Abstract:
OBJECTIVE:Several studies have found an increase in hippocampal volume following electroconvulsive therapy (ECT), but the effect on cortical thickness has been less investigated. We aimed to examine the effects of ECT on cortical thickness and their associations with clinical outcome. METHOD:Using 3 Tesla MRI scanner, we obtained T1-weighted brain images of 18 severely depressed patients at three time points: before, right after and 6 months after a series of ECT. The thickness of 68 cortical regions was extracted using Free Surfer, and Linear Mixed Model was used to analyze the longitudinal changes. RESULTS:We found significant increases in cortical thickness of 26 regions right after a series of ECT, mainly within the frontal, temporal and insular cortex. The thickness returned to the baseline values at 6-month follow-up. We detected no significant decreases in cortical thickness. The increase in the thickness of the right lateral orbitofrontal cortex was associated with a greater antidepressant effect, r = 0.75, P = 0.0005. None of the cortical regions showed any associations with cognitive side effects. CONCLUSION:The increases in cortical thickness induced by ECT are transient. Further multimodal MRI studies should examine the neural correlates of these increases and their relationship with the antidepressant effect.
journal_name
Acta Psychiatr Scandjournal_title
Acta psychiatrica Scandinavicaauthors
Gbyl K,Rostrup E,Raghava JM,Carlsen JF,Schmidt LS,Lindberg U,Ashraf A,Jørgensen MB,Larsson HBW,Rosenberg R,Videbech Pdoi
10.1111/acps.13068subject
Has Abstractpub_date
2019-09-01 00:00:00pages
205-216issue
3eissn
0001-690Xissn
1600-0447journal_volume
140pub_type
杂志文章abstract::A study sample of 50 patients suffering from schizophrenia was examined at readmission and thereafter every second week until each patient had been interviewed five times i.e. eight weeks in total. Three types of recovery are identified, one with full and two with partial recovery of delusional beliefs. In patients wi...
journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1600-0447.1995.tb09609.x
更新日期:1995-12-01 00:00:00
abstract:OBJECTIVE:To examine the reliability of a brief instrument to assess coping with symptoms by patients with psychotic illness. METHOD:A semi-structured interview (MACS) was developed to assess the amounts of distress, control and coping in relation to psychotic symptoms. Two raters interviewed 23 symptomatic but stable...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0447.2001.00324.x
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abstract::The aim of this 12-week, double-blind, parallel group, placebo-controlled study was to compare paroxetine with clomipramine in 367 patients with DSM-III-R defined panic disorder. Efficacy assessments included the daily panic attack diary, the Clinical Global Impression Scale, the Hamilton Anxiety Rating Scale, the Mar...
journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1600-0447.1997.tb00388.x
更新日期:1997-02-01 00:00:00
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1994.tb08093.x
更新日期:1994-03-01 00:00:00
abstract::As part of a Nordic comparative study on contact rates of new patients and use of services in seven catchment areas, contact rates and use of services for patients with a functional psychosis during a 1-year follow-up period were investigated. The highest contact rates were found in two large city catchment areas in S...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1998.tb10009.x
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:To examine factors contributing to variance in functional outcome in first-episode psychosis (FEP) following 1 year of treatment. METHOD:Naturalistic 1-year follow-up of a FEP cohort (n = 200), from programs in four university centers in Ontario, Canada. Functional recovery was defined by 'Social and Occupat...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1600-0447.2009.01346.x
更新日期:2009-08-01 00:00:00
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1975.tb00047.x
更新日期:1975-11-01 00:00:00
abstract:OBJECTIVE:'Crisis cards' state patients' treatment details and preferences in anticipation of a later occasion when the patient might be too ill to express them directly. We assessed the feasibility of introducing 'crisis cards', or a collaborative form of them, 'joint crisis plans', into a sectorized community psychia...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1999.tb10914.x
更新日期:1999-07-01 00:00:00
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1997.tb10157.x
更新日期:1997-10-01 00:00:00
abstract:OBJECTIVE:Lycanthropy is an unusual psychiatric syndrome involving the delusion of being an animal. Cotard's syndrome is another rare condition in which the patient has nihilistic delusions and ideation of immortality. We report a psychiatric patient who had both syndromes simultaneously. METHOD:A single case was repo...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2004.00438.x
更新日期:2005-03-01 00:00:00
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2005.00600.x
更新日期:2005-12-01 00:00:00
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1986.tb06252.x
更新日期:1986-10-01 00:00:00
abstract::Based on the theory of Henry & Short, it was predicted that suicide rates should be higher and homicide rates lower in countries where the quality of life is better. In 1980, for a sample of 43 countries, this prediction was confirmed for some components of the quality of life (psychological well-being) but not for ot...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1990.tb05459.x
更新日期:1990-04-01 00:00:00
abstract::The prevalence of mental disorders in a representative sample of old people in Gothenburg, Sweden, was studied at 70, 75 and 79. The study comprised 392 subjects at 70, 302 subjects at 75 and 203 at 79. A case was defined by cut-off points on symptom and sign rating scales, and diagnoses were defined operationally as ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1984.tb02526.x
