A comparison of paroxetine, clomipramine and placebo in the treatment of panic disorder. Collaborative Paroxetine Panic Study Investigators.

Abstract:

:The aim of this 12-week, double-blind, parallel group, placebo-controlled study was to compare paroxetine with clomipramine in 367 patients with DSM-III-R defined panic disorder. Efficacy assessments included the daily panic attack diary, the Clinical Global Impression Scale, the Hamilton Anxiety Rating Scale, the Marks Sheehan Phobia Scale and the Sheehan Disability Scale. Paroxetine produced significant improvements compared with placebo in various measurements of panic attack frequency, and was as effective as clomipramine. However, paroxetine appeared to have a more rapid onset of action than clomipramine in reducing the number of panic attacks to zero. There was an equivalent improvement with both paroxetine and clomipramine in the supportive efficacy variables which assessed associated aspects of therapeutic improvement. Significantly more adverse effects were reported in the clomipramine group compared with the paroxetine group, while there was no difference between the paroxetine and placebo groups.

journal_name

Acta Psychiatr Scand

authors

Lecrubier Y,Bakker A,Dunbar G,Judge R

doi

10.1111/j.1600-0447.1997.tb00388.x

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

145-52

issue

2

eissn

0001-690X

issn

1600-0447

journal_volume

95

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Two subtypes of adolescent suicide attempters. An empirical classification.

    abstract::An empirical classification of 203 adolescent suicide attempters (mean age 17.3) was achieved using multiple correspondence analysis. The characteristics upon which the classification is based concern sociodemographic as well as psychological variables. Two groups are identified: the first is predominantly characteriz...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1993.tb03324.x

    authors: Kienhorst CW,de Wilde EJ,van den Bout J,van der Burg E,Diekstra RF,Wolters WH

    更新日期:1993-01-01 00:00:00

  • Impact of substance use on the physical health of patients with bipolar disorder.

    abstract:OBJECTIVE:To describe the impact of tobacco, alcohol and cannabis on metabolic profile and cardiovascular risk in bipolar patients. METHOD:Naturalistic, cross-sectional, multicenter Spanish study. Current use of tobacco, alcohol and cannabis was determined based on patient self-reports. Metabolic syndrome was defined ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/j.1600-0447.2009.01498.x

    authors: Garcia-Portilla MP,Saiz PA,Benabarre A,Florez G,Bascaran MT,Díaz EM,Bousoño M,Bobes J

    更新日期:2010-06-01 00:00:00

  • Determinants of decision-making in the screening procedure of a community psychiatric service.

    abstract::This study is a predictor analysis of the screening procedure followed by a psychiatric service for a period of 1 year preceding and a period of 1 year following the introduction of community psychiatry. Throughout this period, the psychiatric service consisted of a local service within the catchment area and a centra...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1996.tb09841.x

    authors: Søgaard HJ,Søndergaard I

    更新日期:1996-09-01 00:00:00

  • A combined analysis of double-blind studies with risperidone vs. placebo and other antipsychotic agents: factors associated with extrapyramidal symptoms.

    abstract::Combined data from double-blind risperidone studies were used to analyse the severity of extrapyramidal symptoms (EPS) associated with treatment in patients with chronic schizophrenia. Factors associated with maximum EPS severity were increasing risperidone dose (< or = 8 mg/day was similar to placebo), lower baseline...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0447.1999.tb00972.x

    authors: Lemmens P,Brecher M,Van Baelen B

    更新日期:1999-03-01 00:00:00

  • Hippocampal volume in relation to clinical and cognitive outcome after electroconvulsive therapy in depression.

    abstract:OBJECTIVE:In a previous magnetic resonance imaging (MRI) study, we found a significant increase in hippocampal volume immediately after electroconvulsive therapy (ECT) in patients with depression. The aim of this study was to evaluate hippocampal volume up to 1 year after ECT and investigate its possible relation to cl...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/acps.12150

    authors: Nordanskog P,Larsson MR,Larsson EM,Johanson A

    更新日期:2014-04-01 00:00:00

  • Economic impact of antidepressant treatment duration in naturalistic conditions.

