potential biological pathways potentially linking exposure to ACE and cancer development and progression in adulthood. RESULTS:These mechanisms, in interaction with social position, and mediated by subsequent environmental exposures, may ultimately lead to the development of cancer. The experience of acute or chronic stressors during sensitive periods of childhood development which can induce several known biological responses, are likely to have an impact on subsequent biological and behavioural functions depending on the timing of initial exposures, and subsequently mediated by later exposures. For this reason, childhood exposure to adversity is a likely source of both acute and chronic stressors, and can be examined as an important initial exposure on a pathway towards adult ill health. CONCLUSIONS:Such pathways justify a life course approach to understanding cancer aetiology, which may have its origins early in life.
journal_name
Int J Public Healthjournal_title
International journal of public healthauthors
Kelly-Irving M,Mabile L,Grosclaude P,Lang T,Delpierre Cdoi
10.1007/s00038-012-0370-0subject
Has Abstractpub_date
2013-02-01 00:00:00pages
3-11issue
1eissn
1661-8556issn
1661-8564journal_volume
58pub_type
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更新日期：2019-04-01 00:00:00
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更新日期：2018-05-01 00:00:00
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更新日期：2019-03-01 00:00:00
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更新日期：2010-10-01 00:00:00
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更新日期：2012-06-01 00:00:00
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更新日期：2011-06-01 00:00:00
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更新日期：2018-05-01 00:00:00
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更新日期：2018-05-01 00:00:00
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journal_title：International journal of public health
pub_type： 杂志文章
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更新日期：2012-06-01 00:00:00
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更新日期：2019-01-01 00:00:00