更新日期:1984-06-01 00:00:00
abstract::All cases from the county, who were subjected to post-mortem examination at the Department of Forensic Medicine, University of Lund with a diagnosis of suicide during 1949-1984, were compared with the inpatient register at the Department of Psychiatry, University Hospital, Lund during 1949-1969. During these years all...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1987.tb05628.x
更新日期:1987-10-01 00:00:00
abstract::This investigation studied by direct interviews in a randomly selected sample of 58 Swedish unbroken families, factors of importance for the father's experience of his preschool child. The father's experience of his child was shown to correlate with the child's experience of him. Fathers experiencing their child in a ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1980.tb00563.x
更新日期:1980-01-01 00:00:00
abstract::In one of the hypotheses on the causes of schizophrenia it is proposed that viruses may play a role in the etiology and pathogenesis of at least some forms of schizophrenia. In our study, 30 healthy adults and 30 schizophrenic patients were investigated for humoral and cellular immunity against herpes simplex virus (H...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1986.tb02739.x
更新日期:1986-06-01 00:00:00
abstract::Twenty patients with delirium tremens and related states were investigated from the time of admission until the acute state was over. Using strict diagnostic criteria the material was divided into two groups according to the severity of the clinical condition; nine patients had fully developed delirium tremens (grade ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1979.tb00550.x
更新日期:1979-11-01 00:00:00
abstract::By record linkage of a discharge diagnosis registry and a medical birth registry we identified 350 women with manic-depressive disease who had born a child. The total delivery outcome was poorer than expected with a high perinatal death rate and a high malformation rate. Further studies revealed a high rate of perinat...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1983.tb06991.x
更新日期:1983-08-01 00:00:00
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,评审
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更新日期:2003-12-01 00:00:00
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journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.1111/j.1600-0447.1981.tb00668.x
更新日期:1981-03-01 00:00:00
abstract::In Scandinavia during the past decade forensic psychiatry has been the subject of discussions, which have occasionally reached the height of vehement attacks. Changes in penal laws have expressed a declining interest in the cooperation of psychiatrists in the evaluation and treatment of offenders. Scandinavian forensi...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1977.tb00154.x
更新日期:1977-03-01 00:00:00
abstract::The promise of adopting a valid and reliable tool for diagnosing addiction-related problems is offered by the Addiction Severity Index (ASI). Socially determined admissions and poor treatment facilities may have biased the representativeness of our sample, though methodological difficulties were minimal. The ASI was u...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1988.tb06359.x
更新日期:1988-10-01 00:00:00
abstract:OBJECTIVE:To examine the association between physical and mental disorders and the separate and joint effect of physical and mental disorders on work-loss. METHOD:Data was derived from the Netherlands Mental Health Survey and Incidence Study. This was a general population study in which 7076 adults, aged between 18 an...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2005.00513.x
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:Selective outcome reporting poses serious implications on our evidence base for best practice. The extent to which selective outcome reporting and trial registration occurs in the wider psychotherapy literature needs to be investigated. METHOD:Randomized controlled psychotherapy trials published between 2010...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/acps.12647
更新日期:2017-01-01 00:00:00
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journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.1034/j.1600-0447.2003.00156.x
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to analyse the cost-incidence of schizophrenia in two areas with widely differing health service systems. METHOD:The costs of patients with schizophrenia in the 3 years after the first service contact were evaluated (i) in an area (A) with fully developed mental health community prog...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1999.tb10876.x
更新日期:1999-11-01 00:00:00
abstract::We investigated the immune-associated antigens of peripheral lymphocytes from 13 patients with Alzheimer's disease (AD) and 13 age-matched healthy control subjects using two-color analysis with flow cytometry. Four ratios of immune-related antigens, T/B lymphocytes, CD4/CD8, CD4/CD45R and CD4/HLA-DR, were compared for...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1991.tb05573.x
更新日期:1991-06-01 00:00:00
abstract::Thirty-nine phobic patients from India were compared with 39 similarly diagnosed age and sex matched patients from the United Kingdom. The British sample contained significantly more patients with agoraphobia and social phobia compared to the Indian group. Sudden death and illness phobias were more frequent in the Ind...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1986.tb06259.x
更新日期:1986-10-01 00:00:00
abstract::A retrospective study of factors predicting readmissions and follow-up treatment was undertaken of all first-ever episodes of inpatient care (age under 65), excluding psychotic and organic mental disorders, during 1987 and 1988 in University Psychiatric Clinic in Turku City Hospital, Finland. The cohort consisted of 6...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1995.tb09557.x
更新日期:1995-08-01 00:00:00