    abstract:OBJECTIVE:To assess the economic impact of the duration of antidepressant drug treatment in a real-life setting. METHOD:A historical fixed cohort study included 27 917 patients aged 18 and over with a new antidepressant treatment registered in the national insurance database. The economic impact concerned healthcare e...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/acps.12035

    authors: Tournier M,Crott R,Gaudron Y,Verdoux H

    更新日期:2013-05-01 00:00:00

  • Mental disorder in youth suicide. DSM-III-R Axes I and II.

    abstract::A 3-year urban material of suicides in adolescents and young adults (age 15-29 years) was studied retrospectively by means of interviews with survivors (n = 58). Classification of mental disorders according to DSM-III-R showed that major depression was important as background to suicides in 41%, primary (22%) or secon...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1989.tb10292.x

    authors: Runeson B

    更新日期:1989-05-01 00:00:00

  • Torsade de pointes in a patient with complex medical and psychiatric conditions receiving low-dose quetiapine.

    abstract:OBJECTIVE:Describe potential cardiac complications of low-dose quetiapine and other atypical antipsychotic drugs. METHOD:We present a case report of a 45-year-old Black woman with multiple medical and psychiatric problems taking low-dose quetiapine. RESULTS:Coincident with a generalized seizure, the patient developed...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.2005.00592.x

    authors: Vieweg WV,Schneider RK,Wood MA

    更新日期:2005-10-01 00:00:00

  • Self-rated schizotypal cognitions, psychotic symptoms and the onset of schizophrenia in young people at high risk of schizophrenia.

    abstract:OBJECTIVE:To examine the associations between the Rust Inventory of Schizotypal Cognitions (RISC) and psychotic symptoms measured by the Present State Examination (PSE) and to assess the predictive validity of the RISC for later onset of schizophrenia. METHOD:A total of 154 subjects at high risk for schizophrenia but ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0447.2002.1o175.x

    authors: Miller PM,Lawrie SM,Byrne M,Cosway R,Johnstone EC

    更新日期:2002-05-01 00:00:00

  • Persistent auditory hallucinations correlate with the size of the third ventricle in schizophrenic patients.

    abstract::In a study of psychotherapy in schizophrenic patients, the existence of certain clinical and anamnestic variables, such as persistent auditory hallucinations, was found to correlate with a negative outcome. To test whether these clinical variables could be a sign of organic brain abnormality, the records of 33 schizop...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1992.tb03299.x

    authors: Cullberg J,Nybäck H

    更新日期:1992-12-01 00:00:00

  • A clinical trial comparing sustained release amitryptyline (Saroten Retard) and conventional amitriptyline tablets (Saroten) in endogenously depressed patients with simultaneous determination of serum levels of amitryptyline and nortriptyline.

    abstract::The clinical effect of a sustained release preparation of amitriptyline has been compared with that of conventional amitriptyline tablets in a double-blind cross-over study with 24 patients suffering from endogenous depression. The sustained release preparation was given in a single evening dose (9 p.m.) of two thirds...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0447.1978.tb06911.x

    authors: Liisberg P,Mose H,Amdisen A,Jørgensen A,Petersen HE

    更新日期:1978-05-01 00:00:00

  • Validation of psychiatric patients' statements on coercive measures.

    abstract:OBJECTIVE:To investigate the accuracy of psychiatric patients' statements on coercive measures compared with medical file information using empirical methodology, and relating the statements to patients' psychopathology. METHOD:One hundred and forty-three in-patients were identified consecutively, and interviewed usin...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0447.2001.00146.x

    authors: Poulsen HD,Engberg M

    更新日期:2001-01-01 00:00:00

  • Long-term outcome of offspring after maternal severe puerperal disorder.

    abstract:OBJECTIVE:To study adult mental health in offspring of mothers who experienced severe puerperal disorder. METHOD:Mothers, followed up a mean of 23 years after puerperal disorder requiring hospitalization, were interviewed regarding adult psychiatric illness, childhood neurotic symptoms and conduct problems of 48 offsp...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.2004.00406.x

    authors: Abbott R,Dunn VJ,Robling SA,Paykel ES

    更新日期:2004-11-01 00:00:00

  • Sertraline-induced hypomania: a genuine side-effect.

