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Vitamin D binding protein isoforms as candidate predictors of disease extension in childhood arthritis.

Abstract：

INTRODUCTION:Juvenile idiopathic arthritis (JIA) comprises a poorly understood group of chronic autoimmune diseases with variable clinical outcomes. We investigated whether the synovial fluid (SF) proteome could distinguish a subset of patients in whom disease extends to affect a large number of joints. METHODS:SF samples from 57 patients were obtained around time of initial diagnosis of JIA, labeled with Cy dyes and separated by two-dimensional electrophoresis. Multivariate analyses were used to isolate a panel of proteins which distinguish patient subgroups. Proteins were identified using MALDI-TOF mass spectrometry with expression verified by immunochemical methods. Protein glycosylation status was confirmed by hydrophilic interaction liquid chromatography. RESULTS:A truncated isoform of vitamin D binding protein (VDBP) is present at significantly reduced levels in the SF of oligoarticular patients at risk of disease extension, relative to other subgroups (p<0.05). Furthermore, sialylated forms of immunopurified synovial VDBP were significantly reduced in extended oligoarticular patients (p<0.005). CONCLUSION:Reduced conversion of VDBP to a macrophage activation factor may be used to stratify patients to determine risk of disease extension in JIA patients.

journal_name

J Proteomics

journal_title

Journal of proteomics

authors

Gibson DS,Newell K,Evans AN,Finnegan S,Manning G,Scaife C,McAllister C,Pennington SR,Duncan MW,Moore TL,Rooney ME

doi

10.1016/j.jprot.2012.06.024

subject

Has Abstract

pub_date

2012-09-18 00:00:00

pages

5479-92

issue

17

eissn

1874-3919

issn

1876-7737

pii

S1874-3919(12)00490-3

journal_volume

75

pub_type

杂志文章

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