Abstract：
:This study investigated the peripheral frequency of monocytes, CD4 + T cell subsets and the systemic levels of cytokines in lean and obese men with different levels of cardiorespiratory fitness (CRF). Mononuclear cells were obtained from 45 lean and 45 obese men who were assigned into six groups according to their body mass index and CRF (low, moderate, or high VO2Peak ) to analyze the frequency of monocyte subsets and subpopulations of CD4 + T cells (Treg cells, CD4 + CD25high CD127low ; mTeff, CD4 + CD25-CD39+; mTreg, CD4 + CD25+CD39+). The systemic levels of interleukin (IL)-6, IL-10, IL-17a, IL-33, leptin, and tumor necrosis factor-alpha (TNF-α) were also evaluated. Seven sedentary obese men performed one week of high-intensity interval training (HIIT, 3 sessions/week), and blood samples were collected before and 24 hours after the last session for phenotypic analysis of T cells and monocytes. Obese individuals presented an inflammatory profile characterized by lower frequencies of Treg and mTreg cells and higher proportions of proinflammatory monocytes. However, higher CRF status increased the frequencies of Treg cells and mTreg cells and decreased the percentage of CD4 + mTeff cells and intermediate and non-classical monocytes in the peripheral blood from lean and obese men. Systemic lower levels of proinflammatory (IL-6 and TNF-) cytokines and higher concentrations of IL-10 and IL-33 were observed in moderate and higher CRF in all subjects. HIIT increased the proportions of circulating mTreg and Treg cells in sedentary obese individuals. The immunoregulatory role of CRF contributes to the maintenance of low levels of inflammatory mediators.
journal_name
Scand J Med Sci Sportsjournal_title
Scandinavian journal of medicine & science in sportsauthors
Dorneles GP,da Silva I,Boeira MC,Valentini D,Fonseca SG,Dal Lago P,Peres A,Romão PRTdoi
10.1111/sms.13506subject
Has Abstractpub_date
2019-11-01 00:00:00pages
1755-1765issue
11eissn
0905-7188issn
1600-0838journal_volume
29pub_type
杂志文章abstract：:The purpose of this study was to examine the nature, extent and severity of sports injuries in young female players in European team handball and to identify the etiological factors involved in the injuries. Twenty-two teams with 217 players, aged 16-18 years, participated in the study. A very high injury incidence du...
journal_title：Scandinavian journal of medicine & science in sports
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journal_title：Scandinavian journal of medicine & science in sports
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journal_title：Scandinavian journal of medicine & science in sports
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journal_title：Scandinavian journal of medicine & science in sports
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journal_title：Scandinavian journal of medicine & science in sports
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journal_title：Scandinavian journal of medicine & science in sports
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journal_title：Scandinavian journal of medicine & science in sports
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1997-06-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1034/j.1600-0838.2000.010001033.x
更新日期：2000-02-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/j.1600-0838.1998.tb00190.x
更新日期：1998-06-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/j.1600-0838.2008.00801.x
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/j.1600-0838.2010.01181.x
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journal_title：Scandinavian journal of medicine & science in sports
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doi：10.1111/j.1600-0838.2007.00756.x
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章,随机对照试验
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journal_title：Scandinavian journal of medicine & science in sports
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章,随机对照试验
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journal_title：Scandinavian journal of medicine & science in sports
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journal_title：Scandinavian journal of medicine & science in sports
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doi：10.1111/j.1600-0838.2009.01076.x
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journal_title：Scandinavian journal of medicine & science in sports
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