    abstract:OBJECTIVE:Antidepressants including selective serotonin reuptake inhibitor (SSRI)-associated mania or hypomania has been well documented in the literature but these patients with switch have either mood disorders or various risk factors for bipolar disorder. This case report examines SSRI-induced hypomania in a patient...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0447.2003.00080.x

    authors: Mendhekar DN,Gupta D,Girotra V

    更新日期:2003-07-01 00:00:00

  • Immunoglobulins, psychopathology and prognosis in schizophrenia.

    abstract::On admission, IgA, IgG and IgM concentrations were determined in 76 schizophrenics, and the correlations of these concentrations to the variables relating to psychopathology, background and prognosis were investigated in the present study, which is a part of a more extensive unpublished study. On the basis of factoriz...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1977.tb03560.x

    authors: Pulkkinen E

    更新日期:1977-09-01 00:00:00

  • Consistent evidence for a biological subtype of depression characterized by low CSF monoamine levels.

    abstract::Analysis of previously published CSF monoamine data has revealed statistical evidence for a biological subtype of depression, characterized by abnormally low CSF-5HIAA and CSF HVA. Using maximum likelihood gaussian mixture analysis we were able to resolve the empirical frequency distributions of both CSF HVA and CSF 5...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1986.tb06219.x

    authors: Gibbons RD,Davis JM

    更新日期:1986-07-01 00:00:00

  • Acute and transient psychotic disorder: comorbidity with personality disorder.

    abstract::A study sample of 51 patients with acute and transient psychotic disorder (ATPD) (ICD-10) is presented. The findings suggest that, in hospital settings, ATPD is a non-frequent condition with onset in early adult life and most often associated with female sex, good premorbid social functioning and no or minor/moderate ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1996.tb09891.x

    authors: Jørgensen P,Bennedsen B,Christensen J,Hyllested A

    更新日期:1996-12-01 00:00:00

  • The truth about suicide in Portugal.

    abstract::It seems odd that male suicide rates have decreased in Portugal over the last few years, whereas the opposite has happened in most other countries. In order to investigate the reasons for such a decrease, suicide rates were compared with controversial cases (ICD-9 category E 980-989) and with homicide rates. The resul...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1989.tb02989.x

    authors: de Castro EF,Pimenta F,Martins I

    更新日期:1989-10-01 00:00:00

  • A double-blind study of alprazolam and oxazepam in the treatment of anxiety.

    abstract::In a randomized double-blind study with parallel group design involving 60 anxious psychoneurotic outpatients, the anxiolytic activity of alprazolam was compared with that of oxazepam. Following a 4 to 7-day placebo washout period, both groups showed a similar and significant response to treatment during the 4-week ac...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1600-0447.1987.tb02830.x

    authors: Väisänen E,Jalkanen E

    更新日期:1987-05-01 00:00:00

  • Gender differences in the incidence of definite schizophrenia and atypical psychosis--focus on negative symptoms of schizophrenia.

    abstract::In a catchment area study of 101 first inceptions of schizophrenia, mania and atypical psychoses, women were significantly more likely to have atypical psychosis and men were more likely to have definite schizophrenia. Negative symptoms such as affective flattening and poverty of speech were already present in many ca...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1991.tb03182.x

    authors: Ring N,Tantam D,Montague L,Newby D,Black D,Morris J

    更新日期:1991-12-01 00:00:00

  • Dexamethasone suppression and energy balance in eating disorders.

    abstract::The dexamethasone suppression test (DST) was investigated in 45 female anorectic out-patients (cross sectional study) nine of whom were followed serially as in-patients (longitudinal study). DST non-suppression was strongly associated with negative energy balance (low body weight and low Ponderal Index) but there was ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1986.tb02681.x

    authors: Abou-Saleh MT,Oleesky D,Crisp AH,Lacey JH

    更新日期:1986-03-01 00:00:00

  • Psychiatric disorders in a rural practice in the Bendel State of Nigeria.

    abstract::Patients attending a clinic were ascertained for psychiatric morbidity by a general practitioner and reascertained by a psychiatrist. The agreement ranged from 84% for neurosis and 60% for psychosis. The differences were mainly due to a lack of the depression category in the general practitioner's classification. One ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1981.tb00784.x

    authors: Binitie A

    更新日期:1981-10-01 00:00:00

  • Multidimensional hierarchic ordering of psychopathology. Rasch analysis in factor-analytic dimensions.

    abstract::Both the classification based on independent psychiatric categories as well as the concept of an underlying 1-dimensional hierarchy of syndromes are insufficiently valid. At symptom level we previously found 5 factor-analytical components representing 6 dimensions of psychopathology. Rasch analysis based on the preval...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1994.tb01614.x

    authors: Goekoop JG,Zwinderman AH

    更新日期:1994-12-01 00:00:00

  • Early identification of bipolar disorder among young adults - a 22-year community birth cohort.

    abstract:OBJECTIVE:We set forth to build a prediction model of individuals who would develop bipolar disorder (BD) using machine learning techniques in a large birth cohort. METHODS:A total of 3748 subjects were studied at birth, 11, 15, 18, and 22 years of age in a community birth cohort. We used the elastic net algorithm wit...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/acps.13233

    authors: Rabelo-da-Ponte FD,Feiten JG,Mwangi B,Barros FC,Wehrmeister FC,Menezes AM,Kapczinski F,Passos IC,Kunz M

    更新日期:2020-12-01 00:00:00

  • Acculturation is associated with the prevalence of tardive dyskinesia and akathisia in community-treated patients with schizophrenia.

    abstract:OBJECTIVE:Ethnicity is a risk factor for tardive dyskinesia (TD) and other antipsychotic drug-induced movement disorders (ADIMD). It is unclear whether this association is mediated through genetic, environmental or cultural factors individually or in combination. This pilot study aimed to explore this interaction by de...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.2008.01183.x

    authors: Sundram S,Lambert T,Piskulic D

    更新日期:2008-06-01 00:00:00

  • Does the place of treatment influence the quality of life of schizophrenics?

    abstract:OBJECTIVE:Chronically mentally ill patients in community mental health care report a better quality of life (QOL) than those in long-term hospital care, which suggests that the treatment setting per se influences their QOL. METHOD:In a region where both treatment settings are of a comparable high standard, we assessed...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1999.tb10835.x

    authors: Rössler W,Salize HJ,Cucchiaro G,Reinhard I,Kernig C

    更新日期:1999-08-01 00:00:00

  • Non-suicidal self-injury and its co-occurrence with suicidal behavior: An epidemiological-study among adolescents and young adults.

    abstract:OBJECTIVE:Non-suicidal self-injury (NSSI) comprising thoughts and behaviors is common and often co-occurring with suicidal behavior like ideation, plan, and attempt. As limited data are available for adolescents and young adults, this study aims to present prevalence estimates for lifetime NSSI, its co-occurrence with ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/acps.13237

    authors: Voss C,Hoyer J,Venz J,Pieper L,Beesdo-Baum K

    更新日期:2020-12-01 00:00:00

  • A multivariate study of simultaneous escape from suppression by dexamethasone of urinary free cortisol, plasma cortisol, adrenocorticotropic hormone and beta-endorphin in melancholic patients.

    abstract::To investigate the relationships between pre- and postdexamethasone hypothalamic-pituitary-adrenal (HPA) axis functioning in depression, we measured the levels of baseline and postdexamethasone urinary free cortisol (UFC), plasma cortisol, adrenocorticotropic hormone (ACTH) and beta-endorphin. We found that dexamethas...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1991.tb05580.x

    authors: Maes M,Vandervorst C,Suy E,Minner B,Raus J

    更新日期:1991-06-01 00:00:00

  • Polypharmacy among psychiatric patients.

    abstract::The purpose of the present study is to determine the frequency of polypharmacy among psychiatric patients in Helsinki, and to ascertain whether this practice is supported by clinical trials. The drugs prescribed in 1 day to a sample of patients (n = 694) in mental hospitals and outpatient clinics in Helsinki were stud...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0447.1977.tb06676.x

    authors: Hemminki E

    更新日期:1977-11-01 00:00:00

  • Dose-response relationship of sertindole and haloperidol using the pharmacopsychometric triangle.

    abstract:OBJECTIVE:Renewed insight into dose-related effects of sertindole and haloperidol was sought by re-analysing published data for antipsychotic effect, extrapyramidal effect, and patient wellbeing - i.e., the important pharmacopsychometric triangle domains. METHOD:Selected Positive and Negative Syndrome Scale (PANSS) su...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1600-0447.2010.01581.x

    authors: Bech P,Tanghøj P,Andreasson K,Overø KF

    更新日期:2011-02-01 00:00